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Pd(II) compounds: synthesis, cytotoxicity, and DNA binding studies

Abstract

This work deals with the synthesis, characterization, cytotoxicity evaluation and DNA binding studies involving chelated compounds of the type [Pd(N-C)(X)(L)] and [PdX2(N-S)] {N-C = C2,N-bzox, C2,N-mbz, C2,N-bzan (bzox=benzaldehydeoxime, mbz = N-benzylidenemethylamine, bzan = N-Benzylideneaniline); N-S = 1-thiocarbamoylpyrazoles; L = thiourea-type ligands, X=Cl, Br, I, SCN}. The compounds will be characterized by elemental analysis, IR and NMR spectroscopies, ESI/MS mass spectrometry, thermogravimetry (TG) and single crystal X-ray diffraction methods. The citotoxicity of compounds towards normal cells and tumor cell sensitive and resistant to cisplatin will be determined by M.T.T. assay. DNA binding studies will be carried out involving the compounds with promising Resistance Factor (RF) and Therapeutic Index (TI) values aimimg at gaining information about the intensity and kinectics of such interaction. The influence of the compounds on the tertiary structure of DNA will be determined by their ability to modify the electrophoretic mobility of the plasmid DNA. Viscosity experiments and thermal denaturation of DNA will be also carried out depending on the acquisition of the described instruments in this project. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA CUNHA, GISLAINE A.; DE SOUZA, RONAN F. F.; DE FARIAS, RENAN L.; MOREIRA, MARIETE B.; SILVA, DEBORA E. S.; ZANETTI, RENAN D.; GARCIA, DANIEL M.; SPINDOLA, DANIEL G.; MICHELIN, LUIS F. G.; BINCOLETTO, CLAUDIA; DE SOUZA, ALINE A.; ANTUNES, ALYNE A.; JUDICE, WAGNER A. DE S.; LEITAO, RENAN C. F.; DEFLON, VICTOR M.; MAURO, ANTONIO E.; NETTO, ADELINO V. G. Cyclopalladated compounds containing 2,6-lutidine: Synthesis, spectral and biological studies. Journal of Inorganic Biochemistry, v. 203, FEB 2020. Web of Science Citations: 4.
ROCHA, FILLIPE V.; FARIAS, RENAN L.; LIMA, MAURO A.; BATISTA, VICTOR S.; NASCIMENTO-JUNIOR, NAILTON M.; GARRIDO, SAULO S.; LEOPOLDINO, ANDREA M.; GOTO, RENATA N.; OLIVEIRA, ADRIANO B.; BECK, JOHANNES; LANDVOGT, CHRISTIAN; MAURO, ANTONIO E.; NETTO, ADELINO V. G. Computational studies, design and synthesis of Pd(II)-based complexes: Allosteric inhibitors of the Human Topoisomerase-II alpha. Journal of Inorganic Biochemistry, v. 199, OCT 2019. Web of Science Citations: 7.
DE SOUZA, RONAN F. F.; DA CUNHA, GISLAINE A.; PEREIRA, JOSE C. M.; GARCIA, DANIEL M.; BINCOLETTO, CLAUDIA; GOTO, RENATA N.; LEOPOLDINO, ANDREIA M.; DA SILVA, ISABEL C.; PAVAN, FERNANDO R.; DEFLON, VICTOR M.; DE ALMEIDA, EDUARDO T.; MAURO, ANTONIO E.; NETTO, ADELINO V. G. Orthopalladated acetophenone oxime compounds bearing thioamides as ligands: Synthesis, structure and cytotoxic evaluation. Inorganica Chimica Acta, v. 486, p. 617-624, FEB 24 2019. Web of Science Citations: 2.
BOZZA, GABRIELA F.; DE FARIAS, RENAN L.; DE SOUZA, RONAN F. F.; ROCHA, V, FILLIPE; BARRA, V, CAROLINA; DEFLON, VICTOR M.; DE ALMEIDA, EDUARDO T.; MAURO, ANTONIO E.; NETTO, ADELINO V. G. Palladium orthometallated complexes containing acetophenoneoxime: Synthesis, crystal structures and hirshfeld surface analysis. Journal of Molecular Structure, v. 1175, p. 195-207, JAN 5 2019. Web of Science Citations: 3.
NATHÁLIA A. THOMAZELLA; SAHRA C. LEMOS; RONAN F. F. DE SOUZA; RODRIGO A. DE SOUZA; ANTONIO E. MAURO; IRACILDA Z. CARLOS; ADELINO V. G. NETTO. SÍNTESE, CARACTERIZAÇÃO E AVALIAÇÃO DA ATIVIDADE CITOTÓXICA DE COMPOSTOS CICLOPALADADOS CONTENDO COMO LIGANTES BENZALDEIDOXIMA ORTOMETALADA E ETILENOTIOURÉIA. Química Nova, v. 41, n. 10, p. -, Dez. 2018.
DE MOURA, THALES R.; CAVALCANTI, SAHRA L.; DE GODOY, PAULO R. D. V.; SAKAMOTO-HOJO, ELZA T.; ROCHA, FILLIPE V.; DE ALMEIDA, EDUARDO T.; DEFLON, VICTOR M.; MAURO, ANTONIO E.; NETTO, ADELINO V. G. Synthesis, characterization and antitumor activity of palladium(II) complexes of imidazolidine-2-thione. TRANSITION METAL CHEMISTRY, v. 42, n. 6, p. 565-574, SEP 2017. Web of Science Citations: 6.
DA SILVA, CRISTIANA; RIBEIRO, LEONARDO B.; FURUNO, CAIO C.; DA CUNHA, GISLAINE A.; DE SOUZA, RONAN F. F.; NETTO, ADELINO V. G.; MAURO, ANTONIO E.; FREM, REGINA C. G.; FERNANDES, JOSE A.; ALMEIDA PAZ, FILIPE A.; MARINO, LEONARDO B.; PAVAN, FERNANDO R.; LEITE, CLARICE Q. F. Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity. Polyhedron, v. 100, p. 10-16, NOV 4 2015. Web of Science Citations: 5.
DA SILVA, C.; FERREIRA, J. G.; MAURO, A. E.; FREM, R. C. G.; SANTOS, R. H. A.; DA SILVA, P. B.; PAVAN, F. R.; MARINO, L. B.; LEITE, C. Q. F.; NETTO, A. V. G. Synthesis and antimycobacterial activity of new pyrazolate-bridged dinuclear complexes of the type [Pd(mu-L)(N-3)(PPh3)](2) (PPh3 = triphenylphosphine; L = pyrazolates). Inorganic Chemistry Communications, v. 48, p. 153-155, OCT 2014. Web of Science Citations: 4.
BARRA, CAROLINA V.; ROCHA, FILLIPE V.; GAUTIER, ARNAUD; MOREL, LAURENT; QUILLES, MARCELA B.; CARLOS, IRACILDA Z.; TREU-FILHO, OSWALDO; FREM, REGINA C. G.; MAURO, ANTONIO E.; NETTO, ADELINO V. G. Synthesis, cytotoxic activity and DNA interaction of Pd(II) complexes bearing N `-methyl-3,5-dimethyl-1-thiocarbamoylpyrazole. Polyhedron, v. 65, p. 214-220, NOV 28 2013. Web of Science Citations: 9.
ROCHA, FILLIPE VIEIRA; BARRA, CAROLINA VALERIO; MAURO, ANTONIO EDUARDO; CARLOS, IRACILDA Z.; NAUTON, LIONEL; EL GHOZZI, MALIKA; GAUTIER, ARNAUD; MOREL, LAURENT; GODOY NETTO, ADELINO VIEIRA. Synthesis, Characterization, X-ray Structure, DNA Cleavage, and Cytotoxic Activities of Palladium(II) Complexes of 4-Phenyl-3-thiosemicarbazide and Triphenylphosphane. European Journal of Inorganic Chemistry, v. 2013, n. 25, p. 4499-4505, SEP 2 2013. Web of Science Citations: 18.

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