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Cancer of the penis, a real Brazilian problem: from morphology to molecular etiopathogenesis

Grant number: 09/52088-3
Support type:Research Projects - Thematic Grants
Duration: October 01, 2009 - September 30, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:José Vassallo
Grantee:José Vassallo
Home Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
Co-Principal Investigators:Ademar Lopes ; Paula Rahal
Associated grant(s):14/11212-1 - 26th European Congress of pathology, AR.EXT
Associated scholarship(s):09/11203-4 - Functional analysis of genes involved in carcinogenesis and development of penile cancer, BP.PD

Abstract

Carcinoma of the penis (CaPe) is a major health problem in Brazil, especially among economically underprivileged men in north/northeast regions. CaPe is a loco-regional disease and 5 year survival rate drops dramatically in patients with lymph node metastasis. Etiological factors include poor genital hygiene and phymosis, viral infection, ultraviolet radiation, smaking, balanitis xerotica obliterans, and chronic liquen. Although its diagnosis is relatively simple, patients usually seek for medical help in advanced stages of disease. Scientific knowledge, especially of its molecular aspects, is still scarce. The present grant proposal includes a number of studies addressing from clinic morphological aspects, to protein expression and molecular alterations in CaPe. It is intended to validate the WHO classification for these tumors and to establish prognostic variables of the variants of squamous cell carcinomas. A second group of projects deals with immunohistochemical detection of various markers, aiming to establish prognostic and predictive parameters which might foretell lymph node metastasis. Finally, molecular etiopathogenesis will be studied using gene expression techniques, evaluation of chromosomal copy numbers, and search for mutations or hypermethilation of specific genes. With this project we should be able to significantly contribute to a better understanding of this devastating disease. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Molecular markers could help treat penile cancer 

Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOVOLIM, GRAZIELE; DA COSTA, WALTER HENRIQUES; GUIMARAES, GUSTAVO CARDOSO; SOARES, FERNANDO AUGUSTO; DA CUNHA, ISABELA WERNECK. Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype. Virchows Archiv, v. 471, n. 6, p. 815-818, DEC 2017. Web of Science Citations: 0.
MARCHI, FABIO ALBUQUERQUE; MARTINS, DAVID CORREA; BARROS-FILHO, MATEUS CAMARGO; KUASNE, HELLEN; BUSSO LOPES, ARIANE FIDELIS; BRENTANI, HELENA; SOUZA TRINDADE FILHO, JOSE CARLOS; GUIMARAES, GUSTAVO CARDOSO; FARIA, ELINEY F.; SCAPULATEMPO-NETO, CRISTOVAM; LOPES, ADEMAR; ROGATTO, SILVIA REGINA. Multidimensional integrative analysis uncovers driver candidates and biomarkers in penile carcinoma. SCIENTIFIC REPORTS, v. 7, JUL 27 2017. Web of Science Citations: 7.
THOMAZ DA SILVA AMANCIO, ALICE MUGLIA; DA CUNHA, ISABELA WERNECK; NEVES, JOSE IVANILDO; QUETZ, JOSIANE DA SILVA; CARRARO, DIRCE MARIA; ROCHA, RAFAEL MALAGOLI; ZEQUI, STENIO CASSIO; CUBILLA, ANTONIO LEOPOLDO; DA FONSECA, FRANCISCO PAULO; LOPES, ADEMAR; SOCORRO SALDANHA DA CUNHA, MARIA DO PERPETUO; ALVES LIMA, MARCOS VENICIO; VASSALLO, JOSE; GUIMARAES, GUSTAVO CARDOSO; SOARES, FERNANDO AUGUSTO. Epidermal growth factor receptor as an adverse survival predictor in squamous cell carcinoma of the penis. HUMAN PATHOLOGY, v. 61, p. 97-104, MAR 2017. Web of Science Citations: 3.
KUASNE, HELLEN; BARROS-FILHO, MATEUS C.; BUSSO-LOPES, ARIANE; MARCHI, FABIO A.; PINHEIRO, MAISA; MUNOZ, JUAN J. M.; SCAPULATEMPO-NETO, CRISTOVAM; FARIA, ELINEY F.; GUIMARAES, GUSTAVO C.; LOPES, ADEMAR; TRINDADE-FILHO, JOSE C. S.; DOMINGUES, MARIA APARECIDA C.; DRIGO, SANDRA A.; ROGATTO, SILVIA R. Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. ONCOTARGET, v. 8, n. 9, p. 15294-15306, 2017. Web of Science Citations: 10.
MUNOZ, JUAN J.; DRIGO, SANDRA A.; KUASNE, HELLEN; VILLACIS, ROLANDO A. R.; MARCHI, FABIO A.; DOMINGUES, MARIA A. C.; LOPES, ADEMAR; SANTOS, TIAGO G.; ROGATTO, SILVIA R. A comprehensive characterization of cell cultures and xenografts derived from a human verrucous penile carcinoma. TUMOR BIOLOGY, v. 37, n. 8, p. 11375-11384, AUG 2016. Web of Science Citations: 2.
MUNOZ, JUAN J.; DRIGO, SANDRA A.; BARROS-FILHO, MATEUS C.; MARCHI, FABIO A.; SCAPULATEMPO-NETO, CRISTOVAM; PESSOA, GUSTAVO S.; GUIMARAES, GUSTAVO C.; TRINDADE FILHO, JOSE CARLOS S.; LOPES, ADEMAR; ARRUDA, MARCO A. Z.; ROGATTO, SILVIA R. Down-Regulation of SLC8A1 as a Putative Apoptosis Evasion Mechanism by Modulation of Calcium Levels in Penile Carcinoma. JOURNAL OF UROLOGY, v. 194, n. 1, p. 245-251, JUL 2015. Web of Science Citations: 16.
KUASNE, HELLEN; DE SYLLOS COLUS, ILCE MARA; BUSSO, ARIANE FIDELIS; HERNANDEZ-VARGAS, HECTOR; BARROS-FILHO, MATEUS CAMARGO; MARCHI, FABIO ALBUQUERQUE; SCAPULATEMPO-NETO, CRISTOVAM; FARIA, ELINEY FERREIRA; LOPES, ADEMAR; GUIMARAES, GUSTAVO CARDOSO; HERCEG, ZDENKO; ROGATTO, SILVIA REGINA. Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers. CLINICAL EPIGENETICS, v. 7, APR 18 2015. Web of Science Citations: 18.
BUSSO-LOPES, ARIANE F.; MARCHI, FABIO A.; KUASNE, HELLEN; SCAPULATEMPO-NETO, CRISTOVAM; TRINDADE-FILHO, JOSE CARLOS S.; DE JESUS, CARLOS MARCIO N.; LOPES, ADEMAR; GUIMARAES, GUSTAVO C.; ROGATTO, SILVIA R. Genomic Profiling of Human Penile Carcinoma Predicts Worse Prognosis and Survival. Cancer Prevention Research, v. 8, n. 2, p. 149-156, FEB 2015. Web of Science Citations: 21.
KUASNE, HELLEN; MARCHI, FABIO ALBUQUERQUE; ROGATTO, SILVIA REGINA; DE SYLLOS COLUS, ILCE MARA. Epigenetic Mechanisms in Penile Carcinoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 14, n. 6, p. 10791-10808, JUN 2013. Web of Science Citations: 11.
CALMON, MARILIA FREITAS; DE OLIVEIRA MOTA, MANLIO TASSO; BABETO, ERICA; CANDIDO, NATALIA MARIA; GIROL, ANA PAULA; MENDIBURU, CARLOS FABIAN; BONILHA, JANE LOPES; DUARTE SILVESTRE, RODRIGO VELLASCO; ROSA, BRUNO MIZIARA; THOME, JORGE ALBERTO; AMERICO MEDEIROS, GUSTAVO HERNANDEZ; SOARES, FERNANDO AUGUSTO; GUIMARAES, GUSTAVO CARDOSO; FERRAZ DE ARRUDA, JOSE GERMANO; OLIANI, SONIA MARIA; VILLA, LUISA LINA; VASSALLO, JOSE; RAHAL, PAULA. Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs. PLoS One, v. 8, n. 1 JAN 14 2013. Web of Science Citations: 13.

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