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Determination of IL28B polymorphism profile in patients co-infected with Chronic Hepatitis C (HCV) virus and human T-lymphotropic type 1 (HTLV-1)

Grant number: 12/23397-0
Support type:Regular Research Grants
Duration: March 01, 2013 - May 31, 2015
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Jorge Simão do Rosário Casseb
Grantee:Jorge Simão do Rosário Casseb
Home Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Background: HCV infection affects approximately 2 million people in Brazil and several factors determine clinical outcome and response to treatment. Because similarities of transmission routes, other viruses can are also present in HCV-infected subjects, such as HTLV-1 infection. This retrovirus is also prevalent in Brazil, with approximately of one million people infected with HTLV-1. More recently, the profile of the IL28B polymorphism is important in the response to treatment and anti-HCV, however, HCV/HTLV co-infection was not assessed in Brazil. Major Objective: To evaluate the distribution of HCV infection in people living with HTLV-1 infection. Specific Objectives: 1) evaluate the profile of polymorphism haplotypes in this population, 2) Correlate the gene polymorphism IL28b with co-infection and HAM/TSP outcome, 3) Profile of gene IL28B polymorphism in the HTLV-1-infected subjects. Material and Methods: Between July 1997 and May 2011, 798 individuals who sought the outpatient service of HTLV Institute of Infectious Diseases "Emilio Ribas" in São Paulo. A total of 450 individuals were confirmed as positive for HTLV-1 and 120 co-infected with HCV infection. To assess the prevalence of HTLV-1, a group of 1500 patients with HCV be retrospectively analyzed and prospectively for detecting antibodies to HTLV-1 infection. The epidemiological data will be obtained directly from patients invited to participate voluntarily after reading and signing the inform consent. Patients will be evaluated by experts in HCV and / or HTLV. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ASSONE, TATIANE; KANASHIRO, TATIANA M.; BALDASSIN, MAIRA P. M.; PAIVA, ARTHUR; HAZIOT, MICHEL E.; SMID, JERUSA; DE OLIVEIRA, AUGUSTO PENALVA; FONSECA, LUIZ AUGUSTO M.; NORRIS, PHILIP J.; CASSEB, JORGE. In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1. Brazilian Journal of Infectious Diseases, v. 22, n. 2, p. 106-112, MAR-APR 2018. Web of Science Citations: 0.
TATIANE ASSONE; TATIANA M. KANASHIRO; MAIRA P.M. BALDASSIN; ARTHUR PAIVA; MICHEL E. HAZIOT; JERUSA SMID; AUGUSTO PENALVA DE OLIVEIRA; LUIZ AUGUSTO M. FONSECA; PHILIP J. NORRIS; JORGE CASSEB. In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1. Brazilian Journal of Infectious Diseases, v. 22, n. 2, p. -, Mar. 2018.
ASSONE, TATIANE; MALTA, FERNANDA M.; BAKKOUR, SONIA; MONTALVO, LEILANI; PAIVA, ARTHUR M.; SMID, JERUSA; PENALVA DE OLIVEIRA, AUGUSTO CESAR; GONCALVES, FERNANDA DE TOLEDO; LUIZ, OLINDA DO CARMO; FONSECA, LUIZ AUGUSTO M.; NORRIS, PHILIP J.; CASSEB, JORGE. Polymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects. VIRUS RESEARCH, v. 244, n. SI, p. 71-74, JAN 15 2018. Web of Science Citations: 1.
PAIVA, ARTHUR; SMID, JERUSA; HAZIOT, MICHEL E. J.; ASSONE, TATIANE; PINHEIRO, SAMARA; FONSECA, LUIZ A. M.; PENALVA DE OLIVEIRA, AUGUSTO C.; CASSEB, JORGE. High risk of heterosexual transmission of human T-cell lymphotropic virus type 1 infection in Brazil. Journal of Medical Virology, v. 89, n. 7, p. 1287-1294, JUL 2017. Web of Science Citations: 7.
ASSONE, TATIANE; PAIVA, ARTHUR; FONSECA, LUIZ AUGUSTO M.; CASSEB, JORGE. Genetic Markers of the Host in Persons Living with HTLV-1, HIV and HCV Infections. Viruses-Basel, v. 8, n. 2 FEB 2016. Web of Science Citations: 7.
PAIVA, ARTHUR; CASSEB, JORGE. ORIGIN AND PREVALENCE OF HUMAN T-LYMPHOTROPIC VIRUS TYPE 1 (HTLV-1) AND TYPE 2 (HTLV-2) AMONG INDIGENOUS POPULATIONS IN THE AMERICAS. Revista do Instituto de Medicina Tropical de São Paulo, v. 57, n. 1, p. 1-13, JAN-FEB 2015. Web of Science Citations: 22.
ASSONE, TATIANE; DE SOUZA, FERNANDO VIEIRA; GAESTER, KAREN OLIVEIRA; MARCONDES FONSECA, LUIZ AUGUSTO; LUIZ, OLINDA DO CARMO; MALTA, FERNANDA; REBELLO PINHO, JOAO RENATO; GONCALVES, FERNANDA DE TOLEDO; DA SILVA DUARTE, ALBERTO JOSE; PENALVA DE OLIVEIRA, AUGUSTO CESAR; CASSEB, JORGE. IL28B Gene Polymorphism SNP rs8099917 Genotype GG Is Associated with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in HTLV-1 Carriers. PLoS Neglected Tropical Diseases, v. 8, n. 9 SEP 2014. Web of Science Citations: 16.

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