Impact of obstructive sleep apnea and sleep duration on the progression of cardiovascular diseases

• Grant number: 12/02953-2
• Support type: Research Grants - Young Investigators Grants
• Duration: September 01, 2013 - August 31, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Luciano Ferreira Drager
• Grantee: Luciano Ferreira Drager
• Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Assoc. researchers: Carlos Eduardo Rochitte ; Geraldo Lorenzi Filho ; Isabela Judith Martins Bensenor ; Paulo Andrade Lotufo ; Pedro Alves Lemos Neto ; Raimundo Jenner Paraiso Pessoa Junior
• Associated scholarship(s): 14/00003-2 - Prevalence of obstructive sleep apnea and changes in sleep duration in patients with coronary insufficiency undergoing percutaneous angioplasty, BP.IC

Abstract

Obstructive Sleep Apnea (OSA) and sleep duration disturbances are very common medical conditions which affect not only the quality of life but also increases cardiovascular morbidity and mortality. The mechanisms by which these sleep disorders promote cardiovascular disease are still poorly explored, but it is conceivable that metabolic disregulation and the occurrence of atherosclerosis are involved. The present project aims to a comprehensive approach to the impact of OSA on metabolic parameters and markers of atherosclerosis in different populations: 1) people from the Community; 2) patients without established coronary heart disease, but with increased risk for cardiovascular disease - Metabolic Syndrome model; and 3) patients with established coronary heart disease. We will perform several epidemiological and interventional approaches to explore the potential role of OSA in the modulation of metabolic disregulation and progression of atherosclerosis. Moreover, we are going to evaluate in two of the studies whether duration of sleep can also contribute to the metabolic disregulation and atherosclerosis. The accomplishment of this project will not only provide support for a researcher not fully established but also the consolidation of a new core of sleep and extension of an important research area in an Institution with established tradition of research. At the same time, it is expected that the development of projects will result in multidisciplinary and international collaboration, support undergraduate and PhD students as well as generate innovative data with direct clinical implications. (AU)

Scientific publications

(22)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GIATTI, SORAYA; SANTOS, RONALDO B.; AIELO, ALINE N.; SILVA, WAGNER A.; PARISE, BARBARA K.; SOUZA, SILVANA P.; PIO-ABREU, ANDREA; BORTOLOTTO, LUIZ A.; LOTUFO, PAULO A.; BENSENOR, ISABELA M.; DRAGER, LUCIANO F. Association of Sodium with Obstructive Sleep Apnea The ELSA-Brasil Study. ANNALS OF THE AMERICAN THORACIC SOCIETY, v. 18, n. 3, p. 502-510, MAR 2021. Web of Science Citations: 1.

SILVA, WAGNER A.; ALMEIDA-PITITTO, BIANCA; SANTOS, RONALDO B.; AIELO, ALINE N.; GIATTI, SORAYA; PARISE, BARBARA K.; SOUZA, SILVANA P.; VIVOLO, SANDRA F.; LOTUFO, PAULO A.; BENSENOR, ISABELA M.; DRAGER, LUCIANO F. Obstructive sleep apnea is associated with lower adiponectin and higher cholesterol levels independently of traditional factors and other sleep disorders in middle-aged adults: the ELSA-Brasil cohort. Sleep and Breathing, FEB 2021. Web of Science Citations: 0.

FREITAS, LUNARA S.; SILVEIRA, ANDRE C.; MARTINS, FRANCO C.; COSTA-HONG, VALERIA; LEBKUCHEN, ADRIANA; CARDOZO, KARINA H. M.; BERNARDES, FERNANDA M.; BORTOLOTTO, LUIZ A.; LORENZI-FILHO, GERALDO; OLIVEIRA, EDILAMAR M.; DRAGER, LUCIANO F. Severe obstructive sleep apnea is associated with circulating microRNAs related to heart failure, myocardial ischemia, and cancer proliferation. Sleep and Breathing, v. 24, n. 4 JAN 2020. Web of Science Citations: 5.

SANTOS, RONALDO B.; SILVA, WAGNER A.; PARISE, BARBARA K.; GIATTI, SORAYA; AIELO, ALINE N.; SOUZA, SILVANA P.; SANTOS, ITAMAR S.; LOTUFO, PAULO A.; BENSENOR, ISABELA M.; DRAGER, LUCIANO F. Accuracy of global and/or regional anthropometric measurements of adiposity in screening sleep apnea: the ELSA-Brasil cohort. Sleep Medicine, v. 63, p. 115-121, NOV 2019. Web of Science Citations: 0.

DRAGER, LUCIANO F.; SANTOS, RONALDO B.; SILVA, WAGNER A.; PARISE, BARBARA K.; GIATTI, SORAYA; AIELO, ALINE N.; SOUZA, SILVANA P.; FURLAN, SOFIA F.; LORENZI-FILHO, GERALDO; LOTUFO, PAULO A.; BENSENOR, ISABELA M. OSA, Short Sleep Duration, and Their Interactions With Sleepiness and Cardiometabolic Risk Factors in Adults The ELSA-Brasil Study. CHEST, v. 155, n. 6, p. 1190-1198, JUN 2019. Web of Science Citations: 4.

TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; SILVA, VALDO J. D.; MAKI-NUNES, CRISTIANE; CEPEDA, FELIPE X.; ALVES, MARIA JANIEIRE N. N.; CARVALHO, GLAUCE L.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; RONDON, MARIA URBANA P. B. Diet associated with exercise improves baroreflex control of sympathetic nerve activity in metabolic syndrome and sleep apnea patients. Sleep and Breathing, v. 23, n. 1, p. 143-151, MAR 2019. Web of Science Citations: 2.

DRAGER, LUCIANO F.; LEE, CHI-HANG. Treatment of obstructive sleep apnoea as primary or secondary prevention of cardiovascular disease: where do we stand now?. CURRENT OPINION IN PULMONARY MEDICINE, v. 24, n. 6, p. 537-542, NOV 2018. Web of Science Citations: 3.

GENTA-PEREIRA, DANIEL CASTANHO; FURLAN, SOFIA F.; OMOTE, DANIEL Q.; GIORGI, DANTE M. A.; BORTOLOTTO, LUIZ A.; LORENZI-FILHO, GERALDO; DRAGER, LUCIANO F. Nondipping Blood Pressure Patterns Predict Obstructive Sleep Apnea in Patients Undergoing Ambulatory Blood Pressure Monitoring. Hypertension, v. 72, n. 4, p. 979-985, OCT 2018. Web of Science Citations: 5.

FATURETO-BORGES, FERNANDA; JENNER, RAIMUNDO; COSTA-HONG, VALERIA; LOPES, HENO F.; TEIXEIRA, SANDRA H.; MARUM, ELIAS; GIORGI, DANTE A. M.; CONSOLIM-COLOMBO, FERNANDA M.; BORTOLOTTO, LUIZ A.; LORENZI-FILHO, GERALDO; KRIEGER, EDUARDO M.; DRAGER, LUCIANO F. Does Obstructive Sleep Apnea Influence Blood Pressure and Arterial Stiffness in Response to Antihypertensive Treatment?. Hypertension, v. 72, n. 2, p. 399-407, AUG 2018. Web of Science Citations: 1.

LEBKUCHEN, ADRIANA; CARVALHO, VALDEMIR M.; VENTURINI, GABRIELA; SALGUEIRO, JESSICA S.; FREITAS, LUNARA S.; DELLAVANCE, ALESSANDRA; MARTINS, FRANCO C.; LORENZI-FILHO, GERALDO; CARDOZO, KARINA H. M.; DRAGER, LUCIANO F. Metabolomic and lipidomic profile in men with obstructive sleep apnoea: implications for diagnosis and biomarkers of cardiovascular risk. SCIENTIFIC REPORTS, v. 8, JUL 26 2018. Web of Science Citations: 4.

DRAGER, LUCIANO F.; TAVONI, THAUANY M.; SILVA, VANESSA M.; SANTOS, RAUL D.; PEDROSA, RODRIGO P.; BORTOLOTTO, LUIZ A.; VINAGRE, CARMEN G.; POLOTSKY, VSEVOLOD Y.; LORENZI-FILHO, GERALDO; MARANHAO, RAUL C. Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism. Journal of Lipid Research, v. 59, n. 6, p. 1027-1033, JUN 2018. Web of Science Citations: 2.

PEDROSA, RODRIGO P.; MAKI-NUNES, CRISTIANE; MIDLEJ-BRITO, THIAGO; LOPES, HENO F.; FREITAS, LUNARA S.; TROMBETTA, IVANI C.; TOSCHI-DIAS, EDGAR; ALVES, MARIA JANIEIRE N. N.; FRAGA, RAFFAEL F.; RONDON, MARIA U.; NEGRAO, CARLOS E.; BORTOLOTTO, LUIZ A.; LORENZI-FILHO, GERALDO; DRAGER, LUCIANO F. Predictors of Obstructive Sleep Apnea in Consecutive Patients with Metabolic Syndrome. METABOLIC SYNDROME AND RELATED DISORDERS, v. 16, n. 1, p. 2-5, FEB 2018. Web of Science Citations: 2.

UCHOA, CARLOS HENRIQUE G.; PEDROSA, RODRIGO P.; JAVAHERI, SHAHROKH; GEOVANINI, GLAUCYLARA R.; CARVALHO, MARTINHA M. B.; TORQUATRO, ANA CLAUDIA S.; LEITE, ANA PAULA D. L.; GONZAGA, CAROLINA C.; BERTOLAMI, ADRIANA; AMODEO, CELSO; PETISCO, ANA CLAUDIA G. P.; BARBOSA, JOSE EDUARDO M.; MACEDO, THIAGO A.; BORTOLOTTO, LUIZ A.; OLIVEIRA, JR., MUCIO TAVARES; LORENZI-FILHO, GERALDO; DRAGER, LUCIANO F. OSA and Prognosis After Acute Cardiogenic Pulmonary Edema The OSA-CARE Study. CHEST, v. 152, n. 6, p. 1230-1238, DEC 2017. Web of Science Citations: 9.

DRAGER, LUCIANO F.; MCEVOY, R. DOUG; BARBE, FERRAN; LORENZI-FILHO, GERALDO; REDLINE, SUSAN; COLLAB, INCOS-ACT INITIATIVE INT. Sleep Apnea and Cardiovascular Disease: Lessons From Recent Trials and Need for Team Science. Circulation, v. 136, n. 19, p. 1840-1850, NOV 7 2017. Web of Science Citations: 74.

JENNER, RAIMUNDO; FATURETO-BORGES, FERNANDA; COSTA-HONG, VALERIA; LOPES, HENO F.; TEIXEIRA, SANDRA H.; MARUM, ELIAS; GIORGI, DANTE A. M.; CONSOLIM-COLOMBO, FERNANDA M.; BORTOLOTTO, LUIZ A.; LORENZI-FILHO, GERALDO; KRIEGER, EDUARDO M.; DRAGER, LUCIANO F. Association of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension. JOURNAL OF CLINICAL HYPERTENSION, v. 19, n. 9, p. 910-918, SEP 2017. Web of Science Citations: 11.

KOO, CHIEH-YANG; DE LA TORRE, ALICIA SANCHEZ; LOO, GERMAINE; TORRE, MANUEL SANCHEZ-DE-LA; ZHANG, JUNJIE; DURAN-CANTOLLA, JOAQUIN; LI, RUOGU; MAYOS, MERCE; SETHI, RISHI; ABAD, JORGE; FURLAN, SOFIA F.; COLOMA, RAMON; HEIN, THET; HO, HEE-HWA; JIM, MAN-HONG; ONG, THUN-HOW; TAI, BEE-CHOO; TURINO, CECILIA; DRAGER, LUCIANO F.; LEE, CHI-HANG; BARBE, FERRAN. Effects of Ethnicity on the Prevalence of Obstructive Sleep Apnoea in Patients with Acute Coronary Syndrome: A Pooled Analysis of the ISAACC Trial and Sleep and Stent Study. HEART LUNG AND CIRCULATION, v. 26, n. 5, p. 486-494, MAY 2017. Web of Science Citations: 7.

LEE, CHI-HANG; SETHI, RISHI; LI, RUOGU; HO, HEE-HWA; HEIN, THET; JIM, MAN-HONG; LOO, GERMAINE; KOO, CHIEH-YANG; GAO, XIAO-FEI; CHANDRA, SHARAD; YANG, XIAO-XIAO; FURLAN, SOFIA F.; GE, ZHEN; MUNDHEKAR, AJEYA; ZHANG, WEI-WEI; UCHOA, CARLOS HENRIQUE G.; KHARWAR, RAJIV BHARAT; CHAN, PO-FUN; CHEN, SHAO-LIANG; CHAN, MARK Y.; RICHARDS, ARTHUR MARK; TAN, HUAY-CHEEM; ONG, THUN-HOW; ROLDAN, GLENN; TAI, BEE-CHOO; DRAGER, LUCIANO F.; ZHANG, JUN-JIE. Obstructive Sleep Apnea and Cardiovascular Events After Percutaneous Coronary Intervention. Circulation, v. 133, n. 21, p. 2008-2017, MAY 24 2016. Web of Science Citations: 59.

DRAGER, LUCIANO F.; POLOTSKY, VSEVOLOD Y.; O'DONNELL, CHRISTOPHER P.; CRAVO, SERGIO L.; LORENZI-FILHO, GERALDO; MACHADO, BENEDITO H. Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 309, n. 7, p. H1101-H1111, OCT 1 2015. Web of Science Citations: 37.

MESARWI, OMAR A.; SHIN, MI-KYUNG; DRAGER, LUCIANO F.; BEVANS-FONTI, SHANNON; JUN, JONATHAN C.; PUTCHA, NIRUPAMA; TORBENSON, MICHAEL S.; PEDROSA, RODRIGO P.; LORENZI-FILHO, GERALDO; STEELE, KIMBERLEY E.; SCHWEITZER, MICHAEL A.; MAGNUSON, THOMAS H.; LIDOR, ANNE O.; SCHWARTZ, ALAN R.; POLOTSKY, VSEVOLOD Y. Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea. Sleep, v. 38, n. 10, p. 1583-U84, OCT 1 2015. Web of Science Citations: 20.

MAKI-NUNES, CRISTIANE; TOSCHI-DIAS, EDGAR; CEPEDA, FELIPE X.; RONDON, MARIA URBANA P. B.; ALVES, MARIA-JANIEIRE N. N.; FRAGA, RAFFAEL F.; BRAGA, ANA MARIA F. W.; AGUILAR, ADRIANA M.; AMARO, ALINE C.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; TROMBETTA, IVANI C. Diet and exercise improve chemoreflex sensitivity in patients with metabolic syndrome and obstructive sleep apnea. OBESITY, v. 23, n. 8, p. 1582-1590, AUG 2015. Web of Science Citations: 11.

UCHOA, CARLOS HENRIQUE G.; DANZI-SOARES, NAURY DE JESUS; NUNES, FLAVIA S.; DE SOUZA, ALTAY A. L.; NERBASS, FLAVIA B.; PEDROSA, RODRIGO P.; CESAR, LUIZ ANTONIO M.; LORENZI-FILHO, GERALDO; DRAGER, LUCIANO F. Impact of OSA on Cardiovascular Events After Coronary Artery Bypass Surgery. CHEST, v. 147, n. 5, p. 1352-1360, MAY 2015. Web of Science Citations: 37.

DRAGER, LUCIANO F.; BRUNONI, ANDRE R.; JENNER, RAIMUNDO; LORENZI-FILHO, GERALDO; BENSENOR, ISABELA M.; LOTUFO, PAULO A. Effects of CPAP on body weight in patients with obstructive sleep apnoea: a meta-analysis of randomised trials. THORAX, v. 70, n. 3, p. 258-264, MAR 2015. Web of Science Citations: 91.