OCRC - Obesity and Comorbidities Research Center

• Grant number: 13/07607-8
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• Duration: June 01, 2013 - May 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Licio Augusto Velloso
• Grantee: Licio Augusto Velloso
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Pesquisadores principais:( Atuais ): Andrei Carvalho Sposito ; Bruno Geloneze Neto ; Carlos Eduardo Negrão ; Everardo Magalhães Carneiro ; Heitor Moreno Junior ; Helena Coutinho Franco de Oliveira ; Jose Antonio Rocha Gontijo ; Jose Donato Junior ; Marcio Alberto Torsoni ; Ronaldo Aloise Pilli ; Silvana Auxiliadora Bordin da Silva ; Wilson Nadruz Junior
• Pesquisadores principais:( Anteriores ): Aníbal Eugênio Vercesi ; Antonio Carlos Boschiero ; Heraldo Possolo de Souza ; José Barreto Campello Carvalheira ; Marcelo Alves da Silva Mori ; Mario Jose Abdalla Saad
• Associated researchers: Adriana Souza Torsoni ; Alessandro dos Santos Farias ; Amilton dos Santos Junior ; Ana Carolina Junqueira Vasques ; Ana Paula Couto Davel ; Antonio Carlos Boschiero ; Camilo de Lellis Santos ; Carlos Henrique Grossi Sponton ; Celso Darío Ramos ; Claudio Cesar Zoppi ; Daniel Martins-de-Souza ; Dennys Esper Corrêa Cintra ; Eduardo Rochete Ropelle ; Eliana Pereira de Araujo ; Elinton Adami Chaim ; Erika Anne de Freitas Robles Roman ; Fernando Cendes ; Gabriel Forato Anhê ; Helena Cristina de Lima Barbosa ; Ivani Credidio Trombetta ; João Vilhete Viegas d'Abreu ; José Roberto Matos Souza ; José Rodrigo Pauli ; Joseane Morari Ricciardi de Aguiar ; Kelly Lima Calisto da Silva ; Leonardo dos Reis Silveira ; Letícia Ignácio de Souza Zimmermann ; Lígia de Moraes Antunes Corrêa ; Luiz Osório Silveira Leiria ; Marciane Milanski Ferreira ; Marcio Alberto Torsoni ; Marco Aurélio Ramirez Vinolo ; Maria Helena de Melo Lima ; Maria Luiza Moretti ; Otávio Rizzi Coelho-Filho ; Patrícia Aline Boer ; Patrícia de Oliveira Prada ; Paulo Dalgalarrondo ; Pedro Manoel Mendes de Moraes Vieira ; Raquel Franco Leal ; Renata Frazão ; Roberto Schreiber ; Rodrigo Ramos Catharino ; Roger Frigério Castilho ; Ronaldo Aloise Pilli ; Vera Regina Toledo Camargo
• Associated grant(s): 23/01442-9 - Evaluation of the phenotype of mice with NHLH2 deletion in POMC neurons, AP.R; 22/02840-5 - Influence of airway allergic inflammation on platelet infiltration in the lungs of mice consuming hyperlipidic diet or sucrose consumption: possible participation of gut microbiota, AV.EXT; 20/05430-7 - Multicenter, prospective, randomized, double-blind, placebo-controlled study to evaluate the Effect of Diacerein to prevent death or multiple organ dysfunction in patients with ARDS secondary to COVID-19, AP.R; + associated grants 20/04522-5 - Clinical trial for bradykinin inhibition in hospitalized adults with COVID-19 grave, AP.R; 18/25050-4 - EMU granted in the proceeding 2013/07607-8: radiopharmaceutical synthesizer for PET/CT, AP.EMU; 18/14132-0 - EANM'18 - Annual Congress of the European AssociaBon of Nuclear Medicine, AR.EXT; 15/13362-3 - 9th World Congress of Developmental Origins of Health and Disease, AR.EXT - associated grants
• Associated scholarship(s): 23/10783-4 - Evaluation of the effect of photobiomodulation on hidradenitis suppurativa: a prospective study., BP.IC; 23/07111-4 - Evaluation of the planetary health diet index in the participants of Nutritionist´s Health Study (NutriHS), BP.IC; 23/10146-4 - Unveiling the transcription factors related to circadian rhythm regulation in brown adipocytes., BP.IC; + associated scholarships 23/10154-7 - Unveiling the transcription factors responsible for adipocyte transdifferentiation in humans though in silico analysis., BP.IC; 23/06913-0 - EFFECTS OF AGE AND OVARIAN FACTORS ON THE EVALUATION OF HYPOTHALAMIC CELLS INVOLVED IN THE REPRODUCTIVE CONTROL OF MICES., BP.IC; 23/07030-4 - Growth hormone influence in gonads histology of male and female mice., BP.IC; 23/07121-0 - Application of body adiposity, body shape, relative fat mass and body roundness indexes in the evaluation of body adiposity and cardiometabolic health in adults., BP.IC; 23/07137-3 - EFFECTS OF DAPAGLIFLOZIN ON THE BONE TISSUE OF PATIENTS IN HEMODIALYSIS AND PERITONEAL DIALYSIS, BP.IC; 23/01860-5 - Role of peripheral NPY receptors in regulating energy homeostasis, BP.PD; 23/07063-0 - Review and systematic analysis of single-cell RNA sequencing in beige and brown adipocytes, BP.IC; 23/04860-6 - Effects of maternal nutrition in fetal and neonatal periods on monocyte chemotaxis in high-fat diet-induced hypothalamic inflammation in adult life, BP.IC; 22/15297-8 - Associations between chronotypes and brown adipose tissue activation in women with different adiposity phenotypes and metabolic health., BP.IC; 22/16183-6 - Training in research laboratory techniques in endocrine pancreas metabolism., BP.TT; 23/00559-0 - Consequences of gestational stress in kidneys of male mice, BP.IC; 22/13145-6 - Unveiling the transcriptional regulation of GPR3 gene in brown adipocytes, BP.PD; 22/09707-9 - EVALUATION OF ENERGY EXPENDITURE AND MODULATION OF PLASTICITY OF ADIPOSE TISSUE INDUCED BY CONSUMPTION OF INTERESTERIFIED OR PARTIALLY HYDROGENATED FAT IN MICE., BP.IC; 22/12938-2 - Evaluation of modulation of hypothalamic BDNF expression under acute high-fat diet exposition, BP.IC; 22/12820-1 - Scientific dissemination on social networks of the Obesity and Comorbidities Research Center, BP.TT; 21/12441-8 - Long-term modulation of lipoproteins metabolism induced by the use of glucocorticoids during pregnancy, BP.DD; 22/08508-2 - Multi-omic meta-analysis of the immune response to SARS-CoV-2: an integrated approach with cell resolution, BP.DD; 22/09841-7 - Evaluation of the main Th2 cytokines in the maintenance of the temperature of newborns and their relationship with atopy, BP.IC; 21/15062-8 - The impact of a high-fat diet on the structure of brown adipose tissue function in three strains of mice - Interface between genetics and nutrition, BP.MS; 22/09101-3 - Metabolic phenotyping of mice devoid of neuropeptide Y (NPY) specifically in sympathetic neurons, BP.PD; 22/08010-4 - Involvement of the alpha-7 nicotinic receptor (±7nAChR) of the hippocampus and prefrontal cortex in the behavioral and plastic responses resulting from the consumption of a high-fat diet, BP.PD; 22/08172-4 - Validation of the global diet quality score for the Brazilian population, BP.PD; 22/06146-6 - The role of alpha7nAChR signaling in mediating tumor resistance to cancer therapy, BP.PD; 21/14364-0 - Complementary technical training, in the area of physiology and molecular biology, in the Laboratory of Cell Signaling., BP.TT; 21/06461-6 - Integrated mitochondrial stress response and the regulation of pro-opiomelanocortin processing in hypothalamic neuronal cell lines, BP.MS; 22/03416-2 - The effects of high-fat diet consumption on the reproductive behavior and hypothalamic homeostasis in female and male mice, BP.IC; 21/02008-5 - Brown adipose tissue and associated metabolites in women with different cardiometabolic health phenotypes, BP.DR; 22/00956-6 - Effect of the Enzyme PM20D1 on Metabolism and Thermogenesis in Mice and Humans, BP.DR; 21/14184-2 - Training in laboratory techniques of research of the endocrine pancreas metabolism, BP.TT; 21/13498-3 - Study of resident macrophages from adipose tissue of obese individuals through single-cell RNA sequencing, BP.PD; 22/01907-9 - Puberty as an ontogenetic window: the involvement of the autophagy and aging in renal disturbs induced by a high-fat diet, BP.DR; 21/11551-4 - Study of hypothalamic circuits that regulate metabolism and the endocrine system, BP.PD; 21/11089-9 - Prevalence and risk factors of subclinical atherosclerotic cardiovascular disease in diabetic patients: results from the Brazilian Diabetes Study, BP.IC; 21/11436-0 - Assessment of the influence of glycemic variability on the central retinal thickness as an early marker of diabetic retinopathy: results of the Brazilian Diabetes study, BP.IC; 21/08370-8 - Intestinal effects of Nicotinamide Riboside and Pterostilbene: an investigation about permeability, mucus production and nutrient absorption, BP.IC; 21/10279-9 - Effect of palmitate treatment on the expression of genes involved in the regulation of proopiomelanocortina, BP.IC; 21/09662-2 - Insulin therapy in patients with COVID-19: a systematic review, BP.IC; 21/08999-3 - Scientific dissemination as an instrument for disseminating knowledge about Obesity, BP.DR; 21/07288-6 - Characterization of the molecular mechanisms that regulate adult neurogenesis in the hypothalamus in response to reproductive stimulus, BP.DR; 21/06444-4 - Changes in maternal gut microbiota induced by fructose consumption during pregnancy: implications for the inflammatory allergic airway response in the offspring, BP.DR; 21/08366-0 - Training in laboratory techniques of research on endocrine pancreas metabolism, BP.TT; 21/04048-4 - Search for new adipocyte size regulators, BP.DR; 20/14020-7 - Molecular and functional mechanisms involved in the central effects of FGF19 on hypothalamic dysregulation, BP.DR; 21/01322-8 - Evaluation of the effects of interesterified fat on molecular mechanisms involved in the central control of energy homeostasis, BP.MS; 21/04333-0 - Neural and behavioral evaluation during the aging of transgenic mice submitted to gestational protein restriction: investigation of Alzheimer's Disease-related proteins, BP.DR; 20/12112-1 - Characterization of brown adipose tissue of individuals diagnosed with Congenital Ganeralized Lipodystrophy compared to obese dysmetabolic, obese eumetabolic and eutrophic eumetabolic, BP.DR; 21/01147-1 - Study of the influence of arginine metabolism on the immunometabolic profile of macrophages, BP.DD; 21/00443-6 - Evaluation of Kiss1 and Fezf1 neurons functions in adult hypothalamic neurogenesis triggered by hormones and nutritional stimuli, BP.PD; 21/01221-7 - Complementary technical training, in the area of physiology and molecular biology, in the Laboratory of Cell Signaling, BP.TT; 21/00509-7 - Multi-omic meta-analysis of the immune response to SARS-CoV-2: an integrated approach with cell resolution, BP.IC; 20/07991-6 - Preparation and biological evaluation of phosphoryl and phosphonyl derivatives of goniothalamin and piplartine, BP.PD; 20/09992-0 - The role of inflammation on GnRH synthesis in a hypothalamic cell line, BP.IC; 19/17953-7 - Investigating the impact of fructose consumption on the airway inflammatory response during allergic asthma: focus on the gut microbiota, BE.PQ; 20/06057-8 - Exploring new mechanisms of intercellular communication in metabolic diseases, BP.PD; 20/09112-0 - Effects evaluation of selective BDNF inhibition on FezF1 and Kiss1 hypothalamic neurons on the regulation of energy metabolism and thermogenesis, BP.DR; 20/05425-3 - Impact of adiponectin concentration on endothelial vasomotor function in patients with type 2 diabetes, BP.IC; 20/09717-9 - Molecular mechanisms involved in cardiovascular changes triggered by fetal excess glucocorticoids, BP.DR; 20/10102-9 - Study of the effects induced by GH receptor ablation in neurons of the lateral hypothalamic area, BP.PD; 20/07257-0 - Hormonal, nutritional and inflammatory factors and microRNAs modulation related to the altered cholinergic anti-inflammatory response in Obesity, BP.PD; 20/06397-3 - Study of cellular senescence in rodents subjected to Obesity, BP.PD; 20/06661-2 - Role of alpha7nAChR cholinergic receptors in hypothalamic POMC neurons on the control of energy homeostasis in mice, BP.DR; 20/03924-2 - Evaluation of the role of immunomodulation on brown adipose tissue activity in immunodeficient mice, BP.IC; 20/08489-2 - Combined effect of GLP-1 and GPRS 40 and 120 agonists in the treatment of experimental Obesity, BP.DR; 20/07673-4 - Clinical trial for bradykinin inhibition in hospitalized adults with severe COVID-19, BP.PD; 19/19488-0 - The effect of agomelatine in human platelets aggregation and adhesion, BP.MS; 20/05575-5 - Determination of molecular and cellular mechanisms involved in adult hypothalamus neurogenesis in response to reproductive stimuli, BP.PD; 19/03751-3 - Influence of the history of Obesity originated at different moments of life in allergic pulmonary inflammation, BP.PD; 20/03956-1 - Investigation of the involvement of the microbiota-intestine-brain axis in the etiology of endocrine pancreatic dysfunction in mice subjected to protein malnutrition, BP.DR; 20/04074-2 - The hypothalamic cellular ontology: a single-cell RNA sequencing integrative approach, BP.IC; 19/23819-1 - Evaluation of Non-Transcriptional Pathways of High Density Lipoprotein-Mediated Ischemic Post-Conditioning, BP.DR; 20/02539-8 - TRAINING IN RESEARCH LABORATORY TECHNIQUES IN ENDOCRINE PANCREAS METABOLISM, BP.TT; 18/17792-0 - HDL-S1P against pyroptosis damage after Acute Myocardial Infarction, BP.PD; 19/00728-0 - The role of gut-pancreas axis upon glycemic homeostasis maintenance in obese mice submitted to vertical gastrectomy: a molecular and functional approach, BP.PD; 18/17832-2 - EFFECTS OF INTERSTERIFIED FAT ON THE INTESTINAL PERMEABILITY OF HEALTHY AND OBESES ANIMALS, BP.PD; 19/05210-0 - Evaluation of Interleukin-10 Modulation in Brown Adipose Tissue Termogenesis in Newborn: Therapeutic Strategies., BP.PD; 19/00330-7 - Effect of palmitate treatment in pc1/3 expression in a hypothalamic cell lineage, BP.MS; 18/19942-0 - Central role of GLP-1 agonists (liraglutide) and antiepileptic (topiramate) in treatment of high-fat diet-induced Obesity, BP.DR; 16/24768-3 - Evaluation of metabolic parameters of experimental animal models in response to dietary interesterified fat: underlaying molecular mechanisms, BP.DR; 18/01863-6 - Role of hypothalamic cholinergic receptor alpha7 (alpha7nAChR) in control of energy homeostasis and association with leptin signaling in mice, BP.MS; 18/07970-9 - Complementary technical training, in the area of physiology and molecular biology, in the laboratory of cell signaling, BP.TT; 17/22586-8 - Association between body composition and brown adipose tissue activity in human adults, BP.IC; 18/00543-8 - The role of endothelial and macrophage mineralocorticoid receptor in inflammation response and anti-contractile function of perivascular adipose tissue in obese male and female, BP.PD; 18/05979-9 - Training in research techniques of research on endocrine pancreas metabolism, BP.TT; 16/00977-2 - Evaluation of expression and distribution of Nhlh2 protein in the hypothalamus of animals subjected to high fat diet, BP.DR; 16/01245-5 - Evaluation of the involvement of TRIL in inflammation and apoptosis of POMC neurons in the hypothalamus of obese mice, BP.DR; 17/13410-3 - Possible contribution of tauroursodeoxycholic acid (TUDCA) on the remission of type 2 diabetes in mice submitted to Duodenal-Jejunal Bypass, BP.PD; 17/06245-6 - The role of a Peroxisome Proliferator-Activated Receptor Gamma agonist (PPAR-³) in the recruitment of inducible brown adipose tissue in humans by stabilizing proteins involved in the transcriptional cascade of adipogenesis, BP.IC; 17/14298-2 - Combined effect of GLP-1 and GPRs 40 and 120 agonists in the treatment of experimental obesity, BP.DR; 17/15382-7 - Assessment of theoretical and scientific knowledge diffusion on nutrition and healthy eating effectiveness for students, residents and healthcare professionals at UNICAMP, BP.IC; 16/24289-8 - The role of pyruvate carboxylase on insulin sensitivity of skeletal muscle cells line of mice submitted to aminoacids deprivation: Involviment of ACILCARNITINES, BP.PD; 17/06146-8 - Development of nanocarriers based on dendrimers and polymer nanoparticles for selective delivery of goniothalamin, piplartine and Monastrol, BP.PD; 17/11138-4 - Effect of pregnancy followed by lactation on miRNAs modulation of maternal pancreatic islets, BP.IC; 16/20472-2 - Evaluation of the long-term changes in the lipid profile of woman that underwent antenatal corticotherapy during pregnancy, BP.IC; 17/06389-8 - Effects of circadian misalignment on brown adipose tissue activity in humans, BP.IC; 17/08200-0 - Evaluation of serum factors effects obtained from mice with and without predisposition to obesity on inflammatory aspects in microglia line and hypothalamic neurons, BP.IC; 16/25783-6 - Molecular and functional analysis of taurine action on apoptosis and redox balance pathways in cells/tissues submitted to amino acid restriction, BP.PD; 16/23833-6 - Role of alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in preventing insulin resistance in hypothalamic cells., BP.DR; 16/20488-6 - Evaluation of the long-term changes in insulin sensitivity of woman that underwent antenatal corticotherapy during pregnancy, BP.IC; 16/09270-9 - Orexin participation in the interaction between hunger and reward control systems in spontaneously lean and obese animals kept with normocaloric diet, BP.PD; 16/14461-8 - In vivo and in vitro endothelial effects of taurine in protein restriction, BP.PD; 16/17102-9 - Function of myostatin in epigenetic control of pancreatic beta cells proliferation, BP.PD; 16/07361-7 - The role of maternal obesity on modulation of offspring hypothalamic miRNAs and metabolic consequences associated, BP.PD; 16/08865-9 - Modulation of adiponectin receptor AdipoR1 and miR-221 in skeletal muscle of trained and high-fat diet fed C57BL/6 mice, BP.IC; 16/10616-7 - Effect of monounsaturated fatty acids consumption in brown/beige adipose tissue activity in human adults, BP.PD; 16/05312-9 - Effect of a new inhibitor of adenosine kinase (ADK) in energetic metabolism in obese mice, BP.PD; 16/08569-0 - Synthesis of glibenclamide new derivatives in order to obtain potential antihyperglycemic drugs, BP.PD; 15/25710-6 - Hypothalamic autophagy evaluation in response to treatment with saturated fatty acid in vitro and in vivo: connections with inflammatory pathways, BP.DR; 16/03047-6 - MicroRNAs analysis in the hypothalamus of trained and high fat diet-fed C57BL/6 mice, BP.IC; 16/04256-8 - Subcutaneous adipose tissue formation mechanisms in a lymphedema experimental model, BP.IC; 16/04723-5 - The influence of gut microbiota in blood pressure modulation of rodents: the role of hydrogen sulfide (H2S) and short-chain fatty acids., BP.DR; 15/20353-0 - Hemodynamic responses of 0.9% saline solution infusion in obese resistant hypertensive patients, BP.IC; 15/10078-2 - Effect of a high caloric diet in the expression of Hypoxia- inducible factor-1 (HIF1): Role in obesity through deregulation of pomc gene, BP.PD; 15/23285-6 - Endocrine pancreas maturation and differentiation in offspring of females submitted to dexamethasone treatment during pregnancy, BP.PD; 15/23969-2 - "EFFECTS OF DAPAGLIFLOZIN A SGLT2 INHIBITOR ON BLOOD PRESSURE, CARDIOVASCULAR REMODELING AND OBESITY PROFILE IN RESISTANT HYPERTENSION SUBJECTS ", BP.DR; 15/25597-5 - Hepatic microRNA expression profile in Goto-Kakizaki rats and Wistar rats subjected to metabolic programming by prenatal exposure to glucocorticoid excess, BP.DR; 15/12020-1 - The effects of body mass reduction on the blood levels of Th17 family citokynes in subjects submitted to Roux-en-Y gastric bypass, BP.IC; 14/05635-7 - Genetic polymorphisms of matrix metalloproteinases in resistant hypertension, BE.PQ; 14/26591-8 - Acute effect of dapagliflozin SGLT-2 inhibitory on brain and hypothalamic functionality in humans and mice C57BL/6, BP.MS; 14/26942-5 - Evaluation of intracerebroventricular treatment effect with selective agonists of GPR120 and GPR40 receptors and in high fat diet induced-obesity mice, BP.PD; 14/07496-4 - Role of the transcription factor IRX3 in inducing hypothalamic neurogenesis in adult mice, BP.PD; 15/02913-9 - Structural and molecular analysis of the hypotalamus median eminence of mice born from high fat diet fed mothers, BP.PD; 15/03645-8 - Hormone peptides PYY and TFF2 action on leptin signaling pathway in CLU189 cells, BP.IC; 15/00360-2 - Cardiac and renal effects in rats offspring subjected to protein restriction during gestation and lactation: influence of enriched environment on these effects, BP.IC; 14/24050-0 - The role of hypothalamic stearoil-CoA 2 (SCD2) in neurogenesis de novo, BP.IC; 14/24515-2 - Role of inflammassome in hypothalamic inflammation in response to hyperlipidic diet, BP.IC; 14/17384-9 - Autophagy in hypothalamic neurons in obesity, BP.PD; 14/09532-8 - Functional and molecular analysis of estrogen receptors in the islets of Langerhans and peripheral tissues of malnourished mice and their involvement in glycemic control, BP.PD; 14/06840-3 - BMP-SMADs pathway in the pancreatic beta cell as a modulator of glucose-stimulated insulin secretion, BP.PD; 14/09118-7 - The involvement of microRNAs in the accelerated ageing process caused by obesity and the potential intervention by caloric restriction, fatty acid supplementation and exercise, BP.PD; 14/00742-0 - Characterization of rapid POMC regulation mechanisms involved in high-fat diet response, BP.PD; 14/03285-9 - Obesity and target organs damage in resistant hypertension: role of metaloproteinases, BP.PD; 13/26319-3 - Evaluation of the temporal progression of the installation of inflammation, endoplasmic reticulum stress and mitochondrial dysfunction in the hypothalamus of mice subjected to a high fat diet, BP.MS; 13/24026-9 - Evaluation of the role of dsRNA-dependent protein kinase (PKR) in the pathogenesis of insulin resistance and intestinal permeability in obesity., BP.PD; 14/02977-4 - Epigenetic mechanisms associated with obesity and chronic inflammation, BP.PD; 13/25847-6 - INVOLVEMENT OF THE AUTONOMIC NERVOUS SYSTEM UPON GLUCOSE CONTROL AND PANCREATIC ISLETS FUNCTION IN MALNOURISHED MICE FED A HIGH-FAT DIET, BP.DR; 14/02819-0 - Investigation of glucose and lipid metabolism alterations in a model of nicotinamide nucleotide transhydrogenase mitochondrial (NNT)deficiency ., BP.DR; 14/03905-7 - Circadian modulation of peripheral insulin sensitivity in malnourished mice submitted to hyperlipidic diet, BP.IC; 13/25415-9 - Evaluation Of Adaptive Immune Response in Inflammation of the Hypothalamus in Obesity, BP.DR; 13/22815-6 - Distribution of adipocytes, adipocytokines and cardiovascular characteristics in individuals with spinal cord injury, BP.IC; 13/20539-1 - Analysis of the neural effects of in utero protein restriction in rats subjected or not to caloric overload: study parameters neuro-behavioral, morpho-functional molecular and during development in rats, BP.DR; 13/22321-3 - Chronic insulin receptor blockade in amygdala: effects on energy metabolism, BP.IC; 13/22276-8 - Role of hypothalamic stearoyl-CoA desaturase 2 in neuronal apoptosis and obesity, BP.PD; 12/17416-2 - REGULATION OF MITOCHONDRIAL FUNCTION AND METABOLISM OF GLUCOSE AND FATTY ACIDS BY FACTOR OF HYPOXIA INDUCIBLE (HIF-1a) MUSCLE CELLS IN INSULIN RESISTANCE, BP.PD; 12/24629-2 - Insulin signaling pathway and HSR action in rodent longevity., BP.PD; 12/02669-2 - MOLECULAR MECANISMS OF PULMONARY ARTERIAL HYPERTENSION ASSOCIATED TO INSULIN RESISTANCE: STUDIES IN ANIMAL MODEL OF OBESITY., BP.PD; 11/22217-6 - Modulation of Amino Acids metabolism in Muscle and Adipose Tissue: Effects of Physical Exercise and Bariatric Gastric Bypass Surgery., BP.PD - associated scholarships

Abstract

Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected that by the year 2020 up to 20% Brazilians will be obese and approximately 50%, overweigh. Obesity is highly associated with a number of diseases such as diabetes, hypertension, atherosclerosis and certain types of cancer. Because of the absolute lack of appropriate preventive and therapeutic approaches to deal with obesity, the overall mortality directly and indirectly associated with this disease is rapidly increasing in the world. Obesity results from an imbalance between caloric intake and energy expenditure. Although great advance was recently obtained in the characterization of the mechanisms of control of feeding and thermogenesis, the complexity of the neural circuits that control these functions and the difficulties imposed by anatomical constrains to study human hypothalamus, have contributed to hamper a rapid advance in the treatment of obesity. The main objective of OCRC is to coordinate the efforts to find solutions for obesity and associated diseases. Some of the most productive Brazilian scientists in these fields will work in concert to provide advance in the understanding of the mechanisms leading to obesity and its associated conditions. In addition, the search for new pharmacological nutritional and physical activity approaches to deal with these diseases will be pursued. Regarding education, OCRC will invest on the orientation of high-school students and senior citizens regarding preventive and screening methods for early detection of these diseases. Also, OCRC will foster programs for improving the education of undergraduate students in the field of nutrition and increasing the interest for research in these fields. Finally, OCRC staff will be in contact with industry and other potential users of the knowledge and products obtained in order to speed up the transfer of knowledge to society. (AU)

Scientific publications

(115)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LORZA-GIL, ESTELA; DE SOUZA, JANE C.; GARCIA-AREVALO, MARTA; VETTORAZZI, JEAN F.; MARQUES, ANA CAROLINA; SALERNO, ALESSANDRO G.; TRIGO, JOSE ROBERTO; OLIVEIRA, HELENA C. F.. Coenzyme Q(10) protects against -cell toxicity induced by pravastatin treatment of hypercholesterolemia. Journal of Cellular Physiology, v. 234, n. 7, p. 11047-11059, JUL 2019. (11/50400-0, 13/07607-8)

PAIVA, ADRIENE A.; RAPOSO, HELENA F.; WANSCHEL, AMARYLIS C. B. A.; NARDELLI, TARLLIZA R.; OLIVEIRA, HELENA C. F.. Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. (11/50400-0, 13/07607-8)

DE TOLEDO, IAN; GRIGOLO, THIAGO; BENNETT, JAMES M.; ELKINS, JONATHAN M.; PILLI, RONALDO A.. Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors. Journal of Organic Chemistry, v. 84, n. 21, p. 14187-14201, NOV 1 2019. (13/07607-8, 19/13104-5)

RAITZ, ISMAEL; DE SOUZA FILHO, ROBERTO Y.; DE ANDRADE, LORENA P.; CORREA, JOSE R.; NETO, BRENNO A. D.; PILLI, RONALDO A.. Preferential Mitochondrial Localization of a Goniothalamin Fluorescent Derivative. ACS OMEGA, v. 2, n. 7, p. 3774-3784, JUL 2017. (09/51602-5, 16/12541-4, 13/07607-8)

-FELICE, FRANCO DELLA; SAROTTI, ARIEL M.; PILLI, RONALDO A.. Catalytic Asymmetric Synthesis and Stereochemical Revision of (+)-Cryptoconcatone H. Journal of Organic Chemistry, v. 82, n. 17, p. 9191-9197, SEP 1 2017. (14/25474-8, 16/12541-4, 13/07607-8)

DABAJA, MOHAMED ZIAD; LIMA, ESTELA DE OLIVEIRA; DE OLIVEIRA, DIOGO NOIN; GUERREIRO, TATIANE MELINA; ODIR RODRIGUES MELO, CARLOS FERNANDO; MORISHITA, KAREN NODA; LANCELLOTTI, MARCELO; TASCA GOIS RUIZ, ANA LUCIA; GOULART, GISELE; DUARTE, DIEGO ANDREAZZI; et al. Metabolic alterations induced by attenuated Zika virus in glioblastoma cells. CELL AND BIOSCIENCE, v. 8, SEP 4 2018. (15/06809-1, 11/50400-0, 16/17066-2, 13/07607-8)

DORIGHELLO, GABRIEL G.; PAIM, BRUNO A.; LEITE, ANA CATARINA R.; VERCESI, ANIBAL E.; OLIVEIRA, HELENA C. F.. Spontaneous experimental atherosclerosis in hypercholesterolemic mice advances with ageing and correlates with mitochondrial reactive oxygen species. Experimental Gerontology, v. 109, n. SI, p. 47-50, AUG 2018. (11/50400-0, 13/07607-8)

POVOA, VALERIA C. O.; DOS SANTOS, GIOVANNA J. V. P.; PICHETH, GUILHERME F.; JARA, CARLOS P.; DA SILVA, LAURA C. E.; DE ARAUJO, ELIANA P.; DE OLIVEIRA, MARCELO G.. Wound healing action of nitric oxide-releasing self-expandable collagen sponge. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 14, n. 6, MAY 2020. (13/07607-8, 18/14142-5, 17/04615-0, 16/02414-5, 17/19253-7)

DE OLIVEIRA, DIOGO N.; LIMA, ESTELA O.; MELO, CARLOS F. O. R.; DELAFIORI, JEANY; GUERREIRO, TATIANE M.; RODRIGUES, RAFAEL G. M.; MORISHITA, KAREN N.; SILVEIRA, CYNTHIA; MURARO, STEFANIE PRIMON; DE SOUZA, GABRIELA FABIANO; et al. Inflammation markers in the saliva of infants born from Zika-infected mothers: exploring potential mechanisms of microcephaly during fetal development. SCIENTIFIC REPORTS, v. 9, SEP 20 2019. (18/03321-6, 11/50400-0, 13/07607-8, 16/17066-2)

PAYOLLA, TANYARA B.; TEIXEIRA, CAIO J.; SATO, FABIO T.; MURATA, GILSON M.; ZONTA, GIZELA A.; SODRE, FRHANCIELLY S.; CAMPOS, CAROLINA V.; MESQUITA, FILIPHE N.; ANHE, GABRIEL F.; BORDIN, SILVANA. In Utero Dexamethasone Exposure Exacerbates Hepatic Steatosis in Rats That Consume Fructose During Adulthood. NUTRIENTS, v. 11, n. 9, SEP 2019. (13/07607-8, 14/08913-8, 15/25597-5)

DELLA-FELICE, FRANCO; PILLI, RONALDO A.; SAROTTI, ARIEL M.. Computer-Guided Total Synthesis of Natural Products. Recent Examples and Future Perspectives. Journal of the Brazilian Chemical Society, v. 29, n. 5, p. 1041-1075, MAY 2018. (14/25474-8, 16/12541-4, 13/07607-8)

SANTOS, ROBERTA DE SOUZA; CAMARGO, RAFAEL L.; VANZELA, EMERIELLE C.; BATISTA, THIAGO M.; MORATO, PRISCILA N.; LEITE, NAYARA C.; ROVANI, JULIANA C.; GARCIA-AREVALO, MARTA; CLEGG, DEBORAH J.; CARNEIRO, EVERARDO M.. Diet-induced glucose homeostasis dysregulation is enhanced by taurine supplementation in ovariectomized mice. Amino Acids, v. 50, n. 3-4, p. 469-477, APR 2018. (13/07607-8)

GALAVERNA, RENAN; BREITKREITZ, MARCIA C.; PASTRE, JULIO C.. Conversion of D-Fructose to 5-(Hydroxymethyl)furfural: Evaluating Batch and Continuous Flow Conditions by Design of Experiments and In-Line FTIR Monitoring. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 6, n. 3, p. 4220-4230, MAR 2018. (14/25770-6, 16/05636-9, 06/57897-9, 14/26378-2, 13/07607-8)

HUANG, XIAOQIANG. Visible-Light-Activated Catalytic Enantioselective beta-Alkylation of alpha, beta-Unsaturated 2-Acyl Imidazoles Using Hantzsch Esters as Radical Reservoirs. Journal of Organic Chemistry, v. 83, n. 18, p. 10922-10932, SEP 21 2018. (17/06836-4, 13/07607-8)

ROSA, LUCAS R. O.; SOARES, GABRIELA M.; SILVEIRA, LEONARDO R.; BOSCHERO, ANTONIO C.; BARBOSA-SAMPAIO, HELENA C. L.. ARHGAP21 as a master regulator of multiple cellular processes. Journal of Cellular Physiology, v. 233, n. 11, p. 8477-8481, NOV 2018. (12/14993-9, 13/07607-8, 15/12611-0)

PILLI, RONALDO A.; DE ASSIS, FRANCISCO F.. Organic Synthesis: New Vistas in the Brazilian Landscape. Anais da Academia Brasileira de Ciências, v. 90, n. 1, 1, p. 895-941, 2018. (13/07607-8, 16/12541-4, 16/08569-0, 17/06836-4)

DE-LIMA-JUNIOR, JOSE C.; SOUZA, GABRIELA F.; MOURA-ASSIS, ALEXANDRE; GASPAR, RODRIGO S.; GASPAR, JOANA M.; ROCHA, ANDREA L.; FERRUCCI, DANILO L.; LIMA, TANES I.; VICTORIO, SHEILA C.; BONFANTE, IVAN L. P.; et al. Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency. EBIOMEDICINE, v. 39, p. 436-447, JAN 2019. (13/07607-8)

KURAUTI, MIRIAN A.; COSTA-JUNIOR, JOSE M.; FERREIRA, SANDRA M.; DOS SANTOS, GUSTAVO J.; PROTZEK, ANDRE O. P.; NARDELLI, TARLLIZA R.; DE REZENDE, LUIZ F.; BOSCHERO, ANTONIO C.. Acute exercise restores insulin clearance in diet-induced obese mice. Journal of Endocrinology, v. 229, n. 3, p. 221-232, JUN 2016. (13/21283-0, 13/07607-8)

MENDES, MARIA CAROLINA S.; PIMENTEL, GUSTAVO D.; COSTA, FELIPE O.; CARVALHEIRA, JOSE B. C.. Molecular and neuroendocrine mechanisms of cancer cachexia. Journal of Endocrinology, v. 226, n. 3, p. R29-R43, SEP 2015. (13/07607-8, 14/22347-5)

PIROVANI, RODRIGO V.; BRITO, GILMAR A.; BARCELOS, ROSIMEIRE C.; PILLI, RONALDO A.. Enantioselective Total Synthesis of (+)-Lyngbyabellin M. MARINE DRUGS, v. 13, n. 6, p. 3309-3324, JUN 2015. (10/00336-0, 09/51602-5, 13/07607-8, 10/00219-4)

MENDES, NATALIA FERREIRA; CASTRO, GISELE; GUADAGNINI, DIOZE; TOBAR, NATALIA; COGNUCK, SUSANA QUIROS; KAGOHARA ELIAS, LUCILA LEICO; BOER, PATRICIA ALINE; PRADA, PATRICIA OLIVEIRA. Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 70, p. 1-11, MAY 2017. (15/00343-0, 13/07607-8)

MORSELLI, EUGENIA; SANTOS, ROBERTA S.; CRIOLLO, ALFREDO; NELSON, MICHAEL D.; PALMER, BIFF F.; CLEGG, DEBORAH J.. The effects of oestrogens and their receptors on cardiometabolic health. NATURE REVIEWS ENDOCRINOLOGY, v. 13, n. 6, p. 352-364, JUN 2017. (13/07607-8)

DE PAULA SIMINO, LAIS ANGELICA; DE FANTE, THAIS; FONTANA, MARINA FIGUEIREDO; BORGES, FERNANDA OLIVEIRA; TORSONI, MARCIO ALBERTO; MILANSKI, MARCIANE; VELLOSO, LICIO AUGUSTO; TORSONI, ADRIANA SOUZA. Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet. NUTRITION & METABOLISM, v. 14, FEB 20 2017. (11/22156-7, 13/07607-8, 14/18165-9)

ZANOTTO, TAMIRES M.; QUARESMA, PAULA G. F.; GUADAGNINI, DIOZE; WEISSMANN, LAIS; SANTOS, ANDRESSA C.; VECINA, JULIANA F.; CALISTO, KELLY; SANTOS, ANDREY; PRADA, PATRCIA O.; SAAD, MARIO J. A.. Blocking iNOS and endoplasmic reticulum stress synergistically improves insulin resistance in mice. MOLECULAR METABOLISM, v. 6, n. 2, FEB 2017. (12/15009-0, 13/07607-8, 16/07122-2)

SANTOS, ROBERTA S.; BATISTA, THIAGO M.; CAMARGO, RAFAEL L.; MORATO, PRISCILA N.; BORCK, PATRICIA C.; LEITE, NAYARA C.; KURAUTI, MIRIAN A.; WANSCHEL, AMARYLIS C. B. A.; NADAL, ANGEL; CLEGG, DEBORAH J.; et al. Lacking of estradiol reduces insulin exocytosis from pancreatic beta-cells and increases hepatic insulin degradation. Steroids, v. 114, n. SI, p. 16-24, OCT 2016. (15/05801-7, 13/07607-8)

DE SOUZA, GABRIELA F. P.; NOVAES, LUIZ F. T.; AVILA, CAROLINA M.; NASCIMENTO, LUCAS F. R.; VELLOSO, LICIO A.; PILLI, RONALDO A.. (-)-Tarchonanthuslactone Exerts a Blood Glucose-Increasing Effect in Experimental Type 2 Diabetes Mellitus. Molecules, v. 20, n. 3, p. 5038-5049, 2015. (12/09254-2, 10/08673-6, 13/07607-8)

BUSANELLO, ESTELA N. B.; MARQUES, ANA C.; LANDER, NOELIA; DE OLIVEIRA, DIOGO N.; CATHARINO, RODRIGO R.; OLIVEIRA, HELENA C. F.; VERCESI, ANIBAL E.. Pravastatin Chronic Treatment Sensitizes Hypercholesterolemic Mice Muscle to Mitochondrial Permeability Transition: Protection by Creatine or Coenzyme Q(10). FRONTIERS IN PHARMACOLOGY, v. 8, APR 5 2017. (14/00084-2, 14/11261-2, 14/08995-4, 13/07607-8, 11/50400-0)

BOUCHARD, CLAUDE; ANTUNES-CORREA, LIGIA M.; ASHLEY, EUAN A.; FRANKLIN, NINA; HWANG, PAUL M.; MATTSSON, C. MIKAEL; NEGRAO, CARLOS E.; PHILLIPS, SHANE A.; SARZYNSKI, MARK A.; WANG, PING-YUAN; et al. Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventionse. PROGRESS IN CARDIOVASCULAR DISEASES, v. 57, n. 4, p. 337-346, JAN-FEB 2015. (10/50048-1, 13/15651-7, 13/07607-8)

NAVARRO, CLAUDIA D. C.; FIGUEIRA, TIAGO R.; FRANCISCO, ANNELISE; DAL'BO, GENOEFA A.; RONCHI, JULIANA A.; ROVANI, JULIANA C.; ESCANHOELA, CECILIA A. F.; OLIVEIRA, HELENA C. F.; CASTILHO, ROGER F.; VERCESI, ANIBAL E.. Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice. Free Radical Biology and Medicine, v. 113, p. 190-202, DEC 2017. (14/02819-0, 11/50400-0, 15/22063-0, 13/07607-8)

VICENTE, JULIA MODESTO; TEIXEIRA, CAIO JORDAO; SANTOS-SILVA, JUNIA CAROLINA; DE SOUZA, DAILSON NOGUEIRA; TOBAR, NATALIA; FURTUOSO, FABIOLA SALES; ADABO, ISABEL GOUVEIA; SODRE, FRHANCIELLY SHIRLEY; MURATA, GILSON; BORDIN, SILVANA; et al. The absence of lactation after pregnancy induces long-term lipid accumulation in maternal liver of mice. Life Sciences, v. 217, p. 261-270, JAN 15 2019. (13/07607-8, 15/12680-1)

MENDES, NATALIA F.; GASPAR, JOANA M.; LIMA-JUNIOR, JOSE C.; DONATO, JR., JOSE; VELLOSO, LICIO A.; ARAUJO, ELIANA P.. TGF-beta 1 down-regulation in the mediobasal hypothalamus attenuates hypothalamic inflammation and protects against diet-induced obesity. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 85, p. 171-182, AUG 2018. (17/02983-2, 15/10078-2, 13/07607-8, 16/17810-3)

DAMIAO, MARIANA C. F. C. B.; GALAVERNA, RENAN; KOZIKOWSKI, ALAN P.; EUBANKS, JAMES; PASTRE, JULIO C.. Telescoped continuous flow generation of a library of highly substituted 3-thio-1,2,4-triazoles. REACTION CHEMISTRY & ENGINEERING, v. 2, n. 6, p. 896-907, DEC 2017. (15/18572-6, 14/25770-6, 14/26378-2, 13/07607-8)

PILLI, RONALDO ALOISE; DE TOLEDO, IAN; MEIRELLES, MATHEUS ANDRADE; GRIGOLO, THIAGO AUGUSTO. Goniothalamin-Related Styryl Lactones: Isolation, Synthesis, Biological Activity and Mode of Action. Current Medicinal Chemistry, v. 26, n. 41, p. 7372-7451, 2019. (16/12541-4, 13/07607-8)

ENGEL, DAIANE F.; BOBBO, VANESSA C. D.; SOLON, CARINA S.; NOGUEIRA, GUILHERME A.; MOURA-ASSIS, ALEXANDRE; MENDES, NATALIA F.; ZANESCO, ARIANE M.; PAPANGELIS, ATHANASIOS; ULVEN, TROND; VELLOSO, LICIO A.. Activation of GPR40 induces hypothalamic neurogenesis through p38-and BDNF-dependent mechanisms. SCIENTIFIC REPORTS, v. 10, n. 1, JUL 6 2020. (13/07607-8, 14/50938-8, 18/01360-4, 19/10961-4)

MENDES, NATALIA F.; KIM, YOUNG-BUM; VELLOSO, LICIO A.; ARAUJO, ELIANA P.. Hypothalamic Microglial Activation in Obesity: A Mini-Review. FRONTIERS IN NEUROSCIENCE, v. 12, NOV 15 2018. (17/22511-8, 13/07607-8, 17/02983-2, 16/17810-3)

BUSANELLO, ESTELA N. B.; FIGUEIRA, TIAGO R.; MARQUES, ANA C.; NAVARRO, CLAUDIA D. C.; OLIVEIRA, HELENA C. F.; VERCESI, ANIBAL E.. Facilitation of Ca2+-induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment. Cell Biology International, v. 42, n. 6, SI, p. 742-746, JUN 2018. (06/59786-0, 11/50400-0, 14/11261-2, 13/07607-8)

MEIRELLES, MATHEUS A.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; PILLI, RONALDO A.. Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells. CHEMMEDCHEM, v. 14, n. 15, JULY 2019. (13/07607-8, 18/02093-0, 17/06146-8)

TEIXEIRA, CAIO JORDAO; SANTOS-SILVA, JUNIA CAROLINA; DE SOUZA, DAILSON NOGUEIRA; RAFACHO, ALEX; ANHE, GABRIEL FORATO; BORDIN, SILVANA. Dexamethasone during pregnancy impairs maternal pancreatic beta-cell renewal during lactation. ENDOCRINE CONNECTIONS, v. 8, n. 2, p. 120-131, FEB 2019. (13/07607-8)

BOBBO, VANESSA C. D.; JARA, CARLOS P.; MENDES, NATALIA F.; MORARI, JOSEANE; VELLOSO, LICIO A.; ARAUJO, ELIANA P.. Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic Review. BIOMED RESEARCH INTERNATIONAL, v. 2019, AUG 22 2019. (13/07607-8)

COSTA, S. O.; SOUZA, C. M.; LANZA, P. G.; SARTORI, J. O.; IGNACIO-SOUZA, L. M.; CANDREVA, T.; RODRIGUES, H. G.; TORSONI, A. S.; MILANSKI, M.; TORSONI, M. A.. Maternal high fat diet consumption reduces liver alpha7 nicotinic cholinergic receptor expression and impairs insulin signalling in the offspring. SCIENTIFIC REPORTS, v. 10, n. 1, JAN 8 2020. (16/23484-1, 13/07607-8)

GARCIA-AREVALO, MARTA; LORZA-GIL, ESTELA; CARDOSO, LEANDRO; BATISTA, THIAGO MARTINS; ARAUJO, THIAGO REIS; FERREIRA RAMOS, LUIZ ALBERTO; AREAS, MIGUEL ARCANJO; NADAL, ANGEL; CARNEIRO, EVERARDO MAGALHAES; DAVEL, ANA PAULA. Ventricular Fibrosis and Coronary Remodeling Following Short-Term Exposure of Healthy and Malnourished Mice to Bisphenol A. FRONTIERS IN PHYSIOLOGY, v. 12, APR 12 2021. (18/26080-4, 14/09532-8, 14/01717-9, 13/07607-8)

PASTRE, JULIO C.; MURRAY, PHILIP R. D.; BROWNE, DUNCAN L.; BRANCAGLION, GUILHERME A.; GALAVERNA, RENAN S.; PILLI, RONALDO A.; LEY, V, STEVEN. Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin. ACS OMEGA, v. 5, n. 29, p. 18472-18483, JUL 28 2020. (13/07607-8, 12/05909-4, 14/26378-2)

DE SOUZA, DAILSON NOGUEIRA; TEIXEIRA, CAIO JORDAO; VERONESI, VANESSA BARBOSA; MURATA, GILSON MASAHIRO; SANTOS-SILVA, JUNIA CAROLINA; HECHT, FERNANDA BALLERINI; VICENTE, JULIA MODESTO; BORDIN, SILVANA; ANHE, GABRIEL FORATO. Dexamethasone programs lower fatty acid absorption and reduced PPAR-gamma and fat/CD36 expression in the jejunum of the adult rat offspring. Life Sciences, v. 265, JAN 15 2021. (13/07607-8, 20/06397-3, 19/03196-0, 16/13138-9, 15/23285-6)

ZANGEROLAMO, LUCAS; VETTORAZZI, JEAN F.; SOLON, CARINA; BRONCZEK, GABRIELA A.; ENGEL, DAIANE F.; KURAUTI, MIRIAN A.; SOARES, GABRIELA M.; RODRIGUES, KARINA S.; VELLOSO, LICIO A.; BOSCHERO, ANTONIO C.; et al. The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model. Molecular and Cellular Endocrinology, v. 521, FEB 5 2021. (13/07607-8, 15/12611-0, 17/13410-3, 15/23729-1, 18/06363-1, 18/20213-2)

MANSOUR, ELI; BUENO, FLAVIA F.; DE LIMA-JUNIOR, JOSE C.; PALMA, ANDRE; MONFORT-PIRES, MILENA; BOMBASSARO, BRUNA; ARAUJO, ELIANA P.; BERNARDES, ANA FLAVIA; ULAF, RAISA G.; NUNES, THYAGO A.; et al. Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial. Trials, v. 22, n. 1, JAN 20 2021. (13/07607-8, 20/04522-5)

RIBEIRO, LUCIANA C.; BENITES, BRUNO DELTREGGIA; ULAF, RAISA G.; NUNES, THYAGO A.; COSTA-LIMA, CAROLINA; ADDAS-CARVALHO, MARCELO; PROENCA-MODENA, JOSE LUIZ; GRANJA, FABIANA; DA COSTA, VITOR ANTONIO; SANTOS DUARTE, ADRIANA DA SILVA; et al. Rapid clinical recovery of a SARS-CoV-2 infected common variable immunodeficiency patient following the infusion of COVID-19 convalescent plasma. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, v. 17, n. 1, DEC 5 2021. (20/04558-0, 20/04522-5, 13/07607-8, 16/00194-8)

PASCOAL, LIVIA BITENCOURT; RODRIGUES, PATRICIA BRITO; GENARO, LIVIA MOREIRA; DOS SANTOS PEREIRA GOMES, ARILSON BERNARDO; TOLEDO-TEIXEIRA, DANIEL AUGUSTO; PARISE, PIERINA LORENCINI; BISPO-DOS-SANTOS, KARINA; SIMEONI, CAMILA LOPES; GUIMARAES, PAULA VERI; BUSCARATTI, LUCAS ILDEFONSO; et al. Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples. GUT MICROBES, v. 13, n. 1, p. 1-9, JAN 1 2021. (20/04558-0, 20/04583-4, 20/02448-2, 20/02312-3, 19/14342-7, 20/04746-0, 17/26908-0, 20/04579-7, 20/04919-2, 19/06372-3, 13/07607-8, 20/02159-0)

MANSOUR, ELI; PALMA, ANDRE C.; ULAF, RAISA G.; RIBEIRO, LUCIANA C.; BERNARDES, ANA FLAVIA; NUNES, THYAGO A.; AGRELA, V, MARCUS; BOMBASSARO, BRUNA; MONFORT-PIRES, MILENA; CAMARGO, RAFAEL L.; et al. Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin-Kallikrein System in Severe COVID-19. Viruses-Basel, v. 13, n. 2, FEB 2021. (20/04522-5, 13/07607-8)

SANTOS-SILVA, JUNIA CAROLINA; DA SILVA, PRISCILLA MUNIZ RIBEIRO; DE SOUZA, DAILSON NOGUEIRA; TEIXEIRA, CAIO JORDAO; BORDIN, SILVANA; ANHE, GABRIEL FORATO. In utero exposure to dexamethasone programs the development of the pancreatic beta- and alpha-cells during early postnatal life. Life Sciences, v. 255, AUG 15 2020. (15/23285-6, 13/07607-8)

ROSA, LUCAS RODOLFO DE OLIVEIRA; VETTORAZZI, JEAN FRANCIESCO; ZANGEROLAMO, LUCAS; CARNEIRO, EVERARDO MAGALHAES; BARBOSA, HELENA CRISTINA DE LIMA. UDCA receptors and their role on pancreatic beta cell. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, v. 167, p. 26-31, DEC 2021. (19/23951-7, 12/14993-9, 15/12611-0, 13/07607-8, 18/06363-1)

DRAGANO, NATHALIA R.; MONFORT-PIRES, MILENA; VELLOSO, LICIO A.. Mechanisms Mediating the Actions of Fatty Acids in the Hypothalamus. Neuroscience, v. 447, p. 15-27, NOV 1 2020. (13/07607-8)

PEREIRA, GIZELA A.; SODRE, FRHANCIELLY S.; MURATA, GILSON M.; AMARAL, ANDRESSA G.; PAYOLLA, TANYARA B.; CAMPOS, CAROLINA V.; SATO, FABIO T.; ANHE, GABRIEL F.; BORDIN, SILVANA. Fructose Consumption by Adult Rats Exposed to Dexamethasone In Utero Changes the Phenotype of Intestinal Epithelial Cells and Exacerbates Intestinal Gluconeogenesis. NUTRIENTS, v. 12, n. 10, OCT 2020. (19/03196-0, 13/07607-8)

ZANGEROLAMO, LUCAS; SOLON, CARINA; SOARES, GABRIELA M.; ENGEL, DAIANE F.; VELLOSO, LICIO A.; BOSCHERO, ANTONIO C.; CARNEIRO, EVERARDO M.; BARBOSA, HELENA CRISTINA L.. Energy homeostasis deregulation is attenuated by TUDCA treatment in streptozotocin-induced Alzheimer's disease mice model. SCIENTIFIC REPORTS, v. 11, n. 1, SEP 13 2021. (13/07607-8, 18/20213-2, 18/06363-1)

GRIGOLO, THIAGO A.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; RUSSOWSKY, DENNIS; FERREIRA-SILVA, GUILHERME A.; IONTA, MARISA; PILLI, RONALDO A.. Hybrids of 4-hydroxy derivatives of goniothalamin and piplartine bearing a diester or a 1,2,3-triazole linker as antiproliferative agents. BIOORGANIC CHEMISTRY, v. 116, NOV 2021. (17/06146-8, 18/02093-0, 13/07607-8, 19/13104-5)

MARTINS, I. C. A.; CONTIERI, L. S.; AMARAL, C. L.; COSTA, S. O.; SOUZA, A. C. P.; IGNACIO-SOUZA, L. M.; MILANSKI, M.; TORSONI, A. S.; TORSONI, M. A.. Omega-3 Supplementation Prevents Short-Term High-Fat Diet Effects on the alpha 7 Nicotinic Cholinergic Receptor Expression and Inflammatory Response. Mediators of Inflammation, v. 2021, AUG 10 2021. (16/23484-1, 18/01863-6, 13/07607-8, 19/07615-7)

GUIZONI, DANIELE M.; FREITAS, ISRAELLE N.; VICTORIO, JAMAIRA A.; POSSEBOM, ISABELA R.; ARAUJO, THIAGO R.; CARNEIRO, EVERARDO M.; DAVEL, ANA P.. Taurine treatment reverses protein malnutrition-induced endothelial dysfunction of the pancreatic vasculature: The role of hydrogen sulfide. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 116, MAR 2021. (14/01717-9, 13/07607-8, 16/14461-8)

ZANGEROLAMO, LUCAS; VETTORAZZI, JEAN F.; ROSA, LUCAS R. O.; CARNEIRO, EVERARDO M.; BARBOSA, HELENA C. L.. The bile acid TUDCA and neurodegenerative disorders: An overview. Life Sciences, v. 272, MAY 1 2021. (13/07607-8, 18/06363-1, 15/23729-1, 18/20213-2, 15/12611-0)

MOURA-ASSIS, ALEXANDRE; FRIEDMAN, JEFFREY M.; VELLOSO, LICIO A.. Gut-to-brain signals in feeding control. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 320, n. 2, p. E326-E332, FEB 2021. (13/07607-8)

ROCHA, WALTER E. M.; OLIVEIRA, MATHEUS F. R. A.; SOARES, JULIA D.; L'ARMEE, VICTOR M. F. S.; MARTINS, MAYARA P. G.; ROCHA, ALOISIO M.; FEITOSA, AUDES D. M.; LIMA, RICARDO C.; OLIVEIRA, PEDRO P. M.; SILVEIRA-FILHO, LINDEMBERG M.; et al. Left Ventricular Concentric Geometric Patterns Are Associated With Worse Prognosis Among Patients With Type-A Aortic Dissection. JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 10, n. 5, MAR 2 2021. (13/07607-8)

MENDES, NATALIA FERREIRA; JARA, CARLOS POBLETE; ZANESCO, ARIANE MARIA; DE ARAUJO, ELIANA PEREIRA. Hypothalamic Microglial Heterogeneity and Signature under High Fat Diet-Induced Inflammation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 5, MAR 2021. (19/00330-7, 17/22511-8, 16/17810-3, 13/07607-8)

OLIVEIRA, MATHEUS F. R. A.; ROCHA, WALTER E. M.; SOARES, JULIA D.; L'ARMEE, VICTOR M. F. S.; MARTINS, MAYARA P. G.; ROCHA, ALOISIO M.; FEITOSA, AUDES D. M.; LIMA, RICARDO C.; OLIVEIRA, PEDRO P. M.; SILVEIRA-FILHO, LINDEMBERG M.; et al. mpact of Hypertension History and Blood Pressure at Presentation on Cardiac Remodeling and Mortality in Aortic Dissectio. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 8, JAN 21 2022. (13/07607-8)

LEITE, NAYARA CARVALHO; DE PAULA, FLAVIA; BORCK, PATRICIA CRISTINE; VETTORAZZI, JEAN FRANCIESCO; SOUTO BRANCO, RENATO CHAVES; LUBACZEUSKI, CAMILA; BOSCHERO, ANTONIO CARLOS; ZOPPI, CLAUDIO CESAR; CARNEIRO, EVERARDO MAGALHAES. Protein malnutrition potentiates the amplifying pathway of insulin secretion in adult obese mice. SCIENTIFIC REPORTS, v. 6, SEP 16 2016. (11/19536-2, 13/07607-8, 11/09012-6)

DELLA-FELICE, FRANCO; DE ASSIS, FRANCISCO F.; SAROTTI, ARIEL M.; PILLI, RONALDO A.. Palladium-Catalyzed Formation of Substituted Tetrahydropyrans: Mechanistic Insights and Structural Revision of Natural Products. SYNTHESIS-STUTTGART, v. 51, n. 7, p. 1545-1560, APR 2019. (13/07607-8, 16/12541-4, 14/25474-8)

CHAMPEAU, MATHILDE; POVOA, VALERIA; MILITAO, LUCAS; CABRINI, FLAVIA M.; PICHETH, GUILHERME F.; MENEAU, FLORIAN; JARA, CARLOS P.; DE ARAUJO, ELIANA P.; DE OLIVEIRA, MARCELO G.. Supramolecular poly(acrylic acid)/F127 hydrogel with hydration-controlled nitric oxide release for enhancing wound healing. Acta Biomaterialia, v. 74, p. 312-325, JUL 1 2018. (16/02414-5, 17/19253-7, 14/24955-2, 15/17515-9, 13/07607-8)

MARQUES, ANA C.; BUSANELLO, ESTELA N. B.; DE OLIVEIRA, DIOGO N.; CATHARINO, RODRIGO R.; OLIVEIRA, HELENA C. F.; VERCESI, ANIBAL E.. Coenzyme Q10 or Creatine Counteract Pravastatin-Induced Liver Redox Changes in Hypercholesterolemic Mice. FRONTIERS IN PHARMACOLOGY, v. 9, JUN 27 2018. (11/50400-0, 17/17728-8, 13/07607-8)

PASCOAL, LIVIA B.; BOMBASSARO, BRUNA; RAMALHO, ALBINA F.; COOPE, ANDRESSA; MOURA, RODRIGO F.; CORREA-DA-SILVA, FELIPE; IGNACIO-SOUZA, LETICIA; RAZOLLI, DANIELA; DE OLIVEIRA, DIOGO; CATHARINO, RODRIGO; et al. Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity. JOURNAL OF NEUROINFLAMMATION, v. 14, JAN 5 2017. (13/07607-8)

HADDAD-TOVOLLI, ROBERTA; DRAGANO, NATHALIA R. V.; RAMALHO, ALBINA F. S.; VELLOSO, LICIO A.. Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control. FRONTIERS IN NEUROSCIENCE, v. 11, APR 21 2017. (15/50278-0, 15/02913-9, 14/26942-5, 16/01868-2, 13/07607-8)

SILVEIRA, ANDRE C.; FERNANDES, TIAGO; SOCI, URSULA P. R.; GOMES, JOAO L. P.; BARRETTI, DIEGO L.; MOTA, GLORIA G. F.; NEGRAO, CARLOS EDUARDO; OLIVEIRA, EDILAMAR M.. Exercise Training Restores Cardiac MicroRNA-1 and MicroRNA-29c to Nonpathological Levels in Obese Rats. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. (10/50048-1, 13/07607-8, 09/18370-3)

KURAUTI, MIRIAN A.; FREITAS-DIAS, RICARDO; FERREIRA, SANDRA M.; VETTORAZZI, JEAN F.; NARDELLI, TARLLIZA R.; ARAUJO, HYGOR N.; SANTOS, GUSTAVO J.; CARNEIRO, EVERARDO M.; BOSCHERO, ANTONIO C.; REZENDE, LUIZ F.; et al. Acute Exercise Improves Insulin Clearance and Increases the Expression of Insulin-Degrading Enzyme in the Liver and Skeletal Muscle of Swiss Mice. PLoS One, v. 11, n. 7, JUL 28 2016. (13/07607-8, 14/24719-7)

CARNEIRO, VANIA M. T.; TRIVELLA, DANIELA B. B.; SCORSATO, VALERIA; BERALDO, VIVIANE L.; DIAS, MARIANA P.; SOBREIRA, TIAGO J. P.; APARICIO, RICARDO; PILLI, RONALDO A.. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 97, p. 42-54, JUN 5 2015. (11/00457-5, 10/17544-5, 09/51602-5, 13/07607-8)

WEISSMANN, LAIS; QUARESMA, PAULA G. F.; SANTOS, ANDRESSA C.; DE MATOS, ALEXANDRE H. B.; PASCOAL, VINICIUS D'AVILA BITTENCOURT; ZANOTTO, TAMIRES M.; CASTRO, GISELE; GUADAGNINI, DIOZE; DA SILVA, JOELCIMAR MARTINS; VELLOSO, LICIO A.; et al. IKK epsilon Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity. Diabetes, v. 63, n. 10, p. 3334-3345, OCT 2014. (10/52068-0, 13/07607-8, 12/10338-6)

NOVAES, LUIZ F. T.; SAROTTI, ARIEL M.; PILLI, RONALDO A.. Total Synthesis and Tentative Structural Elucidation of Cryptomoscatone E3: Interplay of Experimental and Computational Studies. Journal of Organic Chemistry, v. 80, n. 24, p. 12027-12037, DEC 18 2015. (09/51602-5, 13/07607-8)

QUARESMA, P. G. F.; REENCOBER, N.; ZANOTTO, T. M.; SANTOS, A. C.; WEISSMANN, L.; DE MATOS, A. H. B.; LOPES-CENDES, I.; FOLLI, F.; SAAD, M. J. A.; PRADA, P. O.. Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway. International Journal of Obesity, v. 40, n. 1, p. 138-146, JAN 2016. (13/07607-8, 12/10338-6)

ZAMBOM DE SOUZA, ALESSANDRA ZANIN; ZAMBOM, ADRIANO ZANIN; ABBOUD, KAHLILE YOUSSEF; REIS, SABRINA KAREN; TANNIHAO, FABIANA; GUADAGNINI, DIOZE; SAAD, MARIO J. A.; PRADA, PATRICIA OLIVEIRA. Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study. NUTRITION, v. 31, n. 6, p. 884-889, JUN 2015. (13/07607-8, 12/10338-6)

QUARESMA, P. G. F.; WEISSMANN, L.; ZANOTTO, T. M.; SANTOS, A. C.; DE MATOS, A. H. B.; FURIGO, I. C.; SIMABUCO, F. M.; DONATO, JR., J.; BITTENCOURT, J. C.; LOPES-CENDES, I.; et al. Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis. International Journal of Obesity, v. 41, n. 2, p. 268-278, FEB 2017. (15/00343-0, 13/07607-8, 12/10338-6)

CONDES AREIAS, MARIA FERNANDA; PRADA, PATRICIA OLIVEIRA. Mechanisms of insulin resistance in the amygdala: Influences on food intake. Behavioural Brain Research, v. 282, p. 209-217, APR 2015. (13/07607-8, 12/10338-6)

MARMENTINI, CARINE; SOARES, GABRIELA M.; BRONCZEK, GABRIELA A.; PIOVAN, SILVANO; MAREZE-COSTA, CECILIA E.; CARNEIRO, EVERARDO M.; BOSCHERO, ANTONIO C.; KURAUTI, MIRIAN A.. Aging Reduces Insulin Clearance in Mice. FRONTIERS IN ENDOCRINOLOGY, v. 12, MAY 12 2021. (15/12611-0, 18/24368-0, 13/07607-8, 17/06475-1)

MOURA-ASSIS, ALEXANDRE; NOGUEIRA, PEDRO A. S.; DE-LIMA-JUNIOR, JOSE C.; SIMABUCO, FERNANDO M.; GASPAR, JOANA M.; DONATO JR, JOSE; VELLOSO, LICIO A.. TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation. SCIENTIFIC REPORTS, v. 11, n. 1, SEP 9 2021. (18/14818-9, 17/02983-2, 13/07607-8)

VICTORIO, JAMAIRA A.; GUIZONI, DANIELE M.; FREITAS, ISRAELLE N.; ARAUJO, THIAGO R.; DAVEL, ANA P.. Effects of High-Fat and High-Fat/High-Sucrose Diet-Induced Obesity on PVAT Modulation of Vascular Function in Male and Female Mice. FRONTIERS IN PHARMACOLOGY, v. 12, SEP 10 2021. (18/16505-8, 13/07607-8, 18/00543-8)

FERNANDES LOPES, PRISCILLA KARLA; ENGEL, DAIANE FATIMA; BERTOLINI, NATALIA OLIVEIRA; DE AZEVEDO MARTINS, MOISES SILVESTRE; PEREIRA, CHRYSTIAN ARAUJO; VELLOSO, LICIO AUGUSTO; THOMASI, SERGIO SCHERRER; DE MOURA, RODRIGO FERREIRA. Behavioral, neuroplasticity and metabolic effects of 7,8-dihydroxy-4-methylcoumarin associated with physical activity in mice. METABOLIC BRAIN DISEASE, v. 36, n. 8, OCT 2021. (13/07607-8, 14/50938-8)

BOBBO, VANESSA C.; ENGEL, DAIANE F.; JARA, CARLOS POBLETE; MENDES, NATALIA F.; HADDAD-TOVOLLI, ROBERTA; PRADO, THAIS P.; SIDARTA-OLIVEIRA, DAVI; MORARI, JOSEANE; VELLOSO, LICIO A.; ARAUJO, ELIANA P.. Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis. JOURNAL OF NEUROINFLAMMATION, v. 18, n. 1, AUG 31 2021. (13/07607-8)

VERONESI, VANESSA BARBOSA; PIOLI, MARIANA RODRIGUES; DE SOUZA, DAILSON NOGUEIRA; TEIXEIRA, CAIO JORDAO; MURATA, GILSON MASAHIRO; SANTOS-SILVA, JUNIA CAROLINA; HECHT, FERNANDA BALLERINI; VICENTE, JULIA MODESTO; BORDIN, SILVANA; ANHE, GABRIEL FORATO. Agomelatine reduces circulating triacylglycerides and hepatic steatosis in fructose-treated rats. BIOMEDICINE & PHARMACOTHERAPY, v. 141, SEP 2021. (16/13138-9, 13/07607-8, 15/23285-6, 20/06397-3, 17/20742-2, 19/03196-0)

CARVALHO-ROMANO, LUIS F. R. S.; BONAFE, RAFAEL P.; PAIM, LAYDE R.; MARQUES, EDMILSON R.; VEGIAN, CAMILA F. L.; PIO-MAGALHAES, JOSE A.; MELLO, DANIEL S. S.; DE ROSSI, GUILHERME; COELHO-FILHO, OTAVIO R.; SCHREIBER, ROBERTO; et al. Association of carotid wall layers with atherosclerotic plaques and cardiac hypertrophy in hypertensive subjects. JOURNAL OF HUMAN HYPERTENSION, JUN 2021. (13/07607-8)

MOREIRA, KARINA GOMES; DO PRADO, THAIS PAULINO; MENDES, NATALIA FERREIRA; BEZERRA, RENAN DE MEDEIROS; JARA, CARLOS POBLETE; MELO LIMA, MARIA HELENA; DE ARAUJO, ELIANA PEREIRA. ccelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen depositio. PLoS One, v. 16, n. 10, OCT 26 2021. (13/07607-8)

BRAGA, CAROLYNE B.; PILLI, RONALDO A.; ORNELAS, CATIA; WECK, MARCUS. ear-Infrared Fluorescent Micelles from Poly(norbornene) Brush Triblock Copolymers for Nanotheranostic. Biomacromolecules, v. 22, n. 12, p. 5290-5306, DEC 13 2021. (13/07607-8, 19/13104-5, 14/50906-9, 18/24020-4, 17/06146-8)

BRAGA, RENATA R.; CRISOL, BARBARA M.; BRICOLA, RAFAEL S.; SANT'ANA, MARCELLA R.; NAKANDAKARI, SUSANA C. B. R.; COSTA, SULEYMA O.; PRADA, PATRICIA O.; DA SILVA, ADELINO S. R.; MOURA, LEANDRO P.; PAULI, JOSE R.; et al. Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice. SCIENTIFIC REPORTS, v. 11, n. 1, FEB 15 2021. (17/18695-6, 13/07607-8, 18/07634-9, 19/21709-4)

DA CUNHA, LORENA PIRES; SILVEIRA, MARINA NOGUEIRA; SANTOS MENDES, MARIA CAROLINA; COSTA, FELIPE OSORIO; MACEDO, LIGIA TRALDI; DE SIQUEIRA, NADIA SCLEARUC; CAMPELLO CARVALHEIRA, JOSE BARRETO. Sarcopenia as an independent prognostic factor in patients with metastatic colorectal cancer: A retrospective evaluation. CLINICAL NUTRITION ESPEN, v. 32, p. 107-112, AUG 2019. (10/19503-4, 13/07607-8)

NOGUEIRA, GUILHERME; SOLON, CARINA; CARRARO, RODRIGO S.; ENGEL, DAIANE F.; RAMALHO, ALBINA F.; SIDARTA-OLIVEIRA, DAVI; GASPAR, RODRIGO S.; BOMBASSARO, BRUNA; VASQUES, ANA C.; GELONEZE, BRUNO; et al. Interleukin-17 acts in the hypothalamus reducing food intake. BRAIN BEHAVIOR AND IMMUNITY, v. 87, p. 272-285, JUL 2020. (13/07607-8)

DELAFIORI, JEANY; LIMA, ESTELA DE OLIVEIRA; DABAJA, MOHAMED ZIAD; DIAS-AUDIBERT, FLAVIA LUISA; DE OLIVEIRA, DIOGO NOIN; RODRIGUES MELO, CARLOS FERNANDO ODIR; MORISHITA, KAREN NODA; SALES, GEOVANA MANZAN; TASCA GOIS RUIZ, ANA LUCIA; DA SILVA, GISELE GOULART; et al. Molecular signatures associated with prostate cancer cell line (PC-3) exposure to inactivated Zika virus. SCIENTIFIC REPORTS, v. 9, OCT 25 2019. (13/07607-8, 16/17066-2)

DE ARAUJO, THIAGO MATOS; VELLOSO, LICIO A.. Hypothalamic IRX3: A New Player in the Development of Obesity. TRENDS IN ENDOCRINOLOGY AND METABOLISM, v. 31, n. 5, p. 368-377, MAY 2020. (13/07607-8)

VICENTE, JULIA MODESTO; SANTOS-SILVA, JUNIA CAROLINA; TEIXEIRA, CAIO JORDAO; DE SOUZA, DAILSON NOGUEIRA; VETTORAZZI, JEAN FRANCIESCO; FURTUOSO, FABIOLA SALES; ADABO, ISABEL GOUVEIA; SATO, FABIO TAKEO; RAMIREZ VINOLO, MARCO AURELIO; CARNEIRO, EVERARDO MAGALHAES; et al. Long-term increase of insulin secretion in mice subjected to pregnancy and lactation. ENDOCRINE CONNECTIONS, v. 9, n. 4, p. 299-308, APR 2020. (13/07607-8, 15/12680-1, 17/11138-4)

DAMIAO, MARIANA C. F. C. B.; MARCON, HENRIQUE M.; PASTRE, JULIO CEZAR. Continuous flow synthesis of the URAT1 inhibitor lesinurad. REACTION CHEMISTRY & ENGINEERING, v. 5, n. 5, p. 865-872, MAY 1 2020. (14/25770-6, 14/26378-2, 15/18572-6, 13/07607-8, 18/25233-1)

BRAGA, CAROLYNE B.; KIDO, LARISSA A.; LIMA, ELLEN N.; LAMAS, CELINA A.; CAGNON, VALERIA H. A.; ORNELAS, CATIA; PILLI, RONALDO A.. Enhancing the Anticancer Activity and Selectivity of Goniothalamin Using pH-Sensitive Acetalated Dextran (Ac-Dex) Nanoparticles: A Promising Platform for Delivery of Natural Compounds. ACS BIOMATERIALS SCIENCE & ENGINEERING, v. 6, n. 5, SI, p. 2929-2942, MAY 2020. (18/02093-0, 17/06146-8, 19/13104-5, 13/07607-8)

HECHT, FERNANDA BALLERINI; TEIXEIRA, CAIO JORDAO; DE SOUZA, DAILSON NOGUEIRA; NUNES MESQUITA, FILIPHE DE PAULA; DO VAL ROSO, RYANA ELYZABETH; SODRE, FRHANCIELLY SHIRLEY; VERONESI, VANESSA BARBOSA; DA ROCHA, DEBORAH FABIANA; DANTAS DE MENEZES, YAN GUIDA; PIOLI, MARIANA RODRIGUES; et al. Antenatal corticosteroid therapy modulates hepatic AMPK phosphorylation and maternal lipid metabolism in early lactating rats. BIOMEDICINE & PHARMACOTHERAPY, v. 144, DEC 2021. (19/03196-0, 13/07607-8, 20/09717-9, 16/13138-9, 20/06397-3)

SIDARTA-OLIVEIRA, DAVI; JARA, CARLOS POBLETE; FERRUZZI, ADRIANO J.; SKAF, MUNIR S.; VELANDER, WILLIAM H.; ARAUJO, ELIANA P.; VELLOSO, LICIO A.. SARS-CoV-2 receptor is co-expressed with elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells. SCIENTIFIC REPORTS, v. 10, n. 1, NOV 11 2020. (13/08293-7, 13/07607-8)

RENTZ, THIAGO; WANSCHEL, AMARYLIS C. B. A.; DE CARVALHO MOI, LEONARDO; LORZA-GIL, ESTELA; DE SOUZA, JANE C.; DOS SANTOS, RENATA R.; OLIVEIRA, HELENA C. F.. The Anti-atherogenic Role of Exercise Is Associated With the Attenuation of Bone Marrow-Derived Macrophage Activation and Migration in Hypercholesterolemic Mice. FRONTIERS IN PHYSIOLOGY, v. 11, NOV 23 2020. (17/17728-8, 13/07607-8)

SALERNO, ALESSANDRO G.; RENTZ, THIAGO; DORIGHELLO, GABRIEL G.; MARQUES, ANA CAROLINA; LORZA-GIL, ESTELA; WANSCHEL, AMARYLIS C. B. A.; DE MORAES, AUDREY; VERCESI, ANIBAL E.; OLIVEIRA, HELENA C. F.. Lack of mitochondrial NADP(H)-transhydrogenase expression in macrophages exacerbates atherosclerosis in hypercholesterolemic mice. Biochemical Journal, v. 476, n. 24, p. 3769-3789, DEC 2019. (11/15101-1, 11/15103-4, 11/50400-0, 13/05497-0, 17/17728-8, 13/07607-8, 17/02903-9)

VERCESI, ANIBAL E.; CASTILHO, ROGER F.; KOWALTOWSKI, ALICIA J.; DE OLIVEIRA, HELENA C. F.; DE SOUZA-PINTO, NADJA C.; FIGUEIRA, TIAGO R.; BUSANELLO, ESTELA N. B.. Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition. Free Radical Biology and Medicine, v. 129, p. 1-24, DEC 2018. (17/17728-8, 11/50400-0, 06/59786-0, 14/11261-2, 13/07607-8)

BATISTA, ELLENCRISTINA SILVA; DA SILVA RIOS, THAIANE; MUNOZ, VITOR ROSETTO; JESUS, JOYCE SANTOS; VASCONCELOS, MARCEL MONTEIRO; DA CUNHA, DIOGO THIMOTEO; MARQUES-ROCHA, JOSE LUIS; NAKANDAKARI, SUSANA CASTELO BRANCO RAMOS; LARA, ROBERTA; DA SILVA, ADELINO SANCHEZ RAMOS; et al. Omega-3 mechanism of action in inflammation and endoplasmic reticulum stress in mononuclear cells from overweight non-alcoholic fatty liver disease participants: study protocol for the ``Brazilian Omega Study{''} (BROS)-a randomized controlled trial. Trials, v. 22, n. 1, DEC 18 2021. (12/07129-6, 13/07607-8)

LIMA-SILVA, LINCON FELIPE; LEE, JENNIFER; MORAES-VIEIRA, PEDRO M.. Soluble Carrier Transporters and Mitochondria in the Immunometabolic Regulation of Macrophages. Antioxidants & Redox Signaling, JAN 2022. (13/07607-8, 19/19435-3, 19/25973-8, 15/15626-8)

CARVALHO, LUIZ SERGIO F.; BENSENOR, ISABELA M.; NOGUEIRA, ANA C. C.; DUNCAN, BRUCE B.; SCHMIDT, MARIA I.; BLAHA, MICHAEL J.; TOTH, PETER P.; JONES, STEVEN R.; SANTOS, RAUL D.; LOTUFO, PAULO A.; et al. Increased particle size of triacylglycerol-enriched remnant lipoproteins, but not their plasma concentration or lipid content, augments risk prediction of incident type 2 diabetes. Diabetologia, v. 64, n. 2, NOV 2020. (13/07607-8)

MENDES, NATALIA F.; JARA, CARLOS P.; MANSOUR, ELI; ARAUJO, ELIANA P.; VELLOSO, LICIO A.. Asthma and COVID-19: a systematic review. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, v. 17, n. 1, JAN 6 2021. (13/07607-8, 16/17810-3)

WANSCHEL, AMARYLIS C. B. A.; GUIZONI, DANIELE M.; LORZA-GIL, ESTELA; SALERNO, ALESSANDRO G.; PAIVA, ADRIENE A.; DORIGHELLO, GABRIEL G.; DAVEL, ANA PAULA; BALKAN, WAYNE; HARE, JOSHUA M.; OLIVEIRA, HELENA C. F.. The Presence of Cholesteryl Ester Transfer Protein (CETP) in Endothelial Cells Generates Vascular Oxidative Stress and Endothelial Dysfunction. BIOMOLECULES, v. 11, n. 1, JAN 2021. (16/01746-4, 13/05497-0, 11/50400-0, 13/07607-8, 13/09347-3, 16/01044-0)

DELLA-FELICE, FRANCO; SAROTTI, ARIEL M.; KRISCHE, MICHAEL J.; PILLI, RONALDO A.. Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling. Journal of the American Chemical Society, v. 141, n. 35, p. 13778-13782, SEP 4 2019. (17/18487-4, 16/12541-4, 13/07607-8, 14/25474-8)

DE ARAUJO, THIAGO MATOS; RAZOLLI, DANIELA S.; CORREA-DA-SILVA, FELIPE; DE LIMA-JUNIOR, JOSE C.; GASPAR, RODRIGO S.; SIDARTA-OLIVEIRA, DAVI; VICTORIO, SHEILA C.; DONATO, JR., JOSE; KIM, YOUNG-BUM; VELLOSO, LICIO A.. The partial inhibition of hypothalamic IRX3 exacerbates obesity. EBIOMEDICINE, v. 39, p. 448-460, JAN 2019. (17/02983-2, 13/07607-8)

RAZOLLI, DANIELA S.; DE ARAUJO, THIAGO M.; SANT'ANA, MARCELLA R.; KIRWAN, PETER; CINTRA, DENNYS E.; MERKLE, FLORIAN T.; VELLOSO, LICIO A.. Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity. Neuroendocrinology, v. 110, n. 1-2, p. 92-104, JAN 2020. (13/07607-8)

GUIZONI, DANIELE M.; VETTORAZZI, JEAN F.; CARNEIRO, EVERARDO M.; DAVEL, ANA PAULA. Modulation of endothelium-derived nitric oxide production and activity by taurine and taurine-conjugated bile acids. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 94, p. 48-53, JAN 1 2020. (14/01717-9, 13/07607-8, 16/14461-8)

E-LACERDA, RODRIGO RODRIGUES; TEIXEIRA, CAIO JORDAO; BORDIN, SILVANA; ANTUNES, EDSON; ANHE, GABRIEL FORATO. Maternal Obesity in Mice Exacerbates the Allergic Inflammatory Response in the Airways of Male Offspring. NUTRIENTS, v. 11, n. 12, DEC 2019. (16/22722-6, 17/20742-2, 17/15175-1, 13/07607-8, 15/18997-7)

PARRAS SOUZA, ANELISE CRISTINA; SOUZA, CAMILLA MENDES; AMARA, CAMILA LIBARDI; LEMES, SIMONE FERREIRA; SANTUCCI, LETICIA FOGLIA; MILANSKI, MARCIANE; TORSONI, ADRIANA SOUZA; TORSONI, MARCIO ALBERTO. Short-Term High-Fat Diet Consumption Reduces Hypothalamic Expression of the Nicotinic Acetylcholine Receptor alpha 7 Subunit (alpha 7nAChR) and Affects the Anti-inflammatory Response in a Mouse Model of Sepsis. FRONTIERS IN IMMUNOLOGY, v. 10, MAR 22 2019. (13/07607-8, 16/23484-1)

PAIM, LAYDE R.; SCHREIBER, ROBERTO; DE ROSSI, GUILHERME; MATOS-SOUZA, JOSE R.; COSTA E SILVA, ANSELMO DE A.; CALEGARI, DECIO ROBERTO; CHENG, SUSAN; MARQUES, FRANCINE Z.; SPOSITO, ANDREI C.; GORLA, JOSE I.; et al. Circulating microRNAs, Vascular Risk, and Physical Activity in Spinal Cord-Injured Subjects. JOURNAL OF NEUROTRAUMA, v. 36, n. 6, SEP 27 2018. (13/07607-8)

DATILO, MARCELLA NEVES; SANT'ANA, MARCELLA RAMOS; FORMIGARI, GUILHERME PEDRON; RODRIGUES, PATRICIA BRITO; DE MOURA, LEANDRO PEREIRA; RAMOS DA SILVA, ADELINO SANCHEZ; ROPELLE, EDUARDO ROCHETE; PAULI, JOSE RODRIGO; CINTRA, DENNYS ESPER. Omega-3 from Flaxseed Oil Protects Obese Mice Against Diabetic Retinopathy Through GPR120 Receptor. SCIENTIFIC REPORTS, v. 8, SEP 25 2018. (13/07607-8, 12/07129-6)

DORIGHELLO, GABRIEL G.; INADA, NATALIA M.; PAIM, BRUNO A.; PARDO-ANDREU, GILBERTO L.; VERCESI, ANIBAL E.; OLIVEIRA, HELENA C. F.. Mangifera indica L. extract (Vimang (R)) reduces plasma and liver cholesterol and leucocyte oxidative stress in hypercholesterolemic LDL receptor deficient mice. Cell Biology International, v. 42, n. 6, SI, p. 747-753, JUN 2018. (13/07607-8, 11/50400-0)

GALAVERNA, RENAN; RIBESSI, RAFAEL L.; ROHWEDDER, JARBAS J. R.; PASTRE, JULIO C.. Coupling Continuous Flow Microreactors to MicroNIR Spectroscopy: Ultracompact Device for Facile In-Line Reaction Monitoring. ORGANIC PROCESS RESEARCH & DEVELOPMENT, v. 22, n. 7, p. 780-788, JUL 2018. (14/50951-4, 14/26378-2, 14/25770-6, 13/07607-8)

SCHREIBER, ROBERTO; SOUZA, CRISTIANE M.; PAIM, LAYDE R.; DE ROSSI, GUILHERME; MATOS-SOUZA, JOSE R.; COSTA E SILVA, ANSELMO DE A.; FARIA, FERNANDO R.; AZEVEDO, ELIZA R.; ALONSO, KARINA C.; SPOSITO, ANDREI C.; et al. Impact of Regular Physical Activity on Adipocytokines and Cardiovascular Characteristics in Spinal Cord-Injured Subjects. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, v. 99, n. 8, p. 1561-1567, AUG 2018. (13/07607-8)

LUBACZEUSKI, CAMILA; GONCALVES, LUCIANA MATEUS; VETTORAZZI, JEAN FRANCIESCO; KURAUTI, MIRIAN AYUMI; SANTOS-SILVA, JUNIA CAROLINA; BONFLEUR, MARIA LUCIA; BOSCHERO, ANTONIO CARLOS; COSTA-JUNIOR, JOSE MARIA; CARNEIRO, EVERARDO MAGALHAES. Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence. NEURAL PLASTICITY, 2017. (14/01717-9, 13/07607-8)

Filed patent(s) as a result of this research project