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Biochemical markers related to lipid metabolism in adolescents with juvenile systemic lupus erythematosus (JSLE): relationship with cardiovascular risk and evaluation of the impact of nutritional intervention on lipid profile and body composition

Grant number: 12/08529-8
Support type:Regular Research Grants
Duration: March 01, 2013 - February 28, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Claudio Arnaldo Len
Grantee:Claudio Arnaldo Len
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers:Maria Teresa de Sande e Lemos Ramos Ascensão Terreri ; Roseli Oselka Saccardo Sarni


Juvenile systemic lupus erythematosus (JSLE) is a chronic, autoimmune, multi-systemic disease that affects individuals up to the age of 18. Adult patients with SLE have high rates of morbidity and mortality from cardiovascular disease. In addition, they have some risk factors for developing chronic diseases that can compromise future survival of these individuals, such as high frequency of dyslipidemia, inadequate food consumption, increase of fat mass and lean mass reduction. Objectives: to evaluate the body composition, biochemical markers related to lipid metabolism and enzymes related to cardiovascular risk in adolescents with JSLE; and evaluate the impact of a nutritional intervention protocol in reducing cardiovascular risk, changing in body composition and quality of life of adolescents with JSLE. Methods: All JSLE patients will be evaluated (n = 40), in controlled cross sectional and a randomized interventional studies aged between 10 and 19 years and at least 6 months of disease. At time 0, 15ml of blood will be collected for analysis of biochemical markers related to lipid metabolism and inflammation, and it will also be performed bone densitometry and questionnaires. Laboratory tests will be repeated in a healthy control group, matched for age and pubertal stage. The JSLE patients will be randomized to a diet intervention group or a control group. After four to six months lipid profile and C-reactive protein will be determined and all examinations from the baseline will be performed again 9 to 12 months of intervention. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ABAD, THAIS ORTIZ; SARNI, ROSELI OSELKA; DA SILVA, SIMONE GUERRA; MACHADO, DANIELE; SUANO-SOUZA, FABIOLA I.; LEN, CLAUDIO ARNALDO; TERRERI, MARIA TERESA. Nutritional intervention in patients with juvenile systemic lupus erythematosus: protective effect against the increase in fat mass. RHEUMATOLOGY INTERNATIONAL, v. 38, n. 6, p. 985-992, JUN 2018. Web of Science Citations: 0.
DA SILVA, S. G. L.; TERRERI, M. T.; ABAD, T. T. O.; MACHADO, D.; FONSECA, F. L. A.; HIX, S.; SUANO-SOUZA, F. I.; SARNI, R. O. S.; LEN, C. A. The effect of nutritional intervention on the lipid profile and dietary intake of adolescents with juvenile systemic lupus erythematosus: a randomized, controlled trial. Lupus, v. 27, n. 5, p. 820-827, APR 2018. Web of Science Citations: 2.

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