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Tooth extraction in patients with coronary artery disease in dual antiplatelet therapy: a prospective randomized study

Grant number: 12/16523-0
Support Opportunities:Regular Research Grants
Duration: June 01, 2013 - November 30, 2014
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Karem López Ortega
Grantee:Karem López Ortega
Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated researchers: Frederico Buhatem Medeiros ; Itamara Lucia Itagiba Neves


Acetylsalicylic acid (ASA) and clopidogrel have been used in primary and secondary prevention of cardiovascular events, however, many professionals realize the suspension of therapy in dental surgical procedures in order to reduce the risk of bleeding, but it may provide thromboembolic events. Faced with this dilemma and the lack of clinical scientific research in dental surgical management of this group of patients, we propose to conduct a clinical trial in patients with coronary artery disease on dual antiplatelet therapy (aspirin + clopidogrel) undergoing dental extraction, in order to evaluate quantitatively the trans-operative bleeding in tooth extraction. The study group will consist of 30 patients on dual antiplatelet therapy, and the control group of 30 patients with heart disease, but no changes in hemostasis. Complete blood count, Ivy bleeding time, and platelet aggregation will be obtained prior to dental extractions. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUHATEM MEDEIROS, F.; PEPE MEDEIROS DE REZENDE, N.; BERTOLDI FRANCO, J.; PORRIO DE ANDRADE, A. C.; TIMERMAN, L.; GALLOTTINI, M.; ITAGIBA NEVES, I. L.; ORTEGA, K. L.. Quantification of bleeding during dental extraction in patients on dual antiplatelet therapy. International Journal of Oral and Maxillofacial Surgery, v. 46, n. 9, p. 1151-1157, . (12/16523-0)

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