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Exposure to nonessential metals in São Paulo: blood levels in preschool children and associated risk factors

Grant number: 12/21840-4
Support type:Regular Research Grants
Duration: June 01, 2013 - May 31, 2015
Field of knowledge:Health Sciences - Collective Health - Epidemiology
Principal Investigator:Maria Regina Alves Cardoso
Grantee:Maria Regina Alves Cardoso
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Kelly Polido Kaneshiro Olympio

Abstract

Metals do not break down and they can stay in the body until they is excreted. During this time, the metal may be transformed into another more toxic or less toxic species. In Brazil, there are scarce data on metals contamination, especially in the more vulnerable population composed by preschool children. The aims of this study are: a) to estimate the lead (Pb), cadmium (Cd) and mercury (Hg) blood lead levels in children attending Day Care Centers (DCCs) from the city of São Paulo; b) to correlate the metals levels with the location of DCCs and c) to identify potential associations between elevated levels of those metals found in venous blood and risk factors present in the home and school settings. This study will include 26 DCCs, totalizing around 2,400 children aged 1-3 years. A questionnaire will be applied to parents/guardians to obtain socioeconomic and demographic information and to investigate potential risk factors for metals contamination in children's homes. DCCs also will be checked and potential risk factors found will be registered in a specific form. Venous blood samples will be collected from all the study children, whose parents/guardians have signed the informed consent form, to estimate the metals concentrations. Venous blood samples will be analyzed by GF AAS for determining Pb and Cd and by direct mercury analyzer for Hg analysis. The analysis will be performed by the Applied Spectrometry Laboratory (ASL) of the Chemistry Institute of the USP and by the Toxicological Analysis Sector of the CETESB Laboratory, being that 10% of the blood samples will be analyzed by both for comparison between laboratories. Descriptive statistics, correlation tests and Multiple Regression Analysis will be used. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, A. S.; COSTA, E. A. C.; PEREIRA, E. C.; FREITAS, M. A. S.; FREIRE, B. M.; BATISTA, B. L.; LUZ, M. S.; OLYMPIO, K. P. K. The applicability of fingernail lead and cadmium levels as subchronic exposure biomarkers for preschool children. Science of The Total Environment, v. 758, MAR 1 2021. Web of Science Citations: 0.
LEROUX, ISABELLE NOGUEIRA; DA SILVA FERREIRA, ANA PAULA SACONE; PANIZ, FERNANDA POLLO; DA SILVA, FABIO FERREIRA; LUZ, MACIEL SANTOS; BATISTA, BRUNO LEMOS; MARCHIONI, DIRCE MARIA; KANESHIRO OLYMPIO, KELLY POLIDO. Brazilian preschool children attending day care centers show an inadequate micronutrient intake through 24-h duplicate diet. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 54, p. 175-182, JUL 2019. Web of Science Citations: 0.
LEROUX, ISABELLE NOGUEIRA; SACONE DA SILVA FERREIRA, ANA PAULA; DA ROCHA SILVA, JULIA PRESTES; BEZERRA, FLAVIO FERREIRA; DA SILVA, FABIO FERREIRA; SALLES, FERNANDA JUNQUEIRA; LUZ, MACIEL SANTOS; DE ASSUNCAO, NILSON ANTONIO; ALVES CARDOSO, MARIA REGINA; KANESHIRO OLYMPIO, KELLY POLIDO. Lead exposure from households and school settings: influence of diet on blood lead levels. Environmental Science and Pollution Research, v. 25, n. 31, SI, p. 31535-31542, NOV 2018. Web of Science Citations: 3.
KANESHIRO OLYMPIO, KELLY POLIDO; DA ROCHA SILVA, JULIA PRESTES; DA SILVA, AGNES SOARES; DE OLIVEIRA SOUZA, VANESSA CRISTINA; RABELO BUZALAF, MARILIA AFONSO; BARBOSA, JR., FERNANDO; ALVES CARDOSO, MARIA REGINA. Blood lead and cadmium levels in preschool children and associated risk factors in Sao Paulo, Brazil. Environmental Pollution, v. 240, p. 831-838, SEP 2018. Web of Science Citations: 7.
DA ROCHA SILVA, JULIA PRESTES; SALLES, FERNANDA JUNQUEIRA; LEROUX, ISABELLE NOGUEIRA; SACONE DA SILVA FERREIRA, ANA PAULA; DA SILVA, AGNES SOARES; ASSUNCAO, NILSON ANTONIO; NARDOCCI, ADELAIDE CASSIA; SAYURI SATO, ANA PAULA; BARBOSA, JR., FERNANDO; ALVES CARDOSO, MARIA REGINA; KANESHIRO OLYMPIO, KELLY POLIDO. High blood lead levels are associated with lead concentrations in households and day care centers attended by Brazilian preschool children. Environmental Pollution, v. 239, p. 681-688, AUG 2018. Web of Science Citations: 4.
LEROUX, ISABELLE NOGUEIRA; DA SILVA FERREIRA, ANA PAULA SACONE; PANIZ, FERNANDA POLLO; PEDRON, TATIANA; SALLES, FERNANDA JUNQUEIRA; DA SILVA, FABIO FERREIRA; MALTEZ, HELOISA FRANCA; BATISTA, BRUNO LEMOS; KANESHIRO OLYMPIO, KELLY POLIDO. Lead, Cadmium, and Arsenic Bioaccessibility of 24 h Duplicate Diet Ingested by Preschool Children Attending Day Care Centers in Brazil. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 15, n. 8 AUG 2018. Web of Science Citations: 2.

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