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CIBFar - Center for Innovation in Biodiversity and Drug Discovery

Grant number: 13/07600-3
Support type:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: July 01, 2013 - June 30, 2024
Field of knowledge:Biological Sciences - Biophysics
Principal Investigator:Glaucius Oliva
Grantee:Glaucius Oliva
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Co-Principal Investigators:Adriano Defini Andricopulo ; Carlos Roque Duarte Correia ; Fernando Antonio Santos Coelho ; Leila Maria Beltramini ; Luiz Carlos Dias ; Maysa Furlan ; Paulo Cézar Vieira ; Vanderlan da Silva Bolzani
Assoc. researchers:Alberto José Cavalheiro ; Andre Luis Berteli Ambrosio ; Angela Regina Araújo ; Arlene Gonçalves Corrêa ; Dulce Helena Siqueira Silva ; Eduardo Maffud Cilli ; Fabio Cardoso Cruz ; Ian Castro-Gamboa ; Ilana Lopes Baratella da Cunha Camargo ; Marcia Nasser Lopes ; Márcia Regina Cominetti ; Mônica Tallarico Pupo ; Nelma Regina Segnini Bossolan ; Rafael Victorio Carvalho Guido
Associated grant(s):19/13911-8 - 47th IUPAC world chemistry Congress - 2019, AR.EXT
19/07606-8 - Multi-User Equipment approved in grant 13/07600-3: Omnilog phenotypic microarray, AP.EMU
19/07457-2 - Multi-User Equipment conceived in grant 2013/07600-3 "ROCKIMAGER 1000", AP.EMU
+ associated grants 17/17920-6 - 10th European conference on marine natural products - ECMNP 2017, AR.EXT
16/23279-9 - 5th Annual Conference of AnalytiX-2017, AR.EXT
16/13884-2 - Multi-User Equipment approved in grant 2013/07600-3: MicroScale Thermophoresis (MST), AP.EMU
16/50009-2 - Greening sample preparation of complex matrices by using natural deep eutectic solvents (NADES) together with porous polymeric adsorbents for subsequent analyses by liquid chromatography (LC) and nuclear magnetic resonance (NMR), AP.R
16/11312-1 - 9th joint natural products conference 2016, AR.EXT
15/08181-0 - American society of Pharmacognosy 2015 Annual Meeting, AR.EXT
15/14968-2 - American society of Pharmacognosy 2015 Annual Meeting, AR.EXT
15/06751-3 - Antitrypanosomal acetylene fatty acid derivatives from the seeds of Porcelia macrocarpa (Annonaceae), PUB.ART
14/50304-9 - Stereochemical characterization of cyclotides from Cerrado species using Raman optical activity, AP.R
14/15579-7 - 55th annual American society of Pharmacognosy meeting & 14th annual Oxford International Conference on the science of botanicals, AR.EXT
13/21599-8 - Multicomponent organocatalytic strategies to anticancer natural products, AV.EXT
13/18375-0 - 61st International Congress and Annual Meeting of the society for medicinal plant and natural product research (GA), AR.EXT - associated grants
Associated scholarship(s):18/24894-4 - "dereplication", sequencing and identification of peptides from brazilian plants: a new approach to chemical ecology, BP.PD
18/24344-4 - Optimization of lead compounds for treatment of tropical parasitic diseases in collaboration with the Drugs for Neglected Diseases Initiative (DNDi), BP.DR
19/09067-7 - Discovering the potential of the secondary metabolites from Malouetia tamaquarina (Apocynaceae) and its endophytes against Neglected Tropical Diseases, BP.PD
+ associated scholarships 18/25289-7 - Discovery of new bioactive ligands with anticancer properties, BP.DR
18/14153-7 - Investigation of molecular changes in small selectively activated neural groups (neuronal ensembles) of the nucleus acumbens, which mediate the incubation of the fissure to cocaine induced by the environment, BP.DR
18/25600-4 - Discovery and development of antiviral candidates against Yellow Fever virus based on the structure of the NS2B-NS3 protease complex, BP.DD
19/07603-9 - Rational exploration of Colletotrichum gloeosporiodes, aiming at the production and isolation of bioactive metabolites and scale-up processes, BP.IC
19/06587-0 - Center for Innovation in biodiversity and drug discovery (CIBFar), BP.TT
19/05967-3 - Understanding the biological function of natural products' scaffolds from databases for the design of active compounds for the treatment of infectious diseases, BP.PD
18/23946-0 - Predictive models for the phases from structure factors of centric reflections in protein crystallography by machine learning, BP.IC
18/25773-6 - Antiviral candidates discovery based on the structure of the yellow fever NS5 RNA-dependent RNA polymerase enzyme, BP.MS
19/06034-0 - Pharmacokinetic and biological properties evaluation of drug candidates, BP.PD
19/01762-8 - Natural and synthetic compounds screening targeting proteins from arboviruses, BP.TT
19/04788-8 - Evaluation of activity of natural products and other compounds against multidrug resistant bacteria and their biofilms, BP.TT
18/23675-7 - Multiparametric analysis of the phase problem in protein crystallography by deep learning, BP.IC
18/17095-8 - Structural characterization of the Chikungunya Virus NSP4 RNA-dependent RNA polymerase and search for antiviral agents, BP.DR
18/15887-4 - Optimization and elucidation of cationic peptides antibacterial activity in multidrug-resistant pathogens, BP.DD
18/19574-0 - Structural biology and drug development against the protein NS5 Zika Virus, BP.DD
18/07287-7 - Discovery of acridine and marinoquinoline derivatives as Plasmodium falciparum inhibitors, BP.DR
18/05130-3 - Construction and characterization of a ZIKV sub-genomic replicon system for the discovery of antiviral agents, BP.PD
18/04896-2 - Bioguided study of Talisia esculenta for the identification of secondary metabolites inhibitors of advanced glycation, BP.IC
17/26679-0 - 4-Quinolone derivatives as antimalarial drug candidates: Antiplasmodial activity characterization in vitro, in vivo and of the mode of action, BP.MS
17/16772-3 - Structural and functional studies of the NS5 RNA-dependent RNA polymerase enzyme from yellow fever virus, BP.IC
17/23778-8 - Chemoinformatics strategies for a series of antichagasic compounds, BP.IC
17/22661-0 - Structural and functional studies of the NS2B-NS3 protease complex from yellow fever, BP.IC
17/17098-4 - Application of MALDI imaging (MSI) on non-nodulated and nodulated leaves of Psychotria and Hybanthus: localization, analysis of cyclotides and its relationship with endosymbionts bacteria, BP.PD
17/07229-4 - Structural characterization of Chikungunya Virus proteins and the search for antiviral agents, BP.PD
17/12326-9 - Orbitides from Croton antisyphiliticus and c. sphaerogynus (Euphorbiaceae), chemical-biological characterization and synthesis: rational prospection of low molecular weight peptides with antitumor potential, BP.MS
17/15682-0 - Amides from Piperaceae species: metabolomic studies in complex matrices for bioprospecting antimicrobial compounds, BP.IC
17/04070-4 - Discovery of 4-quinolinones derivatives as lead compound candidates for the development of new antimalarials, BP.IC
16/24714-0 - Structuring of a metabolic database for Casearia sylvestris using LC-DAD-CAD-MS, BP.IC
16/24969-9 - Evaluation of compounds in multidrug resistant bacterial pathogens as part of the Center for Innovation in Biodiversity and Drug Discovery (CIBFar), BP.IC
16/19712-9 - Structural characterization of Zika virus proteins and search for antiviral agents, BP.PD
16/17153-2 - Structural biology and drug development against the protein NS5 Zika virus, BP.DD
16/09235-9 - Metabolic fingerprinting (chromatographic profile) by LC-DAD-MS for quality control of Erythrina species herbal drugs: development and method validation, BP.MS
16/09772-4 - Structural Biology and Medicinal Chemistry studies toward the discovery of new Plasmodium falciparum enolase inhibitors, BP.MS
16/06499-5 - Crystallographic studies of the enzyme cruzain from T.cruzi in complex with inhibitors, BP.IC
16/04004-9 - Exploration of the chemical potential and biotransformation from fungus Rhinocladiella similis aimed biological compounds, BP.IC
15/23244-8 - Development of multifunctional prodrugs for combination therapy against hepatocellular carcinoma and HCV, BP.DR
15/19495-5 - Compounds synthesis for the treatment of Chagas Disease at RIDCs/FAPESP/DNDi, BP.PD
15/25175-3 - Cloning and characterization of Cytochrome P450 oxidoreductase type from Maytenus ilicifolia and their effect on increasing the production of quinonamethide triterpenes by heterologous expression in Saccharomyces ceravisiae, BP.PD
15/18192-9 - Discovery and development of antimalarial drugs: structural biology, medicinal chemistry and parasitology, BP.PD
15/23095-2 - Synthesis and characterization of bioconjugates containing peptides with antitumor activity, BP.IC
15/21272-4 - Computational studies on N-myristoyltransferase enzyme from Plasmodium falciparum and its inhibitors as antimalarial agents, BP.MS
15/09533-7 - Cyclopeptides of extreme environments plants (Caatinga biome): characterization, function, synthesis and evaluation of anti-tumor and immunosuppressive activities, BP.PD
15/11339-4 - Comparative analysis of alkyl resorcinols in sugarcane cultivars and evaluation of possible protective effect against fungal pathogens, BP.IC
14/15145-7 - Structural studies of mitochondrial topoisomerase II from trypanosomatids, BP.PD
14/26313-8 - Discovery and design of Plasmodium falciparum enolase inhibitors as new antimalarial candidates, BP.PD
14/19362-2 - Application of biotechnology to evaluate plant-microorganism interaction during production of secondary metabolites in Peritassa campestris and its endophytes, BP.PD
14/21567-1 - Study of selected microorganisms from Senna spectabilis's rhizosphere aiming the detection of biologically active molecules, BP.IC
14/05538-1 - Synthesis, characterization, study of action mechanism and analysis of different release methods of pBthTX-I, in its monomeric and dimeric forms, BP.PD
14/14067-2 - Prospecting the Quinanomethide derivatives biossynthesis enzymes among biogeografical diverse sampling of Maytenus spp. (Celastraceae), BP.PD
14/02282-6 - Structure-activity relationship studies about of Pilocarpus microphyllus (Rutaceae) alkaloid derivatives against Schistosoma mansoni, BP.PD
14/05935-0 - Co-culture of microorganisms isolated from the rhizosphere of Senna spectabilis aiming to produce new bioactive metabolites, BP.DD
14/02738-0 - Chemical documentation of species from Casearia genus (Salicaceae) of ecological, economical and medicinal relevance, BP.IC
13/15306-8 - Studies concerning the biosynthesis of quinonemethides triterpenes by metabolic engineering: evaluation of the micro- and macromolecular metabolic flow of heterologous system by proteomics and metabolomics techniques, BP.PD
13/25658-9 - Design and development of drug candidates for Chagas Disease, BP.PD
13/24952-0 - Patterns of emergence of multidrug resistant Enterococci and staphylococci in Brazil and search for new drugs, BP.PD
14/00326-6 - Chemical characterization of Ficus guaranitica (Moraceae): prospection of compounds of economic interest and evaluation of biological activities with therapeutic interest, BP.IC
13/15086-8 - Application of metabolomics and proteomics in searching for new biologically active compounds in Malpighiaceae plant species, BP.PD
13/10933-4 - Application of biotechnological tools in Streptomyces olindensis to obtain new natural products with pharmaceutical potential, BP.PD
13/03493-8 - Potential of crude extracts, essential oil and pure compounds obtained from Tagetes patula l. (Asteraceae) as botanical biopesticide against Rhipicephalus (Boophilus) microplus, Haemonchus contortus and Cimex lectularis, BP.PD
11/01544-9 - Proteomic analysis focused on the enzyme P450 oxidoreductase in roots of young plants and adult Maytenus ilicifolia (Celastraceae), BP.PD
11/10379-1 - Cloning and characterization of oxidosqualene cyclases from Maytenus ilicifolia Mart. ex Reissek, BP.PD
11/01003-8 - Proteomic studies in Peperomia obtusifolia (Piperaceae), BP.PD
11/03017-6 - Natural products from plants of Cerrado and Atlantic Forest, potential models and useful for identifying prototypes with oxidizing action on neutrophils and myeloperoxidase (MPO) enzyme, BP.PD - associated scholarships

Abstract

The Center for Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborative research projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), the Institute of Chemistry at the State University of Campinas (UNICAMP), and the Department of Chemistry at the Federal University of São Carlos (UFSCar). The major goals of this Center are to perform basic and applied science and to develop technologies, such as in vitro and in vivo biological and pharmacological evaluations, for all areas of biodiversity and drug discovery that rely on state-of-the-art methods in medicinal chemistry, natural products chemistry, synthetic organic chemistry, and molecular and structural biology. Strategic partnerships with the private sector are always sought, particularly with national and international pharmaceutical companies and research institutes within the health sector. The ultimate goals are the development of clinical candidates for tropical infectious diseases, cancer and central nervous system disorders and the development of new synthetic routes to generic drugs. On the educational front, the Center also relies on the considerable experience that has been acquired over the last eleven years from our previous CEPID-FAPESP. Intensive work has been done on outreach programs focused on science education from elementary school to high school. CIBFar has the benefit of joining research groups in a modern multidisciplinary setting while also providing access to a well-established infrastructure with extensive experience in the areas of technical, financial, educational, technological and executive management. (AU)

Articles published in Pesquisa FAPESP Maganize about the research grant:
Promising structures 
Articles published in other midia outlets (1 total):
Neglected Diseases Continue to Require Attention Despite Progress 

Scientific publications (187)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KUMAGAI, PATRICIA S.; SOUSA, VICTOR K.; DONATO, MARESSA; ITRI, ROSANGELA; BELTRAMINI, LEILA M.; ARAUJO, ANA P. U.; BUERCK, JOCHEN; WALLACE, B. A.; LOPES, JOSE L. S. Unveiling the binding and orientation of the antimicrobial peptide Plantaricin 149 in zwitterionic and negatively charged membranes. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, v. 48, n. 7, p. 621-633, OCT 2019. Web of Science Citations: 0.
INACIO, MARIELLE CASCAES; PAZ, TIAGO ANTUNES; SOARES PEREIRA, ANA MARIA; FURLAN, MAYSA. Maytenin Plays a Special Role in the Regulation of the Endophytic Bacillus megaterium in Peritassa campestris Adventitious Roots. Journal of Chemical Ecology, v. 45, n. 9, p. 789-797, SEP 2019. Web of Science Citations: 0.
MEDINA, REBECA P.; ARAUJO, ANGELA R.; BATISTA JR, JOAO M.; CARDOSO, CARMEN L.; SEIDL, CLAUDIA; VILELA, ADRIANA F. L.; DOMINGOS, V, HELORI; COSTA-LOTUFO, V, LETICIA; ANDERSEN, RAYMOND J.; SILVA, DULCE H. S. Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis - Falkenbergia stage. SCIENTIFIC REPORTS, v. 9, AUG 23 2019. Web of Science Citations: 0.
GONRING-SALARINI, KARLA L.; CONTI, RAPHAEL; DE ANDRADE, JEAN PAULO; BORGES, BARBARA JULIANA P.; AGUIAR, ANNA CAROLINE C.; DE SOUZA, JULIANA O.; ZANINI, CAMILA L.; OLIVA, GLAUCIUS; TENORIO, JUAN CARLOS; ELLENA, JAVIER; BASTIDA, JAUME; GUIDO, RAFAEL V. C.; BORGES, WARLEY DE S. In vitro Antiplasmodial Activities of Alkaloids Isolated from Roots of Worsleya procera (Lem.) Traub (Amaryllidaceae). Journal of the Brazilian Chemical Society, v. 30, n. 8, p. 1624-1633, AUG 2019. Web of Science Citations: 0.
SELEGATO, DENISE MEDEIROS; FREIRE, RAFAEL TEIXEIRA; PILON, ALAN CESAR; BIASETTO, CAROLINA RABAL; DE OLIVEIRA, HAROLDO CESAR; DE ABREU, LUCAS MAGALHAES; ARAUJO, ANGELA REGINA; BOLZANI, VANDERLAN DA SILVA; CASTRO-GAMBOA, IAN. Improvement of bioactive metabolite production in microbial cultures-A systems approach by OSMAC and deconvolution-based (HNMR)-H-1 quantification. Magnetic Resonance in Chemistry, v. 57, n. 8, p. 458-471, AUG 2019. Web of Science Citations: 0.
PALUDO, CAMILA RAQUEL; PISHCHANY, GLEB; ANDRADE-DOMINGUEZ, ANDRES; SILVA-JUNIOR, EDUARDO AFONSO; MENEZES, CRISTIANO; NASCIMENTO, FABIO SANTOS; CURRIE, CAMERON R.; KOLTER, ROBERTO; CLARDY, JON; PUPO, MONICA TALLARICO. Microbial community modulates growth of symbiotic fungus required for stingless bee metamorphosis. PLoS One, v. 14, n. 7 JUL 25 2019. Web of Science Citations: 0.
SOUZA, AMAURI ALVES; VESSECCHI, RICARDO; CASTRO-GAMBOA, IAN; FURLAN, MAYSA. Combined use of tandem mass spectrometry and computational chemistry to study 2H-chromenes from Piper aduncum. Journal of Mass Spectrometry, v. 54, n. 7, p. 634-642, JUL 2019. Web of Science Citations: 0.
MARTELLI, LORENA S. R.; VIEIRA, LUCAS C. C.; PAIXAO, MARCIO W.; ZUKERMAN-SCHPECTOR, JULIO; DE SOUZA, JULIANA O.; AGUIAR, ANNA CAROLINE C.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; CORREA, ARLENE G. Organocatalytic asymmetric vinylogous 1,4-addition of alpha,alpha-Dicyanoolefins to chalcones under a bio-based reaction media: Discovery of new Michael adducts with antiplasmodial activity. Tetrahedron, v. 75, n. 25, p. 3530-3542, JUN 21 2019. Web of Science Citations: 0.
DE SOUZA, ANACLETO S.; FERREIRA, LEONARDO L. G.; DE OLIVEIRA, ALDO S.; ANDRICOPULO, ADRIANO D. Quantitative Structure-Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11 JUN 1 2019. Web of Science Citations: 0.
KOULOURIDI, ELENI; VALLI, MARILIA; NTIE-KANG, FIDELE; BOLZANI, VANDERLAN DA SILVA. A primer on natural product-based virtual screening. PHYSICAL SCIENCES REVIEWS, v. 4, n. 6 JUN 2019. Web of Science Citations: 0.
AGY, ANDRE CAPRETZ; RODRIGUES, JR., MANOEL T.; ZEOLY, LUCAS A.; SIMONI, DEBORAH A.; COELHO, FERNANDO. Palladium-Mediated Oxidative Annulation of delta-Indolyl-alpha,beta-Unsaturated Compounds toward the Synthesis of Cyclopenta[b]indoles and Heterogeneous Hydrogenation To Access Fused Indolines. Journal of Organic Chemistry, v. 84, n. 9, p. 5564-5581, MAY 3 2019. Web of Science Citations: 0.
BIASETTO, CAROLINA R.; SOMENSI, ANDRESSA; ABDALLA, VIVIANE DE C. P.; DE ABREU, LUCAS M.; GUALTIERI, SONIA C. J.; PFENNING, LUDWIG H.; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R. PHYTOTOXIC CONSTITUENTS FROM ENDOPHYTIC FUNGUS Xylaria cubensis ASSOCIATED WITH Eugenia brasiliensis. Química Nova, v. 42, n. 5, p. 485-488, MAY 2019. Web of Science Citations: 0.
LAGO, ELOI M.; SILVA, MARCOS P.; QUEIROZ, TALITA G.; MAZLOUMA, SUSANA F.; RODRIGUES, VINICIUS C.; CARNAUBA, PAULO U.; PINTO, PEDRO L.; ROCHA, JEFFERSON A.; FERREIRA, LEONARDO L. G.; ANDRICOPULO, ADRIANO D.; DE MORAES, JOSUE. Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis. EBIOMEDICINE, v. 43, p. 370-379, MAY 2019. Web of Science Citations: 0.
MONTEIRO, AFIF FELIX; RIGHETTO, GABRIELA MARINHO; SIMOES, LAURA VILAR; DE ALMEIDA, LARISSA COSTA; COSTA-LOTUFO, LETICIA VERAS; BARATELLA DA CUNHA CAMARGO, ILANA LOPES; CASTRO-GAMBOA, IAN. Oxidative functionalization of a halimane diterpenoid achieved by fungal transformation. BIOORGANIC CHEMISTRY, v. 86, p. 550-556, MAY 2019. Web of Science Citations: 1.
SILVA, THIAGO S.; RODRIGUES, JR., MANOEL T.; SANTOS, HUGO; ZEOLY, LUCAS A.; ALMEIDA, WANDA P.; BARCELOS, ROSIMEIRE C.; GOMES, RALPH C.; FERNANDES, FABIO S.; COELHO, FERNANDO. Recent advances in indoline synthesis. Tetrahedron, v. 75, n. 14, p. 2063-2097, APR 5 2019. Web of Science Citations: 4.
FERREIRA SANTOS, NATACHA CARVALHO; VALLI, MARILIA; BOLZANI, VANDERLAN DA SILVA. A brief overview on Brazilian women in chemistry. Pure and Applied Chemistry, v. 91, n. 4, SI, p. 743-749, APR 2019. Web of Science Citations: 0.
SANCHES POLITI, FLAVIO AUGUSTO; FANTATTO, RAFAELA REGINA; DA SILVA, ALEXANDER ALVES; MORO, ISABELA JACOB; SAMPIERI, BRUNO RODRIGUES; CAMARGO-MATHIAS, MARIA IZABEL; FIGUEIREDO, AMANDA; DE SOUZA CHAGAS, ANA CAROLINA; FURLAN, MAYSA. Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). Experimental and Applied Acarology, v. 77, n. 4, p. 601-618, APR 2019. Web of Science Citations: 0.
PAVARINI, DANIEL PETINATTI; SELEGATO, DENISE MEDEIROS; CASTRO-GAMBOA, IAN; SILVA DO SACRAMENTO, LUIZ VITOR; FURLAN, MAYSA. Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection. Molecules, v. 24, n. 6 MAR 2 2019. Web of Science Citations: 0.
MAIARA S. BORGES; CAROLINA R. BIASETTO; VANESSA M. CHAPLA; SAMAD N. EBRAHIMI; MAYRA F. COSTA; VANDERLAN S. BOLZANI; ANGELA R. ARAUJO. Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam.. Journal of the Brazilian Chemical Society, v. 30, n. 3, p. 522-527, Mar. 2019.
BATIGA, SAADIA; VALLI, MARILIA; ZERAIK, MARIA L.; FRAIGE, KARINA; LEME, GABRIEL M.; PITANGUI, NAYLA S.; ALMEIDA, ANA MARISA F.; MICHEL, SYLVIE; YOUNG, MARIA CLAUDIA M.; BOLZANI, VANDERLAN S. Chemical composition and biological properties of Ipomoea procumbens. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 29, n. 2, p. 191-197, MAR-APR 2019. Web of Science Citations: 0.
BORGES, MAIARA S.; BIASETTO, CAROLINA R.; CHAPLA, VANESSA M.; EBRAHIMI, SAMAD N.; COSTA, MAYRA F.; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R. Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam. Journal of the Brazilian Chemical Society, v. 30, n. 3, SI, p. 522-527, MAR 2019. Web of Science Citations: 0.
MEDINA, REBECA P.; ARAUJO, ANGELA R.; ANDERSEN, RAYMOND J.; SOARES, MARCOS A.; SILVA, FABIO DE A.; SILVA, DULCE H. S. Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis-Falkenbergia stage. NATURAL PRODUCT RESEARCH, v. 33, n. 3, p. 443-446, FEB 1 2019. Web of Science Citations: 1.
LIMA, CAROLINA G. S.; MOREIRA, NATALIA M.; PAIXAO, MARCIO W.; CORREA, ARLENE G. Heterogenous green catalysis: Application of zeolites on multicomponent reactions. CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY, v. 15, n. SI, p. 7-12, FEB 2019. Web of Science Citations: 3.
FAGUNDEZ, CATHERINE; SELLANES, DIVER; PENA, STELLA; SCARONE, LAURA; AGUIAR, ANNA C. C.; DE SOUZA, JULIANA O.; GUIDO, RAFAEL V. C.; STEWART, LINDSAY; YARDLEY, VANESSA; OTTILIE, SABINE; WINZELER, ELIZABETH A.; GAMO, FRANCISCO-J.; SANZ, LAURA M.; SERRA, GLORIA L. Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents. ACS Medicinal Chemistry Letters, v. 10, n. 1, p. 137-141, JAN 2019. Web of Science Citations: 0.
FRAIGE, KARINA; ARRUA, R. DARIO; SUTTON, ADAM T.; FUNARI, CRISTIANO SOLEO; CAVALHEIRO, ALBERTO JOSE; HILDER, EMILY F.; BOLZANI, VANDERLAN DA SILVA. Using natural deep eutectic solvents for the extraction of metabolites in Byrsonima intermedia leaves. JOURNAL OF SEPARATION SCIENCE, v. 42, n. 2, p. 591-597, JAN 2019. Web of Science Citations: 2.
SALDIVAR-GONZALEZ, FERNANDA I.; VALLI, MARILIA; ANDRICOPULO, ADRIANO D.; BOLZANI, VANDERLAN DA SILVA; MEDINA-FRANCO, JOSE L. Chemical Space and Diversity of the NuBBE Database: A Chemoinformatic Characterization. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 59, n. 1, p. 74-85, JAN 2019. Web of Science Citations: 6.
LORENZON, ESTEBAN N.; PICCOLI, JULIA P.; SANTOS-FILHO, NORIVAL A.; CILLI, EDUARDO M. Dimerizatiori of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity. PROTEIN AND PEPTIDE LETTERS, v. 26, n. 2, p. 98-107, 2019. Web of Science Citations: 1.
MARILIA VALLI; VANDERLAN S. BOLZANI. Natural Products: Perspectives and Challenges for use of Brazilian Plant Species in the Bioeconomy. Anais da Academia Brasileira de Ciências, v. 91, p. -, 2019.
VALLI, MARILIA; BOLZANI, VANDERLAN S. Natural Products: Perspectives and Challenges for use of Brazilian Plant Species in the Bioeconomy. Anais da Academia Brasileira de Ciências, v. 91, n. 3 2019. Web of Science Citations: 0.
FERNANDES, FABIO S.; RODRIGUES, JR., MANOEL T.; ZEOLY, LUCAS A.; CONTI, CAROLINE; ANGOLINI, CELIO F. F.; EBERLIN, MARCOS NOGUEIRA; COELHO, FERNANDO. Vinyl-1,2,4-oxadiazoles Behave as Nucleophilic Partners in Morita-Baylis-Hillman Reactions. Journal of Organic Chemistry, v. 83, n. 24, p. 15118-15127, DEC 21 2018. Web of Science Citations: 1.
KATTELA, SHIVASHANKAR; DE LUCCA, EMILIO C.; CORREIA, CARLOS ROQUE D. Enantioselective Synthesis of Phthalides and Isochromanones via Heck-Matsuda Arylation of Dihydrofurans. CHEMISTRY-A EUROPEAN JOURNAL, v. 24, n. 67, p. 17691-17696, DEC 3 2018. Web of Science Citations: 0.
OLMO, FRANCISCO; COSTA, FERNANDA C.; MANN, GURDIP SINGH; TAYLOR, MARTIN C.; KELLY, JOHN M. Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation. Molecular and Biochemical Parasitology, v. 226, p. 34-36, DEC 2018. Web of Science Citations: 0.
FERREIRA, LEONARDO L. G.; ANDRICOPULO, ADRIANO D. Chemoinformatics Strategies for Leishmaniasis Drug Discovery. FRONTIERS IN PHARMACOLOGY, v. 9, NOV 1 2018. Web of Science Citations: 2.
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Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180719149 - Universidade Estadual Paulista (UNESP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - October 2018, 24

METHOD FOR EXTRACTING AND ISOLATING ACTIVE SUBSTANCES FROM UMBU PULP, ACTIVE SUBSTANCES, NUTRACEUTICAL AND/OR FUNCTIONAL FOODS COMPRISING SAID ACTIVE SUBSTANCES AND USES THEREOF PCT/BR2015/050172 - Universidade Estadual Paulista (UNESP) . Maria Luiza Zeraik; Emerson Ferreira Queiroz; Ian Castro-Gamboa; Dulce Helena Siqueira Silva; Muriel Cuendet; Laurence Marcourt; Olivier Ciclet; Vanderlan da Silva Bolzani; Jean-Luc Wolfender - October 2015, 07

METHOD FOR EXTRACTING AND ISOLATING ACTIVE SUBSTANCES FROM UMBU PULP, NUTRACEUTICAL AND/OR FUNCTIONAL FOODS AND COSMETICS COMPRISING SAID ACTIVE SUBSTANCES AND USES THEREOF PCT/BR2015/050173 - Universidade Estadual Paulista (UNESP) . Maria Luiza Zeraik; Emerson Ferreira Queiroz; Ian Castro-Gamboa; Dulce Helena Siqueira Silva; Muriel Cuendet; Vanderlan da Silva Bolzani; Jean-Luc Wolfender - October 2015, 07

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