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Study of the effects of antimicrobial photodynamic therapy on induced-periodontitis in rats

Grant number: 05/01756-5
Support type:Regular Research Grants
Duration: October 01, 2005 - March 31, 2008
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Martha Simões Ribeiro
Grantee:Martha Simões Ribeiro
Home Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil


Photodynamic therapy (PDT) has been used for the treatment of neoplasm and antimicrobial reduction. It can be defined as the eradication of target cells by reactive oxygen species produced by the interaction between a photosensitizing agent and a light source of an appropriate wavelength. This therapy is local, repeatable and non-invasive technique, which might be an effective alternative to antibiotics for the treatment of local infections. PDT can also be used in the dental office since the oral microorganisms are well-known. The purpose of this work is to investigate the effects of antimicrobial photodynamic therapy on induced-periodontitis in rats as well as to investigate possible deleterious effects of the therapy by histomorphometry. Optimal conditions of irradiation and the interaction photosensitizer-bacterial medium will be also investigated by optical absorption spectroscopy. Photodynamic therapy will be compared to conventional mechanical treatment of plaque removal in order to verify if this new therapy could be an adjunctive to periodontal practice. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVARENGA, LETICIA HEINECK; PRATES, RENATO ARAUJO; YOSHIMURA, TANIA MATEUS; KATO, ILKA TIEMY; SUZUKI, LUIS CLAUDIO; RIBEIRO, MARTHA SIMOES; FERREIRA, LUIS RODOLFO; DOS SANTOS PEREIRA, SILVIO ANTONIO; MARTINEZ, ELIZABETH FERREIRA; SABA-CHUJFI, EDUARDO. Aggregatibacter actinomycetemcomitans biofilm can be inactivated by methylene blue-mediated photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 12, n. 1, p. 131-135, MAR 2015. Web of Science Citations: 16.
PRATES, RENATO A.; YAMADA, JR., AECIO M.; SUZUKI, LUIS C.; FRANCA, CRISTIANE M.; CAI, SILVANA; MAYER, MARCIA P. A.; RIBEIRO, ADRIANA C.; RIBEIRO, MARTHA S. Histomorphometric and Microbiological Assessment of Photodynamic Therapy as an Adjuvant Treatment for Periodontitis: A Short-Term Evaluation of Inflammatory Periodontal Conditions and Bacterial Reduction in a Rat Model. Photomedicine and Laser Surgery, v. 29, n. 12, p. 835-844, DEC 2011. Web of Science Citations: 25.

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