Evaluation of epidemiological and genetic characteristics associated with severe acute viral bronchiolitis

• Grant number: 12/05458-2
• Support type: Regular Research Grants
• Duration: June 01, 2013 - May 31, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal researcher: Jose Dirceu Ribeiro
• Grantee: Jose Dirceu Ribeiro
• Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Assoc. researchers: Alfonso Eduardo Alvarez Bragunde ; Carmen Sílvia Bertuzzo ; Clarice Weis Arns ; Fernando Augusto de Lima Marson

Abstract

Acute Viral Bronchiolitis by Respiratory Syncytial Virus (RSV) is the main lower respiratory tract infection in children under 2 years of age in the world and the leading cause of hospitalization in this age group in developed countries. In United States almost 100% of children are infected with RSV by the 2 to 3 years of age and occur in this country 3000 to 4000 deaths per year due to this disease. RSV infection has great variability in relation to the seriousness of his presentation, its clinical manifestations range from mild symptoms of upper respiratory infection to bronchiolitis with need of hospitalization in an intensive care unit, mechanical ventilation and death. Recent studies have demonstrated that there are epidemiological factors associated with increased severity, mainly prematurity, passive smoking, age, absence of breastfeeding, chronic lung disease and congenital heart disease. Other studies have investigated the association of polymorphisms in genes of the innate immune response with the severity of the disease, especially genes of the Toll-like receptor, RANTES, vitamin D receptor, JUN, IFNA5 and NOS2. In Brazil, epidemiological studies associating factors with the seriousness of acute viral bronchiolitis and identification of viruses that lead to this disease are scarce, and there are no studies on the association of severity with genetic factors. The objective of this study is to identify in our population which are the epidemiological and genetic factors associated with increased severity of acute viral bronchiolitis, and identify which are the viruses responsible for this disease in our country. Inpatients with acute viral bronchiolitis requiring oxygen therapy will be evaluated and compared to the control group which shall be composed of patients with diagnosis of acute viral bronchiolitis seen in the emergency room that do not require hospitalization. Patients will be evaluated in relation to epidemiological variables, the presence of viruses and the presence of gene polymorphisms. The knowledge of the epidemiological factors and polymorphism in genes associated with severity of acute viral bronchiolitis can allow greater understanding of the disease and identification of populations at risk. New therapies conditioned by pharmacogenetics may be introduced through new studies from data obtained in this project. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVAREZ, ALFONSO EDUARDO; LIMA MARSON, FERNANDO AUGUSTO; BERTUZZO, CARMEN SILVIA; SANTIAGO BASTOS, JULIANA CRISTINA; ELIAS BARACAT, EMILIO CARLOS; BRANDAO, MARCELO BARCIELA; TRESOLDI, ANTONIA TERESINHA; DAS NEVES ROMANELI, MARIANA TRESOLDI; BRESCIANI ALMEIDA, CELIZE CRUZ; DE OLIVEIRA, THEREZINHA; SCHLODTMANN, PATRICIA GODANO; CORREA, ESTER; FERREIRA DE MIRANDA, MARIA LUISA; DOS REIS, MARCELO CONRADO; DE PIERI, JOSE VICENTE; ARNS, CLARICE WEIS; RIBEIRO, JOSE DIRCEU. Association between single nucleotide polymorphisms in TLR4, TLR2, TLR9, VDR, NOS2 and CCL5 genes with acute viral bronchiolitis. Gene, v. 645, p. 7-17, MAR 1 2018. Web of Science Citations: 5.

AGUIAR, K. C. A.; MARSON, F. A. L.; GOMEZ, C. C. S.; PEREIRA, M. C.; PASCHOAL, I. A.; RIBEIRO, A. F.; RIBEIRO, J. D. Physical performance, quality of life and sexual satisfaction evaluation in adults with cystic fibrosis: An: unexplored correlation. Revista Portuguesa de Pneumologia, v. 23, n. 4, p. 179-192, JUL-AUG 2017. Web of Science Citations: 1.