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Oxidative stress induced by metals: new approaches

Grant number: 09/54676-0
Support Opportunities:Research Projects - Thematic Grants
Duration: June 01, 2010 - May 31, 2015
Field of knowledge:Agronomical Sciences - Agronomy
Principal Investigator:Ricardo Antunes de Azevedo
Grantee:Ricardo Antunes de Azevedo
Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Pesquisadores principais:
Marco Aurelio Zezzi Arruda
Associated scholarship(s):13/17514-7 - Comparison of Possible Alterations in protein Soybean Seeds and Plants Transgenic and Non-Transgenic Coming from Distinct Generations, BP.DR
13/25921-1 - Oxidative stress induced by metals (2009/54676-0), subproject 'Analysis of possible changes in lysine metabolism induced by cadmium in maize (Zea mays)' (2012/23981-4), BP.IC
+ associated scholarships 12/23981-4 - Analysis of possible changes in the lysine metabolism induced by cadmium in maize (Zea mays), BP.DR
12/03861-4 - Determination of parameters to cadmium tolerance in tomato plants (Solanum Lycopersicum L.), BP.PD
11/23019-3 - Study of the interaction soil-plant-aluminum using tomato varieties for tolerance to toxic elements, BP.PD
11/50982-9 - Physiological, biochemistry and ultrastructural analysis in tomato (Lycopersicon esculentum Mill. cv. Micro-Tom) mutants exposed to cadmium and aluminum, BP.PD - associated scholarships


The contamination of soils and water with metals has created a major environmental problem, leading to considerable losses in plant productivity and hazardous health effects. Exposure to toxic metals can intensify the production of reactive oxygen species (ROS), which are continuously produced in both unstressed and stressed plants cells. Some of the ROS species are highly toxic and must be detoxified by cellular stress responses, if the plant is to survive and grow. The aim of this work is to assess the mode of action and role of antioxidants in protecting tomato and soybean plants from stress caused by the presence of toxic metals. The major aspects that will be addressed are the biochemical and morphological responses and accumulation of the metals in different tissues of plants. Emerging techniques in new field of metallomics that have greatly improved the identification, localization and quantification of metals within plant tissues will be used to help increasing our understanding of the biological and environmental problems related to toxic metals. Among the toxic metals, cadmium (Cd) and aluminum (AI) can be considered important environmental contaminants related to commercial rejection of crops, besides to become dangerous to human health. Currently there is a great concern with respect to short and long term effects that these toxic metals may cause on public health and the environment. The study of the antioxidant response of tomato plants in the presence of Cd and Al is important for the understanding of tolerance mechanisms, as well as for the characterization of plants used in the process of phytoremediation of contaminated environments. (AU)

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Scientific publications (41)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERENICE K. DE ALCÂNTARA; DANIEL PIZZAIA; FERNANDO A. PIOTTO; LUCÉLIA BORGO; GILVANO E. BRONDANI; RICARDO A. AZEVEDO. Temporal dynamics of the response to Al stress in Eucalyptus grandis × Eucalyptus camaldulensis. Anais da Academia Brasileira de Ciências, v. 87, n. 2, p. 1063-1070, . (09/54676-0)
REIS BORGES, KARINA LIMA; RIEGER HIPPLER, FRANZ WALTER; AMARAL CARVALHO, MARCIA EUGENIA; NALIN, RAFAEL STORTO; MATIAS, FILIPE INACIO; AZEVEDO, RICARDO ANTUNES. Nutritional status and root morphology of tomato under Cd-induced stress: Comparing contrasting genotypes for metal-tolerance. Scientia Horticulturae, v. 246, p. 518-527, . (09/54676-0, 15/26640-1, 16/14349-3, 13/15217-5)
CARVALHO, MARCIA E. A.; GAZIOLA, SALETE A.; CARVALHO, LILIAN A.; AZEVEDO, RICARDO A.. Cadmium effects on plant reproductive organs: Physiological, productive, evolutionary and ecological aspects. Annals of Applied Biology, v. 178, n. 2, SI, . (13/15217-5, 09/54676-0, 16/14349-3, 15/26640-1)
AMARAL CARVALHO, MARCIA EUGENIA; PIOTTO, FERNANDO ANGELO; FRANCO, MONICA REGINA; REIS BORGES, KARINA LIMA; GAZIOLA, SALETE APARECIDA; CAMARGO CASTRO, PAULO ROBERTO; AZEVEDO, RICARDO ANTUNES. Cadmium toxicity degree on tomato development is associated with disbalances in B and Mn status at early stages of plant exposure. ECOTOXICOLOGY, v. 27, n. 10, p. 1293-1302, . (09/54676-0, 13/15217-5)
ALCANTARA, BERENICE KUSSUMOTO; CARVALHO, MARCIA EUGENIA AMARAL; GAZIOLA, SALETE APARECIDA; BORGES, KARINA LIMA REIS; PIOTTO, FERNANDO ANGELO; JACOMINO, ANGELO PEDRO; AZEVEDO, RICARDO ANTUNES. Tolerance of tomato to cadmium-induced stress: analyzing cultivars with different fruit colors. Environmental Science and Pollution Research, v. 28, n. 20, p. 26172-26181, . (09/54676-0, 15/26640-1, 13/15217-5)
ARALDI, CRISTHYANE GARCIA; MEDEIROS COELHO, CILEIDE MARIA; GAZIOLA, SALETE APARECIDA; AZEVEDO, RICARDO ANTUNES. Storage elicits a fast antioxidant enzyme activity in Araucaria angustifolia embryos. ACTA PHYSIOLOGIAE PLANTARUM, v. 38, n. 8, . (09/54676-0)
DOURADO, MANUELLA N.; SOUZA, LUCAS A.; MARTINS, PAULA F.; PETERS, LEILA P.; PIOTTO, FERNANDO A.; AZEVEDO, RICARDO A.. Burkholderia sp SCMS54 Triggers a Global Stress Defense in Tomato Enhancing Cadmium Tolerance. WATER AIR AND SOIL POLLUTION, v. 225, n. 10, . (09/54676-0)
CAPALDI ARRUDA, SANDRA CRISTINA; DINIZ SILVA, ALISSON LUIZ; GALAZZI, RODRIGO MORETTO; AZEVEDO, RICARDO ANTUNES; ZEZZI ARRUDA, MARCO AURELIO. Nanoparticles applied to plant science: A review. Talanta, v. 131, p. 693-705, . (13/15646-3, 09/54676-0, 12/21344-7)
DOURADO, M. N.; FRANCO, M. R.; PETERS, L. P.; MARTINS, P. F.; SOUZA, L. A.; PIOTTO, F. A.; AZEVEDO, R. A.. Antioxidant enzymes activities of Burkholderia spp. strains-oxidative responses to Ni toxicity. Environmental Science and Pollution Research, v. 22, n. 24, p. 19922-19932, . (09/54676-0)
PETERS, LEILA P.; CARVALHO, GISELLE; VILHENA, MILCA B.; CRESTE, SILVANA; AZEVEDO, RICARDO A.; MONTEIRO-VITORELLO, CLAUDIA B.. Functional analysis of oxidative burst in sugarcane smut-resistant and -susceptible genotypes. PLANTA, v. 245, n. 4, p. 749-764, . (13/15014-7, 09/54676-0, 15/07112-4)
SOUZA, LUCAS A.; PIOTTO, FERNANDO A.; DOURADO, MANUELLA N.; SCHMIDT, DAIANA; FRANCO, MONICA R.; BOARETTO, LUIS F.; TEZOTTO, TIAGO; FERREIRA, RENATO R.; AZEVEDO, RICARDO A.. Physiological and biochemical responses of Dolichos lablab L. to cadmium support its potential as a cadmium phytoremediator. Journal of Soils and Sediments, v. 17, n. 5, p. 1413-1426, . (11/21123-8, 09/54676-0)
NOGUEIROL, ROBERTA CORREA; MONTEIRO, FRANCISCO ANTONIO; AZEVEDO, RICARDO ANTUNES. Tropical soils cultivated with tomato: fractionation and speciation of Al. ENVIRONMENTAL MONITORING AND ASSESSMENT, v. 187, n. 4, . (11/23019-3, 09/54676-0)
BOARETTO, LUIS F.; CARVALHO, GISELLE; BORGO, LUCELIA; CRESTE, SILVANA; LANDELL, MARCOS G. A.; MAZZAFERA, PAULO; AZEVEDO, RICARDO A.. Water stress reveals differential antioxidant responses of tolerant and non-tolerant sugarcane genotypes. Plant Physiology and Biochemistry, v. 74, p. 165-175, . (08/58035-6, 09/54676-0)
GRATAO, PRISCILA LUPINO; MONTEIRO, CAROLINA CRISTINA; TEZOTTO, TIAGO; CARVALHO, ROGERIO FALLEIROS; ALVES, LETICIA RODRIGUES; PETERS, LEILA PRISCILA; AZEVEDO, RICARDO ANTUNES. Cadmium stress antioxidant responses and root-to-shoot communication in grafted tomato plants. BIOMETALS, v. 28, n. 5, p. 803-816, . (09/54676-0)
NOGUEIROL, ROBERTA CORREA; MONTEIRO, FRANCISCO ANTONIO; DE SOUZA JUNIOR, JOAO CARDOSO; AZEVEDO, RICARDO ANTUNES. NO3-/NH4(+) proportions affect cadmium bioaccumulation and tolerance of tomato. Environmental Science and Pollution Research, v. 25, n. 14, SI, p. 13916-13928, . (15/20625-0, 11/23019-3, 09/54676-0)
LUCAS ANJOS SOUZA; FERNANDO ANGELO PIOTTO; ROBERTA CORRÊA NOGUEIROL; RICARDO ANTUNES AZEVEDO. Use of non-hyperaccumulator plant species for the phytoextraction of heavy metals using chelating agents. Scientia Agricola, v. 70, n. 4, p. 290-295, . (09/54676-0)
CAROLINA C. MONTEIRO; MILCA B. ROLÃO; MÔNICA R. FRANCO; LEILA P. PETERS; MARIANA C. CIA; FLÁVIA R. CAPALDI; ROGÉRIO F. CARVALHO; PRISCILA L. GRATÃO; MÔNICA L. ROSSI; ADRIANA P. MARTINELLI; et al. Biochemical and histological characterization of tomato mutants. Anais da Academia Brasileira de Ciências, v. 84, n. 2, p. 573-585, . (09/54676-0)
PIOTTO, FERNANDO ANGELO; TULMANN-NETO, AUGUSTO; FRANCO, MONICA REGINA; BOARETTO, LUIS FELIPE; AZEVEDO, RICARDO ANTUNES. Rápida avaliação para seleção de plantas tolerantes a metais pesados. Crop Breeding and Applied Biotechnology, v. 14, n. 1, p. 1-7, . (09/54676-0)
NOGUEIROL, ROBERTA CORREA; MONTEIRO, FRANCISCO ANTONIO; GRATAO, PRISCILA LUPINO; BORGO, LUCELIA; AZEVEDO, RICARDO ANTUNES. Tropical soils with high aluminum concentrations cause oxidative stress in two tomato genotypes. ENVIRONMENTAL MONITORING AND ASSESSMENT, v. 187, n. 3, . (09/54676-0)
ALCANTARA, BERENICE K.; RIZZI, VANESSA; GAZIOLA, SALETE A.; AZEVEDO, RICARDO A.. Soluble amino acid profile, mineral nutrient and carbohydrate content of maize kernels harvested from plants submitted to ascorbic acid seed priming. Anais da Academia Brasileira de Ciências, v. 89, n. 1, S, p. 695-704, . (09/54676-0)
AMARAL CARVALHO, MARCIA EUGENIA; PIOTTO, FERNANDO ANGELO; NOGUEIRA, MARINA LIMA; GOMES-JUNIOR, FRANCISCO GUILHIEN; CARMIGNANI PESCARIN CHAMMA, HELENA MARIA; PIZZAIA, DANIEL; AZEVEDO, RICARDO ANTUNES. Cadmium exposure triggers genotype-dependent changes in seed vigor and germination of tomato offspring. PROTOPLASMA, v. 255, n. 4, p. 989-999, . (09/54676-0, 13/15217-5)
CARVALHO, MARCIA E. A.; PIOTTO, FERNANDO A.; GAZIOLA, SALETE A.; JACOMINO, ANGELO P.; JOZEFCZAK, MARIJKE; CUYPERS, ANN; AZEVEDO, RICARDO A.. New insights about cadmium impacts on tomato: Plant acclimation, nutritional changes, fruit quality and yield. FOOD AND ENERGY SECURITY, v. 7, n. 2, . (09/54676-0, 13/15217-5)
VILHENA, MILCA B.; FRANCO, MONICA R.; SCHMIDT, DAIANA; CARVALHO, GISELLE; AZEVEDO, RICARDO A.. Evaluation of protein extraction methods for enhanced proteomic analysis of tomato leaves and roots. Anais da Academia Brasileira de Ciências, v. 87, n. 3, p. 1853-1863, . (09/54676-0)
POMPEU, GEORGIA B.; VILHENA, MILCA B.; GRATAO, PRISCILA L.; CARVALHO, ROGERIO F.; ROSSI, MONICA L.; MARTINELLI, ADRIANA P.; AZEVEDO, RICARDO A.. Abscisic acid-deficient sit tomato mutant responses to cadmium-induced stress. PROTOPLASMA, v. 254, n. 2, p. 771-783, . (09/54676-0, 11/50982-9)
CARVALHO, R. F.; MONTEIRO, C. C.; CAETANO, A. C.; DOURADO, M. N.; GRATAO, P. L.; HADDAD, C. R. B.; PERES, L. E. P.; AZEVEDO, R. A.. Leaf senescence in tomato mutants as affected by irradiance and phytohormones. Biologia Plantarum, v. 57, n. 4, p. 749-757, . (09/54676-0)
ARRUDA, SANDRA C. C.; BARBOSA, HERBERT S.; AZEVEDO, RICARDO A.; ARRUDA, MARCO A. Z.. Comparative studies focusing on transgenic through cp4EPSPS gene and non-transgenic soybean plants: An analysis of protein species and enzymes. JOURNAL OF PROTEOMICS, v. 93, n. SI, p. 107-116, . (09/54676-0)
DOURADO, M. N.; MARTINS, P. F.; QUECINE, M. C.; PIOTTO, F. A.; SOUZA, L. A.; FRANCO, M. R.; TEZOTTO, T.; AZEVEDO, R. A.. Burkholderia sp SCMS54 reduces cadmium toxicity and promotes growth in tomato. Annals of Applied Biology, v. 163, n. 3, p. 494-507, . (09/54676-0)
PETERS, LEILA PRISCILA; CARVALHO, GISELLE; MARTINS, PAULA FABIANE; DOURADO, MANUELLA NOBREGA; VILHENA, MILCA BARTZ; PILEGGI, MARCOS; AZEVEDO, RICARDO ANTUNES. Differential Responses of the Antioxidant System of Ametryn and Clomazone Tolerant Bacteria. PLoS One, v. 9, n. 11, . (09/54676-0)
DE ALCANTARA, BERENICE K.; PIZZAIA, DANIEL; PIOTTO, FERNANDO A.; BORGO, LUCELIA; BRONDANI, GILVANO E.; AZEVEDO, RICARDO A.. Temporal dynamics of the response to Al stress in Eucalyptus grandis x Eucalyptus camaldulensis. Anais da Academia Brasileira de Ciências, v. 87, n. 2, p. 1063-1070, . (09/54676-0)
CARVALHO, ROGERIO FALLEIROS; PIOTTO, FERNANDO ANGELO; SCHMIDT, DAIANA; PETERS, LEILA PRISCILA; MONTEIRO, CAROLINA CRISTINA; AZEVEDO, RICARDO ANTUNES. Seed priming with hormones does not alleviate induced oxidative stress in maize seedlings subjected to salt stress. Scientia Agricola, v. 68, n. 5, p. 598-602, . (09/54676-0)
AMARAL CARVALHO, MARCIA EUGENIA; PIOTTO, FERNANDO ANGELO; FRANCO, MONICA REGINA; ROSSI, MONICA LANZONI; MARTINELLI, ADRIANA PINHEIRO; CUYPERS, ANN; AZEVEDO, RICARDO ANTUNES. Relationship between Mg, B and Mn status and tomato tolerance against Cd toxicity. Journal of Environmental Management, v. 240, p. 84-92, . (09/54676-0, 15/26640-1, 13/15217-5)
GEORGIA BERTONI POMPEU; GUILHERME BOVI AMBROSANO; MILCA BARTZ VILHENA; ROGÉRIO FALLEIROS CARVALHO; PRISCILA LUPINO GRATÃO; FELIPE ANDRINO; SIMONE POSSEDENTE DE LIRA; RICARDO ANTUNES AZEVEDO. Potential of hydrogen (pH) differentially modulates cadmium stress response in abscisic acid-deficient sitiens tomato mutant. Bragantia, v. 78, n. 3, p. 317-327, . (09/54676-0, 11/50982-9)
REIS BORGES, KARINA LIMA; SALVATO, FERNANDA; ALCANTARA, BERENICE KUSSUMOTO; NALIN, RAFAEL STORTO; PIOTTO, FERNANDO ANGELO; AZEVEDO, RICARDO ANTUNES. Temporal dynamic responses of roots in contrasting tomato genotypes to cadmium tolerance. ECOTOXICOLOGY, v. 27, n. 3, p. 245-258, . (09/54676-0, 16/14349-3)
CARVALHO, MARCIA E. A.; CASTRO, PAULO R. C.; KOZAK, MARCIN; AZEVEDO, RICARDO A.. The sweet side of misbalanced nutrients in cadmium-stressed plants. Annals of Applied Biology, v. 176, n. 3, . (09/54676-0, 15/26640-1, 16/14349-3, 13/15217-5)
PIOTTO, FERNANDO ANGELO; AMARAL CARVALHO, MARCIA EUGENIA; SOUZA, LUCAS ANJOS; SILVA RABELO, FLAVIO HENRIQUE; FRANCO, MONICA REGINA; BATAGIN-PIOTTO, KATHERINE DERLENE; AZEVEDO, RICARDO ANTUNES. Estimating tomato tolerance to heavy metal toxicity: cadmium as study case. Environmental Science and Pollution Research, v. 25, n. 27, SI, p. 27535-27544, . (12/03861-4, 13/15217-5, 16/05788-3, 09/54676-0, 15/26640-1)
CARVALHO, MARCIA E. A.; CASTRO, PAULO R. C.; AZEVEDO, RICARDO A.. Hormesis in plants under Cd exposure: From toxic to beneficial element?. JOURNAL OF HAZARDOUS MATERIALS, v. 384, . (09/54676-0, 15/26640-1, 13/15217-5)
KATO, FABIANA HIBARY; AMARAL CARVALHO, MARCIA EUGENIA; GAZIOLA, SALETE APARECIDA; AZEVEDO, RICARDO ANTUNES. Maize plants have different strategies to protect their developing seeds against cadmium toxicity. THEORETICAL AND EXPERIMENTAL PLANT PHYSIOLOGY, v. 32, n. 3, . (09/54676-0, 13/15217-5, 12/23981-4, 15/26640-1)
REIS BORGES, KARINA LIMA; SALVATO, FERNANDA; LOZIUK, PHILIP L.; MUDDIMAN, DAVID C.; AZEVEDO, RICARDO ANTUNES. Quantitative proteomic analysis of tomato genotypes with differential cadmium tolerance. Environmental Science and Pollution Research, v. 26, n. 25, p. 26039-26051, . (09/54676-0, 16/14349-3)
KATO, FABIANA HIBARY; CARVALHO, MARCIA EUGENIA AMARAL; GAZIOLA, SALETE APARECIDA; PIOTTO, FERNANDO ANGELO; AZEVEDO, RICARDO ANTUNES. Lysine metabolism and amino acid profile in maize grains from plants subjected to cadmium exposure. Scientia Agricola, v. 77, n. 1, . (12/23981-4, 09/54676-0, 15/26640-1, 13/15217-5)

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