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Schizophrenia and other psychotic disorders: social and biological determinants


Schizophrenia and other psychotic disorders (SOP) are highly prevalent with significant morbidity and mortality. However, data on the incidence and course of SOP across the globe are still scarce, especially in developing countries. The etiology of SOP is multifactorial, involving biological and social factors, and a genuine advance in the understanding SOP depends crucially on an integrated approach of the different factors involved in the incidence, pathogenesis, outcome, prognosis and response to treatment of mental disorders, particularly in the early onset of the disorders. This proposal is part of a multicenter study, the European Network of National Networks Studying Schizophrenia Gene-Environment Interactions (EU-GEI;, an international consortium that aims to investigate etiology, mechanisms and prognosis of SOP. This proposal aims to estimate the incidence of SOP in the region of Ribeirão Preto and to investigate possible interactions between social and biological factors in the occurrence of mental disorders. Specifically, we will investigate: a) possible variations in the incidence of SOP, considering urbanicity and internal migration; b) the association between individual, familiar and geographical risk factors and the incidence of SOP; c) the existence of anatomical and functional changes in the brains of individuals with SOP compared with healthy controls and individuals at risk of SOP (healthy siblings); d) the occurrence of genetic and immunological changes in patients with SOP, compared with healthy controls and individuals at risk of SOP (healthy siblings), using Genome Wide Associations; e) the occurrence of interactions between social, genetic, immunological, neuroanatomical and neurofunctional factor on the incidence of SOP. In a period of three years, a case-control study of incident cases of SOP will be conducted. In a population of about 800,000 people at risk per year, or 2.4 million person-years for a total of three years, we estimate a sample of 300 incident cases, 150 siblings and 300 controls. All participants will undergo an extensive battery of socio-demographic, environmental, clinical, neuropsychological and family history assessments, as well as genetic, immunological and neuroimaging evaluations. The novelty of this study is based on this broad and integrated approach of the different components of the etiology and mechanisms involved in SOP. Moreover, this international multicenter consortium, with specific consistent and uniform protocols, is a pioneering strategy that will enable greater integration and cooperation among diverse groups of researchers involved in this research network. (AU)

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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SHUHAMA, ROSANA; RODRIGUES DO CARMO, LORENA DE SOUZA; BUSATTO FILHO, GERALDO; FERREIRA SANTOS, JAIR LICIO; DEL-BEN, CRISTINA MARTA; SCAZUFCA, MARCIA; MENEZES, PAULO ROSSI. From where we came: Absence of internal migration effect on psychosis in two case-control Brazilian samples. SCHIZOPHRENIA RESEARCH, v. 212, p. 241-242, . (13/11167-3, 12/05178-0)
LOUREIRO, CAMILA MARCELINO; CORSI-ZUELLI, FABIANA; FACHIM, HELENE APARECIDA; SHUHAMA, ROSANA; DE SOUZA CHAGAS, NATALIA MOTA; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA; LOUZADA-JUNIOR, PAULO. Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis. Ciênc. saúde coletiva, v. 26, n. 3, p. 1085-1094, . (17/17480-6, 13/08216-2, 13/11167-3, 17/00624-5, 16/12195-9, 12/05178-0, 15/02948-7)
LOUREIRO, C. M.; SHUHAMA, R.; FACHIM, H. A.; MENEZES, P. R.; DEL-BEN, C. M.; LOUZADA-JUNIOR, P.. Low plasma concentrations of N-methyl-D-aspartate receptor subunits as a possible biomarker for psychosis. SCHIZOPHRENIA RESEARCH, v. 202, p. 55-63, . (13/08216-2, 12/05178-0)
FACHIM, HELENE A.; LOUREIRO, CAMILA M.; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; LOUZADA, JR., PAULO; MENEZES, PAULO ROSSI; DALTON, CAROLINE F.; DEL-BEN, CRISTINA MARTA; REYNOLDS, GAVIN P.. GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function. Epigenomics, v. 11, n. 4, p. 401-410, . (16/12195-9, 15/02948-7, 17/17480-6, 12/17626-7, 13/08216-2, 12/05178-0, 13/11167-3)
CORSI-ZUELLI, FABIANA; FACHIM, HELENE APARECIDA; LOUREIRO, CAMILA MARCELINO; SHUHAMA, ROSANA; BERTOZI, GIULIANO; JOCA, SAMIA REGIANE LOURENGO; MENEZES, PAULO ROSSI; LOUZADA-JUNIOR, PAULO; DEL-BEN, CRISTINA MARTA. Prolonged Periods of Social Isolation From Weaning Reduce the Anti-inflammatory Cytokine IL-10 in Blood and Brain. FRONTIERS IN NEUROSCIENCE, v. 12, . (13/11167-3, 13/08216-2, 17/00624-5, 16/12195-9, 15/02948-7, 17/17480-6, 12/05178-0)
VELTHORST, EVA; MOLLON, JOSEPHINE; MURRAY, ROBIN M.; DE HAAN, LIEUWE; GERMEYS, INEZ MYIN; GLAHN, DAVID C.; ARANGO, CELSO; VAN DER VEN, ELS; DI FORTI, MARTA; BERNARDO, MIGUEL; et al. ognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected sibling. MOLECULAR PSYCHIATRY, v. 26, n. 8, p. 4529-4543, . (12/05178-0)
LOUREIRO, CAMILA MARCELINO; FACHIM, HELENE APARECIDA; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; JOCA, SAMIA; MENEZES, PAULO ROSSI; DALTON, CAROLINE F.; DEL-BEN, CRISTINA MARTA; LOUZADA-JUNIOR, PAULO; REYNOLDS, GAVIN P.. Epigenetic-mediated N-methyl-D-aspartate receptor changes in the brain of isolated reared rats. Epigenomics, v. 12, n. 22, . (13/08216-2, 16/12195-9, 12/05178-0, 13/11167-3, 12/17626-7, 15/02948-7, 19/13229-2, 17/00624-5)
CORSI-ZUELLI, FABIANA; LOUREIRO, CAMILA MARCELINO; SHUHAMA, ROSANA; FACHIM, HELENE APARECIDA; MENEZES, PAULO ROSSI; LOUZADA-JUNIOR, PAULO; MONDELLI, VALERIA; DEL-BEN, CRISTINA MARTA. Cytokine profile in first-episode psychosis, unaffected siblings and community-based controls: the effects of familial liability and childhood maltreatment. PSYCHOLOGICAL MEDICINE, v. 50, n. 7, p. 1139-1147, . (16/12195-9, 15/02948-7, 17/17480-6, 13/08216-2, 12/05178-0, 13/11167-3)
FACHIM, HELENE A.; CORSI-ZUELLI, FABIANA; LOUREIRO, CAMILA M.; IAMJAN, SRI-ARUN; SHUHAMA, ROSANA; JOCA, SAMIA; MENEZES, PAULO ROSSI; HEALD, ADRIAN; LOUZADA-JUNIOR, PAULO; DALTON, CAROLINE F.; et al. Early-life stress effects on BDNF DNA methylation in first-episode psychosis and in rats reared in isolation. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 108, . (17/00624-5, 15/02948-7, 17/17480-6, 12/17626-7, 19/13229-2, 13/08216-2, 12/05178-0, 13/11167-3)
LOUREIRO, CAMILA M.; FACHIM, HELENE A.; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; MENEZES, PAULO R.; DALTON, CAROLINE F.; DEL-BEN, CRISTINA M.; REYNOLDS, GAVIN P.; LOUZADA-JUNIOR, PAULO. The relationship of childhood trauma and DNA methylation of NMDA receptor genes in first-episode schizophrenia. Epigenomics, v. 13, n. 12, p. 927-937, . (12/05178-0, 13/11167-3, 17/00624-5, 16/12195-9, 19/13229-2, 15/02948-7, 13/08216-2)
SAN-MARTIN, RODRIGO; ZIMIANI, MARIA INES; DE AVILA, MILTON AUGUSTO VENDRAMINI; SHUHAMA, ROSANA; DEL-BEN, CRISTINA MARTA; MENEZES, PAULO ROSSI; FRAGA, FRANCISCO JOSE; SALUM, CRISTIANE. Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition. BRAIN SCIENCES, v. 12, n. 1, . (12/05178-0, 13/11167-3)
RAGAZZI, TACIANA C. C.; SHUHAMA, ROSANA; SINVAL, JORGE; MAROCO, JOAO; CORSI-ZUELLI, FABIANA; DA ROZA, DAIANE L.; VAN OS, JIM; MENEZES, PAULO R.; DEL-BEN, CRISTINA M.. Validation of the Portuguese version of the Community Assessment of Psychic Experiences and characterization of psychotic experiences in a Brazilian sample. Revista Brasileira de Psiquiatria, v. 42, n. 4, p. 389-397, . (18/07581-2, 19/13229-2, 12/05178-0)
DAS GRACAS CORSI-ZUELLI, FABIANA MARIA; BROGNARA, FERNANDA; DA SILVA QUIRINO, GUSTAVO FERNANDO; HIROKI, CARLOS HIROJI; FAIS, RAFAEL SOBRANO; DEL-BEN, CRISTINA MARTA; ULLOA, LUIS; SALGADO, HELIO CESAR; KANASHIRO, ALEXANDRE; LOUREIRO, CAMILA MARCELINO. Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Acetylcholine the Alpha-7 nicotinic Acetylcholine Receptor. FRONTIERS IN IMMUNOLOGY, v. 8, . (16/12195-9, 15/10378-6, 11/20343-4, 13/20549-7, 12/05178-0, 16/11988-5, 16/07641-0)

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