Croton L. (Euphorbiaceae Juss.): secondary metabolites and biological activity

• Grant number: 12/10079-0
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2012
• End date: September 30, 2014
• Field of knowledge: Biological Sciences - Botany - Applied Botany
• Principal Investigator: Cláudia Maria Furlan
• Grantee: Cláudia Maria Furlan
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Lucimar Barbosa da Motta

Abstract

Croton L., Euphorbiaceae Juss., comprises about 1,300 species of plants, widely distributed in tropical and subtropical regions of the world. Many of them are quite known for their therapeutic use in traditional medicine for the treatment of various ailments such as digestive disorders, inflammation, diabetes, and others. The chemistry of Croton is very diverse. The most common constituents are diterpenoids with different skeletons, as clerodanes, labdanes and podocarpanos. Volatile oils are very common and various species have latex rich in proantociadines, or in some species, proanthocyanidins and alkaloids. Croton alkaloids are similar to those found in Ranunculales as isoboldina and glaucina; flavonoids, mostly, are highly methoxylated aglycones, as artemetin. Since 2009, Laboratory of Phytochemistry (IB-USP) has been working with the screening of substances in hexane, dichloromethane and methanol from Croton native species to perform assays of antioxidant, antimicrobial and antiproliferative. As preliminary results, sections Cleodora (Klotzch) Baill. and Cyclostigma Griseb showed species with potential bioactive substances. This proposal has as main objective the monitored isolation and identification of diterpenes and phenolic compounds of leaves and stems of three Brazilian endemic species: C. vulnerarius Baill., C. echinocarpus Baill. and C. sphaerogynus Baill., investigating their bioactive activities: antioxidant, antiproloferative, anti-HIV and antimicrobial. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, KATIA PEREIRA; SEDANO-PARTIDA, MARTHA DALILA; MOTTA, LUCIMAR BARBOSA; CORDEIRO, INES; FURLAN, CLAUDIA M.. Antioxidant activity of flavonoids from Croton sphaerogynus Baill.. BRAZILIAN JOURNAL OF BOTANY, v. 39, n. 4, p. 1021-1030, DEC 2016. (12/10079-0)

DOS SANTOS, KATIA PEREIRA; SEDANO-PARTIDA, MARTHA DALILA; SALA-CARVALHO, WILTON RICARDO; SAN JUAN LOUREIRO, BEATRIZ ORTEGA; DA SILVA-LUZ, CINTIA LUIZA; FURLAN, CLAUDIA MARIA. Biological activity of Hyptis Jacq. (Lamiaceae) is determined by the environment. INDUSTRIAL CROPS AND PRODUCTS, v. 112, p. 705-715, FEB 2018. (12/10079-0)

RAVANELLI, N.; SANTOS, K. P.; MOTTA, L. B.; LAGO, J. H. G.; FURLAN, C. M.. Alkaloids from Croton echinocarpus Baill.: Anti-HIV potential. SOUTH AFRICAN JOURNAL OF BOTANY, v. 102, p. 153-156, JAN 2016. (12/10079-0)

SANTOS, KATIA PEREIRA; SEDANO-PARTIDA, MARTHA DALILA; MOTTA, LUCIMAR BARBOSA; CORDEIRO, INES; FURLAN, CLAUDIA M.. Antioxidant activity of flavonoids from Croton sphaerogynus Baill.. Rev. bras. Bot., v. 39, n. 4, p. 10-pg., 2016-12-01. (12/10079-0)

DOS SANTOS, KATIA PEREIRA; MOTTA, LUCIMAR B.; SANTOS, DEBORAH Y. A. C.; SALATINO, MARIA L. F.; SALATINO, ANTONIO; PENA FERREIRA, MARCELO J.; LAGO, JOAO HENRIQUE G.; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO E.; FURLAN, CLAUDIA M.. Antiproliferative Activity of Flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae). BIOMED RESEARCH INTERNATIONAL, 2015. (12/10079-0)

DOS SANTOS, KATIA PEREIRA; MOTTA, LUCIMAR B.; SANTOS, DEBORAH Y. A. C.; SALATINO, MARIA L. F.; SALATINO, ANTONIO; PENA FERREIRA, MARCELO J.; LAGO, JOAO HENRIQUE G.; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO E.; FURLAN, CLAUDIA M.. Antiproliferative Activity of Flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae). BIOMED RESEARCH INTERNATIONAL, v. 2015, p. 7-pg., 2015-01-01. (12/10079-0)