Research Grants 12/51257-9 - Gravidez, Qualidade de vida - BV FAPESP
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Investigation on new risk factors and on quality of life related to diabetes or hyperglycemia diagnosis in pregnancy

Abstract

The current literature reports the risks from the association between Metabolic Syndrome and its components in pregnancies complicated by GDM or HGL, suggesting a strong inter-relationship between such conditions. Among the diagnostic criteria of the Metabolic Syndrome, BMI > 30 Kg/m2, chronic arterial hypertension and fasting glycemia >85mg/dL have been acknowledged as risk factors for GDM. However, waist circumference, increased triglycerides and reduced HDL- cholesterol have not yet been sufficiently tested and/or recognized as risk factors for GDM or HGL. Additionally, the impact of pre-existing diabetes or of its diagnosis in pregnancy on maternal psychological and physical changes or on the prognosis of the mother-fetus binomial has not been thoroughly investigated. The objectives of this study are: 1) To test waist circumference >; 80 cm, increased triglycerides (> 150 mg/dL or the specific treatment for such abnormality) and reduced HDL- cholesterol (<50 mg/dL or the specific treatment for such abnormality) as risk factors for the development of GDM or HGL; 2) To evaluate the quality of life (QL) and the psychological aspects related to depression and anxiety in pregnant women with type-1 (DM1), type-2 (DM2) and gestational (GDM) diabetes mellitus (DM) and with Mild Gestational Hyperglycemia (HGL). Methodology: In order to achieve objective 1, an observational prospective study will be used with a diagnostic validation component. The subjects will be recruited from 18 Primary Health Care Units. Ali the pregnant women who sign an informed consent form and begin prenatal care until the gestational 20th week will be included. Ali those with a previous DM diagnosis and GDM diagnosed prior to the 20th gestational week will be excluded. The demand for a first prenatal consultation at the abovementioned services was considered for calculating the sample size. By taking into account 20 to 30% of dropouts, it is estimated that approximately 500 to 580 pregnant women will be included. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VERNINI, JOICE M.; NICOLOSI, BIANCA F.; ARANTES, MARIANA A.; COSTA, ROBERTO A.; MAGALHAES, CLAUDIA G.; CORRENTE, JOSE E.; LIMA, SILVANA A. M.; RUDGE, MARILZA V.; CALDERON, IRACEMA M.. Metabolic syndrome markers and risk of hyperglycemia in pregnancy: a cross-sectional cohort study. SCIENTIFIC REPORTS, v. 10, n. 1, . (12/51257-9)
VERNINI, JOICE MONALIZA; MORELI, JUSCIELE BROGIN; MAGALHAES, CLAUDIA GARCIA; ARAUJO COSTA, ROBERTO ANTONIO; CUNHA RUDGE, MARILZA VIEIRA; PARANHOS CALDERON, IRACEMA MATTOS. Maternal and fetal outcomes in pregnancies complicated by overweight and obesity. Reproductive Health, v. 13, . (12/51257-9)
VERNINI, JOICE MONALIZA; MORELI, JUSCIELE BROGIN; ARAUJO COSTA, ROBERTO ANTONIO; NEGRATO, CARLOS ANTONIO; CUNHA RUDGE, MARILZA VIEIRA; PARANHOS CALDERON, IRACEMA MATTOS. Maternal adipokines and insulin as biomarkers of pregnancies complicated by overweight and obesity. DIABETOLOGY & METABOLIC SYNDROME, v. 8, . (12/51257-9)

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