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Antivial activity of Bacillus SP. isolated from the marine sponge Petromica citrina against bovine viral diarrhea virus, a surrogate model ofthe Hepatitis C Virus

Grant number: 13/08663-9
Support type:Regular Research Grants - Publications - Scientific article
Duration: September 01, 2013 - February 28, 2014
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Fabiana Fantinatti-Garboggini
Grantee:Fabiana Fantinatti-Garboggini
Home Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia, SP, Brazil

Abstract

The Hepatitis C virus causes chronic infections in humans, which can develop to liver cirrhosis and hepatocellular carcinoma. The Bovine viral diarrhea virus is used as a surrogate model for antiviral assays for the HCV. From marine invertebrates and microorganisms isolated from them, extracts were prepared for assessment of their possible antiviral activity. Of the 128 tested, 2 were considered active and 1 was considered promising. The best result was obtained from the extracts produced from the Bacillus sp. isolated from the sponge Petromica citrina. The extracts 555 (500 ¼g/mL, SI>18) and 584 (150 ¼g/mL, SI 27) showed a percentage of protection of 98% against BVDV, and the extract 616, 90% of protection. All of them showed activity during the viral adsorption. Thus, various substances are active on these studied organisms and may lead to the development of drugs which ensure an alternative therapy for the treatment of hepatitis C. (AU)