Cognitive effects of adjuvant chemotherapy in patients with colon cancer

• Grant number: 13/00895-8
• Support Opportunities: Regular Research Grants
• Duration: May 01, 2013 - October 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rachel Simões Pimenta Riechelmann
• Grantee: Rachel Simões Pimenta Riechelmann
• Host Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Celi Santos Andrade ; Claudia Kimie Suemoto ; Daniel Apolinario ; Edson Amaro Junior ; Manuela Vasconcelos de Castro Sales ; Valeria Trunkl Serrao

Abstract

Consistent evidences suggest that systemic chemotherapy for cancer treatment may have deleterious effects on cognition, leading to impairment of memory, attention, processing speed, and executive function. Most previous studies, however, were performed in women with breast cancer, which raises the possibility that the deficit could have been caused by hormonal changes and/or early menopause induced by chemotherapy.The proposed study is a prospective analysis of the cognitive effects of adjuvant chemotherapy in 60 patients with colon cancer stages II and III, in comparison to 60 individuals with stage II colon cancer not treated with chemotherapy. We intend to evaluate changes in some critical cognitive domains using neuropsychological tests and multiparametric brain magnetic resonance imaging (MRI).Structural and functional neuroimaging studies have shown that advanced MRI techniques present good correlation with clinical and neuropsychological parameters of cognitive impairment, working as early disease biomarkers and also pointing to possible neuropathological substrates related to the functional decline.The clinical evaluation will be performed before the chemotherapy (t0), immediately after (t1) and 3 months after the treatment (t2). A subpopulation of the study will undergo MRI study without contrast in a high-field scanner, with volumetric sequences, diffusion tensor imaging, functional MRI, and perfusion with arterial spin labeling technique.This research aims to provide innovative data about the cognitive effects of chemotherapy in patients with colon cancer, with potential implications for their quality of life. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASTRO SALES, MANUELA VASCONCELOS; SUEMOTO, CLAUDIA K.; APOLINARIO, DANIEL; SERRAO, VALERIA T.; ANDRADE, CELI S.; CONCEICAO, DAVID M.; AMARO JR, EDSON; RIBEIRO DE MELO, BRIAN ALVAREZ; RIECHELMANNI, RACHEL P.. Effects of Adjuvant Chemotherapy on Cognitive Function of Patients With Early-stage Colorectal Cancer. CLINICAL COLORECTAL CANCER, v. 18, n. 1, p. 19-27, MAR 2019. (13/00895-8)