Obesity and sex hormones in lung injury

• Grant number: 12/50550-4
• Support Opportunities: Regular Research Grants
• Duration: October 01, 2012 - September 30, 2014
• Field of knowledge: Biological Sciences - Pharmacology
• Convênio/Acordo: King's College London
• Principal Investigator: Wothan Tavares de Lima
• Grantee: Wothan Tavares de Lima
• Principal researcher abroad: Yanira Riffo Vasquez
• Institution abroad: King's College London, England
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

There is no general consensus of a positive correlation between high body mass index (BMI) and trauma-induced mortality. Some studies suggest that obese patients are more likely to have a negative outcome from trauma and sepsis because they already constitutively express many of the inflammatory mediators observed in this condition. However, other studies have reported that mortality it is not positively correlated to body mass index (BMI) but it seems to correlate with morbidity. Interestingly, in some studies a negative correlation between mortality and BMI was found, suggesting a protective role of obesity in cases of acute lung injury. Interestingly, despite the evidence showing the influence of sex hormones or obesity on lung injury and ischemic trauma in general, the interaction between these two factors has been poorly investigated. A recent study has shown a correlation between abdominal adipose mass is associated with an increased risk of myocardial infarct in women but not in men. Conversely, other studies have failed to establish a correlation between gender and ischemic stroke among obese patients. In summary, the main experimental aim of this proposal are to investigate the role of female sex hormones in the physiopathology of intestinal l/R in obese mice with or without ovaries (ovariectomized). We will measure inflammatory cell migration and mediator release, platelet migration and platelet mediators release. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FANTOZZI, EVELYN THAIS; RODRIGUES-GARBIN, SARA; RICARDO-DA-SILVA, FERNANDA YAMAMOTO; OLIVEIRA-FILHO, RICARDO MARTINS; SPINA, DOMENICO; TAVARES-DE-LIMA, WOTHAN; RIFFO-VASQUEZ, YANIRA. Acute lung injury induced by intestinal ischemia and reperfusion is altered in obese female mice. Pulmonary Pharmacology & Therapeutics, v. 49, p. 54-59, APR 2018. (10/51330-2, 12/50550-4)