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A prospective and randomized trial of zoledronic acid to prevent bone loss in the first year after kidney transplantation

Grant number: 11/22962-3
Support type:Regular Research Grants
Duration: August 01, 2012 - July 31, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Elias David-Neto
Grantee:Elias David-Neto
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers: Igor Denizarde Bacelar Marques ; Melani Ribeiro Custódio ; Rosa Maria Affonso Moysés ; Rosa Maria Rodrigues Pereira ; Vanda Jorgetti

Abstract

For the treatment of osteoporosis in the general population, a number of drugs reduce BMD (bone mineral density) loss and the rate of incident fractures. For instance, bisphosphonates improve BMD, reduce hip fracture rates and decrease mortality in post-menopausal women. Because of lack of data on safety and an increased risk of adverse effects, the use of these drugs is controversial in patients with CKD and abnormalities of PTH or vitamin D, an estimated glomerular filtration rate (GFR) less than 30 ml/min/1.73m² (stages 4 and 5) and after transplantation. The efficacy of short and long term bisphosphonate treatment after kidney transplantation has been examined; however, histomorphometric and fracture rate reduction data are lacking. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BACELAR MARQUES, IGOR DENIZARDE; LIMA NEPOMUCENO ARAUJO, MARIA JULIA CORREIA; GRACIOLLI, FABIANA GIORGETTI; DOS REIS, LUCIENE MACHADO; PEREIRA, ROSA MARIA R.; ALVARENGA, JACKELINE C.; CUSTODIO, MELANI RIBEIRO; JORGETTI, VANDA; ELIAS, ROSILENE MOTTA; AFFONSO MOYSES, ROSA MARIA; DAVID-NETO, ELIAS. A Randomized Trial of Zoledronic Acid to Prevent Bone Loss in the First Year after Kidney Transplantation. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v. 30, n. 2, p. 355-365, FEB 2019. Web of Science Citations: 7.
RAMALHO, J.; MARQUES, I. D. B.; HANS, DIDIER; DEMPSTER, DAVID; ZHOU, HUA; PATEL, PARTH; PEREIRA, R. M. R.; JORGETTI, V.; MOYSES, R. M. A.; NICKOLAS, THOMAS L. The trabecular bone score: Relationships with trabecular and cortical microarchitecture measured by HR-pQCT and histomorphometry in patients with chronic kidney disease. BONE, v. 116, p. 215-220, NOV 2018. Web of Science Citations: 5.
HERNANDEZ, MARIEL J.; DOS REIS, LUCIENE M.; MARQUES, IGOR D.; ARAUJO, MARIA J.; TRUYTS, CESAR A. M.; OLIVEIRA, IVONE B.; BARRETO, FELLYPE C.; DAVID-NETO, ELIAS; CUSTODIO, MELANI R.; MOYSES, ROSA M.; BELLORIN-FONT, EZEQUIEL; JORGETTI, VANDA. The effect of vitamin D and zoledronic acid in bone marrow adiposity in kidney transplant patients: A post hoc analysis. PLoS One, v. 13, n. 5 MAY 25 2018. Web of Science Citations: 0.
MARQUES, I. D. B.; ARAUJO, M. J. C. L. N.; GRACIOLLI, F. G.; DOS REIS, L. M.; PEREIRA, R. M.; CUSTODIO, M. R.; JORGETTI, V.; ELIAS, R. M.; DAVID-NETO, E.; MOYSES, R. M. A. Biopsy vs. peripheral computed tomography to assess bone disease in CKD patients on dialysis: differences and similarities. OSTEOPOROSIS INTERNATIONAL, v. 28, n. 5, p. 1675-1683, MAY 2017. Web of Science Citations: 11.

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