Abstract
Sugarcane research has identified and characterized a suite of proteins involved in carbon biosynthesis and sugar sensing. However, current results towards understanding sucrose biosynthesis and accumulation have fallen short of expectations. The molecular mechanisms responsible for the cross talk between these different regulatory and signaling pathways and their diversification in plants still need to be further elucidated to better understand plant growth patterns and biomass production. We are only beginning to produce the detailed gene expression data needed for understanding the network of interactions at a molecular level. To address the rate of gene discovery, high-throughput approaches have being developed for biological experimentation and relevant biological questions regarding gene, protein interactions or networks of biological process can now be addressed. Here, we propose to develop a research approach which integrates molecular and systems biology to improve the knowledge about carbohydrates biosynthesis and sugar regulatory signaling in sugarcane. In this research project we will elaborate ways to apply analyses of regulatory network and dynamic metabolic models in molecular and genetic data of sugarcane related with sucrose biosynthesis, and define the diversification of glucose and sucrose-induced gene expression programs among angiosperms. We expected that the models captures the regulation of many sugarcane genetic components and anticipate that the data will improve our view of sugar signaling in plants. Simulations of our models will provide an efficient tool for the identification of candidate to genetic manipulations that have the best chance to promote increase in sucrose content and for the prioritization of future analyzes. The results will be integrated into databases that could feed projects related to biomass and bioenergy research. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |