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Metabolizing enzymes expression in the oral squamous cell carcinoma of young patients


Oral squamous cell carcinoma (OSCC) affects mainly patients between the 5th and 6th decades of life, being relatively rare in the young (d40 years). There is no report about the protein expression of drug metabolizing enzymes in OSCC in this group. The aim of this study is evaluate the protein expression of CYP1A1, CYP1B1, ALDH-1 and ALDH-2 by Tissue Microarray (TMA) technique. Forty primary OSCC from patients with £ 40 years of age treated in the Department of Head and Neck Surgery and Otorhinolaryngology, Hospital AC Camargo of Sao Paulo, from 1990 to 2007, will be assessed. These cases will be compared to 80 controls selected from patients aged e 50 who have tumors in similar clinical stage and topography. In both groups, the results will be correlated with clinical features and prognosis. The variables between groups compared using the x2 or Fisher exact test. The survival analyzes will be assessed by the Kaplan Meier and proportional hazards model of Cox. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA, FERNANDA HERRERA; RIBEIRO EL ACHKAR, VIVIAN NARANA; COSTA, VICTOR; PALADINI, ISABELA; KOWALSKI, LUIZ PAULO; CARVALHO, YASMIN RODARTE; KAMINAGAKURA, ESTELA. Different Expression of Aldehyde Dehydrogenases 1A1 and 2 in Oral Leukoplakia With Epithelial Dysplasia and in Oral Squamous Cell Carcinoma. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v. 27, n. 7, p. 537-542, AUG 2019. Web of Science Citations: 0.
COSTA, V.; KOWALSKI, L. P.; COUTINHO-CAMILLO, C. M.; BEGNAMI, M. D.; CALSAVARA, V. F.; NEVES, J. I.; KAMINAGAKURA, E. EGFR amplification and expression in oral squamous cell carcinoma in young adults. International Journal of Oral and Maxillofacial Surgery, v. 47, n. 7, p. 817-823, JUL 2018. Web of Science Citations: 5.
KAMINAGAKURA, E.; CARIS, A.; COUTINHO-CAMILLO, C.; SOARES, F. A.; TAKAHAMA-JUNIOR, A.; KOWALSKI, L. P. Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma. International Journal of Oral and Maxillofacial Surgery, v. 45, n. 6, p. 706-712, JUN 2016. Web of Science Citations: 3.

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