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Effects of nutritional suplementation on intestinal permeability, systemic low-grade inflammation and consequences on body composition in elderly individuals

Grant number: 12/15976-0
Support type:Regular Research Grants
Duration: January 01, 2013 - March 31, 2015
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Sandra Maria Lima Ribeiro
Grantee:Sandra Maria Lima Ribeiro
Home Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Body composition modifications due to aging can bring many health issues. Systemic inflammation, possibly started in bowel or adipose tissue, seems to be importantly associated to these modifications. This study aims to test three hypothesis: a-) Modulation of bowel microbiota with symbiotic substances can improve the systemic inflammation pattern, minimizing the loss of free fat mass in elderly; b-) Modulation of intestinal permeability by the intake of a glutamine supplement can improve the loss of free fat mass in elderly; c-) A program of Nutritional Education can be enough to reduce the systemic inflammation and to improve body composition modifications in aging individuals, without the need of nutritional supplements. We intend to study 60 elderly individuals, submitting them to the following procedures: Double blind distribution in three different groups according to the intake of: - symbiotic substance; - glutamine; or - placebo. During the first month before the distribution in groups, and throughout the study, the participants will be submitted to nutrition education activities, weekly (during the first month) and each 15 days (from the second month onward). The participants will be evaluated at the start and at the end of the study, regarding to: anthropometric measures, body composition by DEXA and BIA, physical activity level, level of inflammatory cytokine, intestinal permeability, and food intake. At the end of the study, the results will be compared between groups and intra-groups (comparison between initial and final values) (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOUZADA, ELIANA REGINA; LIMA RIBEIRO, SANDRA MARIA. Synbiotic supplementation, systemic inflammation, and symptoms of brain disorders in elders: A secondary study from a randomized clinical trial. NUTRITIONAL NEUROSCIENCE, v. 23, n. 2, p. 93-100, FEB 1 2020. Web of Science Citations: 3.
GONCALVES DE CARVALHO, C. M. R.; RIBEIRO, S. M. L. Aging, low-grade systemic inflammation and vitamin D: a mini-review. European Journal of Clinical Nutrition, v. 71, n. 4, p. 434-440, APR 2017. Web of Science Citations: 17.

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