Impact of different modalities of renal replacement therapy in patients with the severe form of leptospirosis treated in the intensive care unit of Emilio Ribas Institute of infectology

• Grant number: 07/55258-1
• Support Opportunities: Research Grants - Research in Public Policies
• Duration: April 01, 2008 - May 31, 2010
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Antonio Carlos Seguro
• Grantee: Antonio Carlos Seguro
• Host Institution: Instituto de Infectologia Emílio Ribas (IIER). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Partner institutions: Universidade de São Paulo (USP). Faculdade de Medicina (FM)

Abstract

Leptospirosis is a public-health problem, the severe form of which (Weil's disease) includes acute respiratory distress syndrome, typically accompanied by acute kidney injury (AKI), and is associated with high mortality rates. Recent evidence suggests that dialysis dosage affects outcomes in critically ill patients with sepsis-induced AKI. However, this population varies widely in terms of age, gender, and concomitant conditions, making it difficult to determine the appropriate timing (door-to-dialysis time) and dialysis dosage. It is logical to assume that increasing the dialysis dosage would minimize uremic complications and improve outcomes in such patients. Patients with Weil's disease constitute a homogeneous population and are typically free of comorbidities, therefore presenting an ideal model in which to test this assumption. In a recently published article, we demonstrated that daily hemodialysis was associated with lower mortality in patients with the severe form of leptospirosis. On the basis of this study, it is believed that alternate-day hemodialysis is no longer appropriate for critically ill patients with Weil's disease. Now, we propose to conduct a study to determine whether different modalities of dialysis (hemofiltration or hemodialysis) have any impact on survival in patients with the severe form of leptospirosis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CLETO, SERGIO APARECIDO; RODRIGUES, CAMILA ELEUTERIO; MALAQUE, CEILA MARIA; SZTAJNBOK, JAQUES; SEGURO, ANTONIO CARLOS; ANDRADE, LUCIA. Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study. PLoS One, v. 11, n. 8, AUG 3 2016. (07/55258-1)