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Effects of aerobic exercise on pulmonary fibrosis induced by bleomycin

Grant number: 12/51464-4
Support type:Regular Research Grants
Duration: February 01, 2013 - January 31, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Cooperation agreement: BAYLAT/StMBW - Bavarian Academic Center for Latin America and Bavarian State Ministry of Science and the Arts
Principal researcher:Rodolfo de Paula Vieira
Grantee:Rodolfo de Paula Vieira
Principal researcher abroad: Oliver Eickelberg
Institution abroad: Ludwig Maximilian University of Munich (LMU Munich), Germany
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil

Abstract

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognostic and no effective treatment is available. Although there are a considerable number of studies showing that pulmonary rehabilitation programs for IPF patients result in proved quality of life and disease management, the possible mechanisms involved in this beneficial effects remain to be elucidated. In this context, aerobic exercise has demonstrated to reduce inflammation and remodeling in expermental models of asthma, COPD and acute lung injury. Preliminary results show that aerobic exercise was effective to reduce lung inflammation in a model of pulmonary fibrosis induced by bleomycin. Therefore, the present study aims to evaluate the effects of treadmill aerobic exercise training in lung inflammation, structure and function in a chronic model of bleomycin-induced pulmonary fibrosis... (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
EL-MAFARJEH, ELIAS; MARTINS, GISELE HENRIQUE CARDOSO; PROBST, JESSICA JORGE; SANTOS-DIAS, ALANA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; DE BARROS, MARCELO PAES; DE OLIVEIRA, LUIS VICENTE FRANCO; DE ANDRADE, LEANDRO DAMAS; DA PALMA, RENATA KELLY; MORAES-FERREIRA, RENILSON; DE CAMARGO HIZUME-KUNZLER, DEBORAH; BACHI, ANDRE LUIS LACERDA; VIEIRA, RODOLFO P. Exercise Improves Lung Inflammation, but Not Lung Remodeling and Mechanics in a Model of Bleomycin-Induced Lung Fibrosis. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2020, OCT 17 2020. Web of Science Citations: 0.
ANDRADE-SOUSA, ADILSON SANTOS; PEREIRA, PAULO ROGERIO; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ASSUMPCAO-NETO, ERASMO; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; PEREIRA VELOSA, ANA PAULA; TEODORO, WALCY ROSOLIA; LIGEIRO DE OLIVEIRA, ANA PAULA; DOLHNIKOFF, MARISA; EICKELBERG, OLIVER; VIEIRA, RODOLFO PAULA. Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice. PLoS One, v. 11, n. 9 SEP 27 2016. Web of Science Citations: 5.
PEREIRA, PAULO ROGERIO; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MACKENZIE, BREANNE; DAVINO CHIOVATTO, JAIME EDUARDO; MATOS, YVES; GREIFFO, FLAVIA REGINA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; BRUGEMMAN, THAYSE REGINA; DELLE, HUMBERTO; IDZKO, MARCO; ALBERTINI, REGIANE; LIGEIRO OLIVEIRA, ANA PAULA; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; FERNANDEZ, ISIS ENSIL; CASTRO-FARIA-NETO, HUGO CAIRE; DOLHNIKOFF, MARISA; EICKELBERG, OLIVER; VIEIRA, RODOLFO PAULA. Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 7, p. 1276-1284, JUL 2016. Web of Science Citations: 11.

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