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CEGH-CEL - Human Genome and Stem Cell Research Center

Grant number: 13/08028-1
Support Opportunities:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: July 01, 2013 - June 30, 2025
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Mayana Zatz
Grantee:Mayana Zatz
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
( Atuais )
Ana Cristina Victorino Krepischi ; Eliana Maria Beluzzo Dessen ; Ésper Abrão Cavalheiro ; Maria Rita dos Santos e Passos Bueno ; Mariz Vainzof ; Merari de Fátima Ramires Ferrari ; Oswaldo Keith Okamoto ; Regina Célia Mingroni Netto
Pesquisadores principais:
( Anteriores )
Angela Maria Vianna Morgante ; Carla Rosenberg ; Celia Priszkulnik Koiffmann ; Peter Lees Pearson
Associated researchers:Ana Cristina Victorino Krepischi ; Angela Maria Vianna Morgante ; Carlos Frederico Martins Menck ; Celia Priszkulnik Koiffmann ; David Schlesinger ; Débora Romeo Bertola ; Edson Amaro Junior ; Fernando Kok ; Joao Paulo Fumio Whitaker Kitajima ; Jorge Elias Kalil Filho ; Luciana Amaral Haddad ; Luis Eduardo Soares Netto ; Maria Dulcetti Vibranovski ; Maria Lúcia Lebrão ; Merari de Fátima Ramires Ferrari ; Miguel Mitne Neto ; Nivaldo Alonso ; Peter Lees Pearson ; Rita de Cássia Mingroni Pavanello ; Tatiana Teixeira Torres ; Valdemir Melechco Carvalho ; Venancio Avancini Ferreira Alves ; Verônica Porto Carreiro de Vasconcellos Coelho ; Yeda Aparecida de Oliveira Duarte
Associated grant(s):22/11064-9 - Application of Hi-C and machine-learning tools towards detection and clinical interpretation of novel genomic variants in rare genetic diseases, AV.EXT
22/04037-5 - Multi-user equipment approved in grant 13/08028-1: single cell analysis chromiun, AP.EMU
22/03787-0 - EMU granted in FAPESP process 13/ 08028-1 - Mayana Zatz: BD FACSymphony" Flow Cytometer, AP.EMU
+ associated grants 20/05949-2 - Rapid, low-cost and efficient molecular diagnostics and large-scale population testing strategies for COVID-19 management, AP.R
19/05654-5 - Investigation of alphoid satellite DNA loss in centromeric regions in general population and in pediatric tumors, AV.EXT
16/50021-2 - Cancer stem cell interactome mapping, AP.R SPRINT
14/20796-7 - Synaptopathies in neurodevelopmental disorders: SHANK mutations as a window into synaptic function, AR.EXT - associated grants
Associated scholarship(s):23/14401-9 - The regenerative process in the murine model dy2J, with deficiency in a2-laminin, BP.IC
23/14178-8 - Induction of the resistance to chemotherapy phenotype after prolonged treatment of glioblastoma organoids with Temozolomide, BP.IC
23/07376-8 - Assessment of the therapeutic potential of modifications in Notch3 in mdx mice and DMD pigs, BP.DR
+ associated scholarships 23/02551-6 - Effects of TBCK deficiency, responsible for IHPRF3 Neurodegenerative Syndrome, on the neural differentiation process, BP.DD
23/08741-1 - Phenotypic profile analyzes of stem cell-derived cell lineages., BP.TT
23/08976-9 - Establishment of cortical organoid systems for the investigation of genetic neurodevelopmental disorders., BP.TT
23/07800-4 - Analysis of the degeneration/regeneration process in animal models and patients with neuromuscular diseases, BP.TT
23/09287-2 - Muscular Dystrophies: New Therapeutic Strategies Based on Protective Mechanisms, BP.TT
23/07400-6 - Comparative analysis of animal models of muscular dystrophy - Histopathology, muscle satellite cell location and strength tests, BP.TT
23/01887-0 - Investigation of epigenetic mechanisms in the etiology of Autism Spectrum Disorder in dystrophinopathies, BP.DD
23/02209-6 - Analysis of the oncolytic effect of ZIKV on temozolomide-resistant glioblastoma cells, BP.MS
22/14114-7 - Comparative analysis of muscular dystrophy models - Histopathology, animal cell localization and muscle strength tests, BP.TT
22/03980-5 - GENOMIC AND FUNCTIONAL STUDY OF SYNDROMIC FORMS OF INTELLECTUAL DISABILITY, BP.PD
22/14129-4 - Analysis of possible phenotype-modifying genes of muscular dystrophy, BP.TT
22/14345-9 - Expansion of biological diversity and cost reduction in genomic sequencing in CEGH-CEL, BP.TT
22/07972-7 - Maternal inflammation as a risk factor for cleft lip and palate development in individuals with CDH1 loss of function, BP.MS
22/05677-8 - Causative molecular mechanisms of Autism Spectrum Disorder in patients with dystrophinopathy, BP.DR
22/02212-4 - Development of Blood-Brain Barrier (BBB)-on-a-chip in vitro models to study Zika Virus oncolytic activity and drug permeability in Brain Cancer treatment, BP.PD
22/04953-1 - Implementation and management of a solution for bioinformatics applications in Docker: monitoring users, costs and flows, BP.TT
22/03577-6 - Implementation of pipelines/workflows in the cloud for bioinformatics analysis of genomic data from the Center for Human Genome and Stem Cell Studies (CEGH-CEL), BP.TT
22/02463-7 - Analysis of dysferlin and the formation of its protein tricomplex FAM65b-HDAC6-DYSF during the different phases of muscle differentiation, BP.IC
22/02649-3 - Analysis of the expression of different forms of myosin in vitro in myogenesis process in cellular models for neuromuscular diseases, BP.IC
22/01953-0 - Bioinformatics pipelines implementation to analyze human whole-genome and transcriptome sequencing, BP.TT
21/04323-5 - Evaluation of EZH2 expression and activity as factors of cellular susceptibility to Zika Virus infection in embryonic central nervous system tumors, BP.PD
21/00689-5 - Development of a chimeric antigen receptor for application on glioblastoma treatment, BP.MS
20/11495-4 - Risk variants investigation in patients with Autism Spectrum Disorder, BP.IC
20/08189-9 - In vitro characterization of the redox state and TCOF1 expression during human craniofacial development, BP.IC
19/21290-3 - Database development of genetic variants (Desbravar: Sequence Repository of Brazilian Variants), BP.TT
19/20768-7 - Development and implementation of NGS data processing tools and database for analysis and storage and genetic variants, BP.TT
19/19998-8 - Development of pipeline for copy number variation (CNVs) analysis, BP.TT
19/18469-1 - Development of universal hepatic organoids produced from IPS cells, BP.PD
18/08486-3 - Genetic bases of Syndromic Obesity and molecular mechanisms involved in its physiopathology, BP.DR
18/20373-0 - Characterization of the proteic interactoma of the pluripotency factor L1TD1 in central nervous system tumour stem cells and neural stem cells, BP.IC
18/05961-2 - Identification of genetic variants related to cancer predisposition in cohort of patients with embryonal tumors or pediatric tumors and additional clinical signs, BP.PD
16/14517-3 - Search for "protective" modifying variants/mechanisms in asymptomatic or very mildly affected individuals with pathogenic mutation in SPAST gene, BP.PD
17/16283-2 - Development of tissue bioengineering techniques for the functional reconstruction of ex vivo iPSC cell livers, BP.PD
17/11430-7 - Interaction of genetic and epigenetic factors in response to inflammation for the predisposition to cleft lip-palate, BP.PD
17/05824-2 - Investigation of parents de novo risk variants in Autism Spectrum Disorder (ASD), BP.DR
16/24188-7 - Modelling Richieri-Costa-Pereira Syndrome with the use of induced pluripotent stem cells, BP.PD
16/23648-4 - Investigation of the etiological relevance of novel candidate genes to orofacial clefts, BP.PD
16/17392-7 - ASSOCIATION STUDY OF RARE VARIANTS IN CANDIDATE GENES FOR OROFACIAL CLEFTS IN THE BRAZILIAN POPULATION, BP.DR
15/18914-4 - Study of the regenerative potential of satellite cells in centronuclear myopathy and myogenic capacity of its released microvesicles, BP.DR
15/19435-2 - Therapeutic analysis of human immunoglobulin G in a mouse model for Duchenne Muscular Dystrophy, BP.IC
15/14821-1 - Development of functional hepatic by-pass using iPSCs-derived cells, BP.DR
15/18130-3 - Analysis of the autophagic pathway in the dystrophic muscle., BP.MS
14/23043-0 - Identification of miRNAs with critical function in neurogenesis and oncogenesis, BP.PD
15/08563-0 - DYRK1A regulation by microRNAs in cultured neurons from the hippocampus of mice models of human trisomy 21 and its relation with Alzheimer's Disease, BP.IC
15/06786-1 - Stress of endoplasmic reticulum and expression of VAPB and Rab1 in cultured motor neurons from a mouse model of Amyotrophic Lateral Sclerosis, BP.IC
14/24541-3 - Use of GFP fusions to analyze the mechanisms of toxicity of human VAPB expressed in Saccharomyces cerevisiae, BP.IC
14/17132-0 - Use of Next Generation Sequencing to study karyotypes with different number of X chromosome, BP.PD
14/13056-7 - Characterization of INDELs and small CNVs in patients with autism spectrum disorder, BP.MS
14/10519-6 - Hippo signaling pathway and asymmetric division of cancer stem cells derived from human medulloblastoma, BP.PD
13/14996-0 - Detection of fetal genetic disorders through non-invasive prenatal testing using next-generation sequencing, BP.DR
12/09950-9 - Evolution of HLA genes: population differentiation and signatures of recent selection in native and admixed populations from Brazil, BP.PD
12/50154-1 - Identification of connexin 26 binding proteins, BP.PD
11/50856-3 - Role of cellular microenvironment in molecular mechanisms of resistance to chemotherapy in a human mammary carcinoma model, BP.PD - associated scholarships

Abstract

The Human Genome Research Center (HGRC-CEPID I) was initiated in 2000 with the main goal of increasing our basic knowledge and diagnosis of prevalent genetic diseases in the Brazilian population. The HGRC concentrated largely on Mendelian disorders, mainly neuromuscular, craniofacial, and mental disability. The scope was expanded in 2005 by incorporating stem-cell research, both as a tool to understand gene expression and differentiation in genetic disorders and to evaluate its potential in disease therapy. Our research has allowed us to address questions on the genetic regulation of particular complex disorders such as autism and various neurodegenerative diseases. However, the unanticipated complexity of the transcriptional mechanisms regulating gene expression in humans that emerged from the Human Genome Project, and the modest advances in improving the effectiveness of genetic health care have opened new fields of investigation. In this CEPID 11 application, we have expanded the scientific breadth to include ageing and degeneration and how factors such as genome instability contribute to the aging process; the role of imprinting mechanisms on disease manifestation; which factors determine differences in the rate of brain degeneration between individuals, which constitutes a rapidly increasing health care burdon as the average life-span of the world population rises; what determines phenotypic variability between individuals carrying the same mutation. To address these questions we will use up to date approaches, particularly the use of second generation sequencing and sophisticated cell sorting, incorporate a much broader base of scientific expertise, optimize inter-group synergy as well as national and international research collaboration. The plan also contributes to translational medicine mainly in the application of stem-cells in preclinical studies and therapeutic trials for particular genetic disorders. The great number of patients with different genetic disorders that have been ascertained and registered in our center, the largest one in Latin America, and the ethnic variability of the Brazilian population provides an extremely rich foundation for the proposed studies. We are positive that the knowledge gained from CEPID 11 will have an important impact on genetic health care in Brazil. However, such an ambitious and integrated program can only be expedited by the flexibility and long term security offered by CEPID funding. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
La era de la secuenciación completa de genomas 
The era of whole genome sequencing 
La baja en el costo de la secuenciación del ADN y la mejora en la capacidad de interpretar los datos acercan los test genéticos a la práctica clínica 
The falling cost of DNA sequencing and our increasing ability to interpret data are bringing genetic testing closer to clinical practice 
La tijera de los genes 
El zika contra el cáncer 
Una inmersión en las enfermedades genéticas 
Zika against cancer 
One mutation, several defects 
Una mutación, varios defectos 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (229)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIEIRA, NATASSIA M.; ELVERS, INGEGERD; ALEXANDER, MATTHEW S.; MOREIRA, YURI B.; ERAN, ALAL; GOMES, JULIANA P.; MARSHALL, JAMIE L.; KARLSSON, ELINOR K.; VERJOVSKI-ALMEIDA, SERGIO; LINDBLAD-TOH, KERSTIN; et al. Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype. Cell, v. 163, n. 5, p. 1204-1213, . (13/08028-1)
VILLELA, DARINE; SUEMOTO, CLAUDIA K.; PASQUALUCCI, CARLOS A.; GRINBERG, LEA T.; ROSENBERG, CARLA. Do Copy Number Changes in CACNA2D2, CACNA2D3, and CACNA1D Constitute a Predisposing Risk Factor for Alzheimer's Disease?. FRONTIERS IN GENETICS, v. 7, . (09/00898-1, 10/15503-0, 13/08028-1)
MUNFORD, V.; CASTRO, L. P.; SOUTO, R.; LERNER, L. K.; VILAR, J. B.; QUAYLE, C.; ASIF, H.; SCHUCH, A. P.; DE SOUZA, T. A.; IENNE, S.; et al. A genetic cluster of patients with variant xeroderma pigmentosum with two different founder mutations. British Journal of Dermatology, v. 176, n. 5, p. 1270-1278, . (14/15982-6, 13/08028-1)
SCHUCH, ANDRE PASSAGLIA; MORENO, NATALIA CESTARI; SCHUCH, NATIELEN JACQUES; MARTINS MENCK, CARLOS FREDERICO; MACHADO GARCIA, CAMILA CARRIAO. Sunlight damage to cellular DNA: Focus on oxidatively generated lesions. Free Radical Biology and Medicine, v. 107, p. 110-124, . (14/15982-6, 13/08028-1)
ALTMUELLER, FRANZISKA; LISSEWSKI, CHRISTINA; BERTOLA, DEBORA; FLEX, ELISABETTA; STARK, ZORNITZA; SPRANGER, STEPHANIE; BAYNAM, GARETH; BUSCARILLI, MICHELLE; DYACK, SARAH; GILLIS, JANE; et al. Genotype and phenotype spectrum of NRAS germline variants. European Journal of Human Genetics, v. 25, n. 7, p. 823-831, . (13/08028-1, 11/17299-3)
HOMMA, THAIS K.; KREPISCHI, ANA C. V.; FURUYA, TATIANE K.; HONJO, RACHEL S.; MALAQUIAS, ALEXSANDRA C.; BERTOLA, DEBORA R.; COSTA, SILVIA S.; CANTON, ANA P.; ROELA, ROSIMEIRE A.; FREIRE, BRUNA L.; et al. Recurrent Copy Number Variants Associated with Syndromic Short Stature of Unknown Cause. Hormone Research in Paediatrics, v. 89, n. 1, p. 13-21, . (15/26980-7, 09/00898-1, 13/03236-5, 13/08028-1)
VILLELA, DARINE; SUEMOTO, CLAUDIA K.; LEITE, RENATA; PASQUALUCCI, CARLOS AUGUSTO; GRINBERG, LEA T.; PEARSON, PETER; ROSENBERG, CARLA. Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain. NEURAL PLASTICITY, v. 2018, p. 9-pg., . (13/08028-1, 14/17132-0)
BUENO, ANDRE S.; NUNES, KELLY; DIAS, ALEX M. M.; ALVES, LEANDRO U.; MENDES, BEATRIZ C. A.; SAMPAIO-SILVA, JULIANA; SMITS, JEROEN; YNTEMA, HELGER G.; MEYER, DIOGO; LEZIROVITZ, KARINA; et al. Frequency and origin of the c.2090T > G p.(Leu697Trp) MYO3A variant associated with autosomal dominant hearing loss. European Journal of Human Genetics, v. 30, n. 1, p. 13-21, . (13/08028-1)
CASTRO, LIGIA PEREIRA; BATISTA-VIEIRA, DANILO; DE SOUZA, TIAGO ANTONIO; TIMOTEO, ANA RAFAELA DE SOUZA; COUTINHO, JESSICA DAYANNA LANDIVAR; PINHEIRO DE ALMEIDA, ISABEL CRISTINA; HENRIQUES, SHEILA RAMOS DE MIRANDA; AZEVEDO, FABIO MEDEIROS DE; ROSA, REGINALDO CRUZ ALVES; KANNOUCHE, PATRICIA L.; et al. PC and POLH/XPV Genes Mutated in a Genetic Cluster of Xeroderma Pigmentosum Patients in Northeast Brazi. FRONTIERS IN GENETICS, v. 12, . (19/19435-3, 13/08028-1)
GIRARDI, ANA CRISTINA DE SANCTIS; VAN OPSTAL TAKAHASHI, VANESSA NAOMI; VADASZ, ESTEVAO; COSTA, CLAUDIA ISMANIA SAMOGI; ZACHI, ELAINE CRISTINA; VIANNA-MORGANTE, ANGELA M.; PASSOS-BUENO, MARIA RITA. FMR1 premutation in children with autism spectrum disorders: Should additional diagnostic tests be performed?. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, . (13/08028-1)
SILVA, MATHEUS MOLINA; REILY ROCHA, CLARISSA RIBEIRO; KINKER, GABRIELA SARTI; PELEGRINI, ALESSANDRA LUIZA; MARTINS MENCK, CARLOS FREDERICO. The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells. SCIENTIFIC REPORTS, v. 9, . (14/15982-6, 15/15184-5, 13/08028-1, 17/24217-0)
GUO, LONG; BERTOLA, DEBORA ROMEO; TAKANOHASHI, ASAKO; SAITO, ASUKA; SEGAWA, YUKO; YOKOTA, TAKANORI; ISHIBASHI, SATORU; NISHIDA, YOICHIRO; YAMAMOTO, GUILHERME LOPES; DA SILVA FRANCO, JOSE FRANCISCO; et al. Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation. American Journal of Human Genetics, v. 104, n. 5, p. 925-935, . (15/21783-9, 13/08028-1)
BERTOLA, DEBORA; BUSCARILLI, MICHELLE; STABLEY, DEBORAH L.; BAKER, LAURA; DOYLE, DANIEL; BARTHOLOMEW, DENNIS W.; SOL-CHURCH, KATIA; GRIPP, KAREN W.. Phenotypic spectrum of Costello syndrome individuals harboring the rare HRAS mutation p.Gly13Asp. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, v. 173, n. 5, p. 1309-1318, . (13/08028-1)
ALVIZI, LUCAS; KE, XIAYI; BRITO, LUCIANO ABREU; SESELGYTE, RIMANTE; MOORE, GUDRUN E.; STANIER, PHILIP; PASSOS-BUENO, MARIA RITA. Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects. SCIENTIFIC REPORTS, v. 7, . (13/08028-1)
CARDOSO, FABRIZIO DOS SANTOS; DE SOUZA OLIVEIRA TAVARES, CRISTIANE; ARAUJO, BRUNO HENRIQUE SILVA; MANSUR, FERNANDA; LOPES-MARTINS, RODRIGO ALVARO BRANDAO; GOMES DA SILVA, SERGIO. Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy. Cellular and Molecular Neurobiology, . (13/08028-1, 17/16443-0)
DA SILVA, RODRIGO SALAZAR; GOES DANTAS, VITOR LIMA; ALVES, LEANDRO UCELA; BATISSOCO, ANA CARLA; OITICICA, JEANNE; LAWRENCE, ELIZABETH A.; KAWAFI, ABDELWAHAB; YANG, YUSHI; NICASTRO, FERNANDA STAVALE; NOVAES, BEATRIZ CAIUBY; et al. NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss. Human Molecular Genetics, v. 29, n. 22, p. 3691-3705, . (13/08028-1)
F. ALMEIDA, CAMILA; BITOUN, MARC; VAINZOF, MARIZ. Satellite cells deficiency and defective regeneration in dynamin 2-related centronuclear myopathy. FASEB JOURNAL, v. 35, n. 4, . (17/07376-7, 13/08028-1, 15/18914-4)
MACHADO CANTON, ANA PINHEIRO; VICTORINO KREPISCHI, ANA CRISTINA; MONTENEGRO, LUCIANA RIBEIRO; COSTA, SILVIA; ROSENBERG, CARLA; STEUNOU, VIRGINIE; SOBRIER, MARIE-LAURE; SANTANA, LUCAS; HONJO, RACHEL SAYURI; KIM, CHONG AE; et al. Insights from the genetic characterization of central precocious puberty associated with multiple anomalies. Human Reproduction, v. 36, n. 2, p. 506-518, . (13/08028-1, 18/03198-0)
MAHADEVARAJU, SHARVANI; FEAR, JUSTIN M.; AKEJU, MIRIAM; GALLETTA, BRIAN J.; PINHEIRO, MARA M. L. S.; AVELINO, CAMILA C.; CABRAL-DE-MELLO, DIOGO C.; CONLON, KATIE; DELL'ORSO, STAFANIA; DEMERE, ZELALEM; et al. Dynamic sex chromosome expression in Drosophila male germ cells. NATURE COMMUNICATIONS, v. 12, n. 1, . (15/20844-4, 17/14923-4, 17/26609-2, 15/16661-1, 13/08028-1, 19/15212-0)
PING HSIA, GABRIELLA SHIH; ESPOSITO, JOYCE; DA ROCHA, LETICIA ALVES; GUIMARAES RAMOS, SOFIA LIGIA; OKAMOTO, OSWALDO KEITH. Clinical Application of Human Induced Pluripotent Stem Cell-Derived Organoids as an Alternative to Organ Transplantation. STEM CELLS INTERNATIONAL, v. 2021, . (14/50931-3, 13/08028-1)
GRIESI-OLIVEIRA, K.; FOGO, M. S.; PINTO, B. G. G.; ALVES, A. Y.; SUZUKI, A. M.; MORALES, A. G.; EZQUINA, S.; SOSA, O. J.; SUTTON, G. J.; SUNAGA-FRANZE, D. Y.; et al. Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder. MOLECULAR PSYCHIATRY, . (14/10068-4, 16/50324-5, 13/08028-1)
DA SILVA MONTENEGRO, EDUARDA MORGANA; COSTA, CLAUDIA SAMOGY; CAMPOS, GABRIELE; SCLIAR, MARILIA; DE ALMEIDA, TATIANA FERREIRA; ZACHI, ELAINE CRISTINA; WAHYS SILVA, ISABELA MAYA; CHAN, ADA J. S.; ZARREI, MEHDI; LOURENCO, V, NAILA C.; et al. Meta-Analyses Support Previous and Novel Autism Candidate Genes: Outcomes of an Unexplored Brazilian Cohort. Autism Research, v. 13, n. 2, p. 199-206, . (17/05824-2, 13/08028-1)
GODOY, JULIANA A. P.; PAIVA, RAQUEL M. A.; SOUZA, ALINE M.; KONDO, ANDREA T.; KUTNER, JOSE M.; OKAMOTO, OSWALDO K.. Clinical Translation of Mesenchymal Stromal Cell Therapy for Graft Versus Host Disease. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 7, . (13/08028-1)
LIMA, RAQUEL S.; CARRETTIERO, DANIEL C.; FERRARI, MERARI F. R.. BAG2 prevents Tau hyperphosphorylation and increases p62/SQSTM1 in cell models of neurodegeneration. MOLECULAR BIOLOGY REPORTS, v. N/A, p. 13-pg., . (11/06434-7, 13/08028-1, 18/07592-4, 17/24722-6, 16/04409-9)
SAMOGY-COSTA, CLAUDIA ISMANIA; VARELLA-BRANCO, ELISA; MONFARDINI, FREDERICO; FERRAZ, HELEN; FOCK, RODRIGO AMBROSIO; ALMEIDA BARBOSA, RICARDO HENRIQUE; SANTOS PESSOA, ANDRE LUIZ; ALVAREZ PEREZ, ANA BEATRIZ; LOURENCO, NAILA; VIBRANOVSKI, MARIA; et al. A Brazilian cohort of individuals with Phelan-McDermid syndrome: genotype-phenotype correlation and identification of an atypical case. JOURNAL OF NEURODEVELOPMENTAL DISORDERS, v. 11, . (16/17392-7, 13/08028-1)
GOULART, ERNESTO; DE CAIRES-JUNIOR, LUIZ CARLOS; TELLES-SILVA, KAYQUE ALVES; SILVA ARAUJO, BRUNO HENRIQUE; KOBAYASHI, GERSON S.; MUSSO, CAMILA MANSO; ASSONI, AMANDA FARIA; OLIVEIRA, DANYLLO; CALDINI, ELIA; GERSTENHABER, JONATHAN A.; et al. Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-beta. STEM CELL RESEARCH & THERAPY, v. 10, n. 1, . (13/08028-1)
DOS SANTOS, ALEXSANDRO; CAMPAGNARI, FRANCINE; VICTORINO KREPISCHI, ANA CRISTINA; RIBEIRO CAMARA, MARIA DE LOURDES; DE ARRUDA BRASIL, RITA DE CASSIA E.; VIEIRA, LIGIA; VIANNA-MORGANTE, ANGELA M.; OTTO, PAULO A.; PEARSON, PETER L.; ROSENBERG, CARLA. Insight into the mechanisms and consequences of recurrent telomere capture associated with a sub-telomeric deletion. Chromosome Research, v. 26, n. 3, p. 191-198, . (12/50981-5, 13/08028-1)
BATISSOCO, ANA C.; SALAZAR-SILVA, RODRIGO; OITICICA, JEANNE; BENTO, RICARDO F.; MINGRONI-NETTO, REGINA C.; HADDAD, LUCIANA A.. A Cell Junctional Protein Network Associated with Connexin-26. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 9, . (12/50154-1, 13/08028-1)
MELO, THAIANY QUEVEDO; COPRAY, SJEF J. C. V. M.; FERRARI, MERARI F. R.. Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum. Neurochemical Research, v. 43, n. 12, p. 2212-2223, . (13/08028-1, 11/06434-7, 15/18961-2)
DE OLIVEIRA, JULIANA FERREIRA; VITAL DO PRADO, PAULA FAVORETTI; DA COSTA, SILVIA SOUZA; SFORCA, MAURICIO LUIS; CANATELI, CAMILA; RANZANI, AMERICO TAVARES; MASCHIETTO, MARIANA; LOPES DE OLIVEIRA, PAULO SERGIO; OTTO, PAULO A.; KLEVIT, RACHEL E.; et al. Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability. Nature Chemical Biology, v. 15, n. 1, p. 62+, . (12/50981-5, 13/08028-1, 15/06281-7)
VILLELA, DARINE; SUEMOTO, CLAUDIA K.; LEITE, RENATA; PASQUALUCCI, CARLOS AUGUSTO; GRINBERG, LEA T.; PEARSON, PETER; ROSENBERG, CARLA. Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain. NEURAL PLASTICITY, . (14/17132-0, 13/08028-1)
GOMES, LUCIANA R.; VESSONI, ALEXANDRE T.; MENCK, CARLOS F. M.. Microenvironment and autophagy cross-talk: Implications in cancer therapy. PHARMACOLOGICAL RESEARCH, v. 107, p. 300-307, . (14/15982-6, 13/08028-1)
QUINET, ANNABEL; MARTINS, DAVI JARDIM; VESSONI, ALEXANDRE TEIXEIRA; BIARD, DENIS; SARASIN, ALAIN; STARY, ANNE; MARTINS MENCK, CARLOS FREDERICO. Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells. Nucleic Acids Research, v. 44, n. 12, p. 5717-5731, . (14/15982-6, 13/08028-1)
DE CAIRES, JR., LUIZ CARLOS; GOULART, ERNESTO; MELO, UIRASOUTO; HENRIQUE ARAUJO, BRUNO SILVA; ALVIZI, LUCAS; SCHANOSKI, ALESSANDRA SOARES; DE OLIVEIRA, DANYLLO FELIPE; KOBAYASHI, GERSON SHIGERU; GRIESI-OLIVEIRA, KARINA; MUSSO, CAMILA MANSO; et al. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. NATURE COMMUNICATIONS, v. 9, . (14/50931-3, 14/03620-2, 13/08028-1)
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CASTELLI, ERICK C.; DE CASTRO, MATEUS V.; NASLAVSKY, MICHEL S.; SCLIAR, MARILIA O.; SILVA, NAYANE S. B.; PEREIRA, RAPHAELA N.; CIRIACO, VIVIANE A. O.; CASTRO, CAMILA F. B.; MENDES-JUNIOR, CELSO T.; SILVEIRA, ETIELE DE S.; et al. MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil. FRONTIERS IN IMMUNOLOGY, v. 13, p. 15-pg., . (14/50931-3, 20/09702-1, 17/19223-0, 19/19998-8, 13/08028-1)

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MÉTODO DE PROGNÓSTICO DA AGRESSIVIDADE DE TUMORES E KIT BR1020140155775 - Universidade de São Paulo (USP) . Carolina de Oliveira Rodini ; Gabriela Furukawa ; Oswaldo Keith Okamoto ; Patrícia Benites Gonçalves da Silva - June 2014, 17

COMPOSIÇÕES FARMACÊUTICAS PARA ELIMINAÇÃO DE CÉLULAS-TRONCO TUMORAIS E USO DAS MESMAS BR1020150030169 - Universidade de São Paulo (USP) . OSWALDO KEITH OKAMOTO / MÁRCIA CRISTINA TEIXEIRA DOS SANTOS / PATRÍCIA BENITES GONÇALVES DE SILVA - February 2015, 11

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