The profile of viral infections in chronic diseases of the upper respiratory tract: adenoamigdaliana hypertrophy and secretory otitis media, rhinosinusitis

• Grant number: 09/51818-8
• Support Opportunities: Research Projects - Thematic Grants
• Duration: December 01, 2009 - November 30, 2013
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Wilma Terezinha Anselmo Lima
• Grantee: Wilma Terezinha Anselmo Lima
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais: Eurico de Arruda Neto ; Fabiana Cardoso Pereira Valera
• Associated grant(s): 13/13168-7 - American Society for Virology 32nd Annual Meeting, AR.EXT
• Associated scholarship(s): 12/19131-5 - Assessment of pathogenic mechanisms of Human Respiratory Syncytial Virus (HRSV) related to the development of an acute and latent/persistent disease., BP.PD

Abstract

This 4 year long thematic project, includes three main subject-sections. Three principal researches and other five participants will participate in the project, which will be developed in collaboration between the department of otorhinolaryngology of Hospital of the Medical School of the University of São Paulo in Ribeirão Preto and the Virus Research Unit of the Medical School Faculty of the University of São Paulo in Ribeirão Preto, and will cost R$ 368.140,50 and US$ 54.277,00. The chronic diseases of upper respiratory tract are very common and have great socioeconomic impact. However, very little has been studied about the role of different respiratory viral infections on the genesis of these clinical signs. So, this project proposes to study the role of viral infections in chronic diseases of upper respiratory tract, detecting and quantifying the principal respiratory viruses currently known (human rhinovirus, human respiratory syncytial virus, human influenza virus, human parainfluenza viruses, human metapneumovirus, human enterovirus, human coronavirus, adenovirus and human bocavirus) in nasal and paranasal sinuses washes of patients with chronic rhinosinusitis, in tonsils and adenoids of patients with adenotonsillar hypertrophy, and in middle ear secretions of patients with serous otitis media. Moreover, in this project, it will be investigated the replication of virus in these secretions and examined HBoV and HRV replication ‘in situ’ in tissues obtained from patients these patients. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PROENCA-MODENA, JOSE LUIZ; CARDOSO, RICARDO DE SOUZA; CRIADO, MIRIA FERREIRA; MILANEZ, GUILHERME PAIER; DE SOUZA, WILLIAM MARCIEL; PARISE, PIERINA LORENCINI; BERTOL, JESSICA WILDGRUBE; SANTOS DE JESUS, BRUNA LAIS; MOREIRA PRATES, MIRELA CRISTINA; SILVA, MARIA LUCIA; et al. Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children. Journal of Medical Virology, v. 91, n. 7, p. 1250-1262, JUL 2019. (16/00194-8, 09/51818-8)

PROENCA-MODENA, JOSE LUIZ; GAGLIARDI, TALITA BIANCA; DE PAULA, FLAVIA ESCREMIM; IWAMOTO, MARISA AKIKO; CRIADO, MIRIA FERREIRA; CAMARA, ATAIDE A.; ACRANI, GUSTAVO OLSZANSKI; LEITE CINTRA, OTAVIO AUGUSTO; CERVI, MARIA CELIA; DE PAULA ARRUDA, LUISA KARLA; et al. Detection of Human Bocavirus mRNA in Respiratory Secretions Correlates with High Viral Load and Concurrent Diarrhea. PLoS One, v. 6, n. 6, JUN 20 2011. (08/50617-6, 09/51818-8)

PROENCA-MODENA, JOSE LUIZ; BUZATTO, GUILHERME P.; PAULA, FLAVIA E.; SATURNO, TAMARA H.; DELCARO, LUANA S.; PRATES, MIRELA C.; TAMASHIRO, EDWIN; VALERA, FABIANA C. P.; ARRUDA, EURICO; ANSELMO-LIMA, WILMA T.. Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year. International Journal of Pediatric Otorhinolaryngology, v. 78, n. 10, p. 1655-1661, OCT 2014. (09/51818-8)

PROENCA-MODENA, J. L.; PAULA, F. E.; BUZATTO, G. P.; CARENZI, L. R.; SATURNO, T. H.; PRATES, M. C.; SILVA, M. L.; DELCARO, L. S.; VALERA, F. C. P.; TAMASHIRO, E.; et al. Hypertrophic Adenoid Is a Major Infection Site of Human Bocavirus 1. Journal of Clinical Microbiology, v. 52, n. 8, p. 3030-3037, AUG 2014. (09/51818-8)

PROENCA-MODENA, JOSE LUIZ; PEREIRA VALERA, FABIANA CARDOSO; JACOB, MARCOS GERHARDINGER; BUZATTO, GUILHERME PIETRUCCI; SATURNO, TAMARA HONORATO; LOPES, LUCIA; SOUZA, JAMILA MENDONCA; PAULA, FLAVIA ESCREMIM; SILVA, MARIA LUCIA; CARENZI, LUCAS RODRIGUES; et al. High Rates of Detection of Respiratory Viruses in Tonsillar Tissues from Children with Chronic Adenotonsillar Disease. PLoS One, v. 7, n. 8, AUG 3 2012. (09/51818-8)