Prevention and Treatment of Depression in Older People: A Population-Based Study

• Grant number: 12/50010-0
• Support Opportunities: Research Projects - Thematic Grants
• Duration: March 01, 2013 - February 28, 2019
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Geraldo Busatto Filho
• Grantee: Geraldo Busatto Filho
• Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais: Homero Pinto Vallada Filho
• Associated grant(s): 18/11865-6 - Symposium 'Nutrition for the ageing brain: moving towards clinical applications', AR.EXT
• Associated scholarship(s): 14/05467-7 - Clinical characteristics and structural changes in MRI: importance for the outcome of depression in the elderly, BP.PD; 14/10499-5 - Prevention of Subsyndromic Depression and Anxiety in Older Adults: The Role of Physical Activity, BP.PD

Abstract

Prevention of depressive disorders in the elderly: in two Basic Health Units in the low income region of Butanta, in Sao Paulo city, 2,700 individuals 60 years and older, will be screened for the presence of depressive symptoms and/or clinically significant anxiety (CES-D). The subjects selected will be assessed to identify those with sub-threshold symptom levels (of depression and/or anxiety, but not meet criteria for depressive disorders and/or anxiety. Participants will be invited to participate in a randomized clinical trial with 3 arms of intervention: 2 different stepped-care programs step by step (n = 90 subjects each) or usual care (n = 90). Stepped-care participants will sequentially receive: 1) watchful waiting approach, followed by cognitive-behavior based-bibliotherapy, cognitive-behavior based-problem solving, and referral to drug treatment in the primary care units, if necessary; 2) watchful waiting approach, followed by a 24-week physical activity home-based program, and referral to drug treatment in the primary care units, if necessary. The primary outcome measure will assess the cumulative incidence of major depressive disorder, or disorder of anxiety, after 12 months, using a structured psychiatric interview (MINI). Predictors of response to treatment of major depressive disorder: in a naturalistic clinical trial, 120 elderly patients with major depressive disorder will be followed for 18 months to assess baseline characteristics (psychopathology, personality traits, cognitive performance, neuroimaging findings and genotyping). Patients will undergo a treatment algorithm for depression in the elderly, and will be evaluated every 3 months up to 18 months. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIMON, SHARON S.; HAMPSTEAD, BENJAMIN M.; NUCCI, MARIANA P.; DURAN, FABIO L. S.; FONSECA, LUCIANA M.; MARTINO, MARIA DA GRACA M.; AVILA, RENATA; PORTO, FABIO H. G.; BRUCKI, SONIA M. D.; MARTINS, CAMILA B.; et al. Cognitive and Brain Activity Changes After Mnemonic Strategy Training in Amnestic Mild Cognitive Impairment: Evidence From a Randomized Controlled Tria. FRONTIERS IN AGING NEUROSCIENCE, v. 10, NOV 13 2018. (12/50329-6, 12/50010-0, 12/51699-1)

SIMON, SHARON S.; HAMPSTEAD, BENJAMIN M.; NUCCI, MARIANA P.; DURAN, FABIO L. S.; FONSECA, LUCIANA M.; MARTIN, MARIA DA GRACA M.; AVILA, RENATA; PORTO, FABIO H. G.; BRUCKI, SONIA M. D.; MARTINS, CAMILA B.; et al. Training gains and transfer effects after mnemonic strategy training in mild cognitive impairment: A fMRI study. INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, v. 154, p. 15-26, AUG 2020. (12/50010-0, 12/51699-1, 12/50329-6)

ALEXANDRINO-SILVA, CLOVIS; RIBEIZ, SALMA ROSE; FRIGERIO, MARIA BEATRIZ; BASSOLLI, LUCAS; ALVES, TANIA FERRAZ; BUSATTO, GERALDO; BOTTINO, CASSIO. Prevention of depression and anxiety in community-dwelling older adults: the role of physical activity. ARCHIVES OF CLINICAL PSYCHIATRY, v. 46, n. 1, p. 14-20, JAN-FEB 2019. (14/05467-7, 12/50010-0, 14/10499-5)