Cardio-respiratory capacity, inflammatory profile and autonomic modulation of heart rate in patients undergoing bariatric surgery

• Grant number: 12/12206-0
• Support Opportunities: Regular Research Grants
• Duration: September 01, 2012 - August 31, 2014
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Dirceu Costa
• Grantee: Dirceu Costa
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Memorial. São Paulo , SP, Brazil
• Associated researchers: Rodolfo de Paula Vieira

Abstract

Adipose tissue is an endocrine organ and high secretory metabolic activity, releasing several factors called adipocinas. Obesity promotes an imbalance in the production of those substances which consequently alters the cardio-respiratory function, lung function and autonomic nervous control. Currently, it has been suggested that changing the inflammatory profile present in obese promote amendments shall be considered a cardiorrespiratórias important factor in this population. Thus, the objective of this study is to analyze the inflammatory profile and capacity of obese subjects after cardiopulmonary weight loss induced by bariatric surgery. Evaluate morbidly obese 30 (IMC40 kg/m2), of both genders, before and after six months of Bariatric Surgery. For determination of inflammatory biomarkers profile will be evaluated: leptin, adiponectin, inflammatory factor of tumor necrosis factor (TNF), Interleukin 6 (IL 6), interleukin 8, Interleukin-1-²eta. Cardio-respiratory capacity assessment will be carried out by testing: spirometry, ergoespirométrico, by autonômico nervous control of the heart rate variability, six minutes walk test and manovacuômetria. The choice of statistical tests will depend on the types of distributions found and homogeneity of variances or not. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEREIRA DO NASCIMENTO, ELOISA SANCHES; MALOSA SAMPAIO, LUCIANA MARIA; PEIXOTO-SOUZA, FABIANA SOBRAL; DIAS, FERNANDA DULTRA; FREITAS DANTAS GOMES, EVELIM LEAL; GREIFFO, FLAVIA REGINA; LIGEIRO DE OLIVEIRA, ANA PAULA; STIRBULOV, ROBERTO; VIEIRA, RODOLFO PAULA; COSTA, DIRCEU. Home-based pulmonary rehabilitation improves clinical features and systemic inflammation in chronic obstructive pulmonary disease patients. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 10, p. 645-653, 2015. (12/12206-0, 14/26545-6)

PEIXOTO-SOUZA, FABIANA SOBRAL; MALOSA SAMPAIO, LUCIANA MARIA; DE CAMPOS, ELAINE CRISTINA; BARBALHO-MOULIM, MARCELA CANGUSSU; DE ARAUJO, POLIANE NASCIMENTO; LAURIN NETO, RAFAEL MELILLO; ARENA, ROSS; COSTA, DIRCEU. Reproducibility of the incremental shuttle walk test for women with morbid obesity. PHYSIOTHERAPY THEORY AND PRACTICE, v. 31, n. 6, p. 428-432, AUG 2015. (12/12206-0)

PEREIRA DO NASCIMENTO, ELOISA SANCHES; MALOSA SAMPAIO, LUCIANA MARIA; PEIXOTO-SOUZA, FABIANA SOBRAL; DIAS, FERNANDA DULTRA; FREITAS DANTAS GOMES, EVELIM LEAL; GREIFFO, FLAVIA REGINA; LIGEIRO DE OLIVEIRA, ANA PAULA; STIRBULOV, ROBERTO; VIEIRA, RODOLFO PAULA; COSTA, DIRCEU. Home-based pulmonary rehabilitation improves clinical features and systemic inflammation in chronic obstructive pulmonary disease patients. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 10, p. 9-pg., 2015-01-01. (14/26545-6, 12/12206-0)