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Role of Fc receptors in bacterial immune evasion

Grant number: 12/51468-0
Support type:Research Projects - Thematic Grants
Duration: February 01, 2013 - January 31, 2016
Field of knowledge:Biological Sciences - Immunology
Cooperation agreement: ANR - Blanc
Principal researcher:Irineu Tadeu Velasco
Grantee:Irineu Tadeu Velasco
Principal researcher abroad: Renato Monteiro
Institution abroad: Université Paris Diderot - Paris 7, France
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The goal of this project will be to : 1) Characterize the interaction between S. pneumonia and CD89 and analyze its role in vivo in the bacterial invasion through activation of ITAMi signaling using CD89 transgenic models. The role of C reactive protein, a new CD89 ligand, will be also analyzed. 2) Identify bacterial partners of CD16 and CD89 using phage display techniques. We will initially characterize the tridimensional CD16 and E. coli interaction site and investigate if similar approach can be used to elucidate inhibitory signals by different bacteria, such as those following S. pneumonia interaction with the CD89 receptor. 3) Develop new therapeutic tools for sepsis through different blockade approaches of bacterial-receptor interaction and/or ITAMi pathway. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Identificada proteína usada pela bactéria <i>E. coli</i> para driblar sistema imune 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BEPPLER, JAQUELINE; KOEHLER-SANTOS, PATRICIA; PASQUALIM, GABRIELA; MATTE, URSULA; ALHO, CLARICE SAMPAIO; DIAS, FERNANDO SUPARREGUI; KOWALSKI, THAYNE WOYCINCK; VELASCO, IRINEU TADEU; MONTEIRO, RENATO C.; DA SILVA, FABIANO PINHEIRO. Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis. Inflammation, v. 39, n. 2, p. 518-525, APR 2016. Web of Science Citations: 10.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

PEPTÍDEOS, USO DOS MESMOS, POLINUCLEOTÍDEOS E USO DA PROTEÍNA WZXE BR1020160115701 - Universidade de São Paulo (USP) . Fabiano Pinheiro Da Silva; Paulo Sergio Lopes De Oliveira; Irineu Tadeu Velasco; Jaqueline Beppler Lucini; Ricardo José Giordano; Renato Costa Monteiro Filho; Jussara Michaloski Souza - May 2016, 20