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Effect of nutritional intervention and resistance training in ovariectomized rats and/or in rats subjected to an intense workout protocol

Grant number: 12/21087-4
Support type:Regular Research Grants
Duration: May 01, 2013 - October 31, 2015
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Julio Orlando Tirapegui Toledo
Grantee:Julio Orlando Tirapegui Toledo
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Gilberto Eiji Shiguemoto


It is well known that regular moderate exercise brings benefit to health. Thus, the RE is an effective intervention for menopausal women, given the fact that these women have increased body fat and inflammatory indicators that can lead to insulin resistance, osteoporosis and development of other chronic diseases.However, the practice of excessive exercise or training with high intensity and volume, with limited recovery periods (overreaching) can damage health. In these situations occur severe muscular injuries, and chronic systemic inflammation that can reduce performance, compromising the athlete's health and lead to the development of the syndrome of super training.Thus, we note that the practice of RE is related both to the improvement of health and quality of life, and in the same subject, this depends on the shape and intensity in which it is practiced. Thus, nutritional intervention is an ally of paramount importance for the practitioner to exercise, because the choice of an appropriate diet and mainly promotes a balanced improvement in their physiological response and performance. Therefore, this project aims to evaluate both the effect of nutritional intervention through caloric restriction in ovariectomized rats practitioners resistance training, as nutritional intervention through supplementation of L-glutamine in rats subjected to intense resistance training. (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COQUEIRO, AUDREY Y.; RAIZEL, RAQUEL; BONVINI, ANDREA; TIRAPEGUI, JULIO; ROGERO, MARCELO M. Probiotics for inflammatory bowel diseases: a promising adjuvant treatment. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, v. 70, n. 1, p. 20-29, JAN 2 2019. Web of Science Citations: 2.
DE SOUZA LINO, ANDERSON DIOGO; VIANNA, DAIANA; OISHI, JORGE CAMARGO; CAMPOS SOUZA, MARKUS VINICIUS; RUFFONI, LEANDRO DIAS; MARIN, CECILIA TARDIVO; DA SILVA DE AVO, LUCIMAR RETTO; DE ANDRADE PEREZ, SERGIO EDUARDO; RODRIGUES, GERSON JHONATAN; TIRAPEGUI, JULIO; SHIGUEMOTO, GILBERTO EIJI. Resistance training and caloric restriction prevent systolic blood pressure rise by improving the nitric oxide effect on smooth muscle and morphological changes in the aorta of ovariectomized rats. PLoS One, v. 13, n. 8 AUG 22 2018. Web of Science Citations: 0.
RAIZEL, RAQUEL; MOREIRA LEITE, JAQUELINE SANTOS; HYPOLITO, THAIS MENEZES; COQUEIRO, AUDREY YULE; NEWSHOLME, PHILIP; CRUZAT, VINICIUS FERNANDES; TIRAPEGUI, JULIO. Determination of the anti-inflammatory and cytoprotective effects of L-glutamine and L-alanine, or dipeptide, supplementation in rats submitted to resistance exercise. BRITISH JOURNAL OF NUTRITION, v. 116, n. 3, p. 470-479, AUG 14 2016. Web of Science Citations: 8.
MOREIRA LEITE, JAQUELINE SANTOS; RAIZEL, RAQUEL; HYPOLITO, THAIS MENEZES; ROSA, THIAGO DOS SANTOS; CRUZAT, VINICIUS FERNANDES; TIRAPEGUI, JULIO. L-glutamine and L-alanine supplementation increase glutamine-glutathione axis and muscle HSP-27 in rats trained using a progressive high-intensity resistance exercise. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v. 41, n. 8, p. 842-849, AUG 2016. Web of Science Citations: 5.

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