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GB virus C/HGV and prognosis on HIV infected women

Grant number: 05/01072-9
Support type:Regular Research Grants
Duration: February 01, 2006 - April 30, 2008
Field of knowledge:Health Sciences - Medicine
Principal Investigator:José Eduardo Levi
Grantee:José Eduardo Levi
Home Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Researchers from different countries have shown a beneficial effect of the presence of HGV RNA on the long-term survival of HIV-infected patients. The mechanisms for this effect are, as yet, unclear. It has been shown that there are several gender-associated features of HIV/Aids. However, the majority of the studies of the HGV/HIV interaction were performed on casuistics composed mostly by male patients. The HIV epidemic in Brazil is displaying a shift to susceptible populations, noticeably women and teenagers. The proportion of male to female cases has reached 1:1 in 2004, urging to conduct studies focusing on these populations. OBJECTIVES: Perform a retrospective study on the influence of HGV infection on the survival, morbidity, and other HIV clinic-laboratorial parameters in a cohort of HIV-infected women. MATHERIAL AND METHODS: Plasma from 200 HIV-infected women is kept frozen at a repository. These women were part of a cohort participating in a study performed in 1997-1999 on human papillomavirus infection and gynecological abnormalities, as described elsewhere (ref. LEVI et al. 2004). Patients will be contacted and invited to provide a new blood sample, which will be used for HGV-RNA and anti-E2 HGV determination. The same analysis will be performed on the previous sample for those patients agreeing to participate. Other relevant data will be collected during an interview by an infectologist (opportunistic infections, antiretroviral use, etc.). Patients will be stratified into groups according to HGV antibody and viremic status in both samples... (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, SYNARA ARAUJO; RODRIGUES, CELIA LIMA; CAMPOS, ALEIA FAUSTINO; LEVI, JOSE EDUARDO. EVALUATION OF GBV-C/HGV VIREMIA IN HIV-INFECTED WOMEN. Revista do Instituto de Medicina Tropical de São Paulo, v. 54, n. 1, p. 31-35, JAN-FEB 2012. Web of Science Citations: 2.
SYNARA ARAÚJO SILVA; CÉLIA LIMA RODRIGUES; ALÉIA FAUSTINO CAMPOS; JOSÉ EDUARDO LEVI. Evaluation of GBV-C / HVG viremia in HIV-infected women. Revista do Instituto de Medicina Tropical de São Paulo, v. 54, n. 1, p. -, Fev. 2012.
GIRET, MARIA TERESA M.; MIRAGLIA, JOAO LUIZ; ARARIPE SUCUPIRA, MARIA CECILIA; NISHIYA, ANNA; LEVI, JOSE EDUARDO; DIAZ, RICARDO S.; SABINO, ESTER C.; KALLAS, ESPER G. Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil. PLoS One, v. 6, n. 4 APR 5 2011. Web of Science Citations: 22.
CAMPOS, A. F.; TENGAN, F. M.; SILVA, S. A. A.; LEVI, J. E. Influence of hepatitis G virus (GB virus C) on the prognosis of HIV-infected women. INTERNATIONAL JOURNAL OF STD & AIDS, v. 22, n. 4, p. 209-213, APR 2011. Web of Science Citations: 4.
MAIDANA-GIRET, MARIA TERESA; SILVA, TANIA M.; SAUER, MARIANA M.; TOMIYAMA, HELENA; LEVI, JOSE EDUARDO; BASSICHETTO, KATIA C.; NISHIYA, ANNA; DIAZ, RICARDO S.; SABINO, ESTER C.; PALACIOS, RICARDO; KALLAS, ESPER GEORGES. GB virus type C infection modulates T-cell activation independently of HIV-1 viral load. AIDS, v. 23, n. 17, p. 2277-2287, NOV 13 2009. Web of Science Citations: 36.

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