Advanced search
Start date
Betweenand

Sugarcane energetic balance: a systems approach towards understanding regulation of sucrose metabolism and sugar signaling

Abstract

Sugarcane research has identified and characterized a suite of proteins involved in carbon biosynthesis and sugar sensing. However, current results towards understanding sucrose biosynthesis and accumulation have fallen short of expectations. The molecular mechanisms responsible for the cross talk between these different regulatory and signaling pathways and their diversification in plants still need to be further elucidated to better understand plant growth patterns and biomass production. We are only beginning to produce the detailed gene expression data needed for understanding the network of interactions at a molecular level. To address the rate of gene discovery, high-throughput approaches have being developed for biological experimentation and relevant biological questions regarding gene, protein interactions or networks of biological process can now be addressed. Here, we propose to develop a research approach which integrates molecular and systems biology to improve the knowledge about carbohydrates biosynthesis and sugar regulatory signaling in sugarcane. In this research project we will elaborate ways to apply analyses of regulatory network and dynamic metabolic models in molecular and genetic data of sugarcane related with sucrose biosynthesis, and define the diversification of glucose and sucrose-induced gene expression programs among angiosperms. We expected that the models captures the regulation of many sugarcane genetic components and anticipate that the data will improve our view of sugar signaling in plants. Simulations of our models will provide an efficient tool for the identification of candidate to genetic manipulations that have the best chance to promote increase in sucrose content and for the prioritization of future analyzes. The results will be integrated into databases that could feed projects related to biomass and bioenergy research. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VICENTINI, R.; DEL BEM, L. E. V.; VAN SLUYS, M. A.; NOGUEIRA, F. T. S.; VINCENTZ, M.. Gene Content Analysis of Sugarcane Public ESTs Reveals Thousands of Missing Coding-Genes and an Unexpected Pool of Grasses Conserved ncRNAs. TROPICAL PLANT BIOLOGY, v. 5, n. 2, p. 199-205, . (08/52071-0, 08/09105-1, 08/58031-0)
BRITO, MICHAEL SANTOS; NOBILE, PAULA MACEDO; BOTTCHER, ALEXANDRA; DOS SANTOS, ADRIANA BROMBINI; CRESTE, SILVANA; ANDRADE DE LANDELL, MARCOS GUIMARES; VINCENTZ, MICHEL; VICENTINI, RENATO; MAZZAFERA, PAULO. Expression Profile of Sugarcane Transcription Factor Genes Involved in Lignin Biosynthesis. TROPICAL PLANT BIOLOGY, v. 8, n. 1-2, p. 19-30, . (08/58035-6, 08/58031-0)
DE SETTA, NATHALIA; MONTEIRO-VITORELLO, CLAUDIA BARROS; METCALFE, CUSHLA JANE; QUEIROGA CRUZ, GUILHERME MARCELO; DEL BEM, LUIZ EDUARDO; VICENTINI, RENATO; SILVEIRA NOGUEIRA, FABIO TEBALDI; CAMPOS, ROBERTA ALVARES; NUNES, SIDENY LIMA; GASPERAZZO TURRINI, PAULA CRISTINA; et al. Building the sugarcane genome for biotechnology and identifying evolutionary trends. BMC Genomics, v. 15, . (10/05591-9, 08/54201-9, 08/52074-0, 08/58031-0, 08/52197-4, 08/52146-0)
CARDOSO-SILVA, CLAUDIO BENICIO; COSTA, ESTELA ARAUJO; MANCINI, MELINA CRISTINA; ALMEIDA BALSALOBRE, THIAGO WILLIAN; COSTA CANESIN, LUCAS EDUARDO; PINTO, LUCIANA ROSSINI; CARNEIRO, MONALISA SAMPAIO; FRANCO GARCIA, ANTONIO AUGUSTO; DE SOUZA, ANETE PEREIRA; VICENTINI, RENATO. De Novo Assembly and Transcriptome Analysis of Contrasting Sugarcane Varieties. PLoS One, v. 9, n. 2, . (08/52197-4, 08/58031-0)
VICENTINI, RENATO; BOTTCHER, ALEXANDRA; BRITO, MICHAEL DOS SANTOS; DOS SANTOS, ADRIANA BROMBINI; CRESTE, SILVANA; DE ANDRADE LANDELL, MARCOS GUIMARAES; CESARINO, IGOR; MAZZAFERA, PAULO. Large-Scale Transcriptome Analysis of Two Sugarcane Genotypes Contrasting for Lignin Content. PLoS One, v. 10, n. 8, . (08/58035-6, 08/58031-0)
ALVES, LEONARDO CARDOSO; PORTILLA LLERENA, JUAN PABLO; MAZZAFERA, PAULO; VICENTINI, RENATO. Diel oscillations in cell wall components and soluble sugars as a response to short-day in sugarcane (Saccharum sp.). BMC PLANT BIOLOGY, v. 19, . (08/58031-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.