Supramolecular chemistry and nanotechnology

• Grant number: 09/08584-6
• Support Opportunities: Research Projects - Thematic Grants
• Start date: November 01, 2009
• End date: April 30, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Henrique Eisi Toma
• Grantee: Henrique Eisi Toma
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Koiti Araki
• Associated scholarship(s): 12/19941-7 - Development and characterization of iron oxide nanoparticles coated with polymeric cover complexing, BP.IC; 11/18391-0 - Enzyme immobilization on superparamagnetic nanoparticles, BP.IC; 11/00037-6 - Study and application of physical and chemical properties of plasmons nanoparticles in intelligent devices, BP.DD

Abstract

This proposal, submitted by the Supramolecular Nanotech Lab of the University of Sao Paulo, focuses on the development of new functional molecular and combined supermolecule-nanoparticle hybrid systems, as well as of their corresponding functional films, aiming applications in sensors, energy conversion and electronic nanotechnological devices. The Research Group conducted by Profs. Henrique E. Toma and Koiti Araki, comprises more than 20 graduate, undergraduate and post-doctoral researchers, and is strongly dedicated to the development of molecular nanotechnology, a mission which has been very successful thanks to the renewed support from FAPESP. The major achievements have been concentrated on the supramolecular chemistry of porphyrins, porphyrazines and related macrocycles, metal clusters and metal-polyimine complexes, as well as on their many applications in bioinorganic chemistry and advanced materials. It is also pursued the development of hetero-hybrid materials displaying outstanding functionality for nanotechnological applications, combining the supramolecular strategies and the exciting properties of metal (e.g. silver and gold) and metal-oxide (e. g., TiO2, V2O5 and Fe3O4) nanoparticles. In addition to the strong emphasis on supramolecular design and synthetic chemistry, the proposal also focuses on the investigation of fundamental and relevant spectroscopic, photochemical, electrochemical and catalytic properties, using a large variety of techniques, including scanning probe microscopy, surface plasmon resonance and confocal Raman spectroscopy. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DREWES, C. C.; DIAS, R. Y.; BRANCO, V. G.; CAVALCANTE, M. F.; SOUZA, J. G.; ABDALLA, D. S. P.; CHUDZINSKI-TAVASSI, A. M.; FARSKY, S. H. P.. Post-transcriptional control of Amblyomin-X on secretion of vascular endothelial growth factor and expression of adhesion molecules in endothelial cells. Toxicon, v. 101, p. 1-10, JUL 2015. (09/08584-6, 13/07467-1, 12/06944-8, 10/19802-1)

UCHIYAMA, MAYARA KLIMUK; TOMA, SERGIO HIROSHI; DE PAULA RODRIGUES, STEPHEN FERNANDES; BORGES SHIMADA, ANA LUCIA; LOIOLA, RODRIGO AZEVEDO; CERVANTES RODRIGUEZ, HERNAN JOEL; OLIVEIRA, PEDRO VITORIANO; LUZ, MACIEL SANTOS; RABBANI, SAID RAHNAMAYE; TOMA, HENRIQUE EISI; et al. Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 10, p. 16-pg., 2015-01-01. (11/09677-8, 09/08584-6, 11/02438-8)

UCHIYAMA, MAYARA KLIMUK; TOMA, SERGIO HIROSHI; DE PAULA RODRIGUES, STEPHEN FERNANDES; BORGES SHIMADA, ANA LUCIA; LOIOLA, RODRIGO AZEVEDO; CERVANTES RODRIGUEZ, HERNAN JOEL; OLIVEIRA, PEDRO VITORIANO; LUZ, MACIEL SANTOS; RABBANI, SAID RAHNAMAYE; TOMA, HENRIQUE EISI; et al. Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 10, p. 4731-4746, 2015. (09/08584-6, 11/09677-8)

MARQUES NETTO, CATERINA G. C.; ANDRADE, LEANDRO H.; FREITAS, RAFAEL S.; TOMA, HENRIQUE E.. Association of Yeast Alcohol Dehydrogenase with Superparamagnetic Nanoparticles: Improving the Enzyme Stability and Performance. Journal of Nanoscience and Nanotechnology, v. 15, n. 12, p. 9482-9487, DEC 2015. (09/08584-6)

UCHIYAMA, MAYARA KLIMUK; DEDA, DAIANA KOTRA; DE PAULA RODRIGUES, STEPHEN FERNANDES; DREWES, CARINE CRISTIANE; BOLONHEIS, SIMONE MARQUES; KIYOHARA, PEDRO KUNIHIKO; DE TOLEDO, SIMONE PERCHE; COLLI, WALTER; ARAKI, KOITI; POLISELLI FARSKY, SANDRA HELENA. In vivo and In vitro Toxicity and Anti-Inflammatory Properties of Gold Nanoparticle Bioconjugates to the Vascular System. TOXICOLOGICAL SCIENCES, v. 142, n. 2, p. 497-507, DEC 2014. (09/08584-6, 11/19595-9)

ASSUMPCAO, ALINE M. C.; BONACIN, JULIANO A.; TOMA, SERGIO H.; ZAMARION, VITOR M.; TOMA, HENRIQUE E.. Probing surface-complex interactions with the bis(4-thienylterpyridine)iron(II) complex anchored on TiO2 and gold nanoparticles. Canadian Journal of Chemistry, v. 92, n. 10, p. 918-924, OCT 2014. (09/08584-6)

ZUIN, ANDRE; NOVAK, MIGUEL ALEXANDRE; TOMA, SERGIO HIROSHI; ARAKI, KOITI; TOMA, HENRIQUE EISI. Anisotropic magnetic carbon materials based on graphite and magnetite nanoparticles. Carbon, v. 77, p. 600-606, OCT 2014. (09/08584-6)

GUIMARAES, ROBSON R.; PARUSSULO, ANDRE L. A.; TOMA, HENRIQUE E.; ARAKI, KOITI. New tunable ruthenium complex dyes for TiO2 solar cells. Inorganica Chimica Acta, v. 404, p. 23-28, AUG 1 2013. (09/08584-6, 08/01495-5)

Filed patent(s) as a result of this research project