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Theranostic nanoparticles based in superparamagnetic iron oxide for skin cancer therapy by magnetic hyperthermia


The development of multifunctional devices, also called nanoparticles teranósticas (NPT - a strategy that integrates therapy and diagnosis in one step) has been showing strong growth in recent decades. However, it is still evolving and many barriers must be overcome before they can be used clinically. This project is proposed to develop theranostic nanoparticles based in magnetic nanoparticles containing targetable molecules for folate groups on its surface in order to provide skin cancer treatment by magnetic hyperthermia. The multifunctional devices will be evaluated by in vitro and in vivo assays in order to potentialize the application of this system in the nanobiomedical areas. The first part of this project to consiste in the investigation of the magnetite nanoparticles synthesis via modifications in both processes: thermal decomposition and precipitation from aqueous solution containing iron chloride partly reduced. The preparation of teranostic nanoparticles will be performed by surface functionalization with folic acid. In addition, colloidal stability and magnetic hyperthermia studies in order to optimize the system stability for applying multifunctional devices will be realized. In a second step, the synthesized TNP will be tested to determine cell viability by using different cell lines with the aim of analyzing both cytotoxicity and the TNP internalization into the cells. Permeation tests and teranostic nanoparticles dissolution by using a membrane of natural origin, as well as the layers permeation analysis into the the membrane after the TNP application will also realized. Magnetic hyperthermia assays will be performed in mice with chemically induced skin cancer in order the goal of evaluating the effectiveness of treatment via magnetic hyperthermia therapy. Therefore, the theme of this project falls in an area of strategic technology worldwide and thus it is believed that the innovative and impressive results may be obtained. (AU)

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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MA, HUI LING; VARANDA, LAUDEMIR CARLOS; PERUSSI, JANICE RODRIGUES; CARRILHO, EMANUEL. Hypericin-loaded oil-in-water nanoemulsion synthesized by ultrasonication process enhances photodynamic therapy efficiency. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 223, . (13/01284-2, 13/07276-1, 14/50867-3)
PERECIN, CAIO J.; TIRICH, BEATRIZ M.; NAGAMINE, LUIZ C. C. M.; PORTO, GABRIELA; V. ROCHA, FILLIPE; CERIZE, NATALIA N. P.; VARANDA, LAUDEMIR C.. Aqueous synthesis of magnetite nanoparticles for magnetic hyperthermia: Formation mechanism approach, high water-dispersity and stability. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 627, . (20/06501-5, 19/11242-1, 16/21371-5, 13/01284-2)
ALBERS, REBECCA F.; BINI, RAFAEL A.; SOUZA, JR., JOAO B.; MACHADO, DERIK T.; VARANDA, LAUDEMIR C.. A general one-pot synthetic strategy to reduced graphene oxide (rGO) and rGO-nanoparticle hybrid materials. Carbon, v. 143, p. 73-84, . (13/18542-4, 12/02093-3, 13/01284-2)
PERECIN, CAIO J.; SPONCHIONI, MATTIA; AURIEMMA, RENATO; CERIZE, NATALIA N. P.; MOSCATELLI, DAVIDE; VARANDA, LAUDEMIR C.. Magnetite Nanoparticles Coated with Biodegradable Zwitterionic Polymers as Multifunctional Nanocomposites for Drug Delivery and Cancer Treatment. ACS APPLIED NANO MATERIALS, v. 5, n. 11, p. 14-pg., . (20/06501-5, 13/01284-2)
BOTT-NETO, JOSE L.; BECK, JR., WATSON; VARANDA, LAUDEMIR C.; TICIANELLI, EDSON A.. Electrocatalytic activity of platinum nanoparticles supported on different phases of tungsten carbides for the oxygen reduction reaction. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, v. 42, n. 32, p. 20677-20688, . (13/16930-7, 13/01284-2)
NEVES, HERBERT R.; BINI, RAFAEL A.; BARBOSA, JEAM H. O.; SALMON, CARLOS E. G.; VARANDA, LAUDEMIR C.. Dextran-Coated Antiferromagnetic MnO Nanoparticles for a T-1-MRI Contrast Agent with High Colloidal Stability. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, v. 33, n. 3, p. 167-176, . (13/01284-2, 07/07919-9)
BINI, RAFAEL A.; SILVA, MONICA F.; VARANDA, LAUDEMIR C.; DA SILVA, MARCELO A.; DREISS, CECILE A.. Soft nanocomposites of gelatin and poly(3-hydroxybutyrate) nanoparticles for dual drug release. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 157, p. 191-198, . (13/01284-2, 07/07919-9)
MA, HUI L.; LI, WANLU; WANG, MIAN; VARANDA, LAUDEMIR C.; PERUSSI, JANICE R.; ZHANG, Y. SHRIKE; CARRILHO, EMANUEL. In vitro 3D malignant melanoma model for the evaluation of hypericin-loaded oil-in-water microemulsion in photodynamic therapy. BIO-DESIGN AND MANUFACTURING, v. 5, n. 4, p. 14-pg., . (13/01284-2, 14/50867-3, 13/07276-1)
BINI, RAFAEL A.; MORAES, DANIEL A.; VARANDA, LAUDEMIR C.. Preparation of Poly(3-hydroxybutyrate) Micro- and Nanoparticles as Hydrophobic Drugs Carrier Using Self-emulsifying Nanoemulsion Method. BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH, v. 12, n. 6, . (13/01284-2, 07/07919-9)
SECCO DE SOUZA, CAIO GUILHERME; SOUZA, JR., JOAO BATISTA; BECK, JR., WATSON; VARANDA, LAUDEMIR CARLOS. Luminomagnetic Silica-Coated Heterodimers of Core/Shell FePt/Fe3O4 and CdSe Quantum Dots as Potential Biomedical Sensor. Journal of Nanomaterials, . (12/02093-3, 13/01284-2, 07/07919-9)
SOUZA, JR., JOAO B.; VARANDA, LAUDEMIR C.. Magneto-plasmonic Au-Coated Co nanoparticles synthesized via hot-injection method. Nanotechnology, v. 29, n. 6, . (10/04208-7, 12/02093-3, 13/01284-2, 07/07919-9)
FURLAN, DAIANA M.; MORGADO, DANIELLA LURY; DE OLIVEIRA, ADILSON J. A.; FACETO, ANGELO D.; DE MORAES, DANIEL A.; VARANDA, LAUDEMIR C.; FROLLINI, ELISABETE. Sisal cellulose and magnetite nanoparticles: formation and properties of magnetic hybrid films. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, v. 8, n. 2, p. 2170-2179, . (13/07296-2, 12/00116-6, 13/01284-2, 09/54082-2)
MASCARENHAS, BRUNO C.; VARANDA, LAUDEMIR C.. Catalytic hydrogenation of organic dyes by Ag nanoparticles on reduced graphene oxide. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 103, p. 124-135, . (13/01284-2, 13/18542-4, 12/02093-3)
MORAES, DANIEL A.; SOUZA JUNIOR, JOAO B.; FERREIRA, FABIO F.; MOGILI, NAGA VISHNU V.; VARANDA, LAUDEMIR C.. Gold nanowire growth through stacking fault mechanism by oleylamine-mediated synthesis. NANOSCALE, v. 12, n. 25, p. 13316-13329, . (12/02093-3, 13/01284-2)
SECCO DE SOUZA, CAIO GUILHERME; SOUZA, JOAO BATISTA, JR.; BECK, WATSON, JR.; VARANDA, LAUDEMIR CARLOS. Luminomagnetic Silica-Coated Heterodimers of Core/Shell FePt/Fe3O4 and CdSe Quantum Dots as Potential Biomedical Sensor. Journal of Nanomaterials, v. 2017, p. 9-pg., . (13/01284-2, 12/02093-3, 07/07919-9)

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