Influence of instability associated with strength training and regular strength training on the neuromuscular adaptations and functionality associated with muscle weakness in health and Parkinson Disease elderly

• Grant number: 12/03056-4
• Support Opportunities: Regular Research Grants
• Duration: September 01, 2012 - August 31, 2014
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Carlos Ugrinowitsch
• Grantee: Carlos Ugrinowitsch
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The aging process is accompanied by physical, behavioral, and cognitive declines, which produce a great impact on the independency and functionality of the elderly, especially in those individuals with degenerative diseases like Parkinson disease (PD). Muscle weakness is one of the major causes of the decreased functionality on this population as it diminishes mobility and balance, alters the gait pattern, increasing the risk of falls. Muscle weakness is produced by both muscle tissue loss (i.e. sarcopenia) and neural changes (i.e. neural apoptosis). Even though strength training (ST) seems to have a positive impact in the quality of life of healthy elderly individuals and ones with PD, training regimens that impose greater coordinative and motor control demands may have a higher potential to enhance the functionality of this population. In this regard, resistance training performed on instability platforms (IST) seems to be an attractive alternative due to the high proprioceptive overload, and motor control required to perform the training exercises. However, to the best of our knowledge, there are no reports in the literature comparing the functional and neuromuscular adaptations produced by ST and IST. Thus, the purpose of this study is to compare the functional and neuromuscular adaptations produced by ST and IST in healthy and PD elderly. In order to test this hypothesis, 90 old individuals (45 healthy and 45 with PD) will be divided into three groups (i.e. control, ST, and IST). Intervention groups will train for 12 weeks. Maximum dynamic and isometric muscle strength, recruitment and de-recruitment of the motor units, activation deficit and reciprocal and pre-synaptic inhibition will be evaluated pre- and post-intervention. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA-BATISTA, CARLA; TAVARES MATTOS, EUGENIA CASELLA; CORCOS, DANIEL M.; WILSON, JESSICA M.; HECKMAN, CHARLES J.; KANEGUSUKU, HELCIO; PIMENTEL PIEMONTE, MARIA ELISA; DE MELLO, MARCO TULIO; FORJAZ, CLAUDIA; ROSCHEL, HAMILTON; et al. Resistance training with instability is more effective than resistance training in improving spinal inhibitory mechanisms in Parkinson's disease. Journal of Applied Physiology, v. 122, n. 1, p. 1-10, JAN 2017. (12/03056-4, 13/04970-4)

SILVA-BATISTA, CARLA; DE BRITO, LEANDRO C.; CORCOS, DANIEL M.; ROSCHEL, HAMILTON; DE MELLO, MARCO T.; PIEMONTE, MARIA E. P.; TRICOLI, VALMOR; UGRINOWITSCH, CARLOS. RESISTANCE TRAINING IMPROVES SLEEP QUALITY IN SUBJECTS WITH MODERATE PARKINSON'S DISEASE. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 31, n. 8, p. 2270-2277, AUG 2017. (12/03056-4, 13/04970-4)

MIYASATO, ROBERTO S.; SILVA-BATISTA, CARLA; PECANHA, TIAGO; LOW, DAVID A.; DE MELLO, MARCO T.; PIEMONTE, MARIA E. P.; UGRINOWITSCH, CARLOS; FORJAZ, CLAUDIA L. M.; KANEGUSUKU, HELCIO. Cardiovascular Responses During Resistance Exercise in Patients With Parkinson Disease. PM&R, v. 10, n. 11, p. 1145-1152, NOV 2018. (12/03056-4)

SILVA-BATISTA, CARLA; CORCOS, DANIEL M.; KANEGUSUKU, HELCIO; PIMENTEL PIEMONTE, MARIA ELISA; BUCKEN GOBBI, LILIAN TERESA; DE LIMA-PARDINI, ANDREA C.; DE MELLO, MARCO TULIO; FORJAZ, CLAUDIA L. M.; UGRINOWITSCH, CARLOS. Balance and fear of falling in subjects with Parkinson's disease is improved after exercises with motor complexity. GAIT & POSTURE, v. 61, p. 90-97, MAR 2018. (12/03056-4, 13/04970-4)

SILVA-BATISTA, CARLA; CORCOS, DANIEL M.; ROSCHEL, HAMILTON; KANEGUSUKU, HELCIO; BUCKEN GOBBI, LILIAN TERESA; PIMENTEL PIEMONTE, MARIA ELISA; TAVARES MATTOS, EUGENIA CASELLA; DE MELLO, MARCO TULIO; FORJAZ, CLAUDIA L. M.; TRICOLI, VALMOR; et al. Resistance Training with Instability for Patients with Parkinson's Disease. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 9, p. 1678-1687, SEP 2016. (12/03056-4, 13/04970-4)

SILVA-BATISTA, CARLA; CORCOS, DANIEL MONTIE; BARROSO, RENATO; DAVID, FABIAN J.; KANEGUSUKU, HELCIO; FORJAZ, CLAUDIA; DE MELLO, MARCO TULIO; ROSCHEL, HAMILTON; TRICOLI, VALMOR; UGRINOWITSCH, CARLOS. Instability Resistance Training Improves Neuromuscular Outcome in Parkinson's Disease. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 49, n. 4, p. 652-660, APR 2017. (12/03056-4, 13/04970-4)

SILVA-BATISTA, CARLA; KANEGUSUKU, HELCIO; ROSCHEL, HAMILTON; SOUZA, EDUARDO O.; CUNHA, TELMA F.; LAURENTINO, GILBERTO C.; MANOEL, JR., N.; DE MELLO, MARCO T.; PIEMONTE, MARIA E. P.; BRUM, PATRICIA C.; et al. Resistance Training with Instability in Multiple System Atrophy: A Case Report. JOURNAL OF SPORTS SCIENCE AND MEDICINE, v. 13, n. 3, p. 597-603, SEP 2014. (12/03056-4, 13/04970-4)