25- hydroxivitamina D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis

• Grant number: 12/51326-0
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: December 01, 2012
• End date: May 31, 2013
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Maria Teresa de Sande e Lemos Ramos Ascensão Terreri
• Grantee: Maria Teresa de Sande e Lemos Ramos Ascensão Terreri
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

To evaluate the concentrations of 25-hydroxyvitamin-D (25(OH)D), serum calcium, serum phosphorus, alkaline phosphatase and parathormone in patients with polyarticular Juvenile Idiopathic Arthritis (JIA) and to associate them with disease duration and activity, bone mineral density and use of medications. In a cross-sectional and controlled study, 30 patients with polyarticular JIA were evaluated and compered; to 30 healthy individualist age and gender matched. Assessment of clinical status, anthropometry, laboratory markers in both patients and controls, and bone mineral density, only in the patients, were performed. Of the 30 patients included in the study, 76.7% were female, 53.3% non- Caucasian, mean age of 14 years and mean disease duration was 5 years. The mean concentrations of serum calcium and alkaline phosphatase were significantly lower in patients with JIA compared with controls. No differences between the JIA and controls were observed for 25(OH)D, PTH or serum phosphorus. Regarding the concentrations of 25(OH)D, 8 patients (26.7%) and 5 controls (16.7%) had deficiency (lower than 20 ng/mL) and 14 patients (46.7%) and 18 controls (60%) had insufficiency (between 20-32 ng/mL) and were not associated to disease activity, use of medications or bone mineral density. We observed a high frequency of insufficiency and deficiency of 25(OH) D in the studied samples. The compromised bone metabolism emphasizes the importance of follow-up of JIA patients. (AU)