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Molecular aspects of the heterochromatin of Drosophila melanogaster

Grant number: 13/03840-0
Support type:Regular Research Grants
Duration: June 01, 2013 - August 31, 2015
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Eduardo Gorab
Grantee:Eduardo Gorab
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Heterochromatin, of widespread occurrence in eukaryotic cell types, was initially described to make reference to chromosomal regions that do not expand after cell division, and remain thus compacted throughout the cell cycle. The heterochromatin is maily composed of highly repetitive DNA complexed with histone and non histone specific proteins and generally appears associated with chromosome regions that are essential to normal cell function such as centromeres, telomeres and nucleolar organisers. Drosophila melanogaster has provided important findings on the structure and function of the heterochromatin, allowing related studies that can be extended to other organisms. Our group has recently published data suggesting not only the occurrence of triple helical DNA in the heterochromatin of Drosophila melanogaster but also the existence of repetitive sequences that have not been characterised yet in this species with regard to their genomic organisation. The aim of this project is to undertake further studies on the Drosophila heterochromatin. More particularly, emphasis will be given in the characterisation of novel repetitive sequences as well as three-stranded DNA structures. The proposal is based on papers published by the group and also unpublished results presented in specific (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GORAB, EDUARDO. Triple-Helical DNA in Drosophila Heterochromatin. CELLS, v. 7, n. 12 DEC 2018. Web of Science Citations: 0.
GORAB, EDUARDO; PEARSON, PETER LEES. Thiazole Orange as an Alternative to Antibody Binding for Detecting Triple-helical DNA in Heterochromatin of Drosophila and Rhynchosciara. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, v. 66, n. 3, p. 143-154, MAR 2018. Web of Science Citations: 1.

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