MicroRNA and gene expression integrated study on mucoepidermoid carcinomas of salivary glands

• Grant number: 12/10382-5
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2012
• End date: November 30, 2015
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Fabricio Passador-Santos
• Grantee: Fabricio Passador-Santos
• Host Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil
• Associated researchers: Vera Cavalcanti de Araujo

Abstract

Mucoepidermoid carcinoma is the most common malignant tumor of the salivary glands. Although the diagnosis is well established there is a lack of means for prognosis and patients may be undertreated causing the progression of the disease, or overtreated causing severe morbidity. A recurrent translocation t(11:19) was recently confirmed as being responsible for the formation of a fused transcript (CRTC1/MAML2). This transcript is identified mainly, but not exclusively, in low grade mucoepidermoid carcinomas presenting good behavior. Some high grade tumors have also shown to be positive for this translocation, thus making it difficult to use them as a surrogate prognostic marker. There have been few studies on mucoepodermoid carcinoma gene expression. These studies utilized limited numbers of cases and produced inconsistent data. MicroRNAs are small RNAs composed of 25-32 nucleotides that represent a new category of post-transcriptional control for protein expression. In the past decade, their role in the etiology of several tumors has been recognized. Moreover, MicroRNAs have been successfully used as prognostic markers, diagnostic markers and markers for drug response to therapy in several tumors. They may also represent a new therapeutic opportunity. To the best of our knowledge there are no studies in the literature investigating microRNA expression in mucoepidermoid cacinomas. The aim of this study is to evaluate the microRNA expression profile of mucoepidermoid carcinomas comparing it to the presence or absence of the t(11;19) seeking new prognostic markers. The findings will be correlated to clinical and histological characteristics. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BROWN, AMY L.; AL-SAMADI, AHMED; SPERANDIO, MARCELO; SOARES, ANDRESA BORGES; TEIXEIRA, LUCAS NOVAES; MARTINEZ, ELIZABETH F.; DIAS DEMASI, ANA PAULA; ARAUJO, VERA CAVALCANTI; LEIVO, ILMO; SALO, TUULA; et al. MiR-455-3p, miR-150 and miR-375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 48, n. 9, p. 840-845, OCT 2019. (12/10382-5)

NAAKKA, ERIKA; BARROS-FILHO, MATEUS CAMARGO; ADNAN-AWAD, SHADY; AL-SAMADI, AHMED; MARCHI, FABIO ALBUQUERQUE; KUASNE, HELLEN; KORELIN, KATJA; SULEYMANOVA, ILIDA; BROWN, AMY LOUISE; SCAPULATEMPO-NETO, CRISTOVAM; et al. iR-22 and miR-205 Drive Tumor Aggressiveness of Mucoepidermoid Carcinomas of Salivary Gland. FRONTIERS IN ONCOLOGY, v. 11, FEB 9 2022. (12/10382-5, 13/04045-9)