OCRC - Obesity and Comorbidities Research Center

• Grant number: 13/07607-8
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• Start date: June 01, 2013
• End date: October 31, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Licio Augusto Velloso
• Grantee: Licio Augusto Velloso
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• City of the host institution: Campinas
• Principal investigators: Bruno Geloneze Neto ; Carlos Eduardo Negrão ; Everardo Magalhães Carneiro ; Heitor Moreno Junior ; Helena Coutinho Franco de Oliveira ; Jose Antonio Rocha Gontijo ; Jose Donato Junior ; Ronaldo Aloise Pilli ; Silvana Auxiliadora Bordin da Silva ; Wilson Nadruz Junior
• Principal investigators: Andrei Carvalho Sposito ; Aníbal Eugênio Vercesi ; Antonio Carlos Boschiero ; Heraldo Possolo de Souza ; José Barreto Campello Carvalheira ; Marcelo Alves da Silva Mori ; Marcio Alberto Torsoni ; Mario Jose Abdalla Saad
• Associated researchers: Adriana Souza Torsoni ; Alessandro dos Santos Farias ; Amilton dos Santos Junior ; Ana Carolina Junqueira Vasques ; Ana Paula Couto Davel ; Antonio Carlos Boschiero ; Camilo de Lellis Santos ; Carlos Henrique Grossi Sponton ; Caroline Dario Capitani ; Celso Darío Ramos ; Claudio Cesar Zoppi ; Daniel Martins-de-Souza ; Dennys Esper Corrêa Cintra ; Eduardo Rochete Ropelle ; Eliana Pereira de Araujo ; Elinton Adami Chaim ; Erika Anne de Freitas Robles Roman ; Fernando Cendes ; Gabriel Forato Anhê ; Helena Cristina de Lima Barbosa ; Ivani Credidio Trombetta ; João Vilhete Viegas d'Abreu ; José Roberto Matos Souza ; José Rodrigo Pauli ; Joseane Morari Ricciardi de Aguiar ; Kelly Lima Calisto da Silva ; Leonardo dos Reis Silveira ; Letícia Ignácio de Souza Zimmermann ; Lígia de Moraes Antunes Corrêa ; Luiz Osório Silveira Leiria ; Marciane Milanski Ferreira ; Marcio Alberto Torsoni ; Marco Aurélio Ramirez Vinolo ; Maria Helena de Melo Lima ; Maria Luiza Moretti ; Otávio Rizzi Coelho-Filho ; Patrícia Aline Boer ; Patrícia Borges Botelho Gamba ; Patrícia de Oliveira Prada ; Paulo Dalgalarrondo ; Pedro Manoel Mendes de Moraes Vieira ; Raquel Franco Leal ; Renata Frazão ; Roberto Schreiber ; Rodrigo Ramos Catharino ; Roger Frigério Castilho ; Ronaldo Aloise Pilli ; Vera Regina Toledo Camargo
• Associated research grant(s): 23/01442-9 - Evaluation of the phenotype of mice with NHLH2 deletion in POMC neurons, AP.R; 22/02840-5 - Influence of airway allergic inflammation on platelet infiltration in the lungs of mice consuming hyperlipidic diet or sucrose consumption: possible participation of gut microbiota, AV.EXT; 20/05430-7 - Multicenter, prospective, randomized, double-blind, placebo-controlled study to evaluate the Effect of Diacerein to prevent death or multiple organ dysfunction in patients with ARDS secondary to COVID-19, AP.R; + associated grants 20/04522-5 - Clinical trial for bradykinin inhibition in hospitalized adults with COVID-19 grave, AP.R; 18/25050-4 - EMU granted in the proceeding 2013/07607-8: radiopharmaceutical synthesizer for PET/CT, AP.EMU; 18/14132-0 - EANM'18 - Annual Congress of the European AssociaBon of Nuclear Medicine, AR.EXT; 15/13362-3 - 9th World Congress of Developmental Origins of Health and Disease, AR.EXT - associated grants
• Associated scholarship(s): 25/16385-6 - Regulation of Thermogenesis in Adipocytes through Endocannabinoid Receptor 1 (CB1), BP.MS; 25/06669-7 - Metabolic Caracterization of Dlk1 Deletion in AgRP Neurons of Mice., BP.PD; 24/22256-1 - Evaluation of perineuronal nets associated with AgRP neurons in animals with diet-induced hypothalamic inflammation, BP.MS; + associated scholarships 24/14933-3 - The impact of nutrient intervention on the mitochondrial fragmentation process in POMC neurons, BP.MS; 24/21229-0 - The involvement of hypothalamic Sorbs1 in the metabolic phenotype of mice undergoing caloric restriction, BP.DR; 24/17868-8 - Effects of an engineered probiotic to express GLP-1 and GLP-2 peptides in preventing and combating obesity and type 2 diabetes mellitus, BP.PD; 23/16530-0 - Assessment of the function of apolipoprotein-e in proopiomelanocortin neurons of the hypothalamus, BP.DR; 25/01132-5 - Blood biomarkers used in the assessment of biological age: a systematic review, BP.IC; 24/21618-7 - Evaluation of the role of resident microglia cells in the regulation of thermogenesis during hypothalamic inflammation induced by a high-fat diet, BP.DR; 24/21630-7 - Resident B cell function in Brown Adipose Tissue, BP.DR; 24/10814-0 - EVALUATION OF CERAMIDE PATHWAY MODULATION IN RESPONSE TO CONSUMPTION OF A HIGH INTERESTERIFIED FAT DIET IN MICE, BP.DR; 24/15480-2 - Lipolytic effect of using liraglutide in individuals with obesity and type 2 diabetes, BP.IC; 23/00848-1 - Characterization of the GPR139 Receptor as a Potential Target for Obesity Treatment, BP.DR; 24/01959-4 - EVALUATION OF THE EFFECT OF HYPOXIA ON THE ACTIVATION OF PATHWAYS RELATED TO THE CONTROL OF AGING IN PROOPIOMELANOCORTIN NEURONS OF THE HYPOTHALAMUS, BP.MS; 23/16397-9 - The role of CYP2E1 and interacting proteins in the regulation of thermogenesis in brown adipose tissue., BP.IC; 24/00363-0 - Energy balance in the context of body mass regulation and its impact on the development of obesity, BP.JC; 24/00361-8 - How advances in understanding the mechanisms of regulation of hunger and energy expenditure in the hypothalamus have enabled the development of new drugs for the treatment of obesity, BP.JC; 24/00362-4 - How advances in understanding the mechanisms of regulation of hunger and energy expenditure in the hypothalamus have enabled the development of new drugs for the treatment of obesity, BP.JC; 24/00364-7 - Energy balance in the context of body mass regulation and its impact on the development of obesity, BP.JC; 23/17763-9 - EVALUATION OF THE EFFECTS OF INTERESTERIFIED FAT ON ENERGY HOMEOSTASIS AND INSULIN SIGNALING IN THE HYPOTHALAMUS OF MICE, BP.IC; 24/02682-6 - Assessment of the function of apolipoprotein-e in proopiomelanocortin neurons of the hypothalamus, BP.DR; 23/17143-0 - Study of the participation of the transcription factor TCF7L2 in the mediation of the effects of the hormones progesterone and 17²-estradiol on the pancreatic ² cell in obesity, BP.DR; 24/01567-9 - The impact of cycles of fat mass gain and loss on systemic metabolism and energy balance in an experimental model of diet-induced obesity, BP.DR; 24/01619-9 - Functional evaluation of nuclear respiration factor-1 (Nrf1) in hypothalamic prooopiomelanocortin neurons, BP.DR; 24/01896-2 - Scientific dissemination on social media of the Obesity and Comorbidities Research Center, BP.TT; 23/13971-6 - Training in research laboratory techniques in endocrine pancreas metabolism., BP.TT; 23/14840-2 - EVALUATION OF THE EFFECT OF PHOTOBIOMODULATION ON HIDRADENITIS SUPPURATIVA: PROSPECTIVE STUDY, BP.IC; 23/10783-4 - Evaluation of the effect of photobiomodulation on hidradenitis suppurativa: a prospective study., BP.IC; 23/11393-5 - Chemokine expression characterization in the hypothalamus of mice fed a high-fat diet for short and long periods, BP.IC; 23/10154-7 - Unveiling the transcription factors responsible for adipocyte transdifferentiation in humans though in silico analysis., BP.IC; 23/07111-4 - Evaluation of the planetary health diet index in the participants of Nutritionist´s Health Study (NutriHS), BP.IC; 23/10146-4 - Unveiling the transcription factors related to circadian rhythm regulation in brown adipocytes., BP.IC; 23/07063-0 - Review and systematic analysis of single-cell RNA sequencing in beige and brown adipocytes, BP.IC; 23/06913-0 - EFFECTS OF AGE AND OVARIAN FACTORS ON THE EVALUATION OF HYPOTHALAMIC CELLS INVOLVED IN THE REPRODUCTIVE CONTROL OF MICES., BP.IC; 23/07030-4 - Growth hormone influence in gonads histology of male and female mice., BP.IC; 23/07121-0 - Application of body adiposity, body shape, relative fat mass and body roundness indexes in the evaluation of body adiposity and cardiometabolic health in adults., BP.IC; 23/07137-3 - EFFECTS OF DAPAGLIFLOZIN ON THE BONE TISSUE OF PATIENTS IN HEMODIALYSIS AND PERITONEAL DIALYSIS, BP.IC; 23/01860-5 - Role of peripheral NPY receptors in regulating energy homeostasis, BP.PD; 23/04860-6 - Effects of maternal nutrition in fetal and neonatal periods on monocyte chemotaxis in high-fat diet-induced hypothalamic inflammation in adult life, BP.IC; 22/16183-6 - Training in research laboratory techniques in endocrine pancreas metabolism., BP.TT; 23/00559-0 - Consequences of gestational stress in kidneys of male mice, BP.IC; 22/15297-8 - Associations between chronotypes and brown adipose tissue activation in women with different adiposity phenotypes and metabolic health., BP.IC; 22/13145-6 - Unveiling the transcriptional regulation of GPR3 gene in brown adipocytes, BP.PD; 21/12441-8 - Long-term modulation of lipoproteins metabolism induced by the use of glucocorticoids during pregnancy, BP.DD; 22/09707-9 - EVALUATION OF ENERGY EXPENDITURE AND MODULATION OF PLASTICITY OF ADIPOSE TISSUE INDUCED BY CONSUMPTION OF INTERESTERIFIED OR PARTIALLY HYDROGENATED FAT IN MICE., BP.IC; 22/12938-2 - Evaluation of modulation of hypothalamic BDNF expression under acute high-fat diet exposition, BP.IC; 22/12820-1 - Scientific dissemination on social networks of the Obesity and Comorbidities Research Center, BP.TT; 21/15062-8 - The impact of a high-fat diet in the response to a beta-3 adrenergic agonist in three strains of mice, BP.MS; 22/09101-3 - Metabolic phenotyping of mice devoid of neuropeptide Y (NPY) specifically in sympathetic neurons, BP.PD; 22/08508-2 - Multi-omic meta-analysis of the immune response to SARS-CoV-2: an integrated approach with cell resolution, BP.DD; 22/09841-7 - Evaluation of the main Th2 cytokines in the maintenance of the temperature of newborns and their relationship with atopy, BP.IC; 22/08010-4 - Involvement of the alpha-7 nicotinic receptor (±7nAChR) of the hippocampus and prefrontal cortex in the behavioral and plastic responses resulting from the consumption of a high-fat diet, BP.PD; 22/08172-4 - Validation of the global diet quality score for the Brazilian population, BP.PD; 22/06146-6 - The role of alpha7nAChR signaling in mediating tumor resistance to cancer therapy, BP.PD; 21/14364-0 - Complementary technical training, in the area of physiology and molecular biology, in the Laboratory of Cell Signaling., BP.TT; 21/06461-6 - Integrated mitochondrial stress response and the regulation of pro-opiomelanocortin processing in hypothalamic neuronal cell lines, BP.MS; 21/02008-5 - Brown adipose tissue and associated metabolites in women with different cardiometabolic health phenotypes, BP.DR; 22/03416-2 - The effects of high-fat diet consumption on the reproductive behavior and hypothalamic homeostasis in female and male mice, BP.IC; 21/13498-3 - Study of resident macrophages from adipose tissue of obese individuals through single-cell RNA sequencing, BP.PD; 22/01907-9 - Puberty as an ontogenetic window: the involvement of the autophagy and aging in renal disturbs induced by a high-fat diet, BP.DR; 22/00956-6 - Effect of the Enzyme PM20D1 on Metabolism and Thermogenesis in Mice and Humans, BP.DR; 21/14184-2 - Training in laboratory techniques of research of the endocrine pancreas metabolism, BP.TT; 21/11551-4 - Study of hypothalamic circuits that regulate metabolism and the endocrine system, BP.PD; 21/11089-9 - Prevalence and risk factors of subclinical atherosclerotic cardiovascular disease in diabetic patients: results from the Brazilian Diabetes Study, BP.IC; 21/11436-0 - Assessment of the influence of glycemic variability on the central retinal thickness as an early marker of diabetic retinopathy: results of the Brazilian Diabetes study, BP.IC; 21/08370-8 - Intestinal effects of Nicotinamide Riboside and Pterostilbene: an investigation about permeability, mucus production and nutrient absorption, BP.IC; 21/10279-9 - Effect of palmitate treatment on the expression of genes involved in the regulation of proopiomelanocortina, BP.IC; 21/09662-2 - Insulin therapy in patients with COVID-19: a systematic review, BP.IC; 21/06444-4 - Changes in maternal gut microbiota induced by fructose consumption during pregnancy: implications for the inflammatory allergic airway response in the offspring, BP.DR; 21/08366-0 - Training in laboratory techniques of research on endocrine pancreas metabolism, BP.TT; 21/04048-4 - Search for new adipocyte size regulators, BP.DR; 20/14020-7 - Molecular and functional mechanisms involved in the central effects of FGF19 on hypothalamic dysregulation, BP.DR; 21/08999-3 - Scientific dissemination as an instrument for disseminating knowledge about Obesity, BP.DR; 21/07288-6 - Characterization of the molecular mechanisms that regulate adult neurogenesis in the hypothalamus in response to reproductive stimulus, BP.DR; 21/01322-8 - Evaluation of the effects of interesterified fat on molecular mechanisms involved in the central control of energy homeostasis, BP.MS; 21/04333-0 - Neural and behavioral evaluation during the aging of transgenic mice submitted to gestational protein restriction: investigation of Alzheimer's Disease-related proteins, BP.DR; 20/12112-1 - Brown adipose tissue in congenital generalized lipodystrophy and familial partial lipodystrophy, BP.DR; 21/01147-1 - Study of the influence of arginine metabolism on the immunometabolic profile of macrophages, BP.DD; 21/00443-6 - Evaluation of Kiss1 and Fezf1 neurons functions in adult hypothalamic neurogenesis triggered by hormones and nutritional stimuli, BP.PD; 21/01221-7 - Complementary technical training, in the area of physiology and molecular biology, in the Laboratory of Cell Signaling, BP.TT; 21/00509-7 - Multi-omic meta-analysis of the immune response to SARS-CoV-2: an integrated approach with cell resolution, BP.IC; 20/07991-6 - Preparation and biological evaluation of phosphoryl and phosphonyl derivatives of goniothalamin and piplartine, BP.PD; 20/09992-0 - The role of inflammation on GnRH synthesis in a hypothalamic cell line, BP.IC; 19/17953-7 - Investigating the impact of fructose consumption on the airway inflammatory response during allergic asthma: focus on the gut microbiota, BE.PQ; 20/06057-8 - Exploring new mechanisms of intercellular communication in metabolic diseases, BP.PD; 20/09112-0 - Effects evaluation of selective BDNF inhibition on FezF1 and Kiss1 hypothalamic neurons on the regulation of energy metabolism and thermogenesis, BP.DR; 20/05425-3 - Impact of adiponectin concentration on endothelial vasomotor function in patients with type 2 diabetes, BP.IC; 20/09717-9 - Molecular mechanisms involved in cardiovascular changes triggered by fetal excess glucocorticoids, BP.DR; 20/10102-9 - Study of the effects induced by GH receptor ablation in neurons of the lateral hypothalamic area, BP.PD; 20/03924-2 - Evaluation of the role of immunomodulation on brown adipose tissue activity in immunodeficient mice, BP.IC; 20/07257-0 - Hormonal, nutritional and inflammatory factors and microRNAs modulation related to the altered cholinergic anti-inflammatory response in Obesity, BP.PD; 20/06397-3 - Study of cellular senescence in rodents subjected to Obesity, BP.PD; 20/06661-2 - Role of alpha7nAChR cholinergic receptors in hypothalamic POMC neurons on the control of energy homeostasis in mice, BP.DR; 20/08489-2 - Combined effect of GLP-1 and GPRS 40 and 120 agonists in the treatment of experimental Obesity, BP.DR; 20/07673-4 - Clinical trial for bradykinin inhibition in hospitalized adults with severe COVID-19, BP.PD; 19/03751-3 - Influence of the history of Obesity originated at different moments of life in allergic pulmonary inflammation, BP.PD; 19/19488-0 - The effect of agomelatine in human platelets aggregation and adhesion, BP.MS; 20/05575-5 - Determination of molecular and cellular mechanisms involved in adult hypothalamus neurogenesis in response to reproductive stimuli, BP.PD; 19/23819-1 - Evaluation of Non-Transcriptional Pathways of High Density Lipoprotein-Mediated Ischemic Post-Conditioning, BP.DR; 20/03956-1 - Investigation of the involvement of the microbiota-intestine-brain axis in the etiology of endocrine pancreatic dysfunction in mice subjected to protein malnutrition, BP.DR; 20/04074-2 - The hypothalamic cellular ontology: a single-cell RNA sequencing integrative approach, BP.IC; 20/02539-8 - TRAINING IN RESEARCH LABORATORY TECHNIQUES IN ENDOCRINE PANCREAS METABOLISM, BP.TT; 18/17792-0 - HDL-S1P against pyroptosis damage after Acute Myocardial Infarction, BP.PD; 19/00728-0 - The role of gut-pancreas axis upon glycemic homeostasis maintenance in obese mice submitted to vertical gastrectomy: a molecular and functional approach, BP.PD; 18/17832-2 - EFFECTS OF INTERSTERIFIED FAT ON THE INTESTINAL PERMEABILITY OF HEALTHY AND OBESES ANIMALS, BP.PD; 19/05210-0 - Evaluation of Interleukin-10 Modulation in Brown Adipose Tissue Termogenesis in Newborn: Therapeutic Strategies., BP.PD; 18/19942-0 - Central role of GLP-1 agonists (liraglutide) and antiepileptic (topiramate) in treatment of high-fat diet-induced Obesity, BP.DR; 19/00330-7 - Effect of palmitate treatment in pc1/3 expression in a hypothalamic cell lineage, BP.MS; 16/24768-3 - Evaluation of metabolic parameters of experimental animal models in response to dietary interesterified fat: underlaying molecular mechanisms, BP.DR; 18/07970-9 - Complementary technical training, in the area of physiology and molecular biology, in the laboratory of cell signaling, BP.TT; 18/01863-6 - Role of hypothalamic cholinergic receptor alpha7 (alpha7nAChR) in control of energy homeostasis and association with leptin signaling in mice, BP.MS; 18/00543-8 - The role of endothelial and macrophage mineralocorticoid receptor in inflammation response and anti-contractile function of perivascular adipose tissue in obese male and female, BP.PD; 17/22586-8 - Association between body composition and brown adipose tissue activity in human adults, BP.IC; 18/05979-9 - Training in research techniques of research on endocrine pancreas metabolism, BP.TT; 16/00977-2 - Evaluation of expression and distribution of Nhlh2 protein in the hypothalamus of animals subjected to high fat diet, BP.DR; 16/01245-5 - Evaluation of the involvement of TRIL in inflammation and apoptosis of POMC neurons in the hypothalamus of obese mice, BP.DR; 17/13410-3 - Possible contribution of tauroursodeoxycholic acid (TUDCA) on the remission of type 2 diabetes in mice submitted to Duodenal-Jejunal Bypass, BP.PD; 17/06245-6 - The role of a Peroxisome Proliferator-Activated Receptor Gamma agonist (PPAR-³) in the recruitment of inducible brown adipose tissue in humans by stabilizing proteins involved in the transcriptional cascade of adipogenesis, BP.IC; 17/14298-2 - Combined effect of GLP-1 and GPRs 40 and 120 agonists in the treatment of experimental obesity, BP.DR; 17/15382-7 - Assessment of theoretical and scientific knowledge diffusion on nutrition and healthy eating effectiveness for students, residents and healthcare professionals at UNICAMP, BP.IC; 17/06146-8 - Development of nanocarriers based on dendrimers and polymer nanoparticles for selective delivery of goniothalamin, piplartine and Monastrol, BP.PD; 16/24289-8 - The role of pyruvate carboxylase on insulin sensitivity of skeletal muscle cells line of mice submitted to aminoacids deprivation: Involviment of ACILCARNITINES, BP.PD; 17/11138-4 - Effect of pregnancy followed by lactation on miRNAs modulation of maternal pancreatic islets, BP.IC; 17/08200-0 - Evaluation of serum factors effects obtained from mice with and without predisposition to obesity on inflammatory aspects in microglia line and hypothalamic neurons, BP.IC; 16/20472-2 - Evaluation of the long-term changes in the lipid profile of woman that underwent antenatal corticotherapy during pregnancy, BP.IC; 17/06389-8 - Effects of circadian misalignment on brown adipose tissue activity in humans, BP.IC; 16/25783-6 - Molecular and functional analysis of taurine action on apoptosis and redox balance pathways in cells/tissues submitted to amino acid restriction, BP.PD; 16/23833-6 - Role of alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in preventing insulin resistance in hypothalamic cells., BP.DR; 16/20488-6 - Evaluation of the long-term changes in insulin sensitivity of woman that underwent antenatal corticotherapy during pregnancy, BP.IC; 16/09270-9 - Orexin participation in the interaction between hunger and reward control systems in spontaneously lean and obese animals kept with normocaloric diet, BP.PD; 16/14461-8 - In vivo and in vitro endothelial effects of taurine in protein restriction, BP.PD; 16/17102-9 - Function of myostatin in epigenetic control of pancreatic beta cells proliferation, BP.PD; 16/07361-7 - The role of maternal obesity on modulation of offspring hypothalamic miRNAs and metabolic consequences associated, BP.PD; 16/08865-9 - Modulation of adiponectin receptor AdipoR1 and miR-221 in skeletal muscle of trained and high-fat diet fed C57BL/6 mice, BP.IC; 16/10616-7 - Effect of monounsaturated fatty acids consumption in brown/beige adipose tissue activity in human adults, BP.PD; 16/08569-0 - Synthesis of glibenclamide new derivatives in order to obtain potential antihyperglycemic drugs, BP.PD; 16/05312-9 - Effect of a new inhibitor of adenosine kinase (ADK) in energetic metabolism in obese mice, BP.PD; 15/25710-6 - Hypothalamic autophagy evaluation in response to treatment with saturated fatty acid in vitro and in vivo: connections with inflammatory pathways, BP.DR; 16/03047-6 - MicroRNAs analysis in the hypothalamus of trained and high fat diet-fed C57BL/6 mice, BP.IC; 16/04256-8 - Subcutaneous adipose tissue formation mechanisms in a lymphedema experimental model, BP.IC; 16/04723-5 - The influence of gut microbiota in blood pressure modulation of rodents: the role of hydrogen sulfide (H2S) and short-chain fatty acids., BP.DR; 15/23969-2 - "EFFECTS OF DAPAGLIFLOZIN A SGLT2 INHIBITOR ON BLOOD PRESSURE, CARDIOVASCULAR REMODELING AND OBESITY PROFILE IN RESISTANT HYPERTENSION SUBJECTS ", BP.DR; 15/25597-5 - Hepatic microRNA expression profile in Goto-Kakizaki rats and Wistar rats subjected to metabolic programming by prenatal exposure to glucocorticoid excess, BP.DR; 15/20353-0 - Hemodynamic responses of 0.9% saline solution infusion in obese resistant hypertensive patients, BP.IC; 15/10078-2 - Effect of a high caloric diet in the expression of Hypoxia- inducible factor-1 (HIF1): Role in obesity through deregulation of pomc gene, BP.PD; 15/23285-6 - Endocrine pancreas maturation and differentiation in offspring of females submitted to dexamethasone treatment during pregnancy, BP.PD; 15/12020-1 - The effects of body mass reduction on the blood levels of Th17 family citokynes in subjects submitted to Roux-en-Y gastric bypass, BP.IC; 14/05635-7 - Genetic polymorphisms of matrix metalloproteinases in resistant hypertension, BE.PQ; 14/26591-8 - Acute effect of dapagliflozin SGLT-2 inhibitory on brain and hypothalamic functionality in humans and mice C57BL/6, BP.MS; 14/26942-5 - Evaluation of intracerebroventricular treatment effect with selective agonists of GPR120 and GPR40 receptors and in high fat diet induced-obesity mice, BP.PD; 14/07496-4 - Role of the transcription factor IRX3 in inducing hypothalamic neurogenesis in adult mice, BP.PD; 15/02913-9 - Structural and molecular analysis of the hypotalamus median eminence of mice born from high fat diet fed mothers, BP.PD; 15/03645-8 - Hormone peptides PYY and TFF2 action on leptin signaling pathway in CLU189 cells, BP.IC; 15/00360-2 - Cardiac and renal effects in rats offspring subjected to protein restriction during gestation and lactation: influence of enriched environment on these effects, BP.IC; 14/24050-0 - The role of hypothalamic stearoil-CoA 2 (SCD2) in neurogenesis de novo, BP.IC; 14/24515-2 - Role of inflammassome in hypothalamic inflammation in response to hyperlipidic diet, BP.IC; 14/17384-9 - Autophagy in hypothalamic neurons in obesity, BP.PD; 14/09532-8 - Functional and molecular analysis of estrogen receptors in the islets of Langerhans and peripheral tissues of malnourished mice and their involvement in glycemic control, BP.PD; 14/06840-3 - BMP-SMADs pathway in the pancreatic beta cell as a modulator of glucose-stimulated insulin secretion, BP.PD; 14/09118-7 - The involvement of microRNAs in the accelerated ageing process caused by obesity and the potential intervention by caloric restriction, fatty acid supplementation and exercise, BP.PD; 14/00742-0 - Characterization of rapid POMC regulation mechanisms involved in high-fat diet response, BP.PD; 14/03285-9 - Obesity and target organs damage in resistant hypertension: role of metaloproteinases, BP.PD; 13/26319-3 - Evaluation of the temporal progression of the installation of inflammation, endoplasmic reticulum stress and mitochondrial dysfunction in the hypothalamus of mice subjected to a high fat diet, BP.MS; 14/02819-0 - Investigation of glucose and lipid metabolism alterations in a model of nicotinamide nucleotide transhydrogenase mitochondrial (NNT)deficiency ., BP.DR; 14/03905-7 - Circadian modulation of peripheral insulin sensitivity in malnourished mice submitted to hyperlipidic diet, BP.IC; 13/24026-9 - Evaluation of the role of dsRNA-dependent protein kinase (PKR) in the pathogenesis of insulin resistance and intestinal permeability in obesity., BP.PD; 13/25847-6 - INVOLVEMENT OF THE AUTONOMIC NERVOUS SYSTEM UPON GLUCOSE CONTROL AND PANCREATIC ISLETS FUNCTION IN MALNOURISHED MICE FED A HIGH-FAT DIET, BP.DR; 14/02977-4 - Epigenetic mechanisms associated with obesity and chronic inflammation, BP.PD; 13/25415-9 - Evaluation Of Adaptive Immune Response in Inflammation of the Hypothalamus in Obesity, BP.DR; 13/22815-6 - Distribution of adipocytes, adipocytokines and cardiovascular characteristics in individuals with spinal cord injury, BP.IC; 13/20539-1 - Analysis of the neural effects of in utero protein restriction in rats subjected or not to caloric overload: study parameters neuro-behavioral, morpho-functional molecular and during development in rats, BP.DR; 13/22321-3 - Chronic insulin receptor blockade in amygdala: effects on energy metabolism, BP.IC; 13/22276-8 - Role of hypothalamic stearoyl-CoA desaturase 2 in neuronal apoptosis and obesity, BP.PD; 12/17416-2 - REGULATION OF MITOCHONDRIAL FUNCTION AND METABOLISM OF GLUCOSE AND FATTY ACIDS BY FACTOR OF HYPOXIA INDUCIBLE (HIF-1a) MUSCLE CELLS IN INSULIN RESISTANCE, BP.PD; 12/24629-2 - Insulin signaling pathway and HSR action in rodent longevity., BP.PD; 12/02669-2 - MOLECULAR MECANISMS OF PULMONARY ARTERIAL HYPERTENSION ASSOCIATED TO INSULIN RESISTANCE: STUDIES IN ANIMAL MODEL OF OBESITY., BP.PD; 11/22217-6 - Modulation of Amino Acids metabolism in Muscle and Adipose Tissue: Effects of Physical Exercise and Bariatric Gastric Bypass Surgery., BP.PD - associated scholarships

Abstract

Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected that by the year 2020 up to 20% Brazilians will be obese and approximately 50%, overweigh. Obesity is highly associated with a number of diseases such as diabetes, hypertension, atherosclerosis and certain types of cancer. Because of the absolute lack of appropriate preventive and therapeutic approaches to deal with obesity, the overall mortality directly and indirectly associated with this disease is rapidly increasing in the world. Obesity results from an imbalance between caloric intake and energy expenditure. Although great advance was recently obtained in the characterization of the mechanisms of control of feeding and thermogenesis, the complexity of the neural circuits that control these functions and the difficulties imposed by anatomical constrains to study human hypothalamus, have contributed to hamper a rapid advance in the treatment of obesity. The main objective of OCRC is to coordinate the efforts to find solutions for obesity and associated diseases. Some of the most productive Brazilian scientists in these fields will work in concert to provide advance in the understanding of the mechanisms leading to obesity and its associated conditions. In addition, the search for new pharmacological nutritional and physical activity approaches to deal with these diseases will be pursued. Regarding education, OCRC will invest on the orientation of high-school students and senior citizens regarding preventive and screening methods for early detection of these diseases. Also, OCRC will foster programs for improving the education of undergraduate students in the field of nutrition and increasing the interest for research in these fields. Finally, OCRC staff will be in contact with industry and other potential users of the knowledge and products obtained in order to speed up the transfer of knowledge to society. (AU)

Scientific publications

(195)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, ROBERTA S.; BATISTA, THIAGO M.; CAMARGO, RAFAEL L.; MORATO, PRISCILA N.; BORCK, PATRICIA C.; LEITE, NAYARA C.; KURAUTI, MIRIAN A.; WANSCHEL, AMARYLIS C. B. A.; NADAL, ANGEL; CLEGG, DEBORAH J.; et al. Lacking of estradiol reduces insulin exocytosis from pancreatic beta-cells and increases hepatic insulin degradation. Steroids, v. 114, n. SI, p. 16-24, OCT 2016. (15/05801-7, 13/07607-8)

BUSANELLO, ESTELA N. B.; FIGUEIRA, TIAGO R.; MARQUES, ANA C.; NAVARRO, CLAUDIA D. C.; OLIVEIRA, HELENA C. F.; VERCESI, ANIBAL E.. Facilitation of Ca2+-induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment. Cell Biology International, v. 42, n. 6, SI, p. 742-746, JUN 2018. (06/59786-0, 11/50400-0, 14/11261-2, 13/07607-8)

PAIVA, ADRIENE A.; RAPOSO, HELENA F.; WANSCHEL, AMARYLIS C. B. A.; NARDELLI, TARLLIZA R.; OLIVEIRA, HELENA C. F.. Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. (11/50400-0, 13/07607-8)

DORIGHELLO, GABRIEL G.; PAIM, BRUNO A.; LEITE, ANA CATARINA R.; VERCESI, ANIBAL E.; OLIVEIRA, HELENA C. F.. Spontaneous experimental atherosclerosis in hypercholesterolemic mice advances with ageing and correlates with mitochondrial reactive oxygen species. Experimental Gerontology, v. 109, n. SI, p. 47-50, AUG 2018. (11/50400-0, 13/07607-8)

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Filed patent(s) as a result of this research project