Pesticide activities of acetogenins of native species of Annonaceae from Brazilian Savanna

• Grant number: 13/07543-0
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2013
• End date: April 30, 2016
• Field of knowledge: Biological Sciences - Botany - Applied Botany
• Principal Investigator: Déborah Yara Alves Cursino dos Santos
• Grantee: Déborah Yara Alves Cursino dos Santos
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Annonaceae is one of the richest families of wood component of the Brazilian savannas. Among the commonest species of the family are Annona coriacea, A. crassiflora, A. dioica, Duguetia furfuracea and Xylopia aromatica. One of the secondary metabolites present in the family is acetogenin, a polyketide of 35 to 37 carbons connected to a ³-lactone. The hypothesis of the present project is that acetogenins isolated from A. coriacea, A. crassiflora, A. dioica, D. furfuracea and X. aromatica should present pesticide activities. To test this hypothesis, ethylic extracts of the species will be carried out and chromatographic fractionated until the purification and isolation of the acetogenins. The extracts, fractions and compounds will be used in bioassays of allelopathic (coleoptile elongation, seeds germination and seedling growth inhibition), bactericidal, fungicidal (respiration and mycelial growth inhibition) and antiviral (reverse transcriptase inhibition) activity. Besides, initial studies of combinatorial biosynthesis involving the acetogenins of Annonaceae will be implemented and they will allow the increase of the knowledge about their production and mode of action, besides pave the way to the manufacture in large scale. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NOVAES, PAULA; PENA FERREIRA, MARCELO J.; ALVES CURSINO DOS SANTOS, DEBORAH YARA. Flavonols from Annona coriacea Mart. (Annonaceae). Biochemical Systematics and Ecology, v. 78, p. 77-80, JUN 2018. (13/07543-0)

TORRES, PRISCILA BEZERRA; NAGAI, ALICE; PALACIOS JARA, CARMEN EUSEBIA; SANTOS, JANAINA PIRES; CHOW, FUNGYI; ALVES CURSINO DOS SANTOS, DEBORAH YARA. Determination of sulfate in algal polysaccharide samples: a step-by-step protocol using microplate reader. Ocean and Coastal Research, v. 69, 2021. (13/07543-0, 13/50731-1)

PENA-HIDALGO, MIGUEL; FURTADO, LUCIANA COSTA; COSTA-LOTUFO, LETICIA V.; FERREIRA, MARCELO J. P.; SANTOS, DEBORAH Y. A. C.. Alkaloids from the Leaves of Annona crassiflora and Their Cytotoxic Activity. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 31, n. 2, p. 244-248, APR 2021. (17/18235-5, 15/17177-6, 07/06511-6, 13/07543-0)

TORRES, PRISCILA; SANTOS, JANAINA PIRES; CHOW, FUNGYI; DOS SANTOS, DEBORAH Y. A. C.. A comprehensive review of traditional uses, bioactivity potential, and chemical diversity of the genus Gracilaria (Gracilariales, Rhodophyta). ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, v. 37, p. 288-306, JAN 2019. (13/07543-0, 13/50731-1)

TORRES, PRISCILA; NOVAES, PAULA; FERREIRA, LUCIANA GARCIA; SANTOS, JANAINA PIRES; MAZEPA, ESTER; DUARTE, MARIA EUGENIA R.; NOSEDA, MIGUEL D.; CHOW, FUNGYI; DOS SANTOS, DEBORAH Y. A. C.. Effects of extracts and isolated molecules of two species of Gracilaria (Gracilariales, Rhodophyta) on early growth of lettuce. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, v. 32, p. 142-149, JUN 2018. (13/50731-1, 13/07543-0)

TORRES, PRISCILA; NAGAI, ALICE; ALVES TEIXEIRA, DARLIO INACIO; MARINHO-SORIANO, ELIANE; CHOW, FUNGYI; DOS SANTOS, DEBORAH Y. A. C.. Brazilian native species of Gracilaria (Gracilariales, Rhodophyta) as a source of valuable compounds and as nutritional supplements. JOURNAL OF APPLIED PHYCOLOGY, v. 31, n. 5, p. 3163-3173, OCT 2019. (13/07543-0, 13/50731-1)

NOVAES, P.; TORRES, P. B.; CORNU, T. A.; DE CARVALHO LOPES, J.; FERREIRA, M. J. P.; DOS SANTOS, D. Y. A. C.. Comparing antioxidant activities of flavonols from Annona coriacea by four approaches. SOUTH AFRICAN JOURNAL OF BOTANY, v. 123, p. 253-258, JUL 2019. (13/07543-0)

TORRES, PRISCILA; SANTOS, JANAINA PIRES; CHOW, FUNGYI; PENA FERREIRA, MARCELO J.; DOS SANTOS, DEBORAH Y. A. C.. Comparative analysis of in vitro antioxidant capacities of mycosporine-like amino acids (MAAs). ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, v. 34, p. 57-67, SEP 2018. (13/07543-0, 13/50731-1)