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Comparative study of the susceptibility of cattle and buffalo to accumulative copper poisoning

Grant number: 05/03204-0
Support type:Regular Research Grants
Duration: December 01, 2005 - November 30, 2007
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal researcher:Enrico Lippi Ortolani
Grantee:Enrico Lippi Ortolani
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The main aim of this project is to carry out a comparative study of the susceptibility of cattle (crossbred) and buffalo (Murrah) to accumulative copper poisoning, by drenching increasing doses of copper, and studying some clinical and blood variables and the liver Cu concentration. Ten cattle and 10 buffalo steers will be randomly distributed in a control (n=4) and copper supplemented group (n=6). The last group will be initially drenched with 2 mg Cu/kg/BW (as CuSO4.5H2O) daily for a week; every following week, up to the end of the experiment (90th d), this initial dose will be increased of 2 mg Cu/kg/BW. For three times during the experiment (before the 1st drenching, 45th and 90th d) a liver biopsy will be taken to evaluate the degree of copper accumulation in this stocking organ; the body weight and food intake will be followed weekly, as far as blood samples will be taken for determining the globular volume and serum activity of aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT). If any steer might present acute signs of copper poisoning the animal will be immediately treated with the appropriate antidote ammonium tetrathiomolybdate. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MINERVINO, ANTONIO H. H.; BARRETO JUNIOR, RAIMUNDO A.; RODRIGUES, FREDERICO A. M. L.; FERREIRA, RODRIGO N. F.; REIS, LEONARDO F.; HEADLEY, SELWYN A.; ORTOLANI, ENRICO L. Hepatogenous photosensitization associated with liver copper accumulation in buffalos. Research in Veterinary Science, v. 88, n. 3, p. 519-522, JUN 2010. Web of Science Citations: 5.
HAMAD‚ A.H.; BARRÊTO‚ R.A.; FERNANDES‚ R.N. Intoxicação cúprica acumulativa experimental em bovinos. Brazilian Journal of Veterinary Research and Animal Science, v. 44, n. 5, p. 364-372, 2007.

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