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Impact of inhibitors compounds present in hydrolysates of the lignocellulosic materials on the fermentability of Scheffersomyces stipitis

Grant number: 12/51834-6
Support type:Regular Research Grants
Duration: May 01, 2013 - April 30, 2015
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Ines Conceicao Roberto
Grantee:Ines Conceicao Roberto
Home Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil


A major challenge to the viability of ethanol production from lignocellulosic materials is obtaining a cellulosic fraction with high reactivity and accessibility to hydrolytic agents, coupled with a high recovery of hemicellulose sugars. In this sense, the hydrolysis with dilute acid has been identified as a promising technology option since this method promotes an efíicient removal of monomers of xylose in the hemicellulose fraction, producing a celluligin more accessible to enzymatic saccharification. However, during the solubilization of hemicellulose by acid hydrolysis, various chemicals with potential inhibitory action to microbial metabolism are also released and can compromise the efficiency and productivity of the fermentation process. The type and amount of inhibitor compounds present in biomass hydrolysates depends used and severity of the pretreatment, however, in general, compounds such as organic acids, especially acetic acid from the structure of the hemicellulose (acetilxilana) furfural and 5- hydroxymethylfurfural which are degradation products of pentoses and hexoses, respectively, as well as vanillin, ferulic acid, p-coumaric acid among other low-molar mass phenolic from Iignin degradation are commonly found in these hydrolysates. Within this context, this project aims to assess the impact of these inhibitors on the fermentation of xylose by S. stipitis. The project also proposes to study a strategy biodestoxificação and a pre-treatment (coupling of an alkaline extraction step to the process of acid hydrolysis) in order to minimize the Ioad inhibitory hydrolysates. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FONSECA, BRUNO G.; MATEO, SOLEDAD; MOYA, ALBERTO J.; ROBERTO, INES C. Biotreatment optimization of rice straw hydrolyzates for ethanolic fermentation with Scheffersomyces stipitis. BIOMASS & BIOENERGY, v. 112, p. 19-28, MAY 2018. Web of Science Citations: 2.
FONSECA, BRUNO GUEDES; GABRIEL PUENTES, JUAN; MATEO, SOLEDAD; SANCHEZ, SEBASTIAN; MOYA, ALBERTO J.; ROBERTO, INES CONCEICAO. Detoxification of Rice Straw and Olive Tree Pruning Hemicellulosic Hydrolysates Employing Saccharomyces cerevisiae and Its Effect on the Ethanol Production by Pichia stipitis. Journal of Agricultural and Food Chemistry, v. 61, n. 40, p. 9658-9665, OCT 9 2013. Web of Science Citations: 13.

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