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Vibrational spectroscopy applied to biological tissues: cancer diagnosis and chemical characterization of laser irradiated dental tissues

Grant number: 12/02460-6
Support type:Regular Research Grants
Duration: September 01, 2012 - August 31, 2014
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Luciano Bachmann
Grantee:Luciano Bachmann
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The objective of this project is to employ Fourier transform infrared spectroscopy (FTIR) in the diagnosis of cancerous lesions and in the chemical characterization of laser-irradiated enamel and dentine. The first subproject will employ FTIR, which is recognized as a useful technique for cancer diagnosis, but in this project it will be associated with paraffin-embedded samples, which are routinely employed in pathology laboratories but not in FTIR analysis. Currently, there is only one research group working with this association; i.e., FTIR and paraffin-embedded samples and, according to this research team, this technique is disseminating quickly because the use of such kind of samples in FTIR analysis is viable for cancer diagnosis. The second subproject is proposed on the basis of previous works, where we have identified a possible correlation of water loss and enamel opacity with dentin browning and collagen degradation. Herein we propose the validation of this hypothesis and provide irradiation parameters showing that these changes are reversible for some lasers parameters. Additionally, we will determine the collagen degradation by Er:YAG laser-irradiated dentin and the loss of carbonate in the enamel after CO2-10.6µm and Nd:YAG laser irradiation at subsurface regions. The expected results are interesting when it comes to the improvement of irradiation parameters for restorative procedures using Er:YAG lasers and also of parameters for caries prevention using CO2-10.6µm and Nd:YAG lasers. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KREVE, SIMONE; OLIVEIRA, VIVIANE C.; BACHMANN, LUCIANO; ALVES, OSWALDO L.; DOS REIS, ANDREA C. Influence of AgVO3 incorporation on antimicrobial properties, hardness, roughness and adhesion of a soft denture liner. SCIENTIFIC REPORTS, v. 9, AUG 15 2019. Web of Science Citations: 0.
TARTARI, T.; WICHNIESKI, C.; BACHMANN, L.; JAFELICCI, JR., M.; SILVA, R. M.; LETRA, A.; VAN DER HOEVEN, R.; DUARTE, M. A. H.; BRAMANTE, C. M. Effect of the combination of several irrigants on dentine surface properties, adsorption of chlorhexidine and adhesion of microorganisms to dentine. International Endodontic Journal, v. 51, n. 12, p. 1420-1433, DEC 2018. Web of Science Citations: 0.
TARTARI, T.; BACHMANN, L.; ZANCAN, R. F.; VIVAN, R. R.; DUARTE, M. A. H.; BRAMANTE, C. M. Analysis of the effects of several decalcifying agents alone and in combination with sodium hypochlorite on the chemical composition of dentine. International Endodontic Journal, v. 51, n. 1, SI, p. E42-E54, JAN 2018. Web of Science Citations: 9.
BRANDAO, MARIANA P.; IWAKURA, RICARDO; HONORATO-SOBRINHO, ABRAAO A.; HALEPLIAN, KAIQUE; ITO, AMANDO S.; CONTI DE FREITAS, LUIZ C.; BACHMANN, LUCIANO. Optical Characterization of Parathyroid Tissues. Applied Spectroscopy, v. 70, n. 10, p. 1709-1716, OCT 2016. Web of Science Citations: 0.
TARTARI, TALITA; BACHMANN, LUCIANO; ALVES MALIZA, AMANDA GARCIA; DE ANDRADE, FLAVIANA BOMBARDA; HUNGARO DUARTE, MARCO ANTONIO; BRAMANTE, CLOVIS MONTEIRO. Tissue dissolution and modifications in dentin composition by different sodium hypochlorite concentrations. Journal of Applied Oral Science, v. 24, n. 3, p. 291-298, MAY-JUN 2016. Web of Science Citations: 10.
BRANDAO, MARIANA; IWAKURA, RICARDO; BASILIO, FAGNE; HALEPLIAN, KAIQUE; ITO, AMANDO; CONTI DE FREITAS, LUIZ CARLOS; BACHMANN, LUCIANO. Fluorescence lifetime of normal, benign, and malignant thyroid tissues. Journal of Biomedical Optics, v. 20, n. 6 JUN 2015. Web of Science Citations: 6.
RAUCCI-NETO, WALTER; DOS SANTOS, CARLA RAQUEL; DE LIMA, FABRICIO AUGUSTO; PECORA, JESUS DJALMA; BACHMANN, LUCIANO; PALMA-DIBB, REGINA GUENKA. Thermal effects and morphological aspects of varying Er:YAG laser energy on demineralized dentin removal: an in vitro study. Lasers in Medical Science, v. 30, n. 4, p. 1231-1236, MAY 2015. Web of Science Citations: 2.
BRANDAO, M. P.; IWAKURA, R.; BASILIO, F. S.; HALEPLIAN, K.; ITO, A. S.; CONTI DE FREITAS, L. C.; BACHMANN, L. Optical Characterization of Normal, Benign, and Malignant Thyroid Tissue: A Pilot Study. Journal of Fluorescence, v. 25, n. 2, p. 465-471, MAR 2015. Web of Science Citations: 4.
BRANDAO, MARIANA PIMENTA; CONTI DE FREITAS, LUIZ CARLOS; BACHMANN, LUCIANO. Optical Diagnosis for Thyroid and Parathyroid Tissues-A Review. APPLIED SPECTROSCOPY REVIEWS, v. 50, n. 8, p. 670-677, 2015. Web of Science Citations: 0.
CORREA-AFONSO, ALESSANDRA MARQUES; BACHMANN, LUCIANO; DE ALMEIDA, CINTIA GUIMARAES; PALMA DIBB, REGINA GUENKA; MILORI CORONA, SILMARA APARECIDA; BORSATTO, MARIA CRISTINA. CO2-lased enamel microhardness after brushing and cariogenic challenge. Journal of Biomedical Optics, v. 18, n. 10 OCT 2013. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.