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Schizophrenia and other psychotic disorders: social and biological determinants

Grant number: 12/05178-0
Support type:Research Projects - Thematic Grants
Duration: September 01, 2012 - February 28, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Paulo Rossi Menezes
Grantee:Paulo Rossi Menezes
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Co-Principal Investigators:Antonio Carlos dos Santos ; Cristina Marta Del-Ben
Assoc. researchers:Cristina Marta Del-Ben ; Geraldo Busatto Filho ; Jair Licio Ferreira Santos ; Maristela Schaufelberger Spanghero ; Paulo Louzada Junior
Associated scholarship(s):16/17713-8 - Internal migration and urbanicity as risk factors for first-episode psychosis, BP.IC
16/12195-9 - Impact of early life stress in the inflammatory profile of first episode of psychosis (FEP) patients and in the animal model of post-weaning social isolation, BP.MS
15/02948-7 - Study of epigenetic alterations in GABAergic neurotransmission in schizophrenia and other psychoses and in animals undergoing social isolation from weaning, BP.PD
14/23525-4 - Structural and functional brain changes in psychotic disorders, BP.PD

Abstract

Schizophrenia and other psychotic disorders (SOP) are highly prevalent with significant morbidity and mortality. However, data on the incidence and course of SOP across the globe are still scarce, especially in developing countries. The etiology of SOP is multifactorial, involving biological and social factors, and a genuine advance in the understanding SOP depends crucially on an integrated approach of the different factors involved in the incidence, pathogenesis, outcome, prognosis and response to treatment of mental disorders, particularly in the early onset of the disorders. This proposal is part of a multicenter study, the European Network of National Networks Studying Schizophrenia Gene-Environment Interactions (EU-GEI; http://www.eu-gei.eu/), an international consortium that aims to investigate etiology, mechanisms and prognosis of SOP. This proposal aims to estimate the incidence of SOP in the region of Ribeirão Preto and to investigate possible interactions between social and biological factors in the occurrence of mental disorders. Specifically, we will investigate: a) possible variations in the incidence of SOP, considering urbanicity and internal migration; b) the association between individual, familiar and geographical risk factors and the incidence of SOP; c) the existence of anatomical and functional changes in the brains of individuals with SOP compared with healthy controls and individuals at risk of SOP (healthy siblings); d) the occurrence of genetic and immunological changes in patients with SOP, compared with healthy controls and individuals at risk of SOP (healthy siblings), using Genome Wide Associations; e) the occurrence of interactions between social, genetic, immunological, neuroanatomical and neurofunctional factor on the incidence of SOP. In a period of three years, a case-control study of incident cases of SOP will be conducted. In a population of about 800,000 people at risk per year, or 2.4 million person-years for a total of three years, we estimate a sample of 300 incident cases, 150 siblings and 300 controls. All participants will undergo an extensive battery of socio-demographic, environmental, clinical, neuropsychological and family history assessments, as well as genetic, immunological and neuroimaging evaluations. The novelty of this study is based on this broad and integrated approach of the different components of the etiology and mechanisms involved in SOP. Moreover, this international multicenter consortium, with specific consistent and uniform protocols, is a pioneering strategy that will enable greater integration and cooperation among diverse groups of researchers involved in this research network. (AU)

Articles published in Agência FAPESP about the research grant
International survey identifies groups that are vulnerable to severe mental illness 

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FACHIM, HELENE A.; LOUREIRO, CAMILA M.; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; LOUZADA, JR., PAULO; MENEZES, PAULO ROSSI; DALTON, CAROLINE F.; DEL-BEN, CRISTINA MARTA; REYNOLDS, GAVIN P. GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function. Epigenomics, v. 11, n. 4, p. 401-410, MAR 2019. Web of Science Citations: 0.
CORSI-ZUELLI, FABIANA; FACHIM, HELENE APARECIDA; LOUREIRO, CAMILA MARCELINO; SHUHAMA, ROSANA; BERTOZI, GIULIANO; JOCA, SAMIA REGIANE LOURENGO; MENEZES, PAULO ROSSI; LOUZADA-JUNIOR, PAULO; DEL-BEN, CRISTINA MARTA. Prolonged Periods of Social Isolation From Weaning Reduce the Anti-inflammatory Cytokine IL-10 in Blood and Brain. FRONTIERS IN NEUROSCIENCE, v. 12, JAN 11 2019. Web of Science Citations: 0.
LOUREIRO, C. M.; SHUHAMA, R.; FACHIM, H. A.; MENEZES, P. R.; DEL-BEN, C. M.; LOUZADA-JUNIOR, P. Low plasma concentrations of N-methyl-D-aspartate receptor subunits as a possible biomarker for psychosis. SCHIZOPHRENIA RESEARCH, v. 202, p. 55-63, DEC 2018. Web of Science Citations: 1.
SAN-MARTIN, RODRIGO; ZIMIANI, MARIA INES; NOYA, CLAUDEMIRO; VENDRAMINI AVILA, MILTON AUGUSTO; SHUHAMA, ROSANA; DEL-BEN, CRISTINA MARTA; MENEZES, PAULO ROSSI; FRAGA, FRANCISCO JOSE; SALUM, CRISTIANE. A Method for Simultaneous Evaluation of Muscular and Neural Prepulse Inhibition. FRONTIERS IN NEUROSCIENCE, v. 12, SEP 26 2018. Web of Science Citations: 0.
DAS GRACAS CORSI-ZUELLI, FABIANA MARIA; BROGNARA, FERNANDA; DA SILVA QUIRINO, GUSTAVO FERNANDO; HIROKI, CARLOS HIROJI; FAIS, RAFAEL SOBRANO; DEL-BEN, CRISTINA MARTA; ULLOA, LUIS; SALGADO, HELIO CESAR; KANASHIRO, ALEXANDRE; LOUREIRO, CAMILA MARCELINO. Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Acetylcholine the Alpha-7 nicotinic Acetylcholine Receptor. FRONTIERS IN IMMUNOLOGY, v. 8, MAY 31 2017. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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