Synthesis of modified pseudoboehmite for use in drug delivery systems

• Grant number: 10/19157-9
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2012
• End date: August 31, 2013
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Antonio Hortencio Munhoz Junior
• Grantee: Antonio Hortencio Munhoz Junior
• Host Institution: Escola de Engenharia (EE). Universidade Presbiteriana Mackenzie (UPM). São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

The sol-gel process is a methodology for preparation of porous ceramics, vitreous and crystalline materials from molecular precursors. In this process a lattice of oxides can be made by reaction of inorganic materials. This reaction occurs in solution and the name sol-gel is used to describe the synthesis of inorganic oxides obtained in solution. Using the sol-gel process is possible to obtain high purity grade pseudoboehmite which in this project will be used in drug delivery systems. The utilization of nanostructure high performance materials in the production of smart drugs is a reality and the nano particles present a very important role in the drug delivery systems for the human treatment. Nanostructures materials made with ceramics with high specific surface area and polymers with different properties, incorporated in bioactive molecules, represent a significant advance in the pharmaceutical sciences and will play important role in the production of drugs less toxic and more efficient. This project of research deals with the utilization of a pseudoboehmite matrix treated with octadecylamine for release of glucantime®. Glucantime® is considered first-line drug in the treatment of leishmaniasis. Their efficacy and toxicity are thought to be related to their content of pentavalent antimony. The purpose of using pseudoboehmite in this drug delivery system is to reduce the concentration of the drug in the administration. The octadecylamine will be tested as a coupling agent for the pseudoboehmite-drug system. (AU)

Scientific publications

(9)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

MATHEUS FRANCELINO BEZERRA DA SILVA; CAROLINE VALADÃO PACHECO; RENATO MENEGHETTI PERES; LEILA FIGUEIREDO DE MIRANDA; NELSON BATISTA DE LIMA; RENE RAMOS DE OLIVEIRA; AYRTON BERNUSSI; ANTÔNIO HORTENCIO MUNHOZ JUNIOR. Synthesis of pseudoboehmite – effect of acetate ion. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 23, n. 1, 2020-03-13. (17/22396-4, 10/19157-9)

PERES, RENATO MENEGHETTI; LEME SOUSA, JESSICA MAIARA; DE OLIVEIRA, MARIANA OLIVA; ROSSI, MAURA VINCENZA; DE OLIVEIRA, RENE RAMOS; DE LIMA, NELSON BATISTA; BERNUSSI, AYRTON; WARZYWODA, JULIUSZ; SARMENTO, BRUNO; MUNHOZ JR, ANTONIO HORTENCIO. Pseudoboehmite as a drug delivery system for acyclovir. SCIENTIFIC REPORTS, v. 11, n. 1, JUL 29 2021. (17/22396-4, 10/19157-9)

MUNHOZ JUNIOR, ANTONIO HORTENCIO; GALHARDO, GUSTAVO FIGUEIREDO; ORTEGA, FERNANDO DOS SANTOS; DE LIMA, NELSON BATISTA; MORAES, DENISON ANGELOTTI; DE MIRANDA, LEILA FIGUEIREDO; VALENZUELA-DIAZ, FRANCISCO ROLANDO; LI, B; LI, J; IKHMAYIES, S; et al. Alpha-Alumina Synthesis Using Gamma-Alumina Powders. CHARACTERIZATION OF MINERALS, METALS, AND MATERIALS 2019, v. N/A, p. 11-pg., 2019-01-01. (10/19157-9, 17/22396-4)

PACHECO, CAROLINE VALADAO; PERES, RENATO MENEGHETTI; CARRIERI, GABRIELA; MINUSSI, GIULIA REIS; ZAMBRANA, GUIDO PRANDINI; KANG, JESSICA SEONG HYUN; DE OLIVEIRA, RENE RAMOS; DE LIMA, NELSON BATISTA; BERNUSSI, AYRTON; WARZYWODA, JULIUSZ; et al. Cement-Based Composites Incorporating Pseudoboehmite Nanomaterials. JOURNAL OF MATERIALS IN CIVIL ENGINEERING, v. 35, n. 2, p. 11-pg., 2023-02-01. (10/19157-9, 17/22396-4)

MUNHOZ JR, ANTONIO HORTENCIO; ROMERO FILHO, MARCOS; KLEIST, HENRIQUE DE ARRUDA; MORENO, GUILHERME DIAS; DE OLIVEIRA, MARIANA OLIVA; PERES, RENATO MENEGHETTI; ROSSI, MAURA VINCENZA; DE MIRANDA, LEILA FIGUEIREDO; RIBEIRO, ROBERTO RODRIGUES; CARDOSO SARMENTO, BRUNO FILIPE CARMELINO. Synthesis of pseudoboehmite-graphene oxide for drug delivery system. MATERIALS TODAY-PROCEEDINGS, v. 14, p. 8-pg., 2019-01-01. (17/22396-4, 10/19157-9)

MUNHOZ JUNIOR, ANTONIO HORTENCIO; PACHECO, CAROLINE VALADAO; MELO, HENRIQUE TADEU T. S.; PERES, RENATO MENEGHETTI; DE ANDRADE E SILVA, LEONARDO GONDIM; LI, B; LI, J; IKHMAYIES, S; ZHANG, M; KALAY, YE; et al. Characterization of a Composite of High-Impact Polystyrene, Pseudoboehmite and Graphene Oxide. CHARACTERIZATION OF MINERALS, METALS, AND MATERIALS 2019, v. N/A, p. 12-pg., 2019-01-01. (17/22396-4, 10/19157-9)

BEZERRA DA SILVA, MATHEUS FRANCELINO; PACHECO, CAROLINE VALADAO; PERES, RENATO MENEGHETTI; DE MIRANDA, LEILA FIGUEIREDO; DE LIMA, NELSON BATISTA; DE OLIVEIRA, RENE RAMOS; BERNUSSI, AYRTON; MUNHOZ JUNIOR, ANTONIO HORTENCIO. Synthesis of pseudoboehmite - effect of acetate ion. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 23, n. 1, 2020. (17/22396-4, 10/19157-9)

MUNHOZ, ANTONIO HORTENCIO, JR.; DE ANDRADE E SILVA, LEONARDO GONDIN; DE MIRANDA, LEILA FIGUEIREDO; ANDRADES, RAPHAEL CONS; IKHMAYIES, SJ; LI, B; CARPENTER, JS; HWANG, JY; MONTEIRO, SN; LI, J; et al. CHARACTERIZATION OF GAMMA-ALUMINA OBTAINED FROM AGED PSEUDOBOEHMITES. CHARACTERIZATION OF MINERALS, METALS, AND MATERIALS 2016, v. N/A, p. 7-pg., 2016-01-01. (10/19157-9)

MUNHOZ JUNIOR, A. H.; MARTINS, J. S.; RIBEIRO, R. R.; MIRANDA, L. F.; ANDRADES, R. C.; BERTACHINI, K. C.; SILVA, L. G. A.. Use of pseudoboehmite nanoparticles for drug delivery system of glucantime (R). Journal of Nano Research, v. 38, p. 47+, 2016. (10/19157-9)