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Alterations of the TP53 gene in gastric and esophageal carcinogenesis

Grant number: 12/13847-9
Support type:Regular Research Grants - Publications - Scientific article
Duration: August 01, 2012 - January 31, 2013
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Ana Elizabete Silva
Grantee:Ana Elizabete Silva
Home Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

TP53 gene is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic stability. The development of esophageal and gastric cancers is a multistep process resulting in successive accumulation of genetic alterations that culminate in the malignant transformation. Thus, this review highlights the participation of the main genetic alterations of the TP53 gene in esophageal and gastric carcinogenesis. Among these changes, high frequency of TP53 mutations, loss of heterozygosity (LOH), overexpression of the p53 protein and consequently loss of p53 function, which would be early events in esophageal and gastric cancers, as well as an important biomarker of the prognosis and treatment response. Furthermore, Single Nucleotide Polymorphisms (SNPs) of TP53 have been implicated in the development and prognosis of several cancers, mainly TP53 codon 72 polymorphism whose role has been extensively studied in relation to susceptibility for esophageal and gastric cancer development. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BELLINI, MARILANDA FERREIRA; TARGA CADAMURO, ALINE CRISTINA; SUCCI, MAYSA; PROENCA, MARCELA ALCANTARA; SILVA, ANA ELIZABETE. Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012. Web of Science Citations: 47.

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