Analysis of the intestinal microbiota in adults with different dietary patterns and possible associations with inflammatory status, insulin sensitivity and body adiposity

• Grant number: 12/12626-9
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2013
• End date: December 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Sandra Roberta Gouvea Ferreira Vivolo
• Grantee: Sandra Roberta Gouvea Ferreira Vivolo
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The intestinal microbiota is acquired in the postnatal period, consisting of a wide variety of bacteria that play different functions in the human host, including nutrient absorption, protection against pathogens and modulation of the immune system. The intestinal bacterial content is not fully known, but is known to be influenced by internal and mainly by external factors that modulate its composition and function. Therefore, the evaluation of the microbiota may allow the use of different strategies in order to manipulate the bacterial population and promote health. Recent studies indicate that the intestinal microbiota differs in lean and obese individuals, and in those who have different feeding habits. Thus, in this cross-sectional study we aim to analyze possible differences between the microbiota of groups of eutrophic and overweight individuals showing distinct eating habits (vegan, lacto-ovo-vegetarians and omnivores) and to assess associations with inflammatory (CRP, TNF-alfa, IL-6 and IL-1beta) and metabolic (lipid profile, blood glucose and insulin) parameters. The evaluation of the molecular profile of the microbiota will be performed by fecal sample, using the technique of genetic sequence of 16S rRNA. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GREER, RENEE L.; DONG, XIAOXI; MORAES, ANA CAROLINA F.; ZIELKE, RYSZARD A.; FERNANDES, GABRIEL R.; PEREMYSLOVA, EKATERINA; VASQUEZ-PEREZ, STEPHANY; SCHOENBORN, ALEXI A.; GOMES, EVERTON P.; PEREIRA, ALEXANDRE C.; et al. Akkermansia muciniphila mediates negative effects of IFN gamma on glucose metabolism. NATURE COMMUNICATIONS, v. 7, NOV 14 2016. (12/03880-9, 12/12626-9)

DE MORAES, ANA C. F.; FERNANDES, GABRIEL R.; DA SILVA, ISIS T.; ALMEIDA-PITITTO, BIANCA; GOMES, EVERTON P.; PEREIRA, ALEXANDRE DA COSTA; FERREIRA, SANDRA R. G.. Enterotype May Drive the Dietary-Associated Cardiometabolic Risk Factors. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 7, FEB 23 2017. (12/03880-9, 12/12626-9)

FRANCO-DE-MORAES, ANA CAROLINA; DE ALMEIDA-PITITTO, BIANCA; FERNANDES, GABRIEL DA ROCHA; GOMES, EVERTON PADILHA; PEREIRA, ALEXANDRE DA COSTA; FERREIRA, SANDRA ROBERTA G.. Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition. DIABETOLOGY & METABOLIC SYNDROME, v. 9, AUG 15 2017. (12/03880-9, 12/12626-9)