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Photosensitization in life sciences

Grant number: 12/50680-5
Support type:Research Projects - Thematic Grants
Duration: April 01, 2013 - December 31, 2017
Field of knowledge:Biological Sciences - Biophysics
Principal Investigator:Mauricio da Silva Baptista
Grantee:Mauricio da Silva Baptista
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Armando Corbani Ferraz ; Rosangela Itri
Associated grant(s):17/09916-9 - 11th triennial Congress of the world association of theoretical and computational chemists - WATOC 2017, AR.EXT
16/04296-0 - Photosensitization and photodamage of cells and biomimetic models by pterin derivatives, AV.EXT
15/07508-5 - The influence of photo-induced oxidation on peptide-membrane interactions, AV.EXT
+ associated grants 15/07500-4 - Cross-talk between lipid membrane-photooxidation and toxin/peptides interaction through domain formation, AV.EXT
14/50766-2 - Towards understanding the role of oxidized lipid membrane on amyloidogenic diseases: biophysical and structural characterization of membrane-induced GAPDH protofibrils, AP.R
14/26188-9 - The impact of oxidized lipids on biological membranes investigated by phase contrast and fluorescence optical microscopy, AV.EXT
14/15755-0 - The eighth International Conference on quantum, Nano/Bio, and micro technologies - ICQNM 2014, AR.EXT
14/15702-3 - 10th Congress of the World Association of Theoretical and Computational Chemists (WATOC 2014), AR.EXT
14/14728-9 - 10th Congress of the world association of theoretical and computational chemists (WATOC 2014), AR.EXT
14/50134-6 - Photosensitization reactions in membranes: from basic science to research development, AP.R
13/50395-1 - Niobium nanoparticles: preparation, catalytic properties and applications in PDT, AP.R - associated grants
Associated scholarship(s):16/04676-7 - Photodynamic therapy to treat breast cancer: proof of concept pre-clinical studies, BP.PD
15/10025-6 - Time-resolved fluorescence microscopy to study photodynamic therapy in multidrug resistance models, BP.PD
15/07768-7 - Programmed cell death photoinduced mechanisms and different gene expression profiles, BP.PD
+ associated scholarships 14/18123-4 - Protein p53 modulation of autophagic cell death induced by photodynamic therapy, BP.MS
14/02511-5 - Physical damage on model membranes promoted by photosensitization, BP.DD
13/16532-1 - Mechanism of photochemical internalization, BP.DD
13/19302-7 - Chemical incorporation of the antioxidant Trolox into a biodegradable polymer for controlled release, BP.IC
13/11640-0 - Relationship between the photoinduced damage in lipids and membrane permeabilization, BP.DD - associated scholarships

Abstract

Photosensitization occurs when photoactive compounds absorb light and transfer it to neighboring molecules, such that light energy is transformed into chemical. Nature uses the processes of photosensitization in an organized and controlled way. However, due to several factors, these processes can become uncontrolled, generating reactive species that cause damage to cells in tissues, i.e., skin of humans who are over exposed to the sun. Man leamed to use this photo-induced generation of excited and reactive species to destroy cells and tissues and consequently to treat several diseases, in a process called Photodynamic Therapy (PDT). Our research goal is to understand, at the molecular level, the mechanisms of photosensitization that take place during PDT or during exaggerate exposure of animals and plants to the sun, using different systems of study: computational techniques, purified compounds and nanomaterials in solid phase and in isotropic solutions, biomimetic models and cell cultures. These models are usually used/dominated by researchers with distinct expertise's working in different disciplines, namely physics, chemistry, biology, biochemistry, pharmacy and medicine. In this project we will work as a team to address the issue of photosensitization in a multidisciplinary manner, which is the ideal environment for training undergraduates, graduate and postdoctoral fellows and young researchers. In addition, collaboration with medical institutions allows that some of this knowledge is rapidly applied in clinical practice, bringing immediate benefits to the society. To achieve this overall goal we have identified four sub-projects which are: study of the PDT mechanisms, synthesis of new photosensitizer agents for PDT, characterization of the mechanisms of photosensitization induced by UVA, case studies in animals and humans. (AU)

Articles published in Agência FAPESP about the research grant
Researchers discover a method of inducing autophagic cell death 
New photodynamic therapy mechanism described  
Articles published in Revista Pesquisa FAPESP about the project
Further danger from the sun 
More dangerous than the sun 

Scientific publications (51)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BACELLAR, ISABEL O. L.; CORDEIRO, RODRIGO M.; MAHLING, PASCAL; BAPTISTA, MAURICIO S.; ROEDER, BEATE; HACKBARTH, STEFFEN. Oxygen distribution in the fluid/gel phases of lipid membranes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1861, n. 4, p. 879-886, APR 1 2019. Web of Science Citations: 1.
TSUBONE, TAYANA MAZIN; JUNQUEIRA, HELENA COUTO; BAPTISTA, MAURICIO S.; ITRI, ROSANGELA. Contrasting roles of oxidized lipids in modulating membrane microdomains. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1861, n. 3, p. 660-669, MAR 1 2019. Web of Science Citations: 0.
SILVA, ELINEIDES SANTOS; MACHADO, GABRIELA BENEDITO; LINO-DOS-SANTOS-FRANCO, ADRIANA; PAVANI, CHRISTIANE. Combination of Natural Extracts and Photobiomodulation in Keratinocytes Subjected to UVA Radiation. Photochemistry and Photobiology, v. 95, n. 2, p. 644-649, MAR-APR 2019. Web of Science Citations: 0.
FREITAS, JULIANA VESCOVI; JUNQUEIRA, HELENA COUTO; MARTINS, WALESKA KERLLEN; BAPTISTA, MAURICIO S.; GASPAR, LORENA RIGO. Antioxidant role on the protection of melanocytes against visible light-induced photodamage. Free Radical Biology and Medicine, v. 131, p. 399-407, FEB 1 2019. Web of Science Citations: 2.
MARTINS, WALESKA K.; SANTOS, NAYRA FERNANDES; ROCHA, CLEIDIANE DE SOUSA; BACELLAR, ISABEL O. L.; TSUBONE, TAYANA MAZIN; VIOTTO, ANA CLAUDIA; MATSUKUMA, ADRIANA YAMAGUTI; ABRANTES, ALINE B. DE P.; SIANI, PAULO; DIAS, LUIS GUSTAVO; BAPTISTA, MAURICIO S. Parallel damage in mitochondria and lysosomes is an efficient way to photoinduce cell death. AUTOPHAGY, v. 15, n. 2, p. 259-279, FEB 1 2019. Web of Science Citations: 1.
ABRANTES, ALINE B. DE P.; DIAS, GUSTAVO C.; SOUZA-PINTO, NADJA C.; BAPTISTA, MAURICIO S. p53-Dependent and p53-Independent Responses of Cells Challenged by Photosensitization. Photochemistry and Photobiology, v. 95, n. 1, p. 355-363, JAN 2019. Web of Science Citations: 0.
VIGNONI, MARIANA; NOEL URRUTIA, MARIA; JUNQUEIRA, HELENA C.; GREER, ALEXANDER; REIS, ANA; BAPTISTA, MAURICIO S.; ITRI, ROSANGELA; THOMAS, ANDRES H. Photo-Oxidation of Unilamellar Vesicles by a Lipophilic Pterin: Deciphering Biomembrane Photodamage. Langmuir, v. 34, n. 50, p. 15578-15586, DEC 18 2018. Web of Science Citations: 0.
DE ROSA, RAFFAELA; SPINOZZI, FRANCESCO; ITRI, ROSANGELA. Hydroperoxide and carboxyl groups preferential location in oxidized biomembranes experimentally determined by small angle X-ray scattering: Implications in membrane structure. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1860, n. 11, p. 2299-2307, NOV 2018. Web of Science Citations: 3.
DA COLLINA, GABRIELA ALVES; FREIRE, FERNANDA; DA COSTA SANTOS, THABATA PAULINO; SOBRINHO, NATALIA GESSE; AQUINO, SIMONE; PRATES, RENATO ARAUJO; TEIXEIRA DA SILVA, DANIELA DE FATIMA; RATTO TEMPESTINI HORLIANA, ANNA CAROLINA; PAVANI, CHRISTIANE. Controlling methylene blue aggregation: a more efficient alternative to treat Candida albicans infections using photodynamic therapy. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, v. 17, n. 10, p. 1355-1364, OCT 1 2018. Web of Science Citations: 2.
RAZZOKOV, JAMOLIDDIN; YUSUPOV, MAKSUDBEK; CORDEIRO, RODRIGO M.; BOGAERTS, ANNEMIE. Atomic scale understanding of the permeation of plasma species across native and oxidized membranes. JOURNAL OF PHYSICS D-APPLIED PHYSICS, v. 51, n. 36 SEP 12 2018. Web of Science Citations: 3.
CORDEIRO, RODRIGO M. Reactive Oxygen and Nitrogen Species at Phospholipid Bilayers: Peroxynitrous Acid and Its Homolysis Products. Journal of Physical Chemistry B, v. 122, n. 34, p. 8211-8219, AUG 30 2018. Web of Science Citations: 1.
BACELLAR, ISABEL O. L.; OLIYEIRA, MARIA CECILIA; DANTAS, LUCAS S.; COSTA, ELIERGE B.; JUNQUEIRA, HELENA C.; MARTINS, WALESKA K.; DURANTINI, ANDRES M.; COSA, GONZALO; DI MASCIO, PAOLO; WAINWRIGHT, MARK; MIOTTO, RONEI; CORDEIRO, RODRIGO M.; MIYAMOTO, SAYURI; BAPTISTA, MAURICIO S. Photosensitized Membrane Permeabilization Requires Contact-Dependent Reactions between Photosensitizer and Lipids. Journal of the American Chemical Society, v. 140, n. 30, p. 9606-9615, AUG 1 2018. Web of Science Citations: 15.
CORDEIRO, RODRIGO M. Molecular Structure and Permeability at the Interface between Phase-Separated Membrane Domains. Journal of Physical Chemistry B, v. 122, n. 27, p. 6954-6965, JUL 12 2018. Web of Science Citations: 6.
DE SOUZA, THALITA F. M.; ANTONIO, FELIPE C. T.; ZANOTTO, MATEUS; HOMEM-DE-MELLO, PAULA; RIBEIRO, ANDERSON O. Photophysical and Photochemical Properties and Aggregation Behavior of Phthalocyanine and Naphthalocyanine Derivatives. Journal of the Brazilian Chemical Society, v. 29, n. 6, p. 1199-1209, JUN 2018. Web of Science Citations: 2.
YUSUPOV, MAKSUDBEK; YAN, DAYUN; CORDEIRO, RODRIGO M.; BOGAERTS, ANNEMIE. Atomic scale simulation of H2O2 permeation through aquaporin: toward the understanding of plasma cancer treatment. JOURNAL OF PHYSICS D-APPLIED PHYSICS, v. 51, n. 12 MAR 28 2018. Web of Science Citations: 3.
FRANCISCO, CLAUDIA M. L.; GONCALVES, JOSE M. L. A.; BRUM, BRUNO S.; SANTOS, THABATA P. C.; LINO-DOS-SANTOS-FRANCO, ADRIANA; SILVA, DANIELA F. T.; PAVANI, CHRISTIANE. The photodynamic efficiency of phenothiazinium dyes is aggregation dependent. NEW JOURNAL OF CHEMISTRY, v. 41, n. 23, p. 14438-14443, DEC 7 2017. Web of Science Citations: 3.
TARDIVO, JOAO PAULO; SERRANO, RODRIGO; ZIMMERMANN, LIVIA MARIA; MATOS, LEANDRO LUONGO; BAPTISTA, MAURICIO S.; SILVA PINHAL, MARIA APARECIDA; ATALLAH, ALVARO N. Is surgical debridement necessary in the diabetic foot treated with photodynamic therapy?. DIABETIC FOOT & ANKLE, v. 8, n. 1 SEP 19 2017. Web of Science Citations: 2.
DE SOUZA, R. M.; SIANI, P.; SCHMIDT, T. F.; ITRI, R.; DIAS, L. G. Methylene Blue Location in (Hydroperoxized) Cardiolipin Monolayer: Implication in Membrane Photodegradation. Journal of Physical Chemistry B, v. 121, n. 36, p. 8512-8522, SEP 14 2017. Web of Science Citations: 1.
TASSO, THIAGO T.; TSUBONE, TAYANA M.; BAPTISTA, MAURICIO S.; MATTIAZZI, LIA M.; ACUNHA, THIAGO V.; IGLESIAS, BERNARDO A. Isomeric effect on the properties of tetraplatinated porphyrins showing optimized phototoxicity for photodynamic therapy. DALTON TRANSACTIONS, v. 46, n. 33, p. 11037-11045, SEP 7 2017. Web of Science Citations: 4.
BELOTTO, RENATA A.; CHAVANTES, MARIA CRISTINA; TARDIVO, JOAO PAULO; DOS SANTOS, ROBERTO EUZEBIO; MARQUES FERNANDES, RAQUEL CIVOLANI; RATTO TEMPESTINI HORLIANA, ANNA CAROLINA; PAVANI, CHRISTIANE; TEIXEIRA DA SILVA, DANIELA FATIMA. Therapeutic comparison between treatments for Vulvar Lichen Sclerosus: study protocol of a randomized prospective and controlled trial. BMC WOMENS HEALTH, v. 17, AUG 10 2017. Web of Science Citations: 1.
TSUBONE, TAYANA MAZIN; MARTINS, WALESKA KERLLEN; PAVANI, CHRISTIANE; JUNQUEIRA, HELENA COUTO; ITRI, ROSANGELA; BAPTISTA, MAURICIO S. Enhanced efficiency of cell death by lysosome-specific photodamage. SCIENTIFIC REPORTS, v. 7, JUL 27 2017. Web of Science Citations: 14.
BETTANIN, FERNANDA; JURINOVICH, SANDRO; CAPRASECCA, STEFANO; MENNUCCI, BENEDETTA; HOMEM-DE-MELLO, PAULA. A quantum chemical investigation of the solvatochromism of a cross ark phthalocyanine within a lipid bilayer: Comparison between continuum and atomistic models. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, v. 344, p. 42-48, JUL 1 2017. Web of Science Citations: 0.
DOS SANTOS, ANCELY F.; TERRA, LETICIA F.; WAILEMANN, ROSANGELA A. M.; OLIVEIRA, TALITA C.; GOMES, VINICIUS DE MORAIS; MINEIRO, MARCELA FRANCO; MEOTTI, FLAVIA CARLA; BRUNI-CARDOSO, ALEXANDRE; BAPTISTA, MAURICIO S.; LABRIOLA, LETICIA. Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells. BMC CANCER, v. 17, MAR 15 2017. Web of Science Citations: 20.
BETTANIN, FERNANDA; ANTONIO, FELIPE C. T.; HONORIO, KATHIA M.; HOMEM-DE-MELLO, PAULA. Quantum-chemistry descriptors for photosensitizers based on macrocycles. CHEMICAL BIOLOGY & DRUG DESIGN, v. 89, n. 2, p. 207-220, FEB 2017. Web of Science Citations: 3.
MARTINS, WALESKA K.; GOMIDE, ANDREZA B.; COSTA, ERICO T.; JUNQUEIRA, HELENA C.; STOLF, BEATRIZ S.; ITRI, ROSANGELA; BAPTISTA, MAURICIO S. Membrane damage by betulinic acid provides insights into cellular aging. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 1, A, p. 3129-3143, JAN 2017. Web of Science Citations: 3.
SIANI, P.; DE SOUZA, R. M.; DIAS, L. G.; ITRI, R.; KHANDELIA, H. An overview of molecular dynamics simulations of oxidized lipid systems, with a comparison of ELBA and MARTINI force fields for coarse grained lipid simulations. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1858, n. 10, SI, p. 2498-2511, OCT 2016. Web of Science Citations: 13.
NETO, ANTENOR J. P.; CORDEIRO, RODRIGO M. Molecular simulations of the effects of phospholipid and cholesterol peroxidation on lipid membrane properties. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1858, n. 9, p. 2191-2198, SEP 2016. Web of Science Citations: 9.
SALVADOR, MICHELE APARECIDA; COSTA, ANDERSON SILVA; GAETI, MARILISA; MENDES, LIVIA PALMERSTON; LIMA, ELIANA MARTINS; BAKUZIS, ANDRIS FIGUEIROA; MIOTTO, RONEI. Characterization, nanoparticle self-organization, and Monte Carlo simulation of magnetoliposomes. Physical Review E, v. 93, n. 2 FEB 29 2016. Web of Science Citations: 2.
PAVANI, CHRISTIANE; FRANCISCO, CLAUDIA M. L.; GOBO, NICHOLAS R. S.; DE OLIVEIRA, KLEBER T.; BAPTISTA, MAURICIO S. Improved photodynamic activity of a dual phthalocyanine-ALA photosensitiser. NEW JOURNAL OF CHEMISTRY, v. 40, n. 11, p. 9666-9671, 2016. Web of Science Citations: 8.
RODRIGUES, DANIELA; VIOTTO, ANA CLAUDIA; CHECCHIA, ROBERT; GOMIDE, ANDREZA; SEVERINO, DIVINOMAR; ITRI, ROSANGELA; BAPTISTA, MAURICIO S.; MARTINS, WALESKA KERLLEN. Mechanism of Aloe Vera extract protection against UVA: shelter of lysosomal membrane avoids photodamage. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, v. 15, n. 3, p. 334-350, 2016. Web of Science Citations: 11.
ROGÉRIO RODRIGO RAMOS; DORA INÊS KOZUSNY-ANDREANI; ADJACI UCHÔA FERNANDES; MAURICIO DA SILVA BAPTISTA. Photodynamic action of protoporphyrin IX derivatives on Trichophyton rubrum. ANAIS BRASILEIROS DE DERMATOLOGIA, v. 91, n. 2, p. 135-140, Abr. 2016. Web of Science Citations: 0.
UCHOA, ADJACI F.; KONOPKO, AARON M.; BAPTISTA, MAURICIO S. Chlorophyllin Derivatives as Photosensitizers: Synthesis and Photodynamic Properties. Journal of the Brazilian Chemical Society, v. 26, n. 12, p. 2615-2622, DEC 2015. Web of Science Citations: 2.
BETTANIN, FERNANDA; DE CARVALHO FONTINELLES, TANCREDO AUGUSTO; MACIEL, CLEITON DOMINGOS; DIAS, LUIS GUSTAVO; COUTINHO-NETO, MAURICIO DOMINGUES; HOMEM-DE-MELLO, PAULA. Aggregation of photosensitizers: the role of dispersion and solvation on dimer formation energetics. THEORETICAL CHEMISTRY ACCOUNTS, v. 134, n. 12 NOV 20 2015. Web of Science Citations: 6.
MERTINS, OMAR; MATHEWS, PATRICK D.; GOMIDE, ANDREZA B.; BAPTISTA, MAURICIO S.; ITRI, ROSANGELA. Effective protection of biological membranes against photo-oxidative damage: Polymeric antioxidant forming a protecting shield over the membrane. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1848, n. 10, A, p. 2180-2187, OCT 2015. Web of Science Citations: 7.
CORDEIRO, RODRIGO M. Molecular dynamics simulations of the transport of reactive oxygen species by mammalian and plant aquaporins. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1850, n. 9, p. 1786-1794, SEP 2015. Web of Science Citations: 16.
NUNEZ, SILVIA C.; YOSHIMURA, TANIA M.; RIBEIRO, MARTHA S.; JUNQUEIRA, HELENA C.; MACIEL, CLEITON; COUTINHO-NETO, MAURICIO D.; BAPTISTA, MAURICIO S. Urea enhances the photodynamic efficiency of methylene blue. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 150, n. SI, p. 31-37, SEP 2015. Web of Science Citations: 13.
TARDIVO, JOAO PAULO; BAPTISTA, MAURICIO S.; CORREA, JOAO ANTONIO; ADAMI, FERNANDO; SILVA PINHAL, MARIA APARECIDA. Development of the Tardivo Algorithm to Predict Amputation Risk of Diabetic Foot. PLoS One, v. 10, n. 8 AUG 17 2015. Web of Science Citations: 3.
MARTINS, WALESKA K.; COSTA, ERICO T.; CRUZ, MARIO C.; STOLF, BEATRIZ S.; MIOTTO, RONEI; CORDEIRO, RODRIGO M.; BAPTISTA, MAURICIO S. Parallel damage in mitochondrial and lysosomal compartments promotes efficient cell death with autophagy: The case of the pentacyclic triterpenoids. SCIENTIFIC REPORTS, v. 5, JUL 27 2015. Web of Science Citations: 13.
ARAUJO SALOMAO, GUSTAVO HENRIQUE; FERNANDES, ADJACI UCHOA; BAPTISTA, MAURICIO S.; TARDIVO, JOAO PAULO; CHRISTOFOLINI, DENISE MARIA; CORREA, JOAO ANTONIO. Chlorophyllin-M: A new substance for photodynamic therapy in the retina and choroid. Lasers in Surgery and Medicine, v. 47, n. 5, p. 421-425, JUL 2015. Web of Science Citations: 3.
TADA, DAYANE B.; BAPTISTA, MAURICIO S. Photosensitizing nanoparticles and the modulation of ROS generation. FRONTIERS IN CHEMISTRY, v. 3, MAY 27 2015. Web of Science Citations: 21.
SCHMIDT, THAIS F.; CASELI, LUCIANO; OLIVEIRA, JR., OSVALDO N.; ITRI, ROSANGELA. Binding of Methylene Blue onto Langmuir Mono layers Representing Cell Membranes May Explain Its Efficiency as Photosensitizer in Photodynamic Therapy. Langmuir, v. 31, n. 14, p. 4205-4212, APR 14 2015. Web of Science Citations: 17.
SILVA, ALEXANDRE VIEIRA; LOPEZ-SANCHEZ, ALMUDENA; JUNQUEIRA, HELENA COUTO; RIVAS, LUIS; BAPTISTA, MAURICIO S.; ORELLANA, GUILLERMO. Riboflavin derivatives for enhanced photodynamic activity against Leishmania parasites. Tetrahedron, v. 71, n. 3, p. 457-462, JAN 21 2015. Web of Science Citations: 6.
ALBANI, BRYAN A.; PENA, BRUNO; LEED, NICHOLAS A.; DE PAULA, NATALY A. B. G.; PAVANI, CHRISTIANE; BAPTISTA, MAURICIO S.; DUNBAR, KIM R.; TURRO, CLAUDIA. Marked Improvement in Photoinduced Cell Death by a New Tris-heteroleptic Complex with Dual Action: Singlet Oxygen Sensitization and Ligand Dissociation. Journal of the American Chemical Society, v. 136, n. 49, p. 17095-17101, DEC 20 2014. Web of Science Citations: 90.
CHIARELLI-NETO, ORLANDO; FERREIRA, ALAN SILVA; MARTINS, WALESKA KERLLEN; PAVANI, CHRISTIANE; SEVERINO, DIVINOMAR; FAIAO-FLORES, FERNANDA; MARIA-ENGLER, SILVYA STUCHI; ALIPRANDINI, EDUARDO; MARTINEZ, GLAUCIA R.; DI MASCIO, PAOLO; MEDEIROS, MARISA H. G.; BAPTISTA, MAURICIO S. Melanin Photosensitization and the Effect of Visible Light on Epithelial Cells. PLoS One, v. 9, n. 11 NOV 18 2014. Web of Science Citations: 44.
SANTOS, PATRICIA A.; ROCHA, CLEIDIANE S.; BAPTISTA, MAURICIO S. Adhesion and proliferation of He La and fibroblast cells on chemically-modified gold surfaces. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 123, p. 429-438, NOV 1 2014. Web of Science Citations: 12.
KAWAI, CINTIA; FERREIRA, JULIANA C.; BAPTISTA, MAURICIO S.; NANTES, ISELI L. Not Only Oxidation of Cardiolipin Affects the Affinity of Cytochrome c for Lipid Bilayers. Journal of Physical Chemistry B, v. 118, n. 41, p. 11863-11872, OCT 16 2014. Web of Science Citations: 10.
TARDIVO, JOAO PAULO; ADAMI, FERNANDO; CORREA, JOAO ANTONIO; PINHAL, MARIA APARECIDA S.; BAPTISTA, MAURICIO S. A clinical trial testing the efficacy of PDT in preventing amputation in diabetic patients. Photodiagnosis and Photodynamic Therapy, v. 11, n. 3, p. 342-350, SEP 2014. Web of Science Citations: 28.
MOMO, PATRICIA BETONI; PAVANI, CHRISTIANE; BAPTISTA, MAURICIO S.; BROCKSOM, TIMOTHY JOHN; DE OLIVEIRA, KLEBER THIAGO. Chemical Transformations and Photophysical Properties of meso-Tetrathienyl-Substituted Porphyrin Derivatives. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, n. 21, p. 4536-4547, JUL 2014. Web of Science Citations: 11.
MERTINS, OMAR; BACELLAR, ISABEL O. L.; THALMANN, FABRICE; MARQUES, CARLOS M.; BAPTISTA, MAURICIO S.; ITRI, ROSANGELA. Physical Damage on Giant Vesicles Membrane as a Result of Methylene Blue Photoirradiation. BIOPHYSICAL JOURNAL, v. 106, n. 1, p. 162-171, JAN 7 2014. Web of Science Citations: 29.
CORDEIRO, RODRIGO M. Reactive oxygen species at phospholipid bilayers: Distribution, mobility and permeation. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1838, n. 1, B, p. 438-444, JAN 2014. Web of Science Citations: 74.
WEBER, GEORGES; CHARITAT, THIERRY; BAPTISTA, MAURICIO S.; UCHOA, ADJACI F.; PAVANI, CHRISTIANE; JUNQUEIRA, HELENA C.; GUO, YACHONG; BAULIN, VLADIMIR A.; ITRI, ROSANGELA; MARQUES, CARLOS M.; SCHRODER, ANDRE P. Lipid oxidation induces structural changes in biomimetic membranes. SOFT MATTER, v. 10, n. 24, p. 4241-4247, 2014. Web of Science Citations: 38.

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