CRID - Center for Research in Inflammatory Diseases

• Grant number: 13/08216-2
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• Start date: August 01, 2013
• End date: July 31, 2026
• Field of knowledge: Biological Sciences - Pharmacology
• Principal Investigator: Fernando de Queiroz Cunha
• Grantee: Fernando de Queiroz Cunha
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Principal investigators: Helder Takashi Imoto Nakaya ; João Santana da Silva ; José Carlos Farias Alves Filho ; Paulo Louzada Junior ; Thiago Mattar Cunha
• Principal investigators: Carlos Henrique Tomich de Paula da Silva ; Dario Simões Zamboni ; Rita de Cassia Aleixo Tostes Passaglia
• Associated researchers: Ana Maria Ferreira Roselino ; Ana Paula de Carvalho Panzeri Carlotti ; Anibal Basile Filho ; Antônio Pazin Filho ; Beatriz Rossetti Ferreira ; Cacilda da Silva Souza ; Carlos Henrique Tomich de Paula da Silva ; Claudio Miguel da Costa Neto ; Dario Simões Zamboni ; Doralina Guimarães Brum Souza ; Eduardo Antônio Donadi ; Eduardo Barbosa Coelho ; Elcio dos Santos Oliveira Vianna ; Flavio da Silva Emery ; Francisco José Albuquerque de Paula ; Geraldo Aleixo da Silva Passos Júnior ; Helder Takashi Imoto Nakaya ; João Santana da Silva ; José Carlos Farias Alves Filho ; Jose Marcos Chaves Ribeiro ; Luiz Osório Silveira Leiria ; Marcello Henrique Nogueira Barbosa ; Marcos Antonio Rossi ; Marcos de Carvalho Borges ; Renê Donizeti Ribeiro de Oliveira ; Rita de Cassia Aleixo Tostes Passaglia ; Ronaldo de Albuquerque Ribeiro ; Roque Pacheco de Almeida ; Sandra Yasuyo Fukada Alves ; Sérgio Henrique Ferreira ; Thiago Mattar Cunha ; Vanessa Carregaro Pereira ; Vânia Luiza Deperon Bonato ; Virginia Paes Leme Ferriani ; Waldiceu Aparecido Verri Junior
• Associated research grant(s): 24/09228-9 - Exploring the Role and Therapeutic Potential of Gasdermin-D in Sepsis and COVID-19, AP.R; 23/09798-7 - Experimental protocols consolidation using human pathogenic fungi in the Bi-Institutional Platform for Research in Translational Medicine., AV.BR; 23/01533-4 - CGRP and PKM2 immunomodulation during cutaneous leishmaniasis infection, AP.R; + associated grants 22/11885-2 - Identification of critical cellular factors during neurotropic arbovirus infection through global screening with CRISPR-Cas9 libraries, AV.BR; 22/08412-5 - Understanding the molecular regulation of Th17 and regulatory T cells in infections and autoimmune diseases, AP.R; 21/08865-7 - Multi-user equipment approved in grant 2013/08216-2: QuantStudio 5 Real Time PCR System Applied Biosystems, AP.EMU; 20/05211-3 - Evaluation of Amphiregulin as a prognostic biomarker of severity and its participation in the pathophysiology of COVID-19, AP.R; 20/05601-6 - Neutrophil extracelular traps (NETs): role in the pathophysiology and potential as a therapeutic target on COVID-19, AP.R; 20/04860-8 - Global genome screening with CRISPRko libraries to identify essential factors in SARS-CoV2 infection and replication, AP.R; 19/21482-0 - Multi-User Equipment approved in grant 2013/08216-2: chromium" 10x genomics, controller & accessory kit, 12 mo. warranty, AP.EMU; 19/08265-0 - Multi-User Equipment approved in grant 2013/08216-2: analyzer measures oxygen consumption rate, AP.EMU; 18/15235-7 - Macrophage metabolism as a target for cancer therapy, AP.R SPRINT; 18/15192-6 - Contribution of endothelial dysfunction in progression of aortic aneurysm, AP.R SPRINT; 17/23826-2 - Rheumatoid arthritis and periodontal disease: association between microbiome and disease-modifying drugs, AV.BR; 17/20347-6 - Multi-user equipment approved in grant 13/08216-2: flow cytometer, AP.EMU; 17/10255-7 - Molecular mechanisms underlying the resistance to the immunosupression development in neonatal sepsis, AV.EXT; 15/01055-9 - Multi-User Equipment approved in grant 2013/08216-2: sistema de alta performance por imagem, AP.EMU; 14/50268-2 - Deciphering the interactions between Legionella longbeachae and eukaryotic host cells, AP.R - associated grants
• Associated scholarship(s): 25/05544-6 - PKM2, SUCNR1, and AREG mediate resistance to cutaneous leishmaniasis in keratinocytes, BP.PD; 25/15219-5 - Role of voltage-gated sodium channel 1.5 in TrkB-positive neurons in the development of streptozotocin-induced diabetic neuropathic pain., BP.IC; 25/15376-3 - The Role of ERK5 Signaling in Regulatory T Cells (Treg) in Colorectal Cancer Progression, BP.IC; + associated scholarships 25/04111-9 - The role of ferroportin in iron metabolism and its impact on regulatory T cell biology, BP.DR; 25/01935-0 - Role of dorsal root meninges in chronic pain: unraveling the anatomy and ultrastructure by using Light Sheet Microscopy, BE.PQ; 25/05036-0 - The role of dendritic cell-derived amphiregulin in colorectal cancer progression., BP.DR; 25/11434-9 - Dynamics of regulatory T lymphocytes in immunosurveillance and antitumor response, BP.PD; 25/11510-7 - Exploring the role of neutrophil extracellular traps (NETs) and the SWI/SNF complex in regulating the anti-tumor immune response., BP.PD; 25/05531-1 - Manipulation and genotyping of PAD4 knockout transgenic animals in sepsis and rheumatoid arthritis studies, BP.TT; 24/20897-0 - Participation of the NOD2/RIPK2 signaling pathway in the pathophysiology of psoriasis., BP.MS; 23/14926-4 - The role of the p53 and STING signaling pathways integration in the modulation of the Th17 lymphocytes differentiation, BP.DR; 24/06637-5 - DREAM and the dysfunction of perivascular adipose tissue in obesity, BP.DR; 24/04992-2 - Role of sodium channel Nav1.5 in TrKB positive sensory fibers in the development of paclitaxel-induced neuropathic pain, BP.PD; 24/16376-4 - Scientific dissemination contextualized in health sciences., BP.TT; 24/10752-4 - HDL-mediated reverse cholesterol transport as a regulator of hepatic lipogenesis, BP.PD; 24/10526-4 - Metabolic changes in lymphocytes in the face of viral infection, BP.TT; 24/08618-8 - Single-cell transcriptomes of inflammatory diseases, BP.TT; 24/08622-5 - Role of HCAR2 receptor in the development of neuropathic pain, BP.IC; 24/06707-3 - Assessment of immunocompetence and risk factors of infection in patients with systemic lupus erythematosus, BP.IC; 24/03237-6 - Regulation between AIM2/BLIMP-1 in the activation of dendritic cells during in vitro and in vivo L. infantum infection., BP.IC; 24/04906-9 - Mechanisms and consequences of the activation of cytoplasmic receptors by intracellular pathogens, BP.TT; 24/01270-6 - Modulation of the immune response to Cryptococcus neoformans by IL-27 and IL-35, BP.IC; 23/13328-6 - Role of the enzyme Pyruvate Kinase M2 (PKM2) in astrocytes under neuroinflammatory conditions, BP.DR; 24/02507-0 - HDL-mediated reverse transport as a regulator of hepatic lipogenesis, BP.TT; 23/16352-5 - EVALUATION OF THE RELEASE OF NEUTROPHIL EXTRACELLULAR NETWORKS (NETs) IN RESPONSE TO DIFFERENT VARIANTS OF THE SARS-CoV-2 VIRUS, BP.IC; 23/09528-0 - Study of the mechanisms involved in the reduction of endothelin-1 signaling in the vascular bed of spontaneously diabetic mice, BP.MS; 23/13452-9 - Systems Biology Applied to Transcriptomic Analysis of Inflammatory Diseases, BP.PD; 23/05350-1 - Maternal transfer of antibodies and BAT development, BP.PD; 23/11522-0 - Scientific dissemination contextualized in health sciences., BP.TT; 23/07031-0 - Cellular and molecular characterization and origin of leukocytes accumulated in the dorsal root meninges after peripheral and nerve injuries, BP.PD; 23/08211-2 - In vitro and in vivo validation of new pharmacology HITs for the treatment of inflammatory diseases and neuropathic pain, BP.PD; 23/02994-5 - Systems immunology of autoimmune inflammatory diseases, BP.DD; 23/06703-5 - Manipulation and genotyping of Cre-lox transgenic animals, BP.TT; 23/06526-6 - Training in laboratory and colony management of transgenic mice., BP.TT; 22/16903-9 - Role of neutrophil extracellular traps in the pathogenesis of inflammatory bowel disease, BP.DR; 22/16347-9 - Characterization of the autoimmune response in mice deficient for the DDX41 protein on regulatory T cells., BP.MS; 23/02455-7 - Contextualized scientific dissemination in health education, BP.TT; 23/04175-1 - Technical training in autoimmune neurodegenerative diseases, BP.TT; 23/03043-4 - Single-cell transcriptomes of inflammatory diseases, BP.PD; 23/01133-6 - Characterization and structural optimization of protein target ligands related to inflammatory processes studied by CRID, BP.PD; 22/13361-0 - Influence of the metabolic profile of CD4+ T cells on testosterone-induced heart dysfunction in an experimental model of gender affirming hormone therapy, BP.DR; 23/00472-1 - Mechanisms and consequences of activation of cytoplasmic receptors by intracellular pathogens., BP.TT; 22/13842-9 - Bipolar Affective Disorder: a transcriptome data study, BP.IC; 22/15620-3 - Mechanisms involved in Neutrophil Extracellular Traps (NETs) during infectious and inflammatory diseases, BP.PD; 22/04864-9 - Systems Immunology of Inflammatory Diseases, BP.MS; 22/14416-3 - Generation and genotyping of transgenic animals (Cre-lox System) for experimental models, BP.TT; 22/10198-1 - Learning of procedures for obtaining mouse embryos., BP.TT; 22/09144-4 - Implementation, experimental standardization and analysis of multiparametric flow cytometry, BP.TT; 21/10494-7 - Importance of IL-33 in the development of Wallerian degeneration and its actions on immune cells, BP.DR; 22/02651-8 - The importance of STING signaling pathway on the differentiation and function of T regulatory cells, BP.DD; 22/08052-9 - Participation of NETs as a biomarker of autoimmune rheumatic diseases, BP.PD; 22/05647-1 - Genotyping of conditionally deficient animals using the Cre/loxP system, BP.TT; 22/04846-0 - Contribution of endothelin-1 in perivascular adipose tissue dysfunction in obese mice: involvement of transcriptional factor Nrf2 and kinase GSK-3B, BP.IC; 22/02605-6 - Systems Biology Applied to Transcriptomic Analysis of Inflammatory Diseases, BP.PD; 21/00840-5 - Cellular and molecular characterization and origin of the leukocytes accumulated in the leptomeninges of the dorsal roots of neuropathic animals, BP.PD; 22/04449-1 - The importance of iron metabolism in the differentiation, stability, function and pathogenicity of Th17 lymphocytes and its implication in autoimmunity, BP.PD; 21/09854-9 - Role of cytoplasmic DNA sensor, STING, in cisplatin-induced peripheral neuropathic pain development, BP.DR; 22/00951-4 - Scientific diffusion contextualized in health sciences, BP.TT; 21/08847-9 - Contribution of autophagic processes in perivascular adipose tissue hyperinflammation associated with metabolic syndrome, BP.PD; 21/13400-3 - Manipulation and genotyping of transgenic animal Cre-lox, BP.TT; 21/11728-1 - Generation and genotyping of transgenic animals (Cre-Lox System) for use in experimental models, BP.TT; 21/08843-3 - The role of gamma delta T cells in the acute Sepsis, BP.IC; 21/10650-9 - Morphological and functional characterization of sensory neurons expressing neurotensin (NTS), BP.IC; 21/08754-0 - Importance of NFR2 on osteoclastogenis and its impact on bone metabolism, BP.PD; 21/08330-6 - Crosstalk between innate immune cells and thermogenic adipocytes in the regulation of energetic metabolism, BP.PD; 21/08425-7 - Immunopathogenesis of post-Sepsis immunosuppression, BP.PD; 21/08434-6 - Identification and validation of drugs for the treatment of Leishmaniasis, BP.PD; 21/06771-5 - Characterization of resistance and susceptibility genes in Visceral Leishmaniasis, BP.PD; 20/11339-2 - Trimethylamine N-oxide (TMAO) as a link among gut dysbiosis, immune system activation and vascular dysfunction induced by ethanol consumption, BP.PD; 21/02049-3 - DDX41 protein study on the differentiation and function of regulatory T cells (Tregs), BP.IC; 21/03525-3 - Tissue processing for histopathological analysis in experimental models., BP.TT; 21/03420-7 - Role of kinase inhibition of G 2 protein-coupled receptors (GRK2) in the treatment of Sepsis, BP.IC; 21/03506-9 - Contextualized scientific dissemination in health education, BP.TT; 21/04378-4 - ROLE OF O-GLUCONACILATION IN THE ACTIVITY OF THE FOXO1 TRANSCRIPTION FACTOR: VASCULAR ENDOTHELIAL CELL PHYSIOLOGY IN HYPERGLYCEMIA, BP.IC; 21/02047-0 - Determination of the metabolic profile in real time of cells of the immune system, BP.TT; 21/02934-7 - Gene knokouts generation and validation using CRISPR/Cas9 in vitro, BP.TT; 21/00696-1 - Manipulation and genotyping of transgenic animal expressing human ACE2 for COVID-19 studies, BP.TT; 21/02053-0 - Evaluation of leishmanicidal activity of drugs in macrophages infected by L. amazonensis, BP.TT; 21/01213-4 - Identification of therapeutic targets from transcriptomic analysis of the sensory system cells after peripheral nerve injury, BP.IC; 20/11372-0 - Importance of ERK5 in the differentiation and function of regulatory T cells, BP.DR; 19/24921-4 - Role of resistin via CAP1 in perivascular adipose tissue and vascular dysfunction in an experimental Arthritis model, BP.DR; 20/13742-9 - Structural studies and molecular screening for the development of PKM2 and related proteins inhibitors, BP.PD; 20/05446-0 - Origin, dynamics and transcriptional profile of dorsal root ganglion and sciatic nerve macrophages in homeostasis and during neuropathic pain, BP.DD; 20/08109-5 - Molecular mechanisms involved in the desensibilization of ± adrenergic receptors during Sepsis: potential for the treatment of Vasoplegia, BP.PD; 19/20692-0 - Involvement of the NLRP3 inflammasome in cardiac dysfunction associated with supraphysiological levels of testosterone, BP.DR; 18/17542-4 - The role of the STING signaling pathway in the regulation of Th17 cell pathogenicity and its implication for autoimmunity, BP.DR; 20/04170-1 - The role of DDX41 on the differentiation and function of regulatory T lymphocytes, BP.DR; 20/02642-3 - Characterization of the TIGIT+ T regulatory cell subset in response to therapy with disease-modifying anti-rheumatic drugs in patients with Rheumatoid Arthritis, BP.PD; 20/00382-4 - Sting signaling pathway study on the differentiation and function of Regulatory T cells (Tregs), BP.IC; 19/15070-0 - Determination of molecular and cellular mechanisms associated with Sepsis outcome using single cell RNA sequencing, BP.DR; 20/02899-4 - Role of NETs in the pathogenesis of psoriasis, BP.TT; 20/04393-0 - The use of High-content to evaluate the leishmanicidal activity of drugs., BP.TT; 19/25305-5 - Involvement of O-GlcNAcylation in astrocyte activation during development of experimental autoimmune encephalomyelitis, BP.IC; 19/19190-0 - Role of NETs as osteoclastogenesis modulators in Rheumatoid Arthritis , BP.DR; 19/22579-7 - Systems biology applied to transcriptomic analysis of inflammatory diseases, BP.PD; 19/25622-0 - Generation and genotyping of transgenic animals (Cre-Lox system) for use in experimental models, BP.TT; 19/25586-4 - Contribution of tyrosin phosfatase protein DUSP1 in endothelial disfunction induced by lysophosfatidilcolina and participation in the formation of atherosclerosis plaque, BP.IC; 19/15063-4 - Characterization of the role of the sensory fibers a (TRKb+) and fibers C (galanin+/neurotensin+) in nociceptive and pathological pain, BP.DR; 19/18645-4 - Understanding the immune response to Leishmania infantum, BP.PD; 19/14285-3 - Role of succinate/SUCNR1 signalling pathway in sensory neurons in neuropathic pain development, BP.DR; 19/09901-7 - Biochemical and pharmacological characterization of oxytocin forms in New World Monkeys: activities on oxytocin and vasopressin receptors, BP.PD; 19/19555-9 - Development of a transgenic line, with the conditioned expression of Cre recombinase protein to the activation Sucnr1/Gpr91 endogenous promoter., BP.PD; 19/13829-0 - Role of O-GlcNAcylation in the neuroinflammatory functions of astrocytes, BP.DR; 19/10473-0 - Chemical library screening and structural and biochemical characterization of ligands of novel molecular targets for the treatment of inflammatory diseases., BP.PD; 19/04888-2 - Awareness and inflammation: the diffusion of topics related to inflammation and inflammatory diseases, BP.TT; 19/08177-3 - The generation of astrocytes derived from human induced pluripotent stem cells (hiPSC): a powerful tool for the neuroinflammation study, BP.IC; 18/24063-5 - Role of CCL-2/MCP-1 produced by peripheral sensorial neurons in the development of neuropathic pain, BP.DR; 18/23910-6 - Role of PFKFB-3 enzyme in regulatory t cells, BP.MS; 18/23168-8 - Importance of AMP-activated protein kinase (AMPK) in the regulation of TGF-beta pathway and T regulatory cells differentiation, BP.DR; 18/22802-5 - Origin, dynamics and transcriptional profile of macrophages of the sensory ganglia of the dorsal roots and sciatic nerve, BP.MS; 18/19312-6 - Role of S100A9/TLR4 pathway in the metabolic and functional modulation of keratinocytes and activation of dendritic cells: implications on the Psoriasis pathogenesis, BP.DR; 18/20130-0 - Function, mechanisms of activation and regulation of PI3K delta and PI3K gamma signaling pathway in the control of Trypanosoma cruzi infection., BP.PD; 17/26095-9 - Expression and activity of NRF2 in aorta of mice with insulin resistance submitted to the caloric restriction, BP.IC; 18/05102-0 - Cellular metabolite profile analysis in neuropathic pain, BP.PD; 17/25308-9 - Role of lactic acid in the resistance to checkpoint inhibitors (anti-PD-1/PD-L1) used in cancer immunotherapy, BP.PD; 18/09509-7 - Proteomic approach for the evaluation of pathways related to the control of Leishmania major infection dependent on nitric oxide (NO), BP.IC; 18/10444-7 - Evaluation of Naip receptors in NLRC4 inflammasome activation in response to L. amazonensis infection, BP.IC; 17/21926-0 - Influence of the neutrophil infection upon the virulence factors of the Leishmania mexicana and Leishmania major parasites, BE.PQ; 17/24669-8 - Unraveling the molecular bases of the early protein secretory pathway in humans using biophysical techniques, BP.PD; 18/04782-7 - Awareness and inflammation: the dissemination of themes concerning inflammation and inflammatory diseases, BP.TT; 17/12487-2 - Studying Juvenile Idiopathic Arthritis through a network Medicine approach, BP.DD; 18/02587-2 - Histological processing in bone tissue, BP.TT; 17/20692-5 - Regulation and function of O-GlcNAcylation in TAM macrophage differentiation and tumor progression, BP.DR; 17/18264-5 - Biased agonists for the Gq protein pathway in the a1-adrenoceptor subtypes in Septic Vasoplegia treatment, BP.PD; 17/04347-6 - Cooperation between TLR4 and IL-1R signaling pathways in the regulation of immune response during human and murine L. infantum infection, BP.PD; 17/19040-3 - Use of high-content screening to evaluate drug leishmanicidal activity in macrophages, BP.PD; 17/11270-0 - Awareness and inflammation: the dissemination of themes concerning inflammation and inflammatory diseases, BP.TT; 17/13353-0 - Association between inflammation and use of cannabis (Cannabis sativa) in patients in first psychotic episode, BP.IC; 17/03203-0 - Planning of new candidates for anti-inflammatory drugs, BP.PD; 17/06007-8 - Role of methotrexate and pro-resolving mediators in rheumatoid arthritis and in inflammatory response resolution process, BP.PD; 17/01714-8 - PKM2 contribution to neutrophils' activation in experimental systemic lupus erythematosus onset, BP.PD; 17/04936-1 - Evaluating the in vivo effect of potential drugs for the treatment of Arthritis, BP.PD; 17/04200-5 - NEDD4L protein role in the differentiation regulation of TGF-²-induced Treg lymphocytes , BP.PD; 17/03491-6 - RIDCs: Research, Innovation and Dissemination Centers, BP.PD; 17/03211-3 - The role of the H2S donor, ATB-346, in the evolution of experimental sepsis, BP.IC; 17/03775-4 - Control of Sepsis-induced vital organs damage through glycolysis pathway modulation, BP.PD; 16/24155-1 - Biased agonists for the Gq protein pathway in the a1-adrenoceptor subtypes in Septic Vasoplegia treatment, BP.PD; 16/24049-7 - Role of interleukin-17 in the pathogenesis of Legionella longbeachae infection in vivo, BP.IC; 16/24050-5 - Evaluation of caspase-8 activity regulation by caspase-1 in response to Legionella pneumophila infection, BP.IC; 16/18357-0 - Phenotypic and transcriptome evaluation of murine and human leukocytes in Leishmania infantum infection, BP.PD; 16/17773-0 - Validation of new pharmacological hits for the treatment of inflammatory diseases and pain, BP.PD; 16/10280-9 - Involvement of the enzyme pyruvate kinase M2 (PKM2) in the differentiation of Th17 lymphocytes and pathogenesis of experimental autoimmune encephalomyelitis, BP.MS; 16/11405-0 - Immuno-molecular mechanisms involved in the resistance to the development of immunosuppression in neonatal sepsis, BP.DR; 16/16207-1 - Center for Research on Inflammatory Diseases - CRID, BP.PD; 16/13154-4 - Synthesis and biological evaluation of lysine specific demethylase 1 (LSD-1), BP.IC; 16/14188-0 - Relationship of endoplasmic reticulum stress, autophagy, inflammasome and nitric oxide production in inflammatory infectious processes, BP.PD; 16/07602-4 - Role of Dectin-1 and Syk kinase evaluation in Nlrp3 inflammasome activation in murine macrophages infected with L. amazonensis, BP.IC; 16/10867-0 - Development of HaCaT keratinocyte cell line knockouts for PKM2 enzyme, BP.IC; 16/05377-3 - Role of Erk5 pathway on Th17 and Treg cells differentiation and on experimental autoimmune encephalomyelitis, BP.DR; 16/07492-4 - New molecular targets cloning and expression for inflammatory diseases treatment and functional assays validation for selective binders identification, BP.PD; 14/24162-2 - Analyses of the regulatory transcriptional mechanisms mediated by miRNAs in metabolic syndrome, BP.DD; 15/25289-9 - Identification and validation of essential genes responsible for the immune response induction in patients with visceral leishmaniasis, BP.DR; 15/25825-8 - Analysis of metabolic regulatory networks in inflammation, BP.PD; 14/18566-3 - Center for Research in Inflammatory Diseases, BP.PD; 15/03620-5 - Ubiquitination process and autophagic activity evaluation during macrophages infection with Leishmania spp., BP.IC; 14/17740-0 - Planning, development and pharmacological evaluation of new aryl hydrocarbon receptors (AhR) antagonists that are candidates for atheroprotective drugs, BP.PD; 14/11009-1 - Planning of new candidates for anti-inflammatory drugs design, BP.PD; 14/16630-6 - Characterization of a luciferase expression assay induced by aryl hydrocarbon receptor activation, BP.IC; 13/15994-1 - The role of NOD1 and NOD2 receptors in the control of Leishmania (L.) major infection, BP.PD; 13/00579-9 - Role of inflammasomes and IL-1 in experimental infection by Trypanosoma cruzi, BP.PD; 12/23846-0 - Role of succinate/GPR91 signaling in the physiopathology of neuropathic pain, BP.PD; 12/08240-8 - Role of Blimp-1 in differentiation and function of Th9 cells., BP.PD; 12/10100-0 - The role of ectonucleotidases and adenosine in the establishment of sepsis-induced immunosuppression, BP.PD; 12/02438-0 - Role of the induced miRNAs after the aryl hydrocarbon receptor (AhR) activation and their functions in the pathogenesis of rheumatoid arthritis, BP.PD - associated scholarships

Abstract

Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowledge and also identify new therapeutic targets of inflammatory diseases is imperative. The Center for research in inflammatory diseases (CPDI) will be created with this goal. The general objective of the CPDI will be to perform integrative and translational research to identify, validate and target known and novel biological pathways involved with the induction and resolution of inflammation. As a result, we expect the development of innovative therapeutic strategies and drugs that effectively target inflammatory diseases. The project will involve high-throughput genetic screenings, in vivo and in vitro models of diseases, modeling and chemical synthesis, as well as the discovery of new natural molecules from plants and saliva from arthropods. After selecting the potential drugs and bio-drugs, CPDI will protect the intellectual property and, after partnerships with private companies, coordinate pre-clinical toxicological studies and early clinical trials. The CPDI will also dedicate intense efforts to disseminate knowledge to the general public, in order to fulfill the societal objective of spreading education and generating an enthusiasm for science. (AU)

Scientific publications

(363)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PERES, RAPHAEL SANCHES; LIEW, FOO Y.; TALBOT, JHIMMY; CARREGARO, VANESSA; OLIVEIRA, RENE D.; ALMEIDA, SERGIO L.; FRANCA, RAFAEL F. O.; DONATE, PAULA B.; PINTO, LARISSA G.; FERREIRA, FLAVIA I. S.; et al. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, v. 112, n. 8, p. 2509-2514, FEB 24 2015. (13/08216-2, 11/19670-0)

ZAMBONI, DARIO S.; LIMA-JUNIOR, DJALMA S.. Inflammasomes in host response to protozoan parasites. IMMUNOLOGICAL REVIEWS, v. 265, n. 1, SI, p. 156-171, MAY 2015. (13/08216-2, 14/04684-4)

MORICONI, ALESSIO; CUNHA, THIAGO M.; SOUZA, GUILHERME R.; LOPES, ALEXANDRE H.; CUNHA, FERNANDO Q.; CARNEIRO, VICTOR L.; PINTO, LARISSA G.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIZZARRI, CINZIA; et al. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proceedings of the National Academy of Sciences of the United States of America, v. 111, n. 47, p. 16937-16942, NOV 25 2014. (13/08216-2, 11/19670-0)

SISTI, FLAVIA; WANG, SOUJUAN; BRANDT, STEPHANIE L.; GLOSSON-BYERS, NICOLE; MAYO, LINDSEY D.; SON, YOUNG MIN; STURGEON, SARAH; FILGUEIRAS, LUCIANO; JANCAR, SONIA; WONG, HECTOR; et al. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. Science Signaling, v. 11, n. 528, MAY 1 2018. (13/08216-2, 11/19670-0)

SACRAMENTO, LAIS AMORIM; CUNHA, FERNANDO Q.; DE ALMEIDA, ROQUE PACHECO; DA SILVA, JOAO SANTANA; CARREGARO, VANESSA. Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset. BIOMED RESEARCH INTERNATIONAL, 2014. (13/08216-2, 12/14524-9)

PERNOMIAN, LARISSA; GIMENES, LILIAN R.; GOMES, MAYARA S.; DO VALE, BRUNO N.; CARDOSO, CRISTINA R. B.; DE OLIVEIRA, ANA M.; MOREIRA, JOSIMAR D.. Endothelinergic Contractile Hyperreactivity in Rat Contralateral Carotid to Balloon Injury: Integrated Role for ETB Receptors and Superoxide Anion. BIOMED RESEARCH INTERNATIONAL, 2017. (13/08216-2, 12/00640-7, 14/17740-0, 12/09019-3, 09/01005-0)

DA COSTA, RAFAEL MENEZES; FAIS, RAFAEL S.; DECHANDT, CARLOS R. P.; LOUZADA-JUNIOR, PAULO; ALBERICI, LUCIANE C.; LOBATO, NUBIA S.; TOSTES, RITA C.. Increased mitochondrial ROS generation mediates the loss of the anti-contractile effects of perivascular adipose tissue in high-fat diet obese mice. British Journal of Pharmacology, v. 174, n. 20, SI, p. 3527-3541, OCT 2017. (13/08216-2, 10/17259-9)

XAVIER-ELSAS, PEDRO; DE LUCA, BIANCA; QUETO, TULIO; VIEIRA, BRUNO MARQUES; MASID-DE-BRITO, DANIELA; DAHAB, ELIZABETH CHEN; ALVES FILHO, JOSE CARLOS; CUNHA, FERNANDO Q.; GASPAR-ELSAS, MARIA IGNEZ C.. Blockage of Eosinopoiesis by IL-17A Is Prevented by Cytokine and Lipid Mediators of Allergic Inflammation. Mediators of Inflammation, 2015. (13/08216-2)

BASSI, GABRIEL SHIMIZU; ULLOA, LUIS; SANTOS, VICTOR RODRIGUES; DEL VECCHIO, FLAVIO; DELFINO-PEREIRA, POLIANNA; RODRIGUES, GERSON JHONATAN; CASTANIA, JACI AIRTON; CUNHA, FERNANDO DE QUEIROZ; SALGADO, HELIO CESAR; CUNHA, THIAGO MATTAR; et al. Cortical stimulation in conscious rats controls joint inflammation. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 84, n. A, p. 201-213, JUN 8 2018. (13/20549-7, 13/08216-2, 11/20343-4, 12/04237-2)

LOUREIRO, CAMILA MARCELINO; CORSI-ZUELLI, FABIANA; FACHIM, HELENE APARECIDA; SHUHAMA, ROSANA; DE SOUZA CHAGAS, NATALIA MOTA; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA; LOUZADA-JUNIOR, PAULO. Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis. Ciênc. saúde coletiva, v. 26, n. 3, p. 1085-1094, MAR 2021. (17/17480-6, 13/08216-2, 13/11167-3, 17/00624-5, 16/12195-9, 12/05178-0, 15/02948-7)

BRANDAO, W. N.; DE OLIVEIRA, M. G.; ANDREONI, R. T.; NAKAYA, H.; FARIAS, A. S.; PERON, J. P. S.. Neuroinflammation at single cell level: What is new?. Journal of Leukocyte Biology, AUG 2020. (13/08216-2, 18/21934-5, 17/50137-3, 17/26170-0, 12/19278-6, 17/22504-1, 17/21363-5, 18/14933-2, 19/06372-3)

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