Pharmacological evaluation of sulfide hydrogen donors (rapid and slow release) in pruritus and related inflammation in mice skin

• Grant number: 13/04151-3
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2013
• End date: September 30, 2015
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Soraia Katia Pereira Costa
• Grantee: Soraia Katia Pereira Costa
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Marcelo Nicolas Muscara

Abstract

Itching, similar to pain, is an unpleasant sensory sensation associated with the desire to scratch. In contrast to pain, there is a great lack of studies that investigate the mechanisms of action involved in the perception of itch. Currently, the available therapy is restricted to anti-histamines, although not always satisfactory for some forms of itching, such as those common in skin diseases (eg. psoriasis) and systemic diseases (eg. diabetes, cholestasis), thus suggesting the existence of distinct mechanisms. Therefore, the discovery of additional agents to treat itching resistant anti-histamines is required. Interestingly, several studies have proposed to hydrogen sulfide (H2S), the new endogenous gasotransmitters, a potential employment as an anti-nociceptive and anti-inflammatory agent. Moreover, changes in the balance of endogenous H2S have been linked to ² cell dysfunction and hence the symptoms of diabetes. Interestingly, our previous findings show for the first time that H2S donors markedly inhibit itching behavior (and related skin inflammation) in response to i.d. injection of histamine, indicating a new therapeutic role for H2S. However, the characterization of the mechanisms involved in this effect or related to chronic itching has not been yet established. Thus, we intend to deepen this research, in order to better establish the mechanisms of H2S molecule (endogenous and exogenous) involved in the context of pruritus and skin inflammation in both acute (eg. histamine) and chronic (eg. psoriasis) forms of pruritus. The development of this study can be of great contribution to pharmacology, considering the therapeutic potential of H2S in acute or chronic itching. For both in vivo and in vitro assays, the isogenic Balb/C mice will be used. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMPOS, DAIANA; RAVAGNANI, FELIPE G.; GURGUEIRA, SONIA A.; VERCESI, ANIBAL E.; TEIXEIRA, SIMONE A.; COSTA, SORAIA K. P.; MUSCARA, MARCELO N.; FERREIRA, HELOISA H. A.. Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation. International Immunopharmacology, v. 39, p. 57-62, OCT 2016. (14/24518-1, 12/02145-3, 13/04151-3)

COAVOY-SANCHEZ, SILVIA ABIGAIL; MARQUES, LEONARDO ANDRE DA COSTA; COSTA, SORAIA KATIA PEREIRA; MUSCARA, MARCELO NICOLAS. Role of Gasotransmitters in Inflammatory Edema. Antioxidants & Redox Signaling, v. N/A, p. 20-pg., 2023-05-23. (13/04151-3, 14/24518-1, 17/16409-6, 19/14051-2)

COAVOY-SANCHEZ, SILVIA ABIGAIL; CERQUEIRA, ANDERSON ROMERIO AZEVEDO; TEIXEIRA, SIMONE APARECIDA; SANTAGADA, VINCENZO; ANDREOZZI, GIORGIA; CORVINO, ANGELA; SCOGNAMIGLIO, ANTONIA; SPARACO, ROSA; CALIENDO, GIUSEPPE; SEVERINO, BEATRICE; et al. Beneficial Effects of Two Hydrogen Sulfide (H₂S)-Releasing Derivatives of Dexamethasone with Antioxidant Activity on Atopic Dermatitis in Mice. PHARMACEUTICS, v. 15, n. 7, p. 19-pg., 2023-07-01. (13/04151-3, 14/24518-1, 17/16409-6, 19/14051-2)

GIACONE, DANIELA V.; CARVALHO, VANESSA F. M.; COSTA, SORAIA K. P.; LOPES, LUCIANA B.. Evidence That P-glycoprotein Inhibitor (Elacridar)-Loaded Nanocarriers Improve Epidermal Targeting of an Anticancer Drug via Absorptive Cutaneous Transporters Inhibition. Journal of Pharmaceutical Sciences, v. 107, n. 2, p. 698-705, FEB 2018. (16/04913-9, 14/50928-2, 13/16617-7, 16/06146-5, 13/04151-3)