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Bioprocess Systems Engineering (BSE) applied to the production of bioethanol from sugarcane bagasse

Grant number: 08/56246-0
Support type:Program for Research on Bioenergy (BIOEN) - Thematic Grants
Duration: June 01, 2009 - October 31, 2013
Field of knowledge:Engineering - Chemical Engineering
Cooperation agreement: CNPq - Pronex
Principal Investigator:Roberto de Campos Giordano
Grantee:Roberto de Campos Giordano
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Co-Principal Investigators:Antonio José Gonçalves da Cruz ; Raquel de Lima Camargo Giordano
Associated grant(s):12/01707-8 - 34th symposium on biotechnology for fuels and chemicals, AR.EXT
Associated scholarship(s):11/05543-7 - Ethanol production from xilose using glucose isomerase and Saccharomyces cerevisiae co-immobilized in alginate gel, BP.MS
11/02068-6 - Implementation of Particle Swarm multiobjective optimization algorithm to the sugarcane biorefinery in EMSO environment, BP.IC
10/15072-9 - Advanced techniques for chemical and structural characterization of biomass applied to the industrial production of ethanol from sugarcane bagasse, BP.PD
10/08325-8 - Study of fixed bed reactor operation with co-immobilized yeast and enzyme for ethanol production from xylose, BP.IC
09/13325-0 - Development of an integrated environment for simulation and static optimization of the production of ethanol from sugarcane bagasse through a biochemical route, BP.MS


The industrial production of biofuels, understood as fuels produced from biological feedstock, is presently at what can be called a technological crossroad, and a hard competition among different technologies is in course. The winners will be defined by a combination of economical criteria, process robustness and compliance to environmental and sustainability restrictions. In this scenario the optimization of this complex, interconnected process ideally must be pursued ever since its early stages of development, aiming at costs reduction, negative overall CO2 balance, cutback of water usage and of effluent emissions and so forth. Fine-tuned processes, operating at (near-) optimum conditions will have a significant competitive advantage. This project focuses on the rational application of (Bio-)Process Systems Engineering (BSE) techniques to the process for production of bioethanol from an important lignocellulosic material in the Brazilian scenario, sugarcane bagasse. In other words, the same approach that allowed oil refineries to achieve a high productivity is herein applied to biorefineries. The validation of BSE tools for assessing different routes for bioethanol, however, must be based on real data. With this purpose, this project joins efforts of a group of researchers from the Chemical Engineering Department of UFSCar and from Brazilian Agricultural Research Corporation (EMBRAPA Agriculture Instrumentation). A biochemical route for production of ethanol from sugarcane bagasse is our selected case study, encompassing different technologies, some of them still exploratory: in situ production of cellulases in triphasic reactors; feedstock pre-treatment; enzymatic production of pentoses (and their transformation) and of hexoses via a non-conventional process using immobilized enzymes, combined with simultaneous (SSF) or consecutive fermentation (CSF), using S. cerevisiae in conventional and non-conventional bioreactors. A global view is necessary to integrate these processes from the early stage of development. Therefore, this project aims simultaneously at providing the necessary software and at researching new feasible routes for bioethanol which, in addition to their intrinsic value, will be employed for validation of the methodology. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MILESSI, THAIS S.; SILVA, CLAUDIA R.; MORAES, GUILHERME S.; AQUINO, PATRICIA M.; GIORDANO, ROBERTO C.; GIORDANO, RAQUEL L. C.; ZANGIROLAMI, TERESA C. Continuous 2G ethanol production from xylose in a fixed-bed reactor by native Saccharomyces cerevisiae strain through simultaneous isomerization and fermentation. Cellulose, v. 27, n. 8 MAR 2020. Web of Science Citations: 0.
MILESSI-ESTEVES, THAIS S.; CORRADINI, FELIPE A. S.; KOPP, WILLIAN; ZANGIROLAMI, TERESA C.; TARDIOLI, PAULO W.; GIORDANO, ROBERTO C.; GIORDANO, RAQUEL L. C. An Innovative Biocatalyst for Continuous 2G Ethanol Production from Xylo-Oligomers by Saccharomyces cerevisiae through Simultaneous Hydrolysis, Isomerization, and Fermentation (SHIF). CATALYSTS, v. 9, n. 3 MAR 2019. Web of Science Citations: 0.
MILESSI, THAIS SUZANE; AQUINO, PATRICIA M.; SILVA, CLAUDIA R.; MORAES, GUILHERME S.; ZANGIROLAMI, TERESA C.; GIORDANO, ROBERTO C.; GIORDANO, RAQUEL L. C. Influence of key variables on the simultaneous isomerization and fermentation (SIF) of xylose by a native Saccharomyces cerevisiae strain co-encapsulated with xylose isomerase for 2G ethanol production. BIOMASS & BIOENERGY, v. 119, p. 277-283, DEC 2018. Web of Science Citations: 2.
FURLAN, FELIPE FERNANDO; DE ANDRADE LINO, ANDERSON RODRIGO; MATUGI, KARINA; GONCALVES CRUZ, ANTONIO JOSE; SECCHI, ARGIMIRO RESENDE; GIORDANO, ROBERTO DE CAMPOS. A simple approach to improve the robustness of equation-oriented simulators: Multilinear look-up table interpolators. Computers & Chemical Engineering, v. 86, p. 1-4, MAR 4 2016. Web of Science Citations: 2.
CUNHA, F. M.; ESPERANCA, M. N.; FLORENCIO, C.; VASCONCELLOS, V. M.; FARINAS, C. S.; BADINO, A. C. Three-phasic fermentation systems for enzyme production with sugarcane bagasse in stirred tank bioreactors: Effects of operational variables and cultivation method. Biochemical Engineering Journal, v. 97, p. 32-39, MAY 15 2015. Web of Science Citations: 15.
ESPERANCA, M. N.; CUNHA, F. M.; CERRI, M. O.; ZANGIROLAMI, T. C.; FARINAS, C. S.; BADINO, A. C. Gas hold-up and oxygen mass transfer in three pneumatic bioreactors operating with sugarcane bagasse suspensions. Bioprocess and Biosystems Engineering, v. 37, n. 5, p. 805-812, MAY 2014. Web of Science Citations: 6.

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