Circulatory support in pediatric patients: ventricular assist device and extracorporeal membrane oxygenation

• Grant number: 12/50283-6
• Support Opportunities: Research Projects - Thematic Grants
• Duration: May 01, 2013 - July 31, 2019
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Idágene Aparecida Cestari
• Grantee: Idágene Aparecida Cestari
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais:( Últimos ): Julio Romano Meneghini ; Marcelo Biscegli Jatene
• Pesquisadores principais:( Antigos ): Gilberto Orivaldo Chierice
• Associated scholarship(s): 18/11588-2 - Numerical modelling and simulations of the flow within a paediatric pulsatile ventricular assist device, BP.IC; 18/19508-8 - Functionalization of the blood-polymer interface of the InCor ventricular assist device (VAD)., BP.PD; 18/14900-7 - Modeling of the pediatric ventricular assist device (DAV) based on topological optimization, BP.PD; + associated scholarships 17/20994-1 - Fluid-structure simulation of (DAV) InCor pulsatile pediatric ventricular assist device, BP.PD; 14/26066-0 - Experimental study on analyzing the presence of arrhythmogenic substrates during ventricular circulatory support, BP.PD; 14/00695-1 - Development of a mock circulatory system for the evaluation of pediatric ventricular assist devices, BP.DD; 13/24544-0 - Electrical properties of cardiac muscles following ventricular assist device implantation, BP.DD; 13/24543-3 - Contractility changes in isolated cardiomyocytes following pediatric VAD support, BP.DD - associated scholarships

Abstract

Heart transplantation is the most effective treatment for children with advanced heart failure. Mechanical support with Ventricular Assist Devices (VADs) allows the majority of children to be bridged to heart transplantation, improving the efficiency of organ use in children and adolescents and reducing the waiting list mortality. The most common form of mechanical support available for high risk pediatric patients is the extra corporeal membrane oxygenation (ECMO) which is mainly recommended for short-term use. The aim of this research is the development of a VAD and an ECMO system suitable for short and long term cardiac or respiratory support of pediatric patients. This proposal encompasses the development of a pediatric VAD (pVAD) with optimal flow dynamics applied to patients under 25 kg body weight, the development and test of new surface treatment and functionalization to reduce thrombo-embolic and infeccious complications, a high-efficiency extra-corporeal membrane oxygenation system for respiratory and cardiac support and the pre-clinical evaluation of the pVAD. The life-saving technologies to be developed in this proposal are expected to improve the outcomes of mechanical circulatory support with VAD and ECMO in children and lower the risks and costs associated with it. (AU)

Publicações científicas

(13)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

GUIMARAES, DANIEL PERES; CANEO, LUIZ FERNANDO; MATTE, GREGORY S.; CARLETTO, LUCIANA P.; POLICARPO, VALERIA CAMARGO; CASTRO, ANA VITORIA C. X.; MIRANDA, MATHEUS H. C.; COSTA, PRISCILA S.; JATENE, MARCELO B.; CESTARI, IDAGENE; et al. Impact of Vacuum-Assisted Venous Drainage on Forward Flow in Simulated Pediatric Cardiopulmonary Bypass Circuits Utilizing a Centrifugal Arterial Pump Head. Revista Brasileira de Cirurgia Cardiovascular, v. 35, n. 2, p. 134-140, 2020. (12/50283-6)

CORTELLA, LUCAS R. X.; CESTARI, I. A.; S, M.; MAZZETTO, M.; LASAGNI, A. F.; CESTARI, ISMAR N.; BASTOS-FILHO, TF; CALDEIRA, EMD; FRIZERA-NETO, A. Surface Topography Obtained with High Throughput Technology for hiPSC-Derived Cardiomyocyte Conditioning. XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, v. N/A, p. 8-pg., 2022-01-01. (12/50283-6)

MAESTRELLI, L. M. D.; OYAMA, H. T. T.; MUNOZ, P. A. R.; CESTARI, I. A.; FECHINE, G. J. M.. Role of Graphene Oxide on the Mechanical Behaviour of Polycarbonate-Urethane/Graphene Oxide Composites. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 24, n. 3, 2021. (12/50259-8, 12/50283-6, 18/10910-8)

CESTARI, I. A.; MAZZETTO, M.; OYAMA, H. T. T.; BACHT, S.; JATENE, M. B.; CESTARI, I. N.; JATENE, F. B.; COSTAFELIX, R; MACHADO, JC; ALVARENGA, AV. Design and Hydrodynamic Performance of a Pediatric Pulsatile Pump. XXVI BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2018, VOL 1, v. 70, n. 1, p. 4-pg., 2019-01-01. (12/50283-6)

AMARAL, RODRIGO DE LIMA; ANDREGHETTO BORTOLIN, VITOR AUGUSTO; HARRY DINIZ LEMOS, BERNARDO LUIZ; MAZZETO, MARCELO; CESTARI, IDAGENE APARECIDA; MENEGHINI, JULIO ROMANO. A novel method based on the Otsu threshold for instantaneous elimination of light reflection in PIV images. MEASUREMENT SCIENCE & TECHNOLOGY, v. 33, n. 2, FEB 2022. (12/50283-6, 20/15230-5, 14/50279-4)

TORRES, DANIEL S.; MAZZETTO, MARCELO; CESTARI, IDAGENE A.. A novel automated simulator of pediatric systemic circulation: Design and applications. Biomedical Signal Processing and Control, v. 70, SEP 2021. (14/00695-1, 12/50283-6)

HARRY DINIZ LEMOS, BERNARDO LUIZ; ANDREGHETTO BORTOLIN, VITOR AUGUSTO; AMARAL, RODRIGO DE LIMA; MAZZETTO, MARCELO; CESTARI, IDAGENE APARECIDA; MENEGHINI, JULIO ROMANO. Effect of the bileaflet inlet valve angle on the flow of a pediatric ventricular assist device: Experimental analysis. ARTIFICIAL ORGANS, v. N/A, p. 14-pg., 2022-05-15. (20/15230-5, 12/50283-6, 14/50279-4)

CORTELLA, L. R. X.; CESTARI, I. A.; GUENTHER, D.; LASAGNI, A. F.; CESTARI, I. N.. Endothelial cell responses to castor oil-based polyurethane substrates functionalized by direct laser ablation. Biomedical Materials, v. 12, n. 6, DEC 2017. (12/50283-6)

ISLER, JOAO A.; GIORIA, RAFAEL S.; CARMO, BRUNO S.. Bifurcations and convective instabilities of steady flows in a constricted channel. JOURNAL OF FLUID MECHANICS, v. 849, p. 777-804, JUN 26 2018. (12/50283-6)

ARANA, M. C.; LAHUERTA, R. D.; CORTELLA, L. R. X.; MAZZETTO, M.; SOLDERA, M.; LASAGNI, A. F.; CESTARI, I. N.; CESTARI, I. A.; BASTOS-FILHO, TF; CALDEIRA, EMD; et al. Experimental Apparatus for Evaluation of Calcium Fluctuations in Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells. XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, v. N/A, p. 5-pg., 2022-01-01. (12/50283-6)

GUIMARAES, DANIEL PERES; CANEO, LUIZ FERNANDO; MATTE, GREGORY S.; CARLETTO, LUCIANA P.; POLICARPO, VALERIA CAMARGO; CASTRO, ANA VITORIA C. X.; MIRANDA, MATHEUS H. C.; COSTA, PRISCILA S.; JATENE, MARCELO B.; CESTARI, IDAGENE; et al. Impact of Vacuum-Assisted Venous Drainage on Forward Flow in Simulated Pediatric Cardiopulmonary Bypass Circuits Utilizing a Centrifugal Arterial Pump Head. Revista Brasileira de Cirurgia Cardiovascular, v. 35, n. 2, p. 7-pg., 2020-01-01. (12/50283-6)

CORTELLA, LUCAS R. X.; CESTARI, IDAGENE A.; LAHUERTA, RICARDO D.; ARANA, MATHEUS C.; SOLDERA, MARCOS; RANK, ANDREAS; LASAGNI, ANDRES F.; CESTARI, ISMAR N.. Conditioning of hiPSC-derived cardiomyocytes using surface topography obtained with high throughput technology. Biomedical Materials, v. 16, n. 6, NOV 1 2021. (12/50283-6)

MARCHINI, GUSTAVO S.; CESTARI, ISMAR N.; SALEMI, VERA M. C.; IRIGOYEN, MARIA CLAUDIA; ARNOLD, ALEXANDRE; KAKOI, ADELIA; ROCON, CAMILA; AIELLO, VERA D.; CESTARI, IDAGENE A.. Early changes in myocyte contractility and cardiac function in streptozotocin-induced type 1 diabetes in rats. PLoS One, v. 15, n. 8, AUG 21 2020. (12/50283-6, 13/24543-3)